AC T24830
XX
ID T24830
XX
DT 10.03.2005 (created); nvo.
DT 23.12.2014 (updated); spk.
CO Copyright (C), QIAGEN.
XX
FA Smad2
XX
SY HMAD-2; HSMAD2; JV18; JV18-1; MAD, mothers against decapentaplegic homolog 2 (Drosophila); Mad-related protein 2; MADH2; MADR2; MGC22139; MGC34440; Mothers against decapentaplegic homolog 2; Mothers against DPP homolog 2; SMAD family member 2; Smad-2; SMAD2.
XX
OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
XX
IN T23092 BF-1; Mammalia.
IN T15204 brca1; Mammalia.
IN T14435 c-Myc; Mammalia.
IN T15118 CBP; Mammalia.
IN T18378 CBP; human, Homo sapiens.
IN T00261 ER-alpha; human, Homo sapiens.
IN T08515 ER-beta; human, Homo sapiens.
IN T04135 FoxH1; clawed frog, Xenopus laevis.
IN T16696 FoxH1; Mammalia.
IN T30499 gli3; Mammalia.
IN T24827 Gsc; mouse, Mus musculus.
IN T09551 LEF-1; Mammalia.
IN T11357 Lhx9; mouse, Mus musculus.
IN T09402 MEF-2C; Mammalia.
IN T32367 MRG-1-isoform1; mouse, Mus musculus.
IN T17897 myocardin; Mammalia.
IN T19713 NF-1A; Mammalia.
IN T17293 NF-YC; Mammalia.
IN T14258 Nkx3-2; chick, Gallus gallus.
IN T21984 p300; human, Homo sapiens.
IN T23091 p300; Mammalia.
IN T09500 p53; Mammalia.
IN T02103 p53as; mouse, Mus musculus.
IN T06137 p73beta; human, Homo sapiens.
IN T09992 PEA3-isoform1; mouse, Mus musculus.
IN T28503 pitx2a; Mammalia.
IN T32202 Pitx2C; Mammalia.
IN T06377 PML; human, Homo sapiens.
IN T09984 Prep-1; Mammalia.
IN T10141 RBTN2; mouse, Mus musculus.
IN T09072 Smad3; mouse, Mus musculus.
IN T09538 Smad3; Mammalia.
IN T13998 Smad4; Mammalia.
IN T09153 SnoN; human, Homo sapiens.
IN T01853 Sox-9; human, Homo sapiens.
IN T05485 Sox-9; rat, Rattus norvegicus.
IN T08326 Sp1; Mammalia.
IN T16578 TGIF; Mammalia.
IN T08439 TIF2; mouse, Mus musculus.
IN T22793 znf8; mouse, Mus musculus.
XX
MX M03580 V$SMAD2_Q6.
MX M08897 V$SMAD_Q4.
MX M00792 V$SMAD_Q6.
MX M00974 V$SMAD_Q6_01.
XX
BS R39153.
BS R72914.
BS R73968.
XX
DR TRANSPATH: MO000046594.
DR TRANSCOMPEL: C00201.
DR TRANSCOMPEL: C00243.
XX
RN [1]; RE0015642.
RX PUBMED: 9335505.
RA Imamura T., Takase M., Nishihara A., Oeda E., Hanai J., Kawabata M., Miyazono K.
RT Smad6 inhibits signalling by the TGF-beta superfamily
RL Nature 389:622-626 (1997).
RN [2]; RE0016380.
RX PUBMED: 11074002.
RA Pierreux C. E., Nicolas F. J., Hill C. S.
RT Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.
RL Mol. Cell. Biol. 20:9041-9054 (2000).
RN [3]; RE0016418.
RX PUBMED: 10531062.
RA Stroschein S. L., Wang W., Zhou S., Zhou Q., Luo K.
RT Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein.
RL Science 286:771-774 (1999).
RN [4]; RE0018805.
RX PUBMED: 11016919.
RA Lin X., Liang M., Feng X.-H.
RT Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in TGF-beta signaling
RL J. Biol. Chem. 275:36818-36822 (2000).
RN [5]; RE0020636.
RX PUBMED: 8980228.
RA Macias-Silva M., Abdollah S., Hoodless P. A., Pirone R., Attisano L., Wrana J. L.
