AC T16049
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ID T16049
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DT 10.03.2005 (created); nvo.
DT 02.09.2015 (updated); hna.
CO Copyright (C), QIAGEN.
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FA SREBP-2
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OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
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FF reduced HDC promoter activity [10];
FF gastrin treatment reduced the DNA binding activity of SREBP-2 [10];
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IN T09538 Smad3; Mammalia.
IN T08326 Sp1; Mammalia.
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MX M01177 V$SREBP2_Q6.
MX M03852 V$SREBP2_Q6_01.
MX M00776 V$SREBP_Q3.
MX M01168 V$SREBP_Q6.
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BS R24183.
BS R63392.
BS R63397.
BS R63400.
BS R69490.
BS R69491.
BS R58267.
BS R58281.
BS R58282.
BS R58283.
BS R58284.
BS R30548.
BS R30549.
BS R28449.
BS R31277.
BS R41721.
BS R41725.
BS R70834.
BS R70836.
BS R70837.
BS R70838.
BS R70839.
BS R70840.
BS R70841.
BS R70842.
BS R63402.
BS R27982.
BS R27983.
BS R31590.
BS R21067.
BS R30552.
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DR TRANSPATH: MO000046925.
DR TRANSCOMPEL: C00566.
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RN [1]; RE0029395.
RX PUBMED: 10627507.
RA Kotzka J., Muller-Wieland D., Roth G., Kremer L., Munck M., Schurmann S., Knebel B., Krone W.
RT Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade.
RL J. Lipid Res. 41:99-108 (2000).
RN [2]; RE0035600.
RX PUBMED: 10801800.
RA Moon Y. A., Lee J. J., Park S. W., Ahn Y. H., Kim K. S.
RT The roles of sterol regulatory element-binding proteins in the transactivation of the rat ATP citrate-lyase promoter.
RL J. Biol. Chem. 275:30280-30286 (2000).
RN [3]; RE0037392.
RX PUBMED: 10805775.
RA Ye J., Dave U. P., Grishin N. V., Goldstein J. L., Brown M. S.
RT Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease
RL Proc. Natl. Acad. Sci. USA 97:5123-8 (2000).
RN [4]; RE0038571.
RX PUBMED: 12855700.
RA Misawa K., Horiba T., Arimura N., Hirano Y., Inoue J., Emoto N., Shimano H., Shimizu M., Sato R.
RT Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes
RL J. Biol. Chem. 278:36176-82 (2003).
RN [5]; RE0041768.
RX PUBMED: 14654352.
RA Rampler H., Weinhofer I., Netik A., Forss-Petter S., Brown P. J., Oplinger J. A., Bugaut M., Berger J.
RT Evaluation of the therapeutic potential of PPARalpha agonists for X-linked adrenoleukodystrophy
RL Mol. Genet. Metab. 80:398-407 (2003).
RN [6]; RE0043227.
RX PUBMED: 12923220.
RA Shechter I., Dai P., Huo L., Guan G.
RT IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells: evidence that IDH1 may regulate lipogenesis in hepatic cells
RL J. Lipid Res. 44:2169-80 (2003).
RN [7]; RE0043449.
RX PUBMED: 12640139.
RA Giandomenico V., Simonsson M., Gronroos E., Ericsson J.
RT Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors
RL Mol. Cell. Biol. 23:2587-99 (2003).
RN [8]; RE0044593.
RX PUBMED: 12202038.
RA Yang T., Espenshade P. J., Wright M. E., Yabe D., Gong Y., Aebersold R., Goldstein J. L., Brown M. S.
RT Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER
RL Cell 110:489-500 (2002).
RN [9]; RE0052431.
RX PUBMED: 16571675.
RA Du X., Kristiana I., Wong J., Brown A. J.
RT Involvement of Akt in ER-to-Golgi transport of SCAP/SREBP: a link between a key cell proliferative pathway and membrane synthesis.
RL Mol. Biol. Cell 17:2735-2745 (2006).
RN [10]; RE0047999.
RX PUBMED: 16357063.
RA Ai W., Liu Y., Wang T. C.
RT Yin yang 1 (YY1) represses histidine decarboxylase gene expression with SREBP-1a in part through an upstream Sp1 site.
RL Am. J. Physiol. Gastrointest. Liver Physiol. 290:G1096-104 (2006).
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