AC T09552
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ID T09552
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DT 10.03.2005 (created); nvo.
DT 08.09.2015 (updated); hna.
CO Copyright (C), QIAGEN.
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FA AML3
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SY Acute myelogenous leukemia 3; Acute myeloid leukemia 3 protein; AML3; CBF-alpha 1; CBFA1; Core binding factor A1; Core-binding factor, alpha 1 subunit; Osf2; PEBP2alphaA; PEBP2alphaA1; Polyomavirus enhancer binding protein 2 alpha A subunit; Polyomavirus enhancer binding protein 2alphaA; Runt-related transcription factor 2; RUNX2; RUNX2, PEBP2alphaA, CBFA1.
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OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
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FF Runx2 overexpression in mesenchymal progenitor cells (C3H10T1/2) prevents induction of chondrogenesis [30];
FF involved in enhancing chondrocyte proliferation [32];
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IN T23082 ATF-4; Mammalia.
IN T09410 C/EBPbeta; Mammalia.
IN T10398 C/EBPdelta; Mammalia.
IN T02409 Dlx-3; mouse, Mus musculus.
IN T14067 FOXO1A; Mammalia.
IN T21852 HDAC1; Mammalia.
IN T13841 HES-1; Mammalia.
IN T09551 LEF-1; Mammalia.
IN T21984 p300; human, Homo sapiens.
IN T23091 p300; Mammalia.
IN T23072 PEBP2beta; Mammalia.
IN T25008 pRb; Mammalia.
IN T10783 Smad1; Mammalia.
IN T09538 Smad3; Mammalia.
IN T23076 STAT1; Mammalia.
IN T22875 YAP; Mammalia.
XX
MX M07276 V$AML3_Q3.
MX M01856 V$AML3_Q6.
MX M08866 V$AML_Q4.
MX M00769 V$AML_Q6.
MX M00731 V$OSF2_Q6.
MX M00984 V$PEBP_Q6.
XX
BS R32575.
BS R28442.
BS R30358.
BS R41295.
BS R26600.
BS R41297.
BS R20435.
BS R36062.
BS R19712.
BS R56068.
BS R56071.
BS R56072.
BS R61619.
BS R61620.
BS R61621.
BS R61622.
BS R23088.
BS R19732.
BS R19740.
BS R66155.
BS R19708.
BS R19710.
BS R32335.
BS R32337.
BS R20258.
BS R20260.
BS R20262.
BS R20263.
BS R20264.
BS R20265.
BS R20266.
BS R32573.
BS R32574.
BS R29583.
BS R29584.
BS R66771.
BS R66772.
BS R37609.
BS R65932.
BS R65934.
BS R30496.
BS R26924.
BS R26925.
BS R64552.
BS R18142.
BS R65929.
BS R65930.
BS R65931.
BS R61309.
BS R24508.
BS R24509.
BS R65928.
BS R37170.
BS R42006.
BS R42007.
BS R42008.
XX
DR TRANSPATH: MO000047478.
DR TRANSCOMPEL: C00470.
DR TRANSCOMPEL: C00608.
XX
RN [1]; RE0028790.
RX PUBMED: 11395480.
RA Hay E., Lemonnier J., Fromigue O., Marie P. J.
RT Bone morphogenetic protein-2 promotes osteoblast apoptosis through a Smad-independent, protein kinase C-dependent signaling pathway.
RL J. Biol. Chem. 276:29028-36 (2001).
RN [2]; RE0032785.
RX PUBMED: 12738770.
RA Zhao M., Qiao M., Oyajobi B. O., Mundy G. R., Chen D.
RT E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation.
RL J. Biol. Chem. 278:27939-44 (2003).
RN [3]; RE0034097.
RX PUBMED: 15150273.
RA Sowa H., Kaji H., Hendy G. N., Canaff L., Komori T., Sugimoto T., Chihara K.
RT Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2.
RL J. Biol. Chem. 279:40267-75 (2004).
RN [4]; RE0035651.
RX PUBMED: 15456894.
RA Hassan M. Q., Javed A., Morasso M. I., Karlin J., Montecino M., van Wijnen A. J., Stein G. S., Stein J. L., Lian J. B.
RT Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene.
RL Mol. Cell. Biol. 24:9248-9261 (2004).
RN [5]; RE0035837.
RX PUBMED: 16000305.
RA Xiao G., Jiang D., Ge C., Zhao Z., Lai Y., Boules H., Phimphilai M., Yang X., Karsenty G., Franceschi R. T.
RT Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression.
RL J. Biol. Chem. 280:30689-30696 (2005).
RN [6]; RE0035851.
RX PUBMED: 11668178.
RA Gutierrez S., Javed A., Tennant D. K., van Rees M., Montecino M., Stein G. S., Stein J. L., Lian J. B.
RT CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression.
RL J. Biol. Chem. 277:1316-1323 (2002).
RN [7]; RE0035892.
RX PUBMED: 15292260.
RA Schroeder T. M., Kahler R. A., Li X., Westendorf J. J.
RT Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation.
RL J. Biol. Chem. 279:41998-42007 (2004).
RN [8]; RE0035895.
RX PUBMED: 12391164.
RA Westendorf J. J., Zaidi S. K., Cascino J. E., Kahler R., van Wijnen A. J., Lian J. B., Yoshida M., Stein G. S., Li X.
