AC T10783
XX
ID T10783
XX
DT 10.03.2005 (created); nvo.
DT 02.02.2015 (updated); ros.
CO Copyright (C), QIAGEN.
XX
FA Smad1
XX
SY BSP-1; BSP1; JV4-1; JV41; MAD, mothers against decapentaplegic homolog 1 (Drosophila); MADH1; Madr1; SMAD family member 1; SMAD-1; SMAD1.
XX
OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
XX
IN T09552 AML3; Mammalia.
IN T14513 beta-catenin; Mammalia.
IN T23092 BF-1; Mammalia.
IN T18378 CBP; human, Homo sapiens.
IN T10217 GATA-1; Mammalia.
IN T08629 GATA-4; Mammalia.
IN T30499 gli3; Mammalia.
IN T24827 Gsc; mouse, Mus musculus.
IN T09289 HOXA13; mouse, Mus musculus.
IN T09447 JunD; Mammalia.
IN T14258 Nkx3-2; chick, Gallus gallus.
IN T31925 Oligo1; Mammalia.
IN T21984 p300; human, Homo sapiens.
IN T23091 p300; Mammalia.
IN T13888 pax6; Mammalia.
IN T34370 RN3; human, Homo sapiens.
IN T14781 SEC12; mouse, Mus musculus.
IN T04864 SIP1; mouse, Mus musculus.
IN T09072 Smad3; mouse, Mus musculus.
IN T13998 Smad4; Mammalia.
IN T22207 Smad5; Mammalia.
IN T10782 Smad6; Mammalia.
IN T14458 STAT3; Mammalia.
IN T22875 YAP; Mammalia.
IN T22876 YAP; human, Homo sapiens.
IN T22793 znf8; mouse, Mus musculus.
XX
MX M01590 V$SMAD1_01.
MX M03845 V$SMAD1_Q6.
MX M08897 V$SMAD_Q4.
MX M00792 V$SMAD_Q6.
MX M00974 V$SMAD_Q6_01.
XX
BS R22200.
BS R36234.
BS R29096.
BS R29097.
BS R64481.
BS R35790.
BS R35792.
BS R23097.
BS R24448.
BS R34773.
BS R36850.
BS R36851.
BS R36852.
BS R36854.
XX
DR TRANSPATH: MO000047343.
XX
RN [1]; RE0017601.
RX PUBMED: 10400677.
RA Verschueren K., Remacle J. E., Collart C., Kraft H., Baker B. S., Tylzanowski P., Nelles L., Wuytens G., Su M. T., Bodmer R., Smith J. C., Huylebroeck D.
RT SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes.
RL J. Biol. Chem. 274:20489-20498 (1999).
RN [2]; RE0018805.
RX PUBMED: 11016919.
RA Lin X., Liang M., Feng X.-H.
RT Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in TGF-beta signaling
RL J. Biol. Chem. 275:36818-36822 (2000).
RN [3]; RE0018813.
RX PUBMED: 11158580.
RA Zhang Y., Chang C., Gehling D. J., Hemmati-Brivanlou A., Derynck R.
RT Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase
RL Proc. Natl. Acad. Sci. USA 98:974-979 (2001).
RN [4]; RE0020483.
RX PUBMED: 9748228.
RA Macias-Silva M., Hoodless P. A., Tang S. J., Buchwald M., Wrana J. L.
RT Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2
RL J. Biol. Chem. 273:25628-25636 (1998).
RN [5]; RE0028374.
RX PUBMED: 11408477.
RA Izumi M., Fujio Y., Kunisada K., Negoro S., Tone E., Funamoto M., Osugi T., Oshima Y., Nakaoka Y., Kishimoto T., Yamauchi-Takihara K., Hirota H.
RT Bone morphogenetic protein-2 inhibits serum deprivation-induced apoptosis of neonatal cardiac myocytes through activation of the Smad1 pathway.
RL J. Biol. Chem. 276:31133-41 (2001).
RN [6]; RE0028790.
RX PUBMED: 11395480.
RA Hay E., Lemonnier J., Fromigue O., Marie P. J.
RT Bone morphogenetic protein-2 promotes osteoblast apoptosis through a Smad-independent, protein kinase C-dependent signaling pathway.
RL J. Biol. Chem. 276:29028-36 (2001).
RN [7]; RE0031933.
RX PUBMED: 14645520.
RA Lin X., Liang Y. Y., Sun B., Liang M., Shi Y., Brunicardi F. C., Shi Y., Feng X. H.
RT Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription.
RL Mol. Cell. Biol. 23:9081-93 (2003).
RN [8]; RE0032276.
RX PUBMED: 14612411.
RA Kim D. W., Lassar A. B.
RT Smad-dependent recruitment of a histone deacetylase/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2.
RL Mol. Cell. Biol. 23:8704-17 (2003).
