AC T08326
XX
ID T08326
XX
DT 10.03.2005 (created); nvo.
DT 29.06.2016 (updated); mom.
CO Copyright (C), QIAGEN.
XX
FA Sp1
XX
SY specificity protein 1; Stimulating Protein 1.
XX
OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
XX
CL C0001; CH.
XX
FF IL-1beta increases phosphorylation of Sp1 protein [198];
XX
IN T23080 AhR; Mammalia.
IN T08146 AP-2alpha; human, Homo sapiens.
IN T10504 AP-2alpha; Mammalia.
IN T00035 AP-2alphaA; human, Homo sapiens.
IN T08487 AR-isoform1; human, Homo sapiens.
IN T15601 AR; Mammalia.
IN T10818 arnt; Mammalia.
IN T16699 B-Myb; Mammalia.
IN T16043 BCL-6; Mammalia.
IN T10873 c-Ets-1; Mammalia.
IN T10346 c-Fos; Mammalia.
IN T14435 c-Myc; Mammalia.
IN T09410 C/EBPbeta; Mammalia.
IN T10398 C/EBPdelta; Mammalia.
IN T15118 CBP; Mammalia.
IN T10201 COUP-TF1; Mammalia.
IN T17908 CPBP; Mammalia.
IN T03489 Crx; cattle, Bos taurus.
IN T16691 DP-1; Mammalia.
IN T09117 E2F-1; human, Homo sapiens.
IN T09570 E2F-1; Mammalia.
IN T10531 Egr-1; Mammalia.
IN T10659 Elf-1; Mammalia.
IN T00261 ER-alpha; human, Homo sapiens.
IN T09637 ER-alpha; Mammalia.
IN T16015 ER-beta; Mammalia.
IN T10214 GABP-alpha; mouse, Mus musculus.
IN T00305 GATA-1; mouse, Mus musculus.
IN T10217 GATA-1; Mammalia.
IN T17995 GATA-2; Mammalia.
IN T08629 GATA-4; Mammalia.
IN T10358 HMGIY; Mammalia.
IN T08612 HNF-4alpha; Mammalia.
IN T18455 IkappaB-alpha; Mammalia.
IN T14172 KLF15; Mammalia.
IN T14261 LRF; Mammalia.
IN T30592 Msx-1; Mammalia.
IN T10831 Myogenin; Mammalia.
IN T08641 NCOR1-isoform1; mouse, Mus musculus.
IN T14436 NeuroD-1; Mammalia.
IN T08563 NF-YA; Mammalia.
IN T17293 NF-YC; Mammalia.
IN T11025 NFATc1; Mammalia.
IN T11024 NFATc2; Mammalia.
IN T23091 p300; Mammalia.
IN T14288 PLZF; Mammalia.
IN T08628 POU2F1; Mammalia.
IN T09956 PPARalpha; Mammalia.
IN T24182 PR; Mammalia.
IN T14264 RBTN2; Mammalia.
IN T08711 RelA-p65; human, Homo sapiens.
IN T19222 SALL2-isoform1; human, Homo sapiens.
IN T10138 SF-1; Mammalia.
IN T24830 Smad2; Mammalia.
IN T09538 Smad3; Mammalia.
IN T13998 Smad4; Mammalia.
IN T04689 SMRT; human, Homo sapiens.
IN T09095 SREBP-1; Mammalia.
IN T16049 SREBP-2; Mammalia.
IN T14063 SRF; Mammalia.
IN T23076 STAT1; Mammalia.
IN T14458 STAT3; Mammalia.
IN T27798 Tal-1; Mammalia.
IN T14175 TBP; Mammalia.
IN T17428 TFIIB; Mammalia.
IN T10807 USF; Mammalia.
IN T31896 VDR; Mammalia.
IN T09133 YY1; Mammalia.
XX
MX M00008 V$SP1_01.
MX M01303 V$SP1_02.
MX M00933 V$SP1_Q2_01.
MX M07395 V$SP1_Q2_02.
MX M00932 V$SP1_Q4_01.
MX M00196 V$SP1_Q6.
MX M00931 V$SP1_Q6_01.
XX
BS R22546.
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BS R37135.
BS R37368.
BS R41494.
BS R00017.
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BS R31954.
XX
DR TRANSPATH: MO000047759.
DR TRANSCOMPEL: C00005.
DR TRANSCOMPEL: C00006.
DR TRANSCOMPEL: C00007.
DR TRANSCOMPEL: C00010.
DR TRANSCOMPEL: C00027.
DR TRANSCOMPEL: C00028.
DR TRANSCOMPEL: C00038.
DR TRANSCOMPEL: C00039.
DR TRANSCOMPEL: C00055.
DR TRANSCOMPEL: C00070.
DR TRANSCOMPEL: C00204.
DR TRANSCOMPEL: C00205.
DR TRANSCOMPEL: C00218.
DR TRANSCOMPEL: C00243.
DR TRANSCOMPEL: C00244.
DR TRANSCOMPEL: C00254.
DR TRANSCOMPEL: C00271.
DR TRANSCOMPEL: C00272.
DR TRANSCOMPEL: C00283.
DR TRANSCOMPEL: C00326.
DR TRANSCOMPEL: C00327.
DR TRANSCOMPEL: C00355.
DR TRANSCOMPEL: C00359.
DR TRANSCOMPEL: C00441.
DR TRANSCOMPEL: C00497.
DR TRANSCOMPEL: C00501.
DR TRANSCOMPEL: C00516.
DR TRANSCOMPEL: C00524.
DR TRANSCOMPEL: C00529.
DR TRANSCOMPEL: C00531.
DR TRANSCOMPEL: C00566.
DR TRANSCOMPEL: C00570.
DR TRANSCOMPEL: C00571.
DR TRANSCOMPEL: C00573.
DR TRANSCOMPEL: C00578.
DR TRANSCOMPEL: C00588.
DR TRANSCOMPEL: C00591.
DR TRANSCOMPEL: C00598.
DR TRANSCOMPEL: C00650.
XX
RN [1]; RE0006591.
RX PUBMED: 8327494.
RA Lee J.-S., Galvin K. M., Shi Y.
RT Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1
RL Proc. Natl. Acad. Sci. USA 90:6145-6149 (1993).
RN [2]; RE0006696.
RX PUBMED: 8006022.
RA Chamberlin M. E., Lei K.-J., Chou J. Y.
RT Subtle differences in human pregnancy-specific glycoprotein gene promoters allow for differential expression
RL J. Biol. Chem. 269:17152-17159 (1994).
RN [3]; RE0006767.
RX PUBMED: 7565695.
RA Datta P. K., Raychaudhuri P., Bagchi S.
RT Association of p107 with Sp1: genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription
RL Mol. Cell. Biol. 15:5444-5452 (1995).
RN [4]; RE0008556.
RX PUBMED: 8226931.
RA Fischer K. D., Haese A., Nowock J.
RT Cooperation of GATA-1 and Sp1 can result in synergistic transcriptional activation or interference
RL J. Biol. Chem. 268:23915-23923 (1993).
RN [5]; RE0008772.
RX PUBMED: 8106441.
RA Sadasivan E., Cedeno M. M., Rothenberg S. P.
RT Characterization of the gene encoding a folate-binding protein expressed in human placenta
RL J. Biol. Chem. 269:4725-4735 (1994).
RN [6]; RE0010167.
RX PUBMED: 7983009.
RA tugores A., Magness S. T., Brenner D. A.
RT A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene
RL J. Biol. Chem. 269:30789-30797 (1994).
RN [7]; RE0011253.
RX PUBMED: 7615530.
RA Ebert S. E., Wong D. L.
