AC T01083
XX
ID T01083
XX
DT 24.02.1994 (created); ewi.
DT 11.05.2012 (updated); mka.
CO Copyright (C), QIAGEN.
XX
FA CDP
XX
SY CDP; CDP/Cux; cut-like 1 (Drosophila); Cutl1; Cux; Cux-1; NF-muNR; Phox2.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G002313 Cux1.
XX
CL C0006; homeo.
XX
SZ 1293 AA; 140.9 kDa (cDNA) (calc.), 160 kDa (sed.) [3]
XX
SQ TLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKSQAETIALEKEQKLQNDFAEKERKLQ
SQ ETQMSTTSKLEEAEHKLQTLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN
SQ QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQL
SQ VEDVQRLQASLTKLRENSASQISQLEQQLNAKNSTLKQLEEKLKGQADYEEVKKELNTLK
SQ SMEFAPSEGAGTQDSTKPLEVLLLEKNRSLQSENATLRISNSDLSGPYSTNSISSPSPLQ
SQ QSPDVNGMAPSPSQSESAGSISEGEEIDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQG
SQ SVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQE
SQ VPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPVQTSSTSSSGNSDD
SQ AIRSILQQARREMEAQQAALDPALKPAPLSQPDLTILTPKHLSASPMSTVSTYPPLAISL
SQ KKTPAAPETSTAALPSAPALKKEAQDVPTLDPPGSADAAQGVLRPMKSELVRGSTWKDPW
SQ WSPIQPERRNLTSSEETKADETTASGKERAGSSQPRAERSQLQGPSASAEYWKEWPSAES
SQ PYSQSSELSLTGASRSETPQNSPLPSSPIVPMAKPAKPSVPPLTPEQYEVYMYQEVDTIE
SQ LTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLN
SQ GELGQGVLPVQGQQQGPVLHSVASLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESV
SQ KSLTELVQQPCPAIETSKEGKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELD
SQ TYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQL
SQ WLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGIDYSQGASPQPQHQLKKP
SQ RVVLAPEEKEALKRAYQQKPYPSPKTIEELATQLNLKTSTVINWFHNYRSRIRRELFIEE
SQ IQAGSQGQAGASDSPSARSSRAAPSSEGDSCDGVEATDAEEPGGNIVATKSQGGLAEVAA
SQ APADREEATQPAEKAKAQPLCSGTPGQDDGEDASRPRPLPEGLADAPAPVPSLAAPAAGE
SQ DAATSATAPATATEAPGAARAGPAERSSALPSTSAPANAPARRPSSLQSLFGLPEAAGAR
SQ DNLVRKKKAANLNSIIHRLEKAASREEPIEWEF
XX
SC translated from EMBL #AF004225
XX
FT 131 503 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 318 405 
PF02376; CUT domain.
FT 318 405 
PS51042; CUT.
FT 707 794 
PF02376; CUT domain.
FT 707 794 
PS51042; CUT.
FT 890 977 
PF02376; CUT domain.
FT 890 977 
PS51042; CUT.
FT 1015 1075 
PS50071; HOMEOBOX_2.
FT 1016 1076 
PS50560; CUT_HOMEODOMAIN.
FT 1017 1079 
SM00389; HOX_1.
FT 1018 1074 PF00046; Homeobox domain.
XX
SF alternatively spliced form of Cux/CDP T02042 [4];
SF originally suggested to be a tetramer of 40-kDa subunits [3];
SF addition of Zn2+ chelator or excess Zn2+ decreases binding [3];
XX
CP widespread; IgH non-expressing cells.
CN mature B cells [3].
XX
FF negative regulator of IgH enhancer [1];
FF transcription factor, look up the TRANSFAC cross reference for more details;
FF bound regions flanking the IgH enhancer correspond to S/MARs [4];
FF inhibits matrix attachment [2];
XX
MX M00104 V$CDPCR1_01.
MX M00106 V$CDPCR3HD_01.
MX M00105 V$CDPCR3_01.
MX M00095 V$CDP_01.
MX M00102 V$CDP_02.
MX M01342 V$CDP_03.
MX M01344 V$CDP_04.
MX M04610 V$CDP_Q6_01.
XX
BS R03633.
BS R03634.
BS R03635.
BS R03636.
BS R03637.
XX
DR TRANSPATH: MO000025388.
DR SMARTDB: SB000011.
DR EMBL: AF004225; MMAF4225.
DR UniProtKB: P53564; CUTL1_MOUSE.
XX
RN [1]; RE0000776.
RX PUBMED: 2792763.
RA Scheuermann R. H., Chen U.
RT A developmental-specific factor binds to suppressor sites flanking the immunglobulin heavy-chain enhancer
RL Genes Dev. 3:1255-1266 (1989).
RN [2]; RE0006987.
RX PUBMED: 7592598.
RA Zong R.-T., Scheuermann R. H.
RT Mutually exclusive interaction of a novel matrix attachment region binding protein and the NF-muNR enhancer repressor
RL J. Biol. Chem. 270:24010-24018 (1995).
RN [3]; RE0007452.
RX PUBMED: 1730623.
RA Scheuermann R. H.
RT The tetrameric structure of NF-muNR provides a mechanism cooperative binding to the immunoglobulin heavy chain mu enhancer
RL J. Biol. Chem. 267:624-634 (1992).
RN [4]; RE0013403.
RX PUBMED: 9858552.
RA Wang Z., Goldstein A., Zong R. T., Lin D., Neufeld E. J., Scheuermann R. H., Tucker P. W.
RT Cux/CDP homeoprotein is a component of NF-muNR and represses the immunoglobulin heavy chain intronic enhancer by antagonizing the bright transcription activator
RL Mol. Cell. Biol. 19:284-295 (1999).
XX
//