AC T02042
XX
ID T02042
XX
DT 27.01.1997 (created); ewi.
DT 06.03.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA CDP-isoform4
XX
SY CCAAT displacement protein; CDP; CDP/Cux; Clox; cut homeodomain protein; cut-like homeodomain protein; Cux; Cux1; NF-muNR.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G002313 Cux1.
XX
HO cut (Drosophila).
XX
CL C0006; homeo.
XX
SZ 1332 AA; 144.3 kDa (cDNA) (calc.).
XX
SQ MSTTSKLEEAEHKLQTLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA
SQ EVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVED
SQ VQRLQASLTKLRENSASQISQLEQQLNAKNSTLKQLEEKLKGQADYEEVKKELNTLKSME
SQ FAPSEGAGTQDSTKPLEVLLLEKNRSLQSENATLRISNSDLSGSARRKGRDQPESRRPGP
SQ LPASPPPQLPRNTGEQVSNTNGTHHFSPAGLSQDFFSSNLASPSLPLASTGKFALNSLLQ
SQ RQLMQSFYSKAMQEAGSTSTIFSTGPYSTNSISSPSPLQQSPDVNGMAPSPSQSESAGSI
SQ SEGEEIDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKE
SQ PFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRIRASET
SQ GSDEAIKSILEQAKRELQVQKTAEPVQTSSTSSSGNSDDAIRSILQQARREMEAQQAALD
SQ PALKPAPLSQPDLTILTPKHLSASPMSTVSTYPPLAISLKKTPAAPETSTAALPSAPALK
SQ KEAQDVPTLDPPGSADAAQGVLRPMKSELVRGSTWKDPWWSPIQPERRNLTSSEETKADE
SQ TTASGKERAGSSQPRAERSQLQGPSASAEYWKEWPSAESPYSQSSELSLTGASRSETPQN
SQ SPLPSSPIVPMAKPAKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNGICQRIFGE
SQ KVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHS
SQ VASLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPAIETSKEGK
SQ PPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRL
SQ FGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKA
SQ YMKRRHSSVSDSQPCEPPSVGIDYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPY
SQ PSPKTIEELATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSSR
SQ AAPSSEGDSCDGVEATDAEEPGGNIVATKSQGGLAEVAAAPADREEATQPAEKAKAQPLC
SQ SGTPGQDDGEDASRPRPLPEGLADAPAPVPSLAAPAAGEDAATSATAPATATEAPGAARA
SQ GPAERSSALPSTSAPANAPARRPSSLQSLFGLPEAAAARDNPVRKKKAANLNSIIHRLEK
SQ AASREEPIEWEF
XX
SC translated from EMBL #X75013
XX
FT 68 542 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 357 444 
PF02376; CUT domain.
FT 357 444 
PS51042; CUT.
FT 746 833 
PF02376; CUT domain.
FT 746 833 
PS51042; CUT.
FT 929 1016 
PF02376; CUT domain.
FT 929 1016 
PS51042; CUT.
FT 1054 1114 
PS50071; HOMEOBOX_2.
FT 1055 1115 
PS50560; CUT_HOMEODOMAIN.
FT 1056 1118 
SM00389; HOX_1.
FT 1057 1113 PF00046; Homeobox domain.
XX
SF alternatively spliced form T01083 [5];
SF CDP-isoform4 and Cutl2 T04456 are linked on distal chromosome 5 with an interval of 2.4-13.7 cM [7];
XX
CP conflicting results for expression in skeletal muscle: + [2] or - [3] [2] [3].
EX brain,,,Theiler Stage 23; medium; Western blot; protein; [3].
EX brain,,,adult; high; Western blot; protein; [3].
EX cartilage,,,Theiler Stage 23; medium; Western blot; protein; [3].
EX cartilage,,,adult; none; Western blot; protein; [3].
EX choroid plexus of telencephalon,,,Theiler Stage 23; detectable; immunohistochemistry / immunocytochemistry; protein; [3].
EX costal cartilage,chondrocyte,,Theiler Stage 23; detectable; immunohistochemistry / immunocytochemistry; protein; [3].
EX heart,,,Theiler Stage 23; low; Western blot; protein; [3].
EX heart,,,adult; high; Western blot; protein; [3].
EX inner chondrogenic layer,,,Theiler Stage 23; detectable; immunohistochemistry / immunocytochemistry; protein; [3].
EX lens,anuclear cell,,Theiler Stage 23; none; immunohistochemistry / immunocytochemistry; protein; [3].
EX liver,,,Theiler Stage 23; low; Western blot; protein; [3].
EX liver,,,adult; none; Northern blot; total RNA; [2].
EX liver,,,adult; none; Western blot; protein; [3].
EX lung,,,Theiler Stage 23; high; Western blot; protein; [3].
EX lung,,,adult; high; Western blot; protein; [3].
EX mouse, Mus musculus,,,Theiler Stage 11; low; Northern blot; total RNA; [2].
EX mouse, Mus musculus,,,Theiler Stage 13; very low; Northern blot; total RNA; [2].
EX mouse, Mus musculus,,,Theiler Stage 15; low; Northern blot; total RNA; [2].
EX mouse, Mus musculus,,,Theiler Stage 16; very low; Western blot; protein; [3].
EX mouse, Mus musculus,,,Theiler Stage 17; high; Northern blot; total RNA; [2].
EX mouse, Mus musculus,,,Theiler Stage 19; very high; Northern blot; total RNA; [2].