RT Differential activation of the rat phenylethanolamine N-methyltransferase gene by Sp1 and Egr-1
RL J. Biol. Chem. 270:17299-17305 (1995).
RN [8]; RE0012785.
RX PUBMED: 8657142.
RA Lin S.-Y., Black A. R., Kostic D., Pajovic S., Hoover C. N., Azizkhan J. C.
RT Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction
RL Mol. Cell. Biol. 16:1668-1675 (1996).
RN [9]; RE0013040.
RX PUBMED: 8816451.
RA French S. W., Schmidt M. C., Glorioso J. C.
RT Involvement of a high-mobility-group protein in the transcriptional activity of herpes simplex virus latency-active promoter 2
RL Mol. Cell. Biol. 16:5393-5399 (1996).
RN [10]; RE0017847.
RX PUBMED: 11114295.
RA Han B., Liu N., Yang X., Sun H. B., Yang Y.-C.
RT MRG1 expression in fibroblasts is regulated by Sp1/Sp3 and an Ets transcription factor.
RL J. Biol. Chem. 276:7937-7942 (2001).
RN [11]; RE0018226.
RX PUBMED: 9212056.
RA Young P. P., Mendelson C. R.
RT A GT box element is essential for basal and cyclic adenosine 3',5'-monophosphate regulation of the human surfactant protein A2 gene in alveolar type II cells: evidence for the binding of lung nuclear factors distinct from Sp1.
RL Mol. Endocrinol. 11:1082-1093 (1997).
RN [12]; RE0023129.
RX PUBMED: 10644678.
RA Aizencang G. I., Bishop D. F., Forrest D., Astrin K. H., Desnick R. J.
RT Uroporphyrinogen III synthase. An alternative promoter controls erythroid-specific expression in the murine gene.
RL J. Biol. Chem. 275:2295-2304 (2000).
RN [13]; RE0024039.
RX PUBMED: 9512462.
RA Banks E. B., Crish J. F., Welter J. F., Eckert R. L.
RT Characterization of human involucrin promoter distal regulatory region transcriptional activator elements-a role for Sp1 and AP1 binding sites.
RL Biochem. J. 331:61-68 (1998).
RN [14]; RE0024064.
RX PUBMED: 12200429.
RA Jang S. I., Steinert P. M.
RT Loricrin expression in cultured human keratinocytes is controlled by a complex interplay between transcription factors of the Sp1, CREB, AP1, and AP2 families.
RL J. Biol. Chem. 277:42268-42279 (2002).
RN [15]; RE0024220.
RX PUBMED: 11988536.
RA Dunah A. W., Jeong H., Griffin A., Kim Y. M., Standaert D. G., Hersch S. M., Mouradian M. M., Young A. B., Tanese N., Krainc D.
RT Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.
RL Nature 296:2238-2243 (2002).
RN [16]; RE0024910.
RX PUBMED: 11259630.
RA Wong W. K., Chen K., Shih J. C.
RT Regulation of human monoamine oxidase B gene by Sp1 and Sp3.
RL Mol. Pharmacol. 59:852-859 (2001).
RN [17]; RE0025127.
RX PUBMED: 10082523.
RA Biesiada E., Hamamori Y., Kedes L., Sartorelli V.
RT Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter.
RL Mol. Cell. Biol. 19:2577-2584 (1999).
RN [18]; RE0025503.
RX PUBMED: 12554779.
RA Russell D. L., Doyle K. M. H., Gonzales-Robayna I., Pipaon C., Richards J. S.
RT Egr-1 induction in rat granulosa cells by follicle-stimulating hormone and luteinizing hormone: combinatorial regulation by transcription factors cyclic adenosine 3',5'-monophosphate regulatory element binding protein, serum response factor, sp1, and early growth response factor-1.
RL Mol. Endocrinol. 17:520-533 (2003).
RN [19]; RE0025856.
RX PUBMED: 14592960.
RA Wang G., Leiter A. B., Englander E. W., Greeley G. H. Jr.
RT Insulin-like growth factor I increases rat peptide YY promoter activity through Sp1 binding sites.
RL Endocrinology 145:659-66 (2004).
RN [20]; RE0026687.
RX PUBMED: 10829018.
RA Tanaka N., Yonekura H., Yamagishi S., Fujimori H., Yamamoto Y., Yamamoto H.
RT The receptor for advanced glycation end products is induced by the glycation products themselves and tumor necrosis factor-alpha through nuclear factor-kappa B, and by 17beta-estradiol through Sp-1 in human vascular endothelial cells.
RL J. Biol. Chem. 275:25781-90 (2000).
RN [21]; RE0026768.
RX PUBMED: 10976766.
RA Gunther M., Laithier M., Brison O.
RT A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening
RL Mol. Cell. Biochem. 210:131-42 (2000).
RN [22]; RE0027542.
RX PUBMED: 10681512.
RA Saville B., Wormke M., Wang F., Nguyen T., Enmark E., Kuiper G., Gustafsson J. A., Safe S.
RT Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements.
RL J. Biol. Chem. 275:5379-87 (2000).
RN [23]; RE0028514.
RX PUBMED: 9108165.
RA Chen S., Nagy P. L., Zalkin H.
RT Role of NRF-1 in bidirectional transcription of the human GPAT-AIRC purine biosynthesis locus.
RL Nucleic Acids Res. 25:1809-16 (1997).
RN [24]; RE0028908.
RX PUBMED: 9819371.
RA Srivastava S., Weitzmann M. N., Kimble R. B., Rizzo M., Zahner M., Milbrandt J., Ross F. P., Pacifici R.
RT Estrogen blocks M-CSF gene expression and osteoclast formation by regulating phosphorylation of Egr-1 and its interaction with Sp-1.
RL J. Clin. Invest. 102:1850-9 (1998).
RN [25]; RE0029866.
RX PUBMED: 12411446.
RA Schuettengruber B., Doetzlhofer A., Kroboth K., Wintersberger E., Seiser C.
RT Alternate activation of two divergently transcribed mouse genes from a bidirectional promoter is linked to changes in histone modification.
RL J. Biol. Chem. 278:1784-93 (2003).
RN [26]; RE0030031.
RX PUBMED: 12466967.
RA Zhu G. H., Lenzi M., Schwartz E. L.
RT The Sp1 transcription factor contributes to the tumor necrosis factor-induced expression of the angiogenic factor thymidine phosphorylase in human colon carcinoma cells.
RL Oncogene 21:8477-85 (2002).
RN [27]; RE0031578.
RX PUBMED: 11802721.
RA Kardassis D., Falvey E., Tsantili P., Hadzopoulou-Cladaras M., Zannis V.
RT Direct physical interactions between HNF-4 and Sp1 mediate synergistic transactivation of the apolipoprotein CIII promoter.
RL Biochemistry 41:1217-28 (2002).
RN [28]; RE0032023.
RX PUBMED: 11348466.
RA Verrecchia F., Rossert J., Mauviel A.
RT Blocking sp1 transcription factor broadly inhibits extracellular matrix gene expression in vitro and in vivo: implications for the treatment of tissue fibrosis.
RL J. Invest. Dermatol 116:755-63 (2001).
RN [29]; RE0032250.
RX PUBMED: 11493684.
RA Santini M. P., Talora C., Seki T., Bolgan L., Dotto G. P.
RT Cross talk among calcineurin, Sp1/Sp3, and NFAT in control of p21(WAF1/CIP1) expression in keratinocyte differentiation.
RL Proc. Natl. Acad. Sci. USA 98:9575-80 (2001).
RN [30]; RE0032922.
RX PUBMED: 10651903.
RA Suzuki T., Kimura A., Nagai R., Horikoshi M.
