TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T10504 AS T10355. XX ID T10504 XX DT 10.03.2005 (created); nvo. DT 19.05.2016 (updated); mka. CO Copyright (C), QIAGEN. XX FA AP-2alpha XX SY Activating enhancer-binding protein 2 alpha; Activating Protein 2; activator protein 2; AP-2 alpha; AP2-ALPHA; transcription factor AP-2 alpha. XX OS Mammalia OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia XX IN T10504 AP-2alpha; Mammalia. IN T15118 CBP; Mammalia. IN T10531 Egr-1; Mammalia. IN T10446 GR; Mammalia. IN T10516 HIF-1alpha; Mammalia. IN T10358 HMGIY; Mammalia. IN T32083 MRG-1; Mammalia. IN T23091 p300; Mammalia. IN T15350 PARP; Mammalia. IN T08326 Sp1; Mammalia. IN T16163 YB-1; Mammalia. IN T09133 YY1; Mammalia. XX MX M00469 V$AP2ALPHA_01. MX M01045 V$AP2ALPHA_02. MX M01047 V$AP2ALPHA_03. MX M07348 V$AP2ALPHA_Q4. MX M01857 V$AP2ALPHA_Q6. MX M00800 V$AP2_Q3. MX M08867 V$AP2_Q4. MX M00189 V$AP2_Q6. MX M00915 V$AP2_Q6_01. XX BS R41764. BS R21157. BS R21158. BS R73252. BS R73253. BS R73254. BS R73255. BS R73256. BS R29849. BS R29851. BS R29961. BS R31522. BS R35627. BS R21565. BS R21357. BS R18717. BS R20846. BS R23633. BS R23634. BS R24816. BS R24817. BS R30085. BS R33131. BS R20914. BS R20915. BS R20916. BS R20919. BS R20920. BS R20923. BS R20925. BS R20926. BS R20927. BS R20929. BS R20930. BS R20932. BS R20933. BS R20935. BS R20936. BS R21485. BS R41269. BS R41271. BS R20964. BS R21704. BS R64833. BS R69048. BS R69050. BS R33677. BS R04905. BS R21394. BS R37497. BS R37502. XX DR TRANSPATH: MO000046930. DR TRANSCOMPEL: C00346. DR TRANSCOMPEL: C00473. DR TRANSCOMPEL: C00588. XX RN [1]; RE0011067. RX PUBMED: 7813465. RA Thompson D. A., Cronin C. N., Martin F. RT Genomic cloning and sequence analyses of the bovine alpha-, beta A- and beta B-inhibin/activin genes, Identification of transcription factor AP-2-binding sites in the 5-flanking regions by DNase I footprinting RL Eur. J. Biochem. 226:751-764 (1994). RN [2]; RE0014878. RX PUBMED: 10428853. RA Spychala J., Zimmermann A. G., Mitchell B. S. RT Tissue-specific regulation of the ecto-5'-nucleotidase promoter. Role of the camp response element site in mediating repression by the upstream regulatory region RL J. Biol. Chem. 274:22705-22712 (1999). RN [3]; RE0018469. RX PUBMED: 10842319. RA Chikuma S., Murakami M., Tanaka K., Uede T. RT Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4 RL J. Cell. Biochem. 78:241-250 (2000). RN [4]; RE0022724. RX PUBMED: 12072434. RA Eloranta J. J., Hurst H. C. RT Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo. RL J. Biol. Chem. 277:30798-30804 (2002). RN [5]; RE0022748. RX PUBMED: 12586840. RA Braganca J., Eloranta J. J., Bamforth S. D., Ibbitt J. C., Hurst H. C., Bhattacharya S. RT Physical and functional interactions between AP-2 transcription factors, p300/CBP, and CITED2. RL J. Biol. Chem. 278:16021-16029 (2003). RN [6]; RE0022749. RX PUBMED: 11694877. RA Bamforth S. D., Braganca J., Eloranta J. J., Murdoch J. N., Marques F. I., Kranc K. R., Farza H., Henderson D. J., Hurst H. C., Bhattacharya S. RT Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator. RL Nat. Genet. 