EX mouse, Mus musculus,,,Theiler Stage 20; medium; Western blot; protein; [3].
EX mouse, Mus musculus,,,Theiler Stage 20; very high; Northern blot; total RNA; [2].
EX mouse, Mus musculus,,,Theiler Stage 21; medium; Western blot; protein; [3].
EX mouse, Mus musculus,,,Theiler Stage 22; high; Northern blot; total RNA; [2].
EX mouse, Mus musculus,,,Theiler Stage 23; high; Northern blot; total RNA; [2].
EX mouse, Mus musculus,,,Theiler Stage 24; medium; Northern blot; total RNA; [2].
EX mouse, Mus musculus,,,Theiler Stage 25; medium; Northern blot; total RNA; [2].
EX mouse, Mus musculus,,,Theiler Stage 26; medium; Northern blot; total RNA; [2].
EX mouse, Mus musculus,,,Theiler Stage 27; low; Northern blot; total RNA; [2].
EX mouse, Mus musculus,,,Theiler Stage 7; very low; Northern blot; total RNA; [2].
EX mouse, Mus musculus,,,Theiler Stage 9; very low; Northern blot; total RNA; [2].
EX muscles,,,Theiler Stage 23; medium; Western blot; protein; [3].
EX muscles,,,adult; none; Western blot; protein; [3].
EX spinal cord,,,Theiler Stage 23; detectable; immunohistochemistry / immunocytochemistry; protein; [3].
EX telencephalon,,,Theiler Stage 23; detectable; immunohistochemistry / immunocytochemistry; protein; [3].
XX
FF transcription factor, look up the TRANSFAC cross reference for more details;
FF transcriptional repressor [1];
FF strong inhibitor of the NCAM (neural cell adhesion molecule) promoter but inhibition is relieved by Phox-2 T02090 [2];
FF may bind to matrix attached regions (S/MARs) [4];
FF maximal expression during embryogenesis around Theiler stages 19-20 [2];
XX
MX M00104 V$CDPCR1_01.
MX M00106 V$CDPCR3HD_01.
MX M00105 V$CDPCR3_01.
MX M00095 V$CDP_01.
MX M00102 V$CDP_02.
MX M01342 V$CDP_03.
MX M01344 V$CDP_04.
MX M04610 V$CDP_Q6_01.
XX
BS R03477.
BS R00562.
BS R01677.
XX
DR TRANSPATH: MO000026114.
DR SMARTDB: SB000025.
DR EMBL: X75013;
DR UniProtKB: P53564-4;
XX
RN [1]; RE0000346.
RX PUBMED: 3181130.
RA Superti-Furga G., Barberis A., Schaffner G., Busslinger M.
RT The -117 mutation in Greek HPFH affects the binding of three nuclear factors to the CCAAT region of the gamma-globin gene
RL EMBO J. 7:3099-3107 (1988).
RN [2]; RE0004999.
RX PUBMED: 7910552.
RA Valarche T. S., Tissier-Seta J. P., Hirsch M. R., Martinez S. F., Goridis C., Brunet J. F.
RT The Mouse homeodomain protein Phox2 regulates NCAM promoter activity in concert with CUX/CDP and is a putative determinant of neurotransmitter phenotype
RL Development 119:881-896 (1993).
RN [3]; RE0005001.
RX PUBMED: 1363085.
RA Andres V., Nadal-Ginard B., Mahdavi V.
RT Clox, a mammalian homeobox gene related to Drosophila cut, encodes DNA-binding regulatory proteins differentially expressed during development
RL Development 116:321-334 (1992).
RN [4]; RE0007081.
RX PUBMED: 9218488.
RA Banan M., Rojas I. C., Lee W. H., King H. L., Harriss J.V., Kobayashi R., Web C. F., Gottlieb P. D.
RT Interaction of the nuclear matrix-associated region (MAR)-binding proteins, SATB1 and CDP/Cux, with a MAR element (L2a) in an upstream regulatory region of the mouse CD8a gene
RL J. Biol. Chem. 272:18440-18452 (1997).
RN [5]; RE0013403.
RX PUBMED: 9858552.
RA Wang Z., Goldstein A., Zong R. T., Lin D., Neufeld E. J., Scheuermann R. H., Tucker P. W.
RT Cux/CDP homeoprotein is a component of NF-muNR and represses the immunoglobulin heavy chain intronic enhancer by antagonizing the bright transcription activator
RL Mol. Cell. Biol. 19:284-295 (1999).
RN [6]; RE0015033.
RX PUBMED: 9792700.
RA Chattopadhyay S., Whitehurst C. E., Chen J.
RT A nuclear matrix attachment region upstream of the T cell receptor beta gene enhancer binds Cux/CDP and SATB1 and modulates enhancer-dependent reporter gene expression but not endogenous gene expression
RL J. Biol. Chem. 273:29838-29846 (1998).
RN [7]; RE0016102.
RX PUBMED: 8798433.
RA Quaggin S. E., Heuvel G. B., Golden K., Bodmer R., Igarashi P.
RT Primary structure, neural-specific expression, and chromosomal localization of Cux-2, a second murine homeobox gene related to Drosophila cut.
RL J. Biol. Chem. 271:22624-22634 (1996).
RN [8]; RE0048974.
RX PUBMED: 8798762.
RA Coqueret O., Berube G., Nepveu A.
RT DNA binding by cut homeodomain proteins is down-modulated by protein kinase C.
RL J. Biol. Chem. 271:24862-24868 (1996).
XX
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