RT Regulation of interaction of the acetyltransferase region of p300 and the DNA-binding domain of Sp1 on and through DNA binding.
RL Genes Cells 5:29-41 (2000).
RN [31]; RE0033349.
RX PUBMED: 12802284.
RA Alpy F., Boulay A., Moog-Lutz C., Andarawewa K. L., Degot S., Stoll I., Rio M. C., Tomasetto C.
RT Metastatic lymph node 64 (MLN64), a gene overexpressed in breast cancers, is regulated by Sp/KLF transcription factors.
RL Oncogene 22:3770-80 (2003).
RN [32]; RE0033526.
RX PUBMED: 12840021.
RA Bowen H., Lapham A., Phillips E., Yeung I., Alter-Koltunoff M., Levi B. Z., Perry V. H., Mann D. A., Barton C. H.
RT Characterization of the murine Nramp1 promoter: requirements for transactivation by Miz-1.
RL J. Biol. Chem. 278:36017-26 (2003).
RN [33]; RE0035355.
RX PUBMED: 9610763.
RA Hoppe K. L., Francone O. L.
RT Binding and functional effects of transcription factors Sp1 and Sp3 on the proximal human lecithin:cholesterol acyltransferase promoter.
RL J. Lipid Res. 39:969-977 (1998).
RN [34]; RE0035575.
RX PUBMED: 12904181.
RA Boukouvala S., Price N., Plant K. E., Sim E.
RT Structure and transcriptional regulation of the Nat2 gene encoding for the drug-metabolizing enzyme arylamine N-acetyltransferase type 2 in mice.
RL Biochem. J. 375:593-602 (2003).
RN [35]; RE0035577.
RX PUBMED: 11989980.
RA Moon Y. A., Park S. W., Kim K. S.
RT Characterization of cis-acting elements in the rat ATP citrate-lyase gene promoter.
RL Exp. Mol. Med. 34:60-68 (2002).
RN [36]; RE0035613.
RX PUBMED: 10744779.
RA Bakovic M., Waite K. A., Vance D. E.
RT Functional significance of Sp1, Sp2, and Sp3 transcription factors in regulation of the murine CTP:phosphocholine cytidylyltransferase alpha promoter.
RL J. Lipid Res. 41:583-594 (2000).
RN [37]; RE0035967.
RX PUBMED: 9030545.
RA Zhao L., Chang L. S.
RT The human POLD1 gene. Identification of an upstream activator sequence, activation by Sp1 and Sp3, and cell cycle regulation.
RL J. Biol. Chem. 272:4869-4882 (1997).
RN [38]; RE0036250.
RX PUBMED: 9931498.
RA Smits P., Bhalerao J., Merregaert J.
RT Molecular cloning and characterization of the mouse Ecm1 gene and its 5' regulatory sequences
RL Gene 226:253-61 (1999).
RN [39]; RE0036266.
RX PUBMED: 8798472.
RA Ziober B. L., Kramer R. H.
RT Identification and characterization of the cell type-specific and developmentally regulated alpha7 integrin gene promoter
RL J. Biol. Chem. 271:22915-22 (1996).
RN [40]; RE0036458.
RX PUBMED: 11829738.
RA Castoldi M., Chu M. L.
RT Structural and functional characterization of the human and mouse fibulin-1 gene promoters: role of Sp1 and Sp3
RL Biochem. J. 362:41-50 (2002).
RN [41]; RE0036544.
RX PUBMED: 14749362.
RA Lahlil R., Lecuyer E., Herblot S., Hoang T.
RT SCL assembles a multifactorial complex that determines glycophorin A expression
RL Mol. Cell. Biol. 24:1439-52 (2004).
RN [42]; RE0036631.
RX PUBMED: 12752447.
RA Liu M., Leibowitz J. L., Clark D. A., Mendicino M., Ning Q., Ding J. W., D'Abreo C., Fung L., Marsden P. A., Levy G. A.
RT Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3
RL Eur. J. Biochem. 270:2274-86 (2003).
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RX PUBMED: 10976925.
RA Loudig O., Babichuk C., White J., Abu-Abed S., Mueller C., Petkovich M.
RT Cytochrome P450RAI(CYP26) promoter: a distinct composite retinoic acid response element underlies the complex regulation of retinoic acid metabolism
RL Mol. Endocrinol. 14:1483-97 (2000).
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RX PUBMED: 14715707.
RA Knofler M., Saleh L., Bauer S., Galos B., Rotheneder H., Husslein P., Helmer H.
RT Transcriptional regulation of the human chorionic gonadotropin beta gene during villous trophoblast differentiation
RL Endocrinology 145:1685-94 (2004).
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RA Ryu S., Zhou S., Ladurner A. G., Tjian R.
RT The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1
RL Nature 397:446-50 (1999).
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RA Gazzoli I., Kolodner R. D.
RT Regulation of the human MSH6 gene by the Sp1 transcription factor and alteration of promoter activity and expression by polymorphisms
RL Mol. Cell. Biol. 23:7992-8007 (2003).
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RX PUBMED: 12818425.
RA Ekstrom L., Lyrenas L., Jakobsson P. J., Morgenstern R., Kelner M. J.
RT Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is mediated by Sp1 and Sp3
RL Biochim. Biophys. Acta 1627:79-84 (2003).
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RX PUBMED: 9115633.
RA tugores A., Rubio T., Rancano C., Alonso M. A.
RT A tandem array of Sp-1 sites and a reverse initiator element are both required for synergistic transcriptional activation of the T-cell-specific MAL gene
RL DNA Cell Biol. 16:245-55 (1997).
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RA Krikun G., Schatz F., Mackman N., Guller S., Demopoulos R., Lockwood C. J.
RT Regulation of tissue factor gene expression in human endometrium by transcription factors Sp1 and Sp3
RL Mol. Endocrinol. 14:393-400 (2000).
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RX PUBMED: 12423667.
RA Thakker D. R., Standifer K. M.
RT Induction of G protein-coupled receptor kinases 2 and 3 contributes to the cross-talk between mu and ORL1 receptors following prolonged agonist exposure
RL Neuropharmacology 43:979-90 (2002).
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RX PUBMED: 11955626.
RA Lescuyer P., Martinez P., Lunardi J.
RT YY1 and Sp1 activate transcription of the human NDUFS8 gene encoding the mitochondrial complex I TYKY subunit
RL Biochim. Biophys. Acta 1574:164-74 (2002).
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RA Orii K. E., Orii K. O., Souri M., Orii T., Kondo N., Hashimoto T., Aoyama T.
RT Genes for the human mitochondrial trifunctional protein alpha- and beta-subunits are divergently transcribed from a common promoter region
RL J. Biol. Chem. 274:8077-84 (1999).
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RA Schaffler A., Ehling A., Neumann E., Herfarth H., Paul G., Tarner I., Gay S., Buechler C., Scholmerich J., Muller-Ladner U.
RT Role of specificity protein-1, PPARgamma, and pituitary protein transcription factor-1 in transcriptional regulation of the murine CORS-26 promoter
RL Biochim. Biophys. Acta 1678:150-6 (2004).
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RA Knofler M., Krapp A., Hagenbuchle O., Wellauer P. K.
RT Constitutive expression of the gene for the cell-specific p48 DNA-binding subunit of pancreas transcription factor 1 in cultured cells is under control of binding sites for transcription factors Sp1 and alphaCbf
RL J. Biol. Chem. 271:21993-2002 (1996).
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RX PUBMED: 9601089.
RA Hayashi T., Usui M., Nishioka J., Zhang Z. X., Suzuki K.
RT Regulation of the human protein C inhibitor gene expression in HepG2 cells: role of Sp1 and AP2
RL Biochem. J. 332:573-82 (1998).