29:469-474 (2001). RN [7]; RE0029981. RX PUBMED: 12169688. RA Uchida C., Oda T., Sugiyama T., Otani S., Kitagawa M., Ichiyama A. RT The role of Sp1 and AP-2 in basal and protein kinase A--induced expression of mitochondrial serine:pyruvate aminotransferase in hepatocytes. RL J. Biol. Chem. 277:39082-39092 (2002). RN [8]; RE0030014. RX PUBMED: 12391156. RA Decary S., Decesse J. T., Ogryzko V., Reed J. C., Naguibneva I., Harel-Bellan A., Cremisi C. E. RT The retinoblastoma protein binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2. RL Mol. Cell. Biol. 22:7877-88 (2002). RN [9]; RE0031310. RX PUBMED: 12504852. RA Yahata T., Takedatsu H., Dunwoodie S. L., Braganca J., Swingler T., Withington S. L., Hur J., Coser K. R., Isselbacher K. J., Bhattacharya S., Shioda T. RT Cloning of mouse Cited4, a member of the CITED family p300/CBP-binding transcriptional coactivators: induced expression in mammary epithelial cells. RL Genomics 80:601-13 (2002). RN [10]; RE0032766. RX PUBMED: 13679060. RA Khomenko T., Deng X., Jadus M. R., Szabo S. RT Effect of cysteamine on redox-sensitive thiol-containing proteins in the duodenal mucosa. RL Biochem. Biophys. Res. Commun. 309:910-6 (2003). RN [11]; RE0033066. RX PUBMED: 9795195. RA Wong D. L., Siddall B. J., Ebert S. N., Bell R. A., Her S. RT Phenylethanolamine N-methyltransferase gene expression: synergistic activation by Egr-1, AP-2 and the glucocorticoid receptor. RL Brain Res. Mol. Brain Res. 61:154-61 (1998). RN [12]; RE0033479. RX PUBMED: 9889285. RA Kannan P., Yu Y., Wankhade S., Tainsky M. A. RT PolyADP-ribose polymerase is a coactivator for AP-2-mediated transcriptional activation. RL Nucleic Acids Res. 27:866-74 (1999). RN [13]; RE0034881. RX PUBMED: 15047156. RA Khomenko T., Deng X., Sandor Z., Tarnawski A. S., Szabo S. RT Cysteamine alters redox state, HIF-1alpha transcriptional interactions and reduces duodenal mucosal oxygenation: novel insight into the mechanisms of duodenal ulceration. RL Biochem. Biophys. Res. Commun. 317:121-7 (2004). RN [14]; RE0035343. RX PUBMED: 12642581. RA Yu S., Asa S. L., Weigel R. J., Ezzat S. RT Pituitary tumor AP-2alpha recognizes a cryptic promoter in intron 4 of fibroblast growth factor receptor 4. RL J. Biol. Chem. 278:19597-19602 (2003). RN [15]; RE0036998. RX PUBMED: 10998423. RA Fujimori K., Kanaoka Y., Sakaguchi Y., Urade Y. RT Transcriptional activation of the human hematopoietic prostaglandin D synthase gene in megakaryoblastic cells. ROLES OF THE oct-1 ELEMENT IN THE 5'-FLANKING REGION AND THE AP-2 ELEMENT IN THE UNTRANSLATED EXON 1 RL J. Biol. Chem. 275:40511-6 (2000). RN [16]; RE0037691. RX PUBMED: 9446614. RA Coda L., Salcini A. E., Confalonieri S., Pelicci G., Sorkina T., Sorkin A., Pelicci P. G., Di Fiore P. P. RT Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization RL J. Biol. Chem. 273:3003-12 (1998). RN [17]; RE0038096. RX PUBMED: 11018030. RA Wu F., Lee A. S. RT YY1 as a regulator of replication-dependent hamster histone H3.2 promoter and an interactive partner of AP-2 RL J. Biol. Chem. 276:28-34 (2001). RN [18]; RE0038720. RX PUBMED: 10842061. RA Kramer P. R., Guerrero G., Krishnamurthy R., Mitchell P. J., Wray S. RT Ectopic