RT MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling
RL Cell 87:1215-1224 (1996).
RN [6]; RE0025864.
RX PUBMED: 12668667.
RA Soto P., Price-Schiavi S. A., Carraway K. L.
RT SMAD2 and SMAD7 involvement in the post-translational regulation of Muc4 via the transforming growth factor-beta and interferon-gamma pathways in rat mammary epithelial cells.
RL J. Biol. Chem. 278:20338-44 (2003).
RN [7]; RE0027320.
RX PUBMED: 10995736.
RA Melhuish T. A., Wotton D.
RT The interaction of the carboxyl terminus-binding protein with the smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF
RL J. Biol. Chem. 275:39762-6 (2000).
RN [8]; RE0027429.
RX PUBMED: 11160896.
RA Quinn Z. A., Yang C. C., Wrana J. L., McDermott J. C.
RT Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins.
RL Nucleic Acids Res. 29:732-742 (2001).
RN [9]; RE0027983.
RX PUBMED: 11371641.
RA Pessah M., Prunier C., Marais J., Ferrand N., Mazars A., Lallemand F., Gauthier J. M., Atfi A.
RT c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity.
RL Proc. Natl. Acad. Sci. USA 98:6198-203 (2001).
RN [10]; RE0027996.
RX PUBMED: 11278410.
RA Sasaki A., Masuda Y., Ohta Y., Ikeda K., Watanabe K.
RT Filamin associates with Smads and regulates transforming growth factor-beta signaling.
RL J. Biol. Chem. 276:17871-7 (2001).
RN [11]; RE0028090.
RX PUBMED: 11438668.
RA Furuhashi M., Yagi K., Yamamoto H., Furukawa Y., Shimada S., Nakamura Y., Kikuchi A., Miyazono K., Kato M.
RT Axin facilitates Smad3 activation in the transforming growth factor beta signaling pathway.
RL Mol. Cell. Biol. 21:5132-41 (2001).
RN [12]; RE0032129.
RX PUBMED: 14691138.
RA Nawshad A., Hay E. D.
RT TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development.
RL J. Cell Biol. 163:1291-301 (2003).
RN [13]; RE0032276.
RX PUBMED: 14612411.
RA Kim D. W., Lassar A. B.
RT Smad-dependent recruitment of a histone deacetylase/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2.
RL Mol. Cell. Biol. 23:8704-17 (2003).
RN [14]; RE0032548.
RX PUBMED: 15107418.
RA Kim B. C., van Gelder H., Kim T. A., Lee H. J., Baik K. G., Chun H. H., Lee D. A., Choi K. S., Kim S. J.
RT Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells.
RL J. Biol. Chem. 279:28458-65 (2004).
RN [15]; RE0033675.
RX PUBMED: 9651680.
RA Stockwell B. R., Schreiber S. L.
RT Probing the role of homomeric and heteromeric receptor interactions in TGF-beta signaling using small molecule dimerizers.
RL Curr. Biol. 8:761-70 (1998).
RN [16]; RE0034512.
RX PUBMED: 15144564.
RA Nourry C., Maksumova L., Pang M., Liu X., Wang T.
RT Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1.
RL BMC Cell Biol. 5:20 (2004).
RN [17]; RE0037443.
RX PUBMED: 12167862.
RA Kato Y., Habas R., Katsuyama Y., Naar A. M., He X.
RT A component of the ARC/Mediator complex required for TGF beta/Nodal signalling
RL Nature 418:641-6 (2002).
RN [18]; RE0040112.
RX PUBMED: 12023901.
RA Chen F., Ogawa K., Liu X., Stringfield T. M., Chen Y.
RT Repression of Smad2 and Smad3 transactivating activity by association with a novel splice variant of CCAAT-binding factor C subunit
RL Biochem. J. 364:571-7 (2002).
RN [19]; RE0040941.
RX PUBMED: 9920806.
RA Watanabe R., Yamada Y., Ihara Y., Someya Y., Kubota A., Kagimoto S., Kuroe A., Iwakura T., Shen Z. P., Inada A., Adachi T., Ban N., Miyawaki K., Sunaga Y., Tsuda K., Seino Y.
RT The MH1 domains of smad2 and smad3 are involved in the regulation of the ALK7 signals
RL Biochem. Biophys. Res. Commun. 254:707-12 (1999).