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RX PUBMED: 11256962.
RA Tintrup H., Fischer M., Betz H., Kuhse J.
RT Exonic Sp1 sites are required for neural-specific expression of the glycine receptor beta subunit gene
RL Biochem. J. 355:179-87 (2001).
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RA Yamabe Y., Shimamoto A., Goto M., Yokota J., Sugawara M., Furuichi Y.
RT Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53
RL Mol. Cell. Biol. 18:6191-200 (1998).
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RA Tolner B., Singh A., Esaki T., Roy K., Sirotnak F. M.
RT Transcription of the mouse RFC-1 gene encoding a folate transporter. Multiplicity and properties of promoters with minimum requirements for their basal activity
RL Gene 231:163-72 (1999).
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RX PUBMED: 15094066.
RA Xue L., Wu J., Zheng W., Wang P., Li J., Zhang Z., Tong T.
RT Sp1 is involved in the transcriptional activation of p16(INK4) by p21(Waf1) in HeLa cells
RL FEBS Lett. 564:199-204 (2004).
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RA Shimizu C., Fuda H., Lee Y. C., Strott C. A.
RT Transcriptional regulation of human 3'-phosphoadenosine 5'-phosphosulfate synthase 1
RL Biochem. Biophys. Res. Commun. 284:763-70 (2001).
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RA LeGros L., Halim A. B., Chamberlin M. E., Geller A., Kotb M.
RT Regulation of the human MAT2B gene encoding the regulatory beta subunit of methionine adenosyltransferase, MAT II
RL J. Biol. Chem. 276:24918-24 (2001).
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RA Shimizu C., Fuda H., Lee Y. C., Strott C. A.
RT Transcriptional regulation of human 3'-phosphoadenosine 5'-phosphosulphate synthase 2
RL Biochem. J. 363:263-71 (2002).
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RA Xia J., Zhou Z. H., Bubien J. K., Fuller C. M., Markert J. M., Mapstone T. B., Yancey Gillespie G., Benos D. J.
RT Molecular cloning and characterization of human acid sensing ion channel (ASIC)2 gene promoter
RL Gene 313:91-101 (2003).
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RA Su K., Yang X., Roos M. D., Paterson A. J., Kudlow J. E.
RT Human Sug1/p45 is involved in the proteasome-dependent degradation of Sp1
RL Biochem. J. 348:281-9 (2000).
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RA Ungefroren H., Gellersen B., Krull N. B., Kalthoff H.
RT Biglycan gene expression in the human leiomyosarcoma cell line SK-UT-1. Basal and protein kinase A-induced transcription involves binding of Sp1-like/Sp3 proteins in the proximal promoter region
RL J. Biol. Chem. 273:29230-40 (1998).
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RA Kim E., Muga S. J., Fischer S. M.
RT Identification and characterization of a phorbol ester-responsive element in the murine 8S-lipoxygenase gene
RL J. Biol. Chem. 279:11188-97 (2004).
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RA Zhu Q., Liao K.
RT Differential expression of the adipocyte amino acid transporter is transactivated by SP1 and SP3 during the 3T3-L1 preadipocyte differentiation process
RL Biochem. Biophys. Res. Commun. 271:100-6 (2000).
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RA Ai W., Liu Y., Langlois M., Wang T. C.
RT Kruppel-like factor 4 (KLF4) represses histidine decarboxylase gene expression through an upstream Sp1 site and downstream gastrin responsive elements
RL J. Biol. Chem. 279:8684-93 (2004).
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RA Chang C. Y., Huang C., Guo I. C., Tsai H. M., Wu D. A., Chung B. C.
RT Transcription of the human ferredoxin gene through a single promoter which contains the 3',5'-cyclic adenosine monophosphate-responsive sequence and Sp 1-binding site
RL Mol. Endocrinol. 6:1362-70 (1992).
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RA Saito T., Takahashi Y., Hashimoto H., Kamataki T.
RT Novel transcriptional regulation of the human CYP3A7 gene by Sp1 and Sp3 through nuclear factor kappa B-like element
RL J. Biol. Chem. 276:38010-22 (2001).
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RA Liang L., Major T., Bocan T.
RT Characterization of the promoter of human extracellular matrix metalloproteinase inducer (EMMPRIN)
RL Gene 282:75-86 (2002).
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RA Mikkelsen I. M., Huseby N. E., Visvikis A., Moens U.
RT Activation of the gamma-glutamyltransferase promoter 2 in the rat colon carcinoma cell line CC531 by histone deacetylase inhibitors is mediated through the Sp1 binding motif.
RL Biochem. Pharmacol. 64:307-315 (2002).
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RA Hernandez-Sanchez C., Ito Y., Ferrer J., Reitman M., LeRoith D.
RT Characterization of the mouse sulfonylurea receptor 1 promoter and its regulation
RL J. Biol. Chem. 274:18261-70 (1999).
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RA Freemantle S. J., Moran R. G.
RT Transcription of the human folylpoly-gamma-glutamate synthetase gene
RL J. Biol. Chem. 272:25373-9 (1997).
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RA Smith K. T., Coffee B., Reines D.
RT Occupancy and synergistic activation of the FMR1 promoter by Nrf-1 and Sp1 in vivo
RL Hum. Mol. Genet. 13:1611-21 (2004).
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RA Drouin R., Angers M., Dallaire N., Rose T. M., Khandjian E. W., Rousseau F.
RT Structural and functional characterization of the human FMR1 promoter reveals similarities with the hnRNP-A2 promoter region
RL Hum. Mol. Genet. 6:2051-60 (1997).
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RA Meissner M., Stein M., Urbich C., Reisinger K., Suske G., Staels B., Kaufmann R., Gille J.
RT PPARalpha activators inhibit vascular endothelial growth factor receptor-2 expression by repressing Sp1-dependent DNA binding and transactivation
RL Circ. Res. 94:324-32 (2004).
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RA Jinnin M., Ihn H., Asano Y., Yamane K., Trojanowska M., Tamaki K.
RT Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1
RL Oncogene 23:1656-67 (2004).
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RA Kida M., Souri M., Yamamoto M., Saito H., Ichinose A.
RT Transcriptional regulation of cell type-specific expression of the TATA-less A subunit gene for human coagulation factor XIII
RL J. Biol. Chem. 274:6138-47 (1999).
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RA Ye J., Xu R. H., Taylor-Papadimitriou J., Pitha P. M.
RT Sp1 binding plays a critical role in Erb-B2- and v-ras-mediated downregulation of alpha2-integrin expression in human mammary epithelial cells
RL Mol. Cell. Biol. 16:6178-89 (1996).
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RA Grabmaier K., A. de Weijert MC, Verhaegh G. W., Schalken J. A., Oosterwijk E.
RT Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma
RL Oncogene 23:5624-31 (2004).
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RA Heusohn F., Wirries G., Schmidt R. E., Gessner J. E.
RT The Pmed1 gene promoter of human Fc gamma RIIIA can function as a NK/T cell-specific restriction element, which involves binding of Sp1 transcription factor
RL J. Immunol. 168:2857-64 (2002).
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RA Sezaki N., Ishimaru F., Tabayashi T., Kataoka I., Nakase K., Fujii K., Kozuka T., Nakayama H., Harada M., Tanimoto M.
RT The type 1 CD10/neutral endopeptidase 24.11 promoter: functional characterization of the 5'-untranslated region
RL Br. J. Haematol. 123:177-83 (2003).
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RA Too C. K.
RT Rapid induction of Jak2 and Sp1 in T cells by phosphorothioate oligonucleotides
RL Antisense Nucleic Acid Drug Dev. 8:87-94 (1998).
