AC T10516
XX
ID T10516
XX
DT 10.03.2005 (created); nvo.
DT 09.03.2016 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA HIF-1alpha
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SY HIF1alpha; hypoxia Induced Factor 1 alpha; hypoxia-inducible factor 1alpha; member of PAS superfamily 1; MOP1.
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OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
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IN T10504 AP-2alpha; Mammalia.
IN T10818 arnt; Mammalia.
IN T10835 arnt; human, Homo sapiens.
IN T15204 brca1; Mammalia.
IN T09446 c-Jun; Mammalia.
IN T17679 c-Myb; Mammalia.
IN T10531 Egr-1; Mammalia.
IN T02269 elongin C; human, Homo sapiens.
IN T23091 p300; Mammalia.
IN T10303 Pax-5; Mammalia.
IN T29721 Pkm2-isoform-M2; human, Homo sapiens.
IN T30232 Pkm2; human, Homo sapiens.
IN T09538 Smad3; Mammalia.
IN T13998 Smad4; Mammalia.
IN T16672 STAT4; Mammalia.
IN T10807 USF; Mammalia.
IN T09133 YY1; Mammalia.
XX
MX M00976 V$AHRHIF_Q6.
MX M07384 V$HIF1A_Q3.
MX M07043 V$HIF1A_Q5.
MX M02012 V$HIF1A_Q6.
MX M00797 V$HIF1_Q3.
MX M00466 V$HIF1_Q5.
XX
BS R40617.
BS R59190.
BS R59192.
BS R59193.
BS R59194.
BS R59195.
BS R58827.
BS R03219.
BS R24274.
BS R33976.
BS R41060.
BS R30547.
BS R68716.
BS R21396.
BS R60505.
BS R61946.
BS R61949.
BS R66696.
BS R58843.
BS R60855.
BS R28527.
BS R30398.
BS R68301.
BS R66241.
BS R60858.
BS R66222.
XX
DR TRANSPATH: MO000047968.
XX
RN [1]; RE0021482.
RX PUBMED: 12097158.
RA Tsuchiya T., Kominato Y., Ueda M.
RT Human Hypoxic Signal Transduction through a Signature Motif in Hepatocyte Nuclear Factor 4
RL J. Biochem. 132:37-44 (2002).
RN [2]; RE0022199.
RX PUBMED: 11486006.
RA Sanchez-Elsner T., Botella L. M., Velasco B., Corbi A., Attisano L., Bernabeu C.
RT Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression.
RL J. Biol. Chem. 276:38527-38535 (2001).
RN [3]; RE0022293.
RX PUBMED: 11593383.
RA Suzuki H., Tomida A., Tsuruo T.
RT Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia.
RL Oncogene 20:5779-5788 (2001).
RN [4]; RE0022308.
RX PUBMED: 11641274.
RA Mahon P. C., Hirota K., Semenza G. L.
RT FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity.
RL Genes Dev. 15:2675-2686 (2001).
RN [5]; RE0022373.
RX PUBMED: 10551817.
RA Richard D. E., Berra E., Gothie E., Roux D., Pouyssegur J.
RT p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.
RL J. Biol. Chem. 274:32631-32637 (1999).
RN [6]; RE0022420.
RX PUBMED: 11707426.
RA Bae M.-K., Ahn M.-Y., Jeong J.-W., Bae M.-H., Lee Y. M., Bae S.-K., Park J.-W., Kim K.-R., Kim K.-W.
RT Jab1 interacts directly with HIF-1alpha and regulates its stability.
RL J. Biol. Chem. 277:9-12 (2002).
RN [7]; RE0025788.
RX PUBMED: 15121835.
RA Laderoute K. R., Calaoagan J. M., Knapp M., Johnson R. S.
RT Glucose utilization is essential for hypoxia-inducible factor 1 alpha-dependent phosphorylation of c-Jun.
RL Mol. Cell. Biol. 24:4128-37 (2004).
RN [8]; RE0026527.
RX PUBMED: 10799490.
RA Takahashi Y., Takahashi S., Shiga Y., Yoshimi T., Miura T.