expression of luteinizing hormone-releasing hormone and peripherin in the respiratory epithelium of mice lacking transcription factor AP-2alpha RL Mech. Dev. 94:79-94 (2000). RN [19]; RE0038845. RX PUBMED: 9601089. RA Hayashi T., Usui M., Nishioka J., Zhang Z. X., Suzuki K. RT Regulation of the human protein C inhibitor gene expression in HepG2 cells: role of Sp1 and AP2 RL Biochem. J. 332:573-82 (1998). RN [20]; RE0039881. RX PUBMED: 12234931. RA Mishra S. K., Keyel P. A., Hawryluk M. J., Agostinelli N. R., Watkins S. C., Traub L. M. RT Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor RL EMBO J. 21:4915-26 (2002). RN [21]; RE0042747. RX PUBMED: 12488457. RA Fujimori K., Fujitani Y., Kadoyama K., Kumanogoh H., Ishikawa K., Urade Y. RT Regulation of lipocalin-type prostaglandin D synthase gene expression by Hes-1 through E-box and interleukin-1 beta via two NF-kappa B elements in rat leptomeningeal cells RL J. Biol. Chem. 278:6018-26 (2003). RN [22]; RE0043679. RX PUBMED: 12133909. RA Davies S. R., Sakano S., Zhu Y., Sandell L. J. RT Distribution of the transcription factors Sox9, AP-2, and [delta]EF1 in adult murine articular and meniscal cartilage and growth plate RL J. Histochem. Cytochem. 50:1059-65 (2002). RN [23]; RE0043909. RX PUBMED: 7616204. RA Greco D., Zellmer E., Zhang Z., Lewis E. RT Transcription factor AP-2 regulates expression of the dopamine beta-hydroxylase gene RL J. Neurochem 65:510-6 (1995). RN [24]; RE0043910. RX PUBMED: 12145340. RA Ben-Zimra M., Koler M., Orly J. RT Transcription of cholesterol side-chain cleavage cytochrome p450 in the placenta: activating protein-2 assumes the role of steroidogenic factor-1 by binding to an overlapping promoter element RL Mol. Endocrinol. 16:1864-80 (2002). RN [25]; RE0043911. RX PUBMED: 11095974. RA Takahashi H., Oyama N., Itoh Y., Ishida-Yamamoto A., Kaneko F., Iizuka H. RT Transcriptional factor AP-2gamma increases human cystatin A gene transcription of keratinocytes RL Biochem. Biophys. Res. Commun. 278:719-23 (2000). RN [26]; RE0043947. RX PUBMED: 9837956. RA Nagase M., Abe J., Takahashi K., Ando J., Hirose S., Fujita T. RT Genomic organization and regulation of expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) gene RL J. Biol. Chem. 273:33702-7 (1998). RN [27]; RE0043971. RX PUBMED: 14976052. RA Zhou G. P., Wong C., Su R., Crable S. C., Anderson K. P., Gallagher P. G. RT Human potassium chloride cotransporter 1 (SLC12A4) promoter is regulated by AP-2 and contains a functional downstream promoter element RL Blood 103:4302-9 (2004). RN [28]; RE0043977. RX PUBMED: 10987359. RA Schepers U., Lemm T., Herzog V., Sandhoff K. RT Characterization of regulatory elements in the 5'-flanking region of the GM2 activator gene RL Biol. Chem. 381:531-44 (2000). RN [29]; RE0043979. RX PUBMED: 7632730. RA Quinn J. P., McAllister J., Mendelson S. RT Multiple protein complexes, including AP2 and Sp1, interact with a specific site within the rat preprotachykinin-A promoter RL Biochim. Biophys. Acta 1263:25-34 (1995). RN [30]; RE0043980. RX PUBMED: 10333481. RA Yoshitomi H., Yamazaki K., Tanaka I. RT Mechanism of ubiquitous expression of mouse uncoupling