RN [9]; RE0032785.
RX PUBMED: 12738770.
RA Zhao M., Qiao M., Oyajobi B. O., Mundy G. R., Chen D.
RT E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation.
RL J. Biol. Chem. 278:27939-44 (2003).
RN [10]; RE0032786.
RX PUBMED: 14500836.
RA Takizawa T., Ochiai W., Nakashima K., Taga T.
RT Enhanced gene activation by Notch and BMP signaling cross-talk.
RL Nucleic Acids Res. 31:5723-31 (2003).
RN [11]; RE0039860.
RX PUBMED: 11741887.
RA Zebboudj A. F., Imura M., Bostrom K.
RT Matrix GLA protein, a regulatory protein for bone morphogenetic protein-2
RL J. Biol. Chem. 277:4388-94 (2002).
RN [12]; RE0040237.
RX PUBMED: 15198985.
RA Aubin J., Davy A., Soriano P.
RT In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis
RL Genes Dev. 18:1482-94 (2004).
RN [13]; RE0041361.
RX PUBMED: 12649288.
RA Sowa H., Kaji H., Canaff L., Hendy G. N., Tsukamoto T., Yamaguchi T., Miyazono K., Sugimoto T., Chihara K.
RT Inactivation of menin, the product of the multiple endocrine neoplasia type 1 gene, inhibits the commitment of multipotential mesenchymal stem cells into the osteoblast lineage
RL J. Biol. Chem. 278:21058-69 (2003).
RN [14]; RE0041364.
RX PUBMED: 14701756.
RA Li L., Xin H., Xu X., Huang M., Zhang X., Chen Y., Zhang S., Fu X. Y., Chang Z.
RT CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription
RL Mol. Cell. Biol. 24:856-64 (2004).
RN [15]; RE0041647.
RX PUBMED: 12514223.
RA Angley C., Kumar M., Dinsio K. J., Hall A. K., Siegel R. E.
RT Signaling by bone morphogenetic proteins and Smad1 modulates the postnatal differentiation of cerebellar cells
RL J. Neurosci. 23:260-8 (2003).
RN [16]; RE0041656.
RX PUBMED: 10673036.
RA Pearson K. L., Hunter T., Janknecht R.
RT Activation of Smad1-mediated transcription by p300/CBP
RL Biochim. Biophys. Acta 1489:354-64 (1999).
RN [17]; RE0044240.
RX PUBMED: 12370310.
RA Jiao K., Zhou Y., Hogan B. L.
RT Identification of mZnf8, a Mouse Kruppel-Like Transcriptional Repressor, as a Novel Nuclear Interaction Partner of Smad1
RL Mol. Cell. Biol. 22:7633-44 (2002).
RN [18]; RE0046082.
RX PUBMED: 11483516.
RA Itoh F., Asao H., Sugamura K., Heldin C. H., ten Dijke P., Itoh S.
RT Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads
RL EMBO J. 20:4132-42 (2001).
RN [19]; RE0047898.
RX PUBMED: 9843199.
RA Liu F., Massague J., Ruiz i Altaba A.
RT Carboxy-terminally truncated Gli3 proteins associate with Smads.
RL Nat. Genet. 20:325-326 (1998).
RN [20]; RE0048182.
RX PUBMED: 16087734.
RA Williams T. M., Williams M. E., Heaton J. H., Gelehrter T. D., Innis J. W.
RT Group 13 HOX proteins interact with the MH2 domain of R-Smads and modulate Smad transcriptional activation functions independent of HOX DNA-binding capability.
RL Nucleic Acids Res. 33:4475-4484 (2005).
RN [21]; RE0048542.
RX PUBMED: 16580992.
RA Jin W., Takagi T., Kanesashi S. N., Kurahashi T., Nomura T., Harada J., Ishii S.
RT Schnurri-2 controls BMP-dependent adipogenesis via interaction with Smad proteins.
RL Dev. Cell 10:461-471 (2006).
RN [22]; RE0049228.
RX PUBMED: 9722503.
RA Pouponnot C., Jayaraman L., Massague J.
RT Physical and functional interaction of SMADs and p300/CBP.
RL J. Biol. Chem. 273:22865-22868 (1998).
RN [23]; RE0054297.
RX PUBMED: 16801560.
RA Suzuki A., Raya A., Kawakami Y., Morita M., Matsui T., Nakashima K., Gage F. H., Rodriguez-Esteban C., Izpisua Belmonte J. C.
RT Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells.
RL Proc. Natl. Acad. Sci. USA 103:10294-10299 (2006).
RN [24]; RE0073068.
RX PUBMED: 18519565.
RA Yao X., Chen X., Cottonham C., Xu L.
RT Preferential utilization of Imp7/8 in nuclear import of Smads.
RL J. Biol. Chem. 283:22867-22874 (2008).
XX
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