RT Hypoxic induction of prolyl 4-hydroxylase alpha (I) in cultured cells.
RL J. Biol. Chem. 275:14139-46 (2000).
RN [9]; RE0026600.
RX PUBMED: 10777486.
RA Mukhopadhyay C. K., Mazumder B., Fox P. L.
RT Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency.
RL J. Biol. Chem. 275:21048-54 (2000).
RN [10]; RE0027898.
RX PUBMED: 11120745.
RA Chen C., Pore N., Behrooz A., Ismail-Beigi F., Maity A.
RT Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia.
RL J. Biol. Chem. 276:9519-25 (2001).
RN [11]; RE0029520.
RX PUBMED: 12023962.
RA Spinella F., Rosano L., Di Castro V., Natali P. G., Bagnato A.
RT Endothelin-1 Induces Vascular Endothelial Growth Factor by Increasing Hypoxia-inducible Factor-1alpha in Ovarian Carcinoma Cells.
RL J. Biol. Chem. 277:27850-5 (2002).
RN [12]; RE0029666.
RX PUBMED: 11440977.
RA Gorlach A., Diebold I., Schini-Kerth V. B., Berchner-Pfannschmidt U., Roth U., Brandes R. P., Kietzmann T., Busse R.
RT Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22(phox)-containing NADPH oxidase.
RL Circ. Res. 89:47-54 (2001).
RN [13]; RE0030565.
RX PUBMED: 12937141.
RA Stoeltzing O., Liu W., Reinmuth N., Fan F., Parikh A. A., Bucana C. D., Evans D. B., Semenza G. L., Ellis L. M.
RT Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer.
RL Am. J. Pathol. 163:1001-11 (2003).
RN [14]; RE0030994.
RX PUBMED: 15082785.
RA Lee M. J., Kim J. Y., Suk K., Park J. H.
RT Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway.
RL Mol. Cell. Biol. 24:3918-27 (2004).
RN [15]; RE0031493.
RX PUBMED: 15081411.
RA Menzies K., Liu B., Kim W. J., Moschella M. C., Taubman M. B.
RT Regulation of the SM-20 prolyl hydroxylase gene in smooth muscle cells.
RL Biochem. Biophys. Res. Commun. 317:801-10 (2004).
RN [16]; RE0032043.
RX PUBMED: 14729605.
RA Choi J. W., Park S. C., Kang G. H., Liu J. O., Youn H. D.
RT Nur77 activated by hypoxia-inducible factor-1alpha overproduces proopiomelanocortin in von Hippel-Lindau-mutated renal cell carcinoma.
RL Cancer Res. 64:35-9 (2004).
RN [17]; RE0032448.
RX PUBMED: 10749120.
RA Zhong H., Chiles K., Feldser D., Laughner E., Hanrahan C., Georgescu M. M., Simons J. W., Semenza G. L.
RT Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.
RL Cancer Res. 60:1541-5 (2000).
RN [18]; RE0033103.
RX PUBMED: 12761217.
RA Tang T. T., Lasky L. A.
RT The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism.
RL J. Biol. Chem. 278:30125-35 (2003).
RN [19]; RE0034402.
RX PUBMED: 15191555.
RA Kwon Y. W., Kwon K. S., Moon H. E., Ae Park J., Choi K. S., Kim Y. S., Jang H. S., Oh C. K., Lee Y. M., Kwon Y. G., Lee Y. S., Kim K. W.
RT Insulin-like growth factor-II regulates the expression of vascular endothelial growth factor by the human keratinocyte cell line HaCaT.
RL J. Invest. Dermatol 123:152-8 (2004).
RN [20]; RE0034409.
RX PUBMED: 12939282.
RA Kunz M., Moeller S., Koczan D., Lorenz P., Wenger R. H., Glocker M. O., Thiesen H. J., Gross G., Ibrahim S. M.
RT Mechanisms of hypoxic gene regulation of angiogenesis factor Cyr61 in melanoma cells.
RL J. Biol. Chem. 278:45651-60 (2003).
RN [21]; RE0034571.
RX PUBMED: 15300796.