RN [20]; RE0041180.
RX PUBMED: 12815042.
RA Imoto S., Sugiyama K., Muromoto R., Sato N., Yamamoto T., Matsuda T.
RT Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3
RL J. Biol. Chem. 278:34253-8 (2003).
RN [21]; RE0041634.
RX PUBMED: 11571228.
RA Wotton D., Knoepfler P. S., Laherty C. D., Eisenman R. N., Massague J.
RT The Smad transcriptional corepressor TGIF recruits mSin3
RL Cell Growth Differ. 12:457-63 (2001).
RN [22]; RE0041861.
RX PUBMED: 15001984.
RA Jinnin M., Ihn H., Asano Y., Yamane K., Trojanowska M., Tamaki K.
RT Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1
RL Oncogene 23:1656-67 (2004).
RN [23]; RE0041862.
RX PUBMED: 11555647.
RA Matsuda T., Yamamoto T., Muraguchi A., Saatcioglu F.
RT Cross-talk between transforming growth factor-beta and estrogen receptor signaling through Smad3
RL J. Biol. Chem. 276:42908-14 (2001).
RN [24]; RE0042996.
RX PUBMED: 11058129.
RA Itoh S., Ericsson J., Nishikawa Ji, Heldin C. H., Dijke Pt.
RT The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling
RL Nucleic Acids Res. 28:4291-8 (2000).
RN [25]; RE0043321.
RX PUBMED: 14612439.
RA Lee H. J., Lee J. K., Miyake S., Kim S. J.
RT A novel E1A-like inhibitor of differentiation (EID) family member, EID-2, suppresses transforming growth factor (TGF)-beta signaling by blocking TGF-beta-induced formation of Smad3-Smad4 complexes
RL J. Biol. Chem. 279:2666-72 (2004).
RN [26]; RE0043884.
RX PUBMED: 12709399.
RA Li J. H., Huang X. R., Zhu H. J., Oldfield M., Cooper M., Truong L. D., Johnson R. J., Lan H. Y.
RT Advanced glycation end products activate Smad signaling via TGF-beta-dependent and independent mechanisms: implications for diabetic renal and vascular disease
RL FASEB J. 18:176-8 (2004).
RN [27]; RE0044240.
RX PUBMED: 12370310.
RA Jiao K., Zhou Y., Hogan B. L.
RT Identification of mZnf8, a Mouse Kruppel-Like Transcriptional Repressor, as a Novel Nuclear Interaction Partner of Smad1
RL Mol. Cell. Biol. 22:7633-44 (2002).
RN [28]; RE0046983.
RX PUBMED: 15350225.
RA Bai Y., Yang C., Hu K., Elly C., Liu Y. C.
RT Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation
RL Mol. Cell 15:825-31 (2004).
RN [29]; RE0046995.
RX PUBMED: 15221015.
RA Komuro A., Imamura T., Saitoh M., Yoshida Y., Yamori T., Miyazono K., Miyazawa K.
RT Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)
RL Oncogene 23:6914-23 (2004).
RN [30]; RE0047371.
RX PUBMED: 15623506.
RA Furumatsu T., Tsuda M., Taniguchi N., Tajima Y., Asahara H.
RT Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding protein/p300 recruitment.
RL J. Biol. Chem. 280:8343-8350 (2005).
RN [31]; RE0047880.
RX PUBMED: 15356634.
RA Lin H. K., Bergmann S., Pandolfi P. P.
RT Cytoplasmic PML function in TGF-beta signalling.
RL Nature 431:205-211 (2004).
RN [32]; RE0047898.
RX PUBMED: 9843199.
RA Liu F., Massague J., Ruiz i Altaba A.
RT Carboxy-terminally truncated Gli3 proteins associate with Smads.
RL Nat. Genet. 20:325-326 (1998).
RN [33]; RE0047924.
RX PUBMED: 11387212.
RA Hocevar B. A., Smine A., Xu X. X., Howe P. H.
RT The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway.
RL EMBO J. 20:2789-2801 (2001).
RN [34]; RE0048120.
RX PUBMED: 12097320.
RA Lee D. K., Kim B. C., Brady J. N., Jeang K. T., Kim S. J.