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RA Holmes A., Abraham D. J., Chen Y., Denton C., Shi-wen X., Black C. M., Leask A.
RT Constitutive connective tissue growth factor expression in scleroderma fibroblasts is dependent on Sp1
RL J. Biol. Chem. 278:41728-33 (2003).
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RA Gregory P. A., Gardner-Stephen D. A., Lewinsky R. H., Duncliffe K. N., Mackenzie P. I.
RT Cloning and characterization of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 gene promoters: differential regulation through an interior-like region.
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RA Hocker M., Raychowdhury R., Plath T., Wu H., O'Connor D. T., Wiedenmann B., Rosewicz S., Wang T. C.
RT Sp1 and CREB mediate gastrin-dependent regulation of chromogranin A promoter activity in gastric carcinoma cells
RL J. Biol. Chem. 273:34000-7 (1998).
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RA Kanda N., Watanabe S.
RT 17Beta-estradiol inhibits MCP-1 production in human keratinocytes
RL J. Invest. Dermatol 120:1058-66 (2003).
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RA Fujita N., Watanabe S., Ichimura T., Ohkuma Y., Chiba T., Saya H., Nakao M.
RT MCAF mediates MBD1-dependent transcriptional repression
RL Mol. Cell. Biol. 23:2834-43 (2003).
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RA Butta N., Gonzalez-Manchon C., Arias-Salgado E. G., Ayuso M. S., Parrilla R.
RT Cloning and functional characterization of the 5' flanking region of the human mitochondrial malic enzyme gene. Regulatory role of Sp1 and AP-2
RL Eur. J. Biochem. 268:3017-27 (2001).
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RA Masaki S., Kamachi Y., Quinlan R. A., Yonezawa S., Kondoh H.
RT Identification and functional analysis of the mouse lens filensin gene promoter
RL Gene 214:77-86 (1998).
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RA Noti J. D., Johnson A. K., Dillon J. D.
RT Structural and functional characterization of the leukocyte integrin gene CD11d. Essential role of Sp1 and Sp3
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RA Melnikova I. N., Lin H. R., Blanchette A. R., Gardner P. D.
RT Synergistic transcriptional activation by Sox10 and Sp1 family members
RL Neuropharmacology 39:2615-23 (2000).
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RA Melnikova I. N., Yang Y., Gardner P. D.
RT Interactions between regulatory proteins that bind to the nicotinic receptor beta4 subunit gene promoter
RL Eur. J. Pharmacol. 393:75-83 (2000).
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RA Rehli M., Niller H. H., Ammon C., Langmann S., Schwarzfischer L., Andreesen R., Krause S. W.
RT Transcriptional regulation of CHI3L1, a marker gene for late stages of macrophage differentiation
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RA Perrais M., Pigny P., Ducourouble M. P., Petitprez D., Porchet N., Aubert J. P., Van Seuningen I.
RT Characterization of human mucin gene MUC4 promoter: importance of growth factors and proinflammatory cytokines for its regulation in pancreatic cancer cells
RL J. Biol. Chem. 276:30923-33 (2001).
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RA Li H., Melford K., Judson A., Bensadoun A.
RT Murine glypican-4 gene structure and expression; Sp1 and Sp3 play a major role in glypican-4 expression in 3T3-F442A cells
RL Biochim. Biophys. Acta 1679:141-55 (2004).
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RA Mukhopadhyay D., Knebelmann B., Cohen H. T., Ananth S., Sukhatme V. P.
RT The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity
RL Mol. Cell. Biol. 17:5629-39 (1997).
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RA Pang R. T., Lee L. T., Ng S. S., Yung W. H., Chow B. K.
RT CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene
RL Mol. Endocrinol. 18:471-83 (2004).
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RA Cote F., Schussler N., Boularand S., Peirotes A., Thevenot E., Mallet J., Vodjdani G.
RT Involvement of NF-Y and Sp1 in basal and cAMP-stimulated transcriptional activation of the tryptophan hydroxylase (TPH ) gene in the pineal gland
RL J. Neurochem 81:673-85 (2002).
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RA Kim S. Y., Choi S. Y., Chao W., Volsky D. J.
RT Transcriptional regulation of human excitatory amino acid transporter 1 (EAAT1): cloning of the EAAT1 promoter and characterization of its basal and inducible activity in human astrocytes
RL J. Neurochem 87:1485-98 (2003).
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RA Lin C., Chow S., Lau A., Tu R., Lue T. F.
RT Regulation of human PDE5A2 intronic promoter by cAMP and cGMP: identification of a critical Sp1-binding site
RL Biochem. Biophys. Res. Commun. 280:693-9 (2001).
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RA Tanaka T., Kurabayashi M., Aihara Y., Ohyama Y., Nagai R.
RT Inducible expression of manganese superoxide dismutase by phorbol 12-myristate 13-acetate is mediated by Sp1 in endothelial cells
RL Arterioscler. Thromb. Vasc. Biol. 20:392-401 (2000).
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RA Nelson K. K., Ranganathan A. C., Mansouri J., Rodriguez A. M., Providence K. M., Rutter J. L., Pumiglia K., Bennett J. A., Melendez J. A.
RT Elevated sod2 activity augments matrix metalloproteinase expression: evidence for the involvement of endogenous hydrogen peroxide in regulating metastasis
RL Clin. Cancer Res. 9:424-32 (2003).
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RA Kawakami K., Watanabe Y., Araki M., Nagano K.
RT Sp1 binds to the adhesion-molecule-on-glia regulatory element that functions as a positive transcription regulatory element in astrocytes
RL J. Neurosci. Res. 35:138-46 (1993).
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RA Lemercier C., Brown A., Mamani M., Ripoche J., Reiffers J.
RT The rat Mist1 gene: structure and promoter characterization
RL Gene 242:209-18 (2000).
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RA Torigoe T., Izumi H., Ishiguchi H., Uramoto H., Murakami T., Ise T., Yoshida Y., Tanabe M., Nomoto M., Itoh H., Kohno K.
RT Enhanced expression of the human vacuolar H+-ATPase c subunit gene (ATP6L) in response to anticancer agents
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RA Iwano S., Saito T., Takahashi Y., Fujita K., Kamataki T.
RT Cooperative regulation of CYP3A5 gene transcription by NF-Y and Sp family members
RL Biochem. Biophys. Res. Commun. 286:55-60 (2001).
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RA Salowsky R., Heiss N. S., Benner A., Wittig R., Poustka A.
RT Basal transcription activity of the dyskeratosis congenita gene is mediated by Sp1 and Sp3 and a patient mutation in a Sp1 binding site is associated with decreased promoter activity
RL Gene 293:9-19 (2002).
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RA Midgley V. C., Khachigian L. M.
RT Fibroblast growth factor-2 induction of platelet-derived growth factor-C chain transcription in vascular smooth muscle cells is ERK-dependent but not JNK-dependent and mediated by Egr-1
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RA Shao Z., Robbins P. D.
RT Differential regulation of E2F and Sp1-mediated transcription by G1 cyclins
RL Oncogene 10:221-8 (1995).
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RA Davis W. Jr, Chen Z. J., Ile K. E., Tew K. D.
RT Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors
RL Nucleic Acids Res. 31:1097-107 (2003).
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RA Dabrowska M., Sirotnak F. M.
RT Regulation of transcription of the human MRP7 gene. Characteristics of the basal promoter and identification of tumor-derived transcripts encoding additional 5' end heterogeneity
RL Gene 341:129-39 (2004).
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RA Watson F., Kiernan R. S., Deavall D. G., Varro A., Dimaline R.