RA Zhang Q., Zhang Z. F., Rao J. Y., Sato J. D., Brown J., Messadi D. V., Le A. D.
RT Treatment with siRNA and antisense oligonucleotides targeted to HIF-1alpha induced apoptosis in human tongue squamous cell carcinomas.
RL Int. J. Cancer 111:849-57 (2004).
RN [22]; RE0034655.
RX PUBMED: 15280364.
RA Kato H., Tamamizu-Kato S., Shibasaki F.
RT Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity.
RL J. Biol. Chem. 279:41966-74 (2004).
RN [23]; RE0034881.
RX PUBMED: 15047156.
RA Khomenko T., Deng X., Sandor Z., Tarnawski A. S., Szabo S.
RT Cysteamine alters redox state, HIF-1alpha transcriptional interactions and reduces duodenal mucosal oxygenation: novel insight into the mechanisms of duodenal ulceration.
RL Biochem. Biophys. Res. Commun. 317:121-7 (2004).
RN [24]; RE0035053.
RX PUBMED: 11895478.
RA Iida T., Mine S., Fujimoto H., Suzuki K., Minami Y., Tanaka Y.
RT Hypoxia-inducible factor-1alpha induces cell cycle arrest of endothelial cells.
RL Genes Cells 7:143-9 (2002).
RN [25]; RE0037659.
RX PUBMED: 12464182.
RA Jeong J. W., Bae M. K., Ahn M. Y., Kim S. H., Sohn T. K., Bae M. H., Yoo M. A., Song E. J., Lee K. J., Kim K. W.
RT Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation
RL Cell 111:709-20 (2002).
RN [26]; RE0037666.
RX PUBMED: 12912907.
RA Berra E., Benizri E., Ginouves A., Volmat V., Roux D., Pouyssegur J.
RT HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
RL EMBO J. 22:4082-90 (2003).
RN [27]; RE0037775.
RX PUBMED: 12885785.
RA Leonard M. O., Cottell D. C., Godson C., Brady H. R., Taylor C. T.
RT The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia
RL J. Biol. Chem. 278:40296-304 (2003).
RN [28]; RE0037935.
RX PUBMED: 12370277.
RA Synnestvedt K., Furuta G. T., Comerford K. M., Louis N., Karhausen J., Eltzschig H. K., Hansen K. R., Thompson L. F., Colgan S. P.
RT Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia
RL J. Clin. Invest. 110:993-1002 (2002).
RN [29]; RE0040633.
RX PUBMED: 12670503.
RA Cioffi C. L., Liu X. Q., Kosinski P. A., Garay M., Bowen B. R.
RT Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells
RL Biochem. Biophys. Res. Commun. 303:947-53 (2003).
RN [30]; RE0041536.
RX PUBMED: 15016652.
RA Suliman H. B., Ali M., Piantadosi C. A.
RT Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia
RL Blood 104:43-50 (2004).
RN [31]; RE0041652.
RX PUBMED: 11940656.
RA Sang N., Fang J., Srinivas V., Leshchinsky I., Caro J.
RT Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP
RL Mol. Cell. Biol. 22:2984-92 (2002).
RN [32]; RE0042943.
RX PUBMED: 15184875.
RA Grabmaier K., A. de Weijert MC, Verhaegh G. W., Schalken J. A., Oosterwijk E.
RT Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma
RL Oncogene 23:5624-31 (2004).
RN [33]; RE0045306.
RX PUBMED: 11909946.
RA Laderoute K. R., Calaoagan J. M., Gustafson-Brown C., Knapp A. M., Li G. C., Mendonca H. L., Ryan H. E., Wang Z., Johnson R. S.
RT The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent
RL Mol. Cell. Biol. 22:2515-23 (2002).
RN [34]; RE0045843.
RX PUBMED: 15210114.
RA Nakayama K., Frew I. J., Hagensen M., Skals M., Habelhah H., Bhoumik A., Kadoya T., Erdjument-Bromage H., Tempst P., Frappell P. B., Bowtell D. D., Ronai Z.
RT Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia
RL Cell 117:941-52 (2004).
