AC T14258
XX
ID T14258
XX
DT 05.09.2006 (created); rad.
DT 12.02.2009 (updated); smt.
CO Copyright (C), QIAGEN.
XX
FA Nkx3-2
XX
SY Homeobox protein NKX3.2; NK class homeodomain transcription factor NKX3.2; Nkx-3.2.
XX
OS chick, Gallus gallus
OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; neognathae; galliformes; phasianidae
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GE G037271 NKX3-2.
XX
SZ 276 AA; 29.2 kDa (cDNA) (calc.).
XX
SQ MAVRGGGGGGGTALTPFSIQAILNKKEERARGWRLCAARAEAPPPPAPRPPPAWDSDSAL
SQ SEEPESERRSEEESAGGSARPPEAAGRGAAGGGGAALGGGGGAGPGPGRSAQRQRSVGRR
SQ LRSRPGRGGGGGGGRLLAAEEEAAAPKPRKKRSRAAFSHAQVFELERRFNHQRYLSGPER
SQ ADLAASLKLTETQVKIWFQNRRYKTKRRQMAADLLAAAPAAKKVAVKVLVRDDQRQYQPG
SQ EVLRPPSLLALQPSYYYPYYCLPGWALSCAAAAGTQ
XX
SC translated from EMBL:AF138905
XX
FT 148 208 
PS50071; HOMEOBOX_2.
FT 150 212 
SM00389; HOX_1.
FT 151 207 
PF00046; Homeobox.
XX
FF N200Q missense mutation of the homeodomain alters the DNA binding activity of this molecule, keeping the repression activity intact. [2];
FF The DNA binding activity promotes chondrocyte differentiation program in somitic tissue. [2];
XX
IN T21852 HDAC1; Mammalia.
IN T09175 Smad1-isoform1; human, Homo sapiens.
IN T10783 Smad1; Mammalia.
IN T24830 Smad2; Mammalia.
IN T13998 Smad4; Mammalia.
XX
MX M01181 V$NKX32_01.
MX M01482 V$NKX32_02.
XX
BS R23778.
BS R23779.
BS R23780.
BS R23781.
BS R23782.
BS R23784.
BS R23785.
BS R23786.
BS R23787.
BS R23788.
BS R23789.
BS R23790.
BS R23791.
BS R23792.
BS R23793.
BS R23794.
BS R23795.
BS R23796.
BS R23797.
BS R23798.
BS R23799.
BS R23800.
BS R23801.
BS R23802.
BS R23803.
BS R23804.
BS R23805.
BS R23806.
BS R26725.
XX
DR TRANSPATH: MO000086336.
DR TRANSCOMPEL: C00508.
DR EMBL: AF138905;
DR UniProtKB: Q9PRJ1; Q9PRJ1.
XX
RN [1]; RE0032276.
RX PUBMED: 14612411.
RA Kim D. W., Lassar A. B.
RT Smad-dependent recruitment of a histone deacetylase/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2.
RL Mol. Cell. Biol. 23:8704-17 (2003).
RN [2]; RE0052071.
RX PUBMED: 12746429.
RA Kim D. W., Kempf H., Chen R. E., Lassar A. B.
RT Characterization of Nkx3.2 DNA binding specificity and its requirement for somitic chondrogenesis.
RL J. Biol. Chem. 278:27532-27539 (2003).
XX
//