RT Human T-cell lymphotropic virus type 1 tax inhibits transforming growth factor-beta signaling by blocking the association of Smad proteins with Smad-binding element.
RL J. Biol. Chem. 277:33766-33775 (2002).
RN [35]; RE0048224.
RX PUBMED: 14764653.
RA Bailey J. S., Rave-Harel N., McGillivray S. M., Coss D., Mellon P. L.
RT Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1.
RL Mol. Endocrinol. 18:1158-1170 (2004).
RN [36]; RE0048990.
RX PUBMED: 16407286.
RA Choi S. H., Hwang S. B.
RT Modulation of the transforming growth factor-beta signal transduction pathway by hepatitis C virus nonstructural 5A protein.
RL J. Biol. Chem. 281:7468-7478 (2006).
RN [37]; RE0049228.
RX PUBMED: 9722503.
RA Pouponnot C., Jayaraman L., Massague J.
RT Physical and functional interaction of SMADs and p300/CBP.
RL J. Biol. Chem. 273:22865-22868 (1998).
RN [38]; RE0049244.
RX PUBMED: 14728725.
RA Ibarrola N., Kratchmarova I., Nakajima D., Schiemann W. P., Moustakas A., Pandey A., Mann M.
RT Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling.
RL BMC Cell Biol. 5:2 (2004).
RN [39]; RE0049598.
RX PUBMED: 16862174.
RA Inoue Y., Itoh Y., Abe K., Okamoto T., Daitoku H., Fukamizu A., Onozaki K., Hayashi H.
RT Smad3 is acetylated by p300/CBP to regulate its transactivation activity.
RL Oncogene 26:500-508 (2007).
RN [40]; RE0050473.
RX PUBMED: 17478422.
RA Tu A. W., Luo K.
RT Acetylation of Smad2 by the Co-activator p300 Regulates Activin and Transforming Growth Factor beta Response.
RL J. Biol. Chem. 282:21187-21196 (2007).
RN [41]; RE0050544.
RX PUBMED: 17234915.
RA Cordenonsi M., Montagner M., Adorno M., Zacchigna L., Martello G., Mamidi A., Soligo S., Dupont S., Piccolo S.
RT Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation.
RL Science 315:840-843 (2007).
RN [42]; RE0051123.
RX PUBMED: 15735739.
RA Dubrovska A., Kanamoto T., Lomnytska M., Heldin C. H., Volodko N., Souchelnytskyi S.
RT TGFbeta1/Smad3 counteracts BRCA1-dependent repair of DNA damage.
RL Oncogene 24:2289-2297 (2005).
RN [43]; RE0066105.
RX PUBMED: 18022758.
RA Suszko M. I., Antenos M., Balkin D. M., Woodruff T. K.
RT Smad3 and Pitx2 cooperate in stimulation of FSHbeta gene transcription.
RL Mol. Cell. Endocrinol. 281:27-36 (2008).
RN [44]; RE0066347.
RX PUBMED: 16885393.
RA Allen D. L., Unterman T. G.
RT Regulation of myostatin expression and myoblast differentiation by FoxO and SMAD transcription factors.
RL Am. J. Physiol. Cell Physiol. 292:C188-99 (2007).
RN [45]; RE0071921.
RX PUBMED: 18321991.
RA Kim W., Seok Kang Y., Soo Kim J., Shin N. Y., Hanks S. K., Song W. K.
RT The integrin-coupled signaling adaptor p130Cas suppresses Smad3 function in transforming growth factor-beta signaling.
RL Mol. Biol. Cell 19:2135-2146 (2008).
RN [46]; RE0073040.
RX PUBMED: 22393057.
RA Yan X., Zhang J., Sun Q., Tuazon P. T., Wu X., Traugh J. A., Chen Y. G.
RT p21-activated kinase 2 (PAK2) inhibits TGF-beta signaling in madine-darby canine kidney (MDCK) epithelial cells by interfering with the receptor-Smad interaction.
RL J. Biol. Chem. 287:13705-13712 (2012).
RN [47]; RE0073068.
RX PUBMED: 18519565.
RA Yao X., Chen X., Cottonham C., Xu L.
RT Preferential utilization of Imp7/8 in nuclear import of Smads.
RL J. Biol. Chem. 283:22867-22874 (2008).
XX
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