RN [35]; RE0046686.
RX PUBMED: 11532856.
RA Tacchini L., Dansi P., Matteucci E., Desiderio M. A.
RT Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells
RL Carcinogenesis 22:1363-71 (2001).
RN [36]; RE0046696.
RX PUBMED: 11504942.
RA Yu F., White S. B., Zhao Q., Lee F. S.
RT HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation
RL Proc. Natl. Acad. Sci. USA 98:9630-5 (2001).
RN [37]; RE0046697.
RX PUBMED: 10944113.
RA Tanimoto K., Makino Y., Pereira T., Poellinger L.
RT Mechanism of regulation of the hypoxia-inducible factor-1alpha by the von hippel-lindau tumor suppressor protein
RL EMBO J. 19:4298-309 (2000).
RN [38]; RE0046745.
RX PUBMED: 12524225.
RA Dichtl W., Dulak J., Frick M., Alber H. F., Schwarzacher S. P., Ares M. P., Nilsson J., Pachinger O., Weidinger F.
RT HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells
RL Arterioscler. Thromb. Vasc. Biol. 23:58-63 (2003).
RN [39]; RE0046746.
RX PUBMED: 12697836.
RA Turcotte S., Desrosiers R. R., Beliveau R.
RT HIF-1alpha mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma
RL J. Cell Sci. 116:2247-60 (2003).
RN [40]; RE0046747.
RX PUBMED: 11956326.
RA Li J., Shworak N. W., Simons M.
RT Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites
RL J. Cell Sci. 115:1951-9 (2002).
RN [41]; RE0046753.
RX PUBMED: 12719791.
RA Gorlach A., Berchner-Pfannschmidt U., Wotzlaw C., Cool R. H., Fandrey J., Acker H., Jungermann K., Kietzmann T.
RT Reactive oxygen species modulate HIF-1 mediated PAI-1 expression: involvement of the GTPase Rac1
RL Thromb. Haemost. 89:926-35 (2003).
RN [42]; RE0046808.
RX PUBMED: 11566189.
RA Haddad J. J., Land S. C.
RT A non-hypoxic, ROS-sensitive pathway mediates TNF-alpha-dependent regulation of HIF-1alpha
RL FEBS Lett. 505:269-74 (2001).
RN [43]; RE0046809.
RX PUBMED: 12958148.
RA Jung Y. J., Isaacs J. S., Lee S., Trepel J., Neckers L.
RT IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis
RL FASEB J. 17:2115-7 (2003).
RN [44]; RE0046810.
RX PUBMED: 12401798.
RA Liu X. H., Kirschenbaum A., Lu M., Yao S., Dosoretz A., Holland J. F., Levine A. C.
RT Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line
RL J. Biol. Chem. 277:50081-6 (2002).
RN [45]; RE0046811.
RX PUBMED: 12234775.
RA Malhotra R., Tyson D. G., Sone H., Aoki K., Kumagai A. K., Brosius F. C. 3rd.
RT Glucose uptake and adenoviral mediated GLUT1 infection decrease hypoxia-induced HIF-1alpha levels in cardiac myocytes
RL J. Mol. Cell. Cardiol. 34:1063-73 (2002).
RN [46]; RE0046814.
RX PUBMED: 12154057.
RA Kaluz S., Kaluzova M., Chrastina A., Olive P. L., Pastorekova S., Pastorek J., Lerman M. I., Stanbridge E. J.
RT Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 alpha stabilization: a role for phosphatidylinositol 3'-kinase
RL Cancer Res. 62:4469-77 (2002).
RN [47]; RE0046815.
RX PUBMED: 9697772.
RA Carmeliet P., Dor Y., Herbert J. M., Fukumura D., Brusselmans K., Dewerchin M., Neeman M., Bono F., Abramovitch R., Maxwell P., Koch C. J., Ratcliffe P., Moons L., Jain R. K., Collen D., Keshert E., Keshet E.
RT Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
RL Nature 394:485-90 (1998).
RN [48]; RE0046851.
RX PUBMED: 11591789.