RT Transcriptional activation of the rat vesicular monoamine transporter 2 promoter in gastric epithelial cells. regulation by gastrin
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RA Catteau A., Rosewell I., Solomon E., Taylor-Papadimitriou J.
RT A short region of the promoter of the breast cancer associated PLU-1 gene can regulate transcription in vitro and in vivo
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RA Xu J., Kogai T., Brent G. A., Hershman J. M.
RT A GC box in the human sodium iodide symporter gene promoter is essential for full activity
RL Thyroid 12:107-14 (2002).
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RT Hormonal regulation of multiple promoters of the rat mitochondrial glycerol-3-phosphate dehydrogenase gene: identification of a complex hormone-response element in the ubiquitous promoter B
RL Eur. J. Biochem. 268:4095-103 (2001).
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RA Ikeda Y., Yamamoto J., Okamura M., Fujino T., Takahashi S., Takeuchi K., Osborne T. F., Yamamoto T. T., Ito S., Sakai J.
RT Transcriptional regulation of the murine acetyl-CoA synthetase 1 gene through multiple clustered binding sites for sterol regulatory element-binding proteins and a single neighboring site for Sp1
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RA Lei N., Heckert L. L.
RT Sp1 and Egr1 regulate transcription of the Dmrt1 gene in Sertoli cells
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RA Ho Y. S., Howard A. J.
RT Cloning and characterization of the rat glutathione peroxidase gene
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RT Modulation of the folate receptor type beta gene by coordinate actions of retinoic acid receptors at activator Sp1/ets and repressor AP-1 sites
RL Blood 101:4551-60 (2003).
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RT Human ribonucleotide reductase M2 subunit gene amplification and transcriptional regulation in a homogeneous staining chromosome region responsible for the mechanism of drug resistance
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RT Bidirectional promoter of human monoamine oxidase A (MAO A) controlled by transcription factor Sp1
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RT Expression of the human ADH2 gene: an unusual Sp1-binding site in the promoter of a gene expressed at high levels in liver
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RA Hadri L., Ozog A., Soncin F., Lompre A. M.
RT Basal transcription of the mouse sarco(endo)plasmic reticulum Ca2+-ATPase type 3 gene in endothelial cells is controlled by Ets-1 and Sp1
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RA Miyamoto N., Higuchi Y., Tsurudome M., Ito M., Nishio M., Kawano M., Sudo A., Kato K., Uchida A., Ito Y.
RT Induction of c-Src in human blood monocytes by anti-CD98/FRP-1 mAb in an Sp1-dependent fashion
RL Cell. Immunol. 204:105-13 (2000).
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RT Role of Sp1 and Sp3 in the nutrient-regulated expression of the human asparagine synthetase gene
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RT Transcriptional regulation of type B human natriuretic Peptide receptor gene promoter: dependence on Sp1
RL Hypertension 44:283-8 (2004).
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RX PUBMED: 15100293.
RA Chen Q. Y., Jackson N.
RT Human CD1D gene has TATA boxless dual promoters: an SP1-binding element determines the function of the proximal promoter
RL J. Immunol. 172:5512-21 (2004).
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RX PUBMED: 11844788.
RA Im H. J., Pittelkow M. R., Kumar R.
RT Divergent regulation of the growth-promoting gene IEX-1 by the p53 tumor suppressor and Sp1
RL J. Biol. Chem. 277:14612-21 (2002).
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RX PUBMED: 10861849.
RA Zeng W., Remold-O'Donnell E.
RT Human monocyte/neutrophil elastase inhibitor (MNEI) is regulated by PU.1/Spi-1, Sp1, and NF-kappaB
RL J. Cell. Biochem. 78:519-32 (2000).
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RA Jacobson D., Pribnow D., Herson P. S., Maylie J., Adelman J. P.
RT Determinants contributing to estrogen-regulated expression of SK3
RL Biochem. Biophys. Res. Commun. 303:660-8 (2003).
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RA Toyoda A., Fukumaki Y., Hattori M., Sakaki Y.
RT Mode of activation of the GC box/Sp1-dependent promoter of the human NADH-cytochrome b5 reductase-encoding gene
RL Gene 164:351-5 (1995).
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RX PUBMED: 15383623.
RA Hempel N., Wang H., LeCluyse E. L., McManus M. E., Negishi M.
RT The human sulfotransferase SULT1A1 gene is regulated in a synergistic manner by Sp1 and GA binding protein
RL Mol. Pharmacol. 66:1690-701 (2004).
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RA Tzeng S. J., Huang J. D.
RT Transcriptional regulation of the rat Mrp3 promoter in intestine cells
RL Biochem. Biophys. Res. Commun. 291:270-7 (2002).
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RA Konduri S. D., Yanamandra N., Dinh D. H., Olivero W. C., Gujrati M., Foster D. C., Kisiel W., Rao J. S.
RT Physiological and chemical inducers of tissue factor pathway inhibitor-2 in human glioma cells
RL Int. J. Oncol. 22:1277-83 (2003).
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RA Li N., Seetharam S., Seetharam B.
RT Characterization of the human transcobalamin II promoter. A proximal GC/GT box is a dominant negative element
RL J. Biol. Chem. 273:16104-11 (1998).
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RA Furihata T., Hosokawa M., Satoh T., Chiba K.
RT Synergistic role of specificity proteins and upstream stimulatory factor 1 in transactivation of the mouse carboxylesterase 2/microsomal acylcarnitine hydrolase gene promoter
RL Biochem. J. 384:101-10 (2004).
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RX PUBMED: 11445565.
RA Baek S. J., Horowitz J. M., Eling T. E.
RT Molecular cloning and characterization of human nonsteroidal anti-inflammatory drug-activated gene promoter. Basal transcription is mediated by Sp1 and Sp3
RL J. Biol. Chem. 276:33384-92 (2001).
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RA Guttridge D. C., Cunningham D. D.
RT Characterization of the human protease nexin-1 promoter and its regulation by Sp1 through a G/C-rich activation domain
RL J. Neurochem 67:498-507 (1996).
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RA Halder S. K., Fink M., Waterman M. R., Rozman D.
RT A cAMP-responsive element binding site is essential for sterol regulation of the human lanosterol 14alpha-demethylase gene (CYP51)
RL Mol. Endocrinol. 16:1853-63 (2002).
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RA Wright R. M., Riley M. G., Weigel L. K., Ginger L. A., Costantino D. A., McManaman J. L.
RT Activation of the human aldehyde oxidase (hAOX1) promoter by tandem cooperative Sp1/Sp3 binding sites: identification of complex architecture in the hAOX upstream DNA that includes a proximal promoter, distal activation sites, and a silencer element
RL DNA Cell Biol. 19:459-74 (2000).
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RA Wijesuriya S. D., Bristow J., Miller W. L.
RT Localization and analysis of the principal promoter for human tenascin-X
RL Genomics 80:443-52 (2002).
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RA Wu X., McIntyre T. M., Zimmerman G. A., Prescott S. M., Stafforini D. M.
RT Molecular characterization of the constitutive expression of the plasma platelet-activating factor acetylhydrolase gene in macrophages
RL Biochem. J. 375:351-63 (2003).
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RA Liu M., Whetstine J. R., Payton S. G., Ge Y., Flatley R. M., Matherly L. H.
RT Roles of USF, Ikaros and Sp proteins in the transcriptional regulation of the human reduced folate carrier B promoter
RL Biochem. J. 383:249-57 (2004).
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RA Ashcroft F. J., Varro A., Dimaline R., Dockray G. J.
RT Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element
RL Biochem. J. 381:397-403 (2004).
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RA Tachikui H., Kurosawa N., Kadomatsu K., Muramatsu T.
