TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T22207 XX ID T22207 XX DT 10.03.2005 (created); nvo. DT 13.03.2014 (updated); yre. CO Copyright (C), QIAGEN. XX FA Smad5 XX SY Smad-5. XX OS Mammalia OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia XX IN T13888 pax6; Mammalia. IN T34370 RN3; human, Homo sapiens. IN T10783 Smad1; Mammalia. IN T13998 Smad4; Mammalia. IN T22793 znf8; mouse, Mus musculus. XX MX M03846 V$SMAD5_Q5. MX M08829 V$SMAD5_Q5_01. MX M08897 V$SMAD_Q4. MX M00974 V$SMAD_Q6_01. XX BS R36234. BS R36228. XX DR TRANSPATH: MO000046670. XX RN [1]; RE0020483. RX PUBMED: 9748228. RA Macias-Silva M., Hoodless P. A., Tang S. J., Buchwald M., Wrana J. L. RT Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2 RL J. Biol. Chem. 273:25628-25636 (1998). RN [2]; RE0020548. RX PUBMED: 9442019. RA Nishimura R., Kato Y., Chen D., Harris S. E., Mundy G. R., Yoneda T. RT Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12 RL J. Biol. Chem. 273:1872-1879 (1998). RN [3]; RE0027996. RX PUBMED: 11278410. RA Sasaki A., Masuda Y., Ohta Y., Ikeda K., Watanabe K. RT Filamin associates with Smads and regulates transforming growth factor-beta signaling. RL J. Biol. Chem. 276:17871-7 (2001). RN [4]; RE0032157. RX PUBMED: 12151083. RA Nishimura R., Hata K., Harris S. E., Ikeda F., Yoneda T. RT Core-binding factor alpha 1 (Cbfa1) induces osteoblastic differentiation of C2C12 cells without interactions with Smad1 and Smad5. RL Bone 31:303-12 (2002). RN [5]; RE0041361. RX PUBMED: 12649288. RA Sowa H., Kaji H., Canaff L., Hendy G. N., Tsukamoto T., Yamaguchi T., Miyazono K., Sugimoto T., Chihara K. RT Inactivation of menin, the product of the multiple endocrine neoplasia type 1 gene, inhibits the commitment of multipotential mesenchymal stem cells into the osteoblast lineage RL J. Biol. Chem. 278:21058-69 (2003). RN [6]; RE0041363. RX PUBMED: 14701828. RA Zhao M., Qiao M., Harris S. E., Oyajobi B. O., Mundy G. R., Chen D. RT Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo RL J. Biol. Chem. 279:12854-9 (2004). RN [7]; RE0044240. RX PUBMED: 12370310. RA Jiao K., Zhou Y., Hogan B. L. RT Identification of mZnf8, a Mouse Kruppel-Like Transcriptional Repressor, as a Novel Nuclear Interaction Partner of Smad1 RL Mol. Cell. Biol. 22:7633-44 (2002). RN [8]; RE0045801. RX PUBMED: 15107829. RA Frontelo P., Leader J. E., Yoo N., Potocki A. C., Crawford M., Kulik M., Lechleider R. J. RT Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression RL Oncogene 23:5242-51 (2004). RN [9]; RE0045802. RX PUBMED: 15047707. RA Wang S., Hirschberg R. RT Bone morphogenetic protein-7 signals opposing transforming growth factor beta in mesangial cells RL J. Biol. Chem. 279:23200-6 (2004). RN [10]; RE0068581. RX PUBMED: 20484049. RA Nie J., Xie P., Liu L., Xing G., Chang Z., Yin Y., Tian C., He F., Zhang L. RT Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2. RL J. Biol. Chem. 285:22818-22830 (2010). RN [11]; RE0069851. RX PUBMED: 18641638. RA Lu K., Yin X., Weng T., Xi S., Li L., Xing G., Cheng X., Yang X., Zhang L., He F. RT Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1. RL Nat. Cell Biol. 10:994-1002 (2008). XX //