RA Qian J., Ramroop K., McLeod A., Bandari P., Livingston D. H., Harrison J. S., Rameshwar P.
RT Induction of hypoxia-inducible factor-1alpha and activation of caspase-3 in hypoxia-reoxygenated bone marrow stroma is negatively regulated by the delayed production of substance p
RL J. Immunol. 167:4600-8 (2001).
RN [49]; RE0046852.
RX PUBMED: 15169887.
RA Wakisaka N., Kondo S., Yoshizaki T., Murono S., Furukawa M., Pagano J. S.
RT Epstein-Barr virus latent membrane protein 1 induces synthesis of hypoxia-inducible factor 1 alpha
RL Mol. Cell. Biol. 24:5223-34 (2004).
RN [50]; RE0048835.
RX PUBMED: 15876874.
RA Rizos H., Woodruff S., Kefford R. F.
RT p14ARF interacts with the SUMO-conjugating enzyme Ubc9 and promotes the sumoylation of its binding partners.
RL Cell Cycle 4:597-603 (2005).
RN [51]; RE0050474.
RX PUBMED: 16543242.
RA Kang H. J., Kim H. J., Rih J. K., Mattson T. L., Kim K. W., Cho C. H., Isaacs J. S., Bae I.
RT BRCA1 plays a role in the hypoxic response by regulating HIF-1alpha stability and by modulating vascular endothelial growth factor expression.
RL J. Biol. Chem. 281:13047-13056 (2006).
RN [52]; RE0064662.
RX PUBMED: 17875644.
RA Baek J. H., Liu Y. V., McDonald K. R., Wesley J. B., Zhang H., Semenza G. L.
RT Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha.
RL J. Biol. Chem. 282:33358-33366 (2007).
RN [53]; RE0066737.
RX PUBMED: 19648120.
RA Mahimainathan L., Ghosh-Choudhury N., Venkatesan B., Das F., Mandal C. C., Dey N., Habib S. L., Kasinath B. S., Abboud H. E., Ghosh Choudhury G.
RT TSC2 deficiency increases PTEN via HIF1alpha.
RL J. Biol. Chem. 284:27790-27798 (2009).
RN [54]; RE0068728.
RX PUBMED: 16288748.
RA Arnesen T., Kong X., Evjenth R., Gromyko D., Varhaug J. E., Lin Z., Sang N., Caro J., Lillehaug J. R.
RT Interaction between HIF-1 alpha (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1 alpha.
RL FEBS Lett. 579:6428-6432 (2005).
RN [55]; RE0068774.
RX PUBMED: 15721254.
RA Baek J. H., Mahon P. C., Oh J., Kelly B., Krishnamachary B., Pearson M., Chan D. A., Giaccia A. J., Semenza G. L.
RT OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.
RL Mol. Cell 17:503-512 (2005).
RN [56]; RE0068794.
RX PUBMED: 18838541.
RA Koh M. Y., Darnay B. G., Powis G.
RT Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation.
RL Mol. Cell. Biol. 28:7081-7095 (2008).
RN [57]; RE0068903.
RX PUBMED: 19147576.
RA Aprelikova O., Pandolfi S., Tackett S., Ferreira M., Salnikow K., Ward Y., Risinger J. I., Barrett J. C., Niederhuber J.
RT Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response.
RL Cancer Res. 69:616-624 (2009).
RN [58]; RE0069699.
RX PUBMED: 16397226.
RA Csiki I., Yanagisawa K., Haruki N., Nadaf S., Morrow J. D., Johnson D. H., Carbone D. P.
RT Thioredoxin-1 modulates transcription of cyclooxygenase-2 via hypoxia-inducible factor-1alpha in non-small cell lung cancer.
RL Cancer Res. 66:143-150 (2006).
RN [59]; RE0070477.
RX PUBMED: 21193393.
RA Ryu J. H., Li S. H., Park H. S., Park J. W., Lee B., Chun Y. S.
RT Hypoxia-inducible factor alpha subunit stabilization by NEDD8 conjugation is reactive oxygen species-dependent.
RL J. Biol. Chem. 286:6963-6970 (2011).
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