protein 2 mRNA: control by cis-acting DNA element in 5'-flanking region RL Biochem. J. 340:397-404 (1999). RN [31]; RE0043983. RX PUBMED: 9067290. RA Martinez R., Venturelli D., Perrotti D., Veronese M. L., Kastury K., Druck T., Huebner K., Calabretta B. RT Gene structure, promoter activity, and chromosomal location of the DR- nm23 gene, a related member of the nm23 gene family RL Cancer Res. 57:1180-7 (1997). RN [32]; RE0043986. RX PUBMED: 11335942. RA Tu Z. J., Pan W., Gong Z., Kiang D. T. RT Involving AP-2 transcription factor in connexin 26 up-regulation during pregnancy and lactation RL Mol. Reprod. Dev. 59:17-24 (2001). RN [33]; RE0043987. RX PUBMED: 11672442. RA Kaluzova M., Pastorekova S., Svastova E., Pastorek J., Stanbridge E. J., Kaluz S. RT Characterization of the MN/CA 9 promoter proximal region: a role for specificity protein (SP) and activator protein 1 (AP1) factors RL Biochem. J. 359:669-77 (2001). RN [34]; RE0044014. RX PUBMED: 10612627. RA Carrillo C., Cisneros B., Montanez C. RT Sp1 and AP2 transcription factors are required for the human fragile mental retardation promoter activity in SK-N-SH neuronal cells RL Neurosci. Lett. 276:149-52 (1999). RN [35]; RE0044015. RX PUBMED: 11358520. RA Butta N., Gonzalez-Manchon C., Arias-Salgado E. G., Ayuso M. S., Parrilla R. RT Cloning and functional characterization of the 5' flanking region of the human mitochondrial malic enzyme gene. Regulatory role of Sp1 and AP-2 RL Eur. J. Biochem. 268:3017-27 (2001). RN [36]; RE0044016. RX PUBMED: 12359331. RA Billing-Marczak K., Buzanska L., Winsky L., Nowotny M., Rudka T., Isaacs K., Belin M. F., Kuznicki J. RT AP2-like cis element is required for calretinin gene promoter activity in cells of neuronal phenotype differentiated from multipotent human cell line DEV RL Biochim. Biophys. Acta 1577:412-20 (2002). RN [37]; RE0044017. RX PUBMED: 1316546. RA Kurten R. C., Levy L. O., Shey J., Durica J. M., Richards J. S. RT Identification and characterization of the GC-rich and cyclic adenosine 3',5'-monophosphate (cAMP)-inducible promoter of the type II beta cAMP-dependent protein kinase regulatory subunit gene RL Mol. Endocrinol. 6:536-50 (1992). RN [38]; RE0044018. RX PUBMED: 8920946. RA Ciaccio P. J., Walsh E. S., Tew K. D. RT Promoter analysis of a human dihydrodiol dehydrogenase RL Biochem. Biophys. Res. Commun. 228:524-9 (1996). RN [39]; RE0044019. RX PUBMED: 9203630. RA Fornasari D., Battaglioli E., Flora A., Terzano S., Clementi F. RT Structural and functional characterization of the human alpha3 nicotinic subunit gene promoter RL Mol. Pharmacol. 51:250-61 (1997). RN [40]; RE0044020. RX PUBMED: 9651486. RA Masaki S., Kamachi Y., Quinlan R. A., Yonezawa S., Kondoh H. RT Identification and functional analysis of the mouse lens filensin gene promoter RL Gene 214:77-86 (1998). RN [41]; RE0053460. RX PUBMED: 16707431. RA Paonessa F., Foti D., Costa V., Chiefari E., Brunetti G., Leone F., Luciano F., Wu F., Lee A. S., Gulletta E., Fusco A., Brunetti A. RT Activator protein-2 overexpression accounts for increased insulin receptor expression in human breast cancer. RL Cancer Res. 66:5085-5093 (2006). XX //