RT Genomic organization and promoter activity of embigin, a member of the immunoglobulin superfamily
RL Gene 240:325-32 (1999).
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RA Holmes M. L., Bartle N., Eisbacher M., Chong B. H.
RT Cloning and analysis of the thrombopoietin-induced megakaryocyte-specific glycoprotein VI promoter and its regulation by GATA-1, Fli-1, and Sp1
RL J. Biol. Chem. 277:48333-41 (2002).
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RA Qin C., Singh P., Safe S.
RT Transcriptional activation of insulin-like growth factor-binding protein-4 by 17beta-estradiol in MCF-7 cells: role of estrogen receptor-Sp1 complexes
RL Endocrinology 140:2501-8 (1999).
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RA Huber R., Schlessinger D., Pilia G.
RT Multiple Sp1 sites efficiently drive transcription of the TATA-less promoter of the human glypican 3 (GPC3) gene
RL Gene 214:35-44 (1998).
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RA Palmer G., Manen D., Bonjour J. P., Caverzasio J.
RT Species-specific mechanisms control the activity of the Pit1/PIT1 phosphate transporter gene promoter in mouse and human
RL Gene 279:49-62 (2001).
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RA Wu Z., Chiang J. Y.
RT Transcriptional regulation of human oxysterol 7 alpha-hydroxylase gene (CYP7B1) by Sp1
RL Gene 272:191-7 (2001).
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RA Jiang P., Kumar A., Parrillo J. E., Dempsey L. A., Platt J. L., Prinz R. A., Xu X.
RT Cloning and characterization of the human heparanase-1 (HPR1) gene promoter: role of GA-binding protein and Sp1 in regulating HPR1 basal promoter activity
RL J. Biol. Chem. 277:8989-98 (2002).
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RA Gregory R. C., Taxman D. J., Seshasayee D., Kensinger M. H., Bieker J. J., Wojchowski D. M.
RT Functional interaction of GATA1 with erythroid Kruppel-like factor and Sp1 at defined erythroid promoters
RL Blood 87:1793-801 (1996).
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RA Holmes K. W., Hales R., Chu S., Maxwell M. J., Mogayzel P. J. Jr, Zeitlin P. L.
RT Modulation of Sp1 and Sp3 in lung epithelial cells regulates ClC-2 chloride channel expression
RL Am. J. Respir. Cell Mol. Biol. 29:499-505 (2003).
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RA Uchida Y., Itoh M., Taguchi Y., Yamaoka S., Umehara H., Ichikawa S., Hirabayashi Y., Holleran W. M., Okazaki T.
RT Ceramide reduction and transcriptional up-regulation of glucosylceramide synthase through doxorubicin-activated Sp1 in drug-resistant HL-60/ADR cells
RL Cancer Res. 64:6271-9 (2004).
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RA Chou S. F., Chen H. L., Lu S. C.
RT Sp1 and Sp3 are involved in up-regulation of human deoxyribonuclease II transcription during differentiation of HL-60 cells
RL Eur. J. Biochem. 270:1855-62 (2003).
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RA Han J. A., Park S. C.
RT Transglutaminase-dependent modulation of transcription factor Sp1 activity
RL Mol. Cells 10:612-8 (2000).
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RA Roder K., Latasa M. J., Sul H. S.
RT Murine H-rev107 gene encoding a class II tumor suppressor: gene organization and identification of an Sp1/Sp3-binding GC-box required for its transcription
RL Biochem. Biophys. Res. Commun. 293:793-9 (2002).
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RA Zhu Q., Center M. S.
RT Evidence that SP1 modulates transcriptional activity of the multidrug resistance-associated protein gene
RL DNA Cell Biol. 15:105-11 (1996).
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RA Lu Y., Lotan D., Lotan R.
RT Differential regulation of constitutive and retinoic acid-induced galectin-1 gene transcription in murine embryonal carcinoma and myoblastic cells
RL Biochim. Biophys. Acta 1491:13-9 (2000).
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RA Niimi T., Hayashi Y., Sekiguchi K.
RT Identification of an upstream enhancer in the mouse laminin alpha 1 gene defining its high level of expression in parietal endoderm cells
RL J. Biol. Chem. 278:9332-8 (2003).
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RA Luk J. M., Tong M. K., Mok B. W., Tam P. C., Yeung W. S., Lee K. F.
RT Sp1 site is crucial for the mouse claudin-19 gene expression in the kidney cells
RL FEBS Lett. 578:251-6 (2004).
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RA Le Goff W., Guerin M., Petit L., Chapman M. J., Thillet J.
RT Regulation of human CETP gene expression: role of SP1 and SP3 transcription factors at promoter sites -690, -629, and -37
RL J. Lipid Res. 44:1322-31 (2003).
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RA Costello J. F., Futscher B. W., Kroes R. A., Pieper R. O.
RT Methylation-related chromatin structure is associated with exclusion of transcription factors from and suppressed expression of the O-6-methylguanine DNA methyltransferase gene in human glioma cell lines
RL Mol. Cell. Biol. 14:6515-21 (1994).
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RA Wilkerson D. C., Wolfe S. A., Grimes S. R.
RT Sp1 and Sp3 activate the testis-specific histone H1t promoter through the H1t/GC-box
RL J. Cell. Biochem. 86:716-25 (2002).
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RA Deakin S., Leviev I., Brulhart-Meynet M. C., James R. W.
RT Paraoxonase-1 promoter haplotypes and serum paraoxonase: a predominant role for polymorphic position - 107, implicating the Sp1 transcription factor
RL Biochem. J. 372:643-9 (2003).
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RA Liang F., Schaufele F., Gardner D. G.
RT Sp1 dependence of natriuretic peptide receptor A gene transcription in rat aortic smooth muscle cells
RL Endocrinology 140:1695-701 (1999).
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RA Jinawath A., Miyake S., Yanagisawa Y., Akiyama Y., Yuasa Y.
RT Transcriptional regulation of the human DNA methyltransferase 3A and 3B genes by Sp3 and Sp1 zinc finger proteins
RL Biochem. J. 385:557-64 (2005).
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RA Birnbaum M. J., Wright K. L., van Wijnen A. J., Ramsey-Ewing A. L., Bourke M. T., Last T. J., Aziz F., Frenkel B., Rao B. R., Aronin N., et al.
RT Functional role for Sp1 in the transcriptional amplification of a cell cycle regulated histone H4 gene
RL Biochemistry 34:7648-58 (1995).
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RA Lietard J., Musso O., Theret N., L'Helgoualc'h A., Campion J. P., Yamada Y., Clement B.
RT Sp1-mediated transactivation of LamC1 promoter and coordinated expression of laminin-gamma1 and Sp1 in human hepatocellular carcinomas
RL Am. J. Pathol. 151:1663-72 (1997).
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RA Too C. K.
RT Induction of Sp1 activity by prolactin and interleukin-2 in Nb2 T-cells: differential association of Sp1-DNA complexes with Stats
RL Mol. Cell. Endocrinol. 129:7-16 (1997).
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RA Okamoto Y., Sakata M., Yamamoto T., Nishio Y., Adachi K., Ogura K., Yamaguchi M., Takeda T., Tasaka K., Murata Y.
RT Involvement of nuclear transcription factor Sp1 in regulating glucose transporter-1 gene expression during rat trophoblast differentiation
RL Biochem. Biophys. Res. Commun. 288:940-8 (2001).
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RA Ge Y., Matherly L. H., Taub J. W.
RT Transcriptional regulation of cell-specific expression of the human cystathionine beta -synthase gene by differential binding of Sp1/Sp3 to the -1b promoter
RL J. Biol. Chem. 276:43570-9 (2001).
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RA Li B., Lee M. Y.
RT Transcriptional regulation of the human DNA polymerase delta catalytic subunit gene POLD1 by p53 tumor suppressor and Sp1
RL J. Biol. Chem. 276:29729-39 (2001).
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RA Marban C., Redel L., Suzanne S., van Lint C., Lecestre D., Chasserot-Golaz S., Leid M., Aunis D., Schaeffer E., Rohr O.
RT COUP-TF interacting protein 2 represses the initial phase of HIV-1 gene transcription in human microglial cells.
RL Nucleic Acids Res. 33:2318-2331 (2005).
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RA Kawada H., Nishiyama C., Takagi A., Tokura T., Nakano N., Maeda K., Mayuzumi N., Ikeda S., Okumura K., Ogawa H.
RT Transcriptional regulation of ATP2C1 gene by Sp1 and YY1 and reduced function of its promoter in Hailey-Hailey disease keratinocytes.
RL J. Invest. Dermatol 124:1206-1214 (2005).
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RA Lee J. A., Suh D. C., Kang J. E., Kim M. H., Park H., Lee M. N., Kim J. M., Jeon B. N., Roh H. E., Yu M. Y., Choi K. Y., Kim K. Y., Hur M. W.
RT Transcriptional activity of Sp1 is regulated by molecular interactions between the zinc finger DNA binding domain and the inhibitory domain with corepressors, and this interaction is modulated by MEK.
RL J. Biol. Chem. 280:28061-28071 (2005).
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RA Curtin D., Jenkins S., Farmer N., Anderson A. C., Haisenleder D. J., Rissman E., Wilson E. M., Shupnik M. A.
RT Androgen suppression of GnRH-stimulated rat LHbeta gene transcription occurs through Sp1 sites in the distal GnRH-responsive promoter region.
RL Mol. Endocrinol. 15:1906-1917 (2001).
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RA Chapman N. R., Perkins N. D.
RT Inhibition of the RelA(p65) NF-kappaB subunit by Egr-1.
RL J. Biol. Chem. 275:4719-4725 (2000).
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RA Shimakura J., Terada T., Shimada Y., Katsura T., Inui K.
RT The transcription factor Cdx2 regulates the intestine-specific expression of human peptide transporter 1 through functional interaction with Sp1.
RL Biochem. Pharmacol. 71:1581-1588 (2006).
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RA Deng X., Yellaturu C., Cagen L., Wilcox H. G., Park E. A., Raghow R., Elam M. B.
RT Expression of the rat sterol regulatory element-binding protein-1c gene in response to insulin is mediated by increased transactivating capacity of specificity protein 1 (Sp1).
RL J. Biol. Chem. 282:17517-17529 (2007).
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RA Paonessa F., Foti D., Costa V., Chiefari E., Brunetti G., Leone F., Luciano F., Wu F., Lee A. S., Gulletta E., Fusco A., Brunetti A.
RT Activator protein-2 overexpression accounts for increased insulin receptor expression in human breast cancer.
RL Cancer Res. 66:5085-5093 (2006).
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RA Keates A. C., Keates S., Kwon J. H., Arseneau K. O., Law D. J., Bai L., Merchant J. L., Wang T. C., Kelly C. P.
RT ZBP-89, Sp1, and nuclear factor-kappa B regulate epithelial neutrophil-activating peptide-78 gene expression in Caco-2 human colonic epithelial cells.
RL J. Biol. Chem. 276:43713-43722 (2001).
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RA Chen Y. J., Wang Y. N., Chang W. C.
RT ERK2-mediated C-terminal serine phosphorylation of p300 is vital to the regulation of epidermal growth factor-induced keratin 16 gene expression.
RL J. Biol. Chem. 282:27215-27228 (2007).
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RA Tapias A., Ciudad C. J., Noe V.
RT Transcriptional regulation of the 5'-flanking region of the human transcription factor Sp3 gene by NF-1, c-Myb, B-Myb, AP-1 and E2F.
RL Biochim. Biophys. Acta 1779:318-329 (2008).
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RA Okada Y., Yano K., Jin E., Funahashi N., Kitayama M., Doi T., Spokes K., Beeler D. L., Shih S. C., Okada H., Danilov T. A., Maynard E., Minami T., Oettgen P., Aird W. C.
RT A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium.
RL Circ. Res. 100:1712-1722 (2007).
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RA Huang Y. C., Chang W. C., Su J. G., Cai J. L., Chen C. C., Hung J. J., Liu Y. W.
RT Peptidoglycan enhances transcriptional expression of CCAAT/enhancer-binding protein delta gene in mouse macrophages.
RL J. Biomed. Sci. 14:407-418 (2007).
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RA Gao S. Y., Li E. M., Cui L., Lu X. F., Meng L. Y., Yuan H. M., Xie J. J., Du Z. P., Pang J. X., Xu L. Y.
RT Sp1 and AP-1 regulate expression of the human gene VIL2 in esophageal carcinoma cells.
RL J. Biol. Chem. 284:7995-8004 (2009).
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RA Lerner L. E., Peng G. H., Gribanova Y. E., Chen S., Farber D. B.
RT Sp4 is expressed in retinal neurons, activates transcription of photoreceptor-specific genes, and synergizes with Crx.
RL J. Biol. Chem. 280:20642-20650 (2005).
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RA Lee D. K., Suh D., Edenberg H. J., Hur M. W.
RT POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1.
RL J. Biol. Chem. 277:26761-26768 (2002).
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RA Mura C., Le Gac G., Jacolot S., Ferec C.
RT Transcriptional regulation of the human HFE gene indicates high liver expression and erythropoiesis coregulation.
RL FASEB J. 18:1922-1924 (2004).
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RA Zhou B., Francis T. A., Yang H., Tseng W., Zhong Q., Frenkel B., Morrisey E. E., Ann D. K., Minoo P., Crandall E. D., Borok Z.
RT GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1.
RL Am. J. Physiol. Cell Physiol. 295:C1141-50 (2008).
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RX PUBMED: 18513187.
RA Guo D., Dong L. Y., Wu Y., Yang L., An W.
RT Down-regulation of hepatic nuclear factor 4alpha on expression of human hepatic stimulator substance via its action on the proximal promoter in HepG2 cells.
RL Biochem. J. 415:111-121 (2008).
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RA Poree B., Kypriotou M., Chadjichristos C., Beauchef G., Renard E., Legendre F., Melin M., Gueret S., Hartmann D. J., Mallein-Gerin F., Pujol J. P., Boumediene K., Galera P.
RT Interleukin-6 (IL-6) and/or soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular chondrocytes requires a decrease of Sp1.Sp3 ratio and of the binding activity of both factors to the COL2A1 promoter.
RL J. Biol. Chem. 283:4850-4865 (2008).
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RA Kwon H. S., Kim M. S., Edenberg H. J., Hur M. W.
RT Sp3 and Sp4 can repress transcription by competing with Sp1 for the core cis-elements on the human ADH5/FDH minimal promoter.
RL J. Biol. Chem. 274:20-28 (1999).
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RA Yu Z., Li M., Zhang D., Xu W., Kone B. C.
RT Sp1 trans-activates the murine H(+)-K(+)-ATPase alpha(2)-subunit gene.
RL Am. J. Physiol. Renal Physiol. 297:F63-70 (2009).
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RA Tanaka T., Kanai H., Sekiguchi K., Aihara Y., Yokoyama T., Arai M., Kanda T., Nagai R., Kurabayashi M.
RT Induction of VEGF gene transcription by IL-1 beta is mediated through stress-activated MAP kinases and Sp1 sites in cardiac myocytes.
RL J. Mol. Cell. Cardiol. 32:1955-1967 (2000).
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