RT Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter.
RL Mol. Cell. Biol. 22:7982-7992 (2002).
RN [9]; RE0035930.
RX PUBMED: 15456860.
RA Paredes R., Arriagada G., Cruzat F., Villagra A., Olate J., Zaidi K., van Wijnen A., Lian J. B., Stein G. S., Stein J. L., Montecino M.
RT Bone-specific transcription factor Runx2 interacts with the 1alpha,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells.
RL Mol. Cell. Biol. 24:8847-8861 (2004).
RN [10]; RE0036275.
RX PUBMED: 12145306.
RA Willis D. M., Loewy A. P., Charlton-Kachigian N., Shao J. S., Ornitz D. M., Towler D. A.
RT Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex
RL J. Biol. Chem. 277:37280-91 (2002).
RN [11]; RE0036881.
RX PUBMED: 14500368.
RA Pratap J., Galindo M., Zaidi S. K., Vradii D., Bhat B. M., Robinson J. A., Choi J. Y., Komori T., Stein J. L., Lian J. B., Stein G. S., van Wijnen A. J.
RT Cell growth regulatory role of Runx2 during proliferative expansion of preosteoblasts
RL Cancer Res. 63:5357-62 (2003).
RN [12]; RE0037505.
RX PUBMED: 12086466.
RA Rossi F., MacLean H. E., Yuan W., Francis R. O., Semenova E., Lin C. S., Kronenberg H. M., Cobrinik D.
RT p107 and p130 Coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone development
RL Dev. Biol. 247:271-85 (2002).
RN [13]; RE0038752.
RX PUBMED: 12529404.
RA Cui C. B., Cooper L. F., Yang X., Karsenty G., Aukhil I.
RT Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZ
RL Mol. Cell. Biol. 23:1004-13 (2003).
RN [14]; RE0039092.
RX PUBMED: 11545733.
RA Thomas D. M., Carty S. A., Piscopo D. M., Lee J., Wang W., Forrester W. C., Hinds P. W.
RT The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation
RL Mol. Cell 8:303-16 (2001).
RN [15]; RE0039386.
RX PUBMED: 15136142.
RA Aberg T., Wang X. P., Kim J. H., Yamashiro T., Bei M., Rice R., Ryoo H. M., Thesleff I.
RT Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis
RL Dev. Biol. 270:76-93 (2004).
RN [16]; RE0039460.
RX PUBMED: 10617663.
RA Lutterbach B., Westendorf J. J., Linggi B., Isaac S., Seto E., Hiebert S. W.
RT A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia
RL J. Biol. Chem. 275:651-6 (2000).
RN [17]; RE0039819.
RX PUBMED: 11965546.
RA Pelletier N., Champagne N., Stifani S., Yang X. J.
RT MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2
RL Oncogene 21:2729-40 (2002).
RN [18]; RE0039840.
RX PUBMED: 10088730.
RA Lee M. H., Javed A., Kim H. J., Shin H. I., Gutierrez S., Choi J. Y., Rosen V., Stein J. L., van Wijnen A. J., Stein G. S., Lian J. B., Ryoo H. M.
RT Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation
RL J. Cell. Biochem. 73:114-25 (1999).
RN [19]; RE0040127.
RX PUBMED: 12923053.
RA Kim S., Koga T., Isobe M., Kern B. E., Yokochi T., Chin Y. E., Karsenty G., Taniguchi T., Takayanagi H.
RT Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation
RL Genes Dev. 17:1979-91 (2003).
RN [20]; RE0041636.
RX PUBMED: 9830051.
RA Xiao G., Wang D., Benson M. D., Karsenty G., Franceschi R. T.
RT Role of the alpha2-integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor
RL J. Biol. Chem. 273:32988-94 (1998).
RN [21]; RE0041873.
RX PUBMED: 11331591.
RA Alliston T., Choy L., Ducy P., Karsenty G., Derynck R.
RT TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation
RL EMBO J. 20:2254-72 (2001).
RN [22]; RE0041882.
RX PUBMED: 10412038.
RA Lecka-Czernik B., Gubrij I., Moerman E. J., Kajkenova O., Lipschitz D. A., Manolagas S. C., Jilka R. L.
RT Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARgamma2
RL J. Cell. Biochem. 74:357-71 (1999).
RN [23]; RE0041892.
RX PUBMED: 10228168.
RA Yagi R., Chen L. F., Shigesada K., Murakami Y., Ito Y.
RT A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator
RL EMBO J. 18:2551-62 (1999).
RN [24]; RE0042557.
RX PUBMED: 15138260.
RA Jin Y. H., Jeon E. J., Li Q. L., Lee Y. H., Choi J. K., Kim W. J., Lee K. Y., Bae S. C.
RT Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation
RL J. Biol. Chem. 279:29409-17 (2004).
RN [25]; RE0044009.
RX PUBMED: 10942429.
RA Zhou Y. X., Xu X., Chen L., Li C., Brodie S. G., Deng C. X.
RT A Pro250Arg substitution in mouse fgfr1 causes increased expression of cbfa1 and premature fusion of calvarial sutures
RL Hum. Mol. Genet. 9:2001-8 (2000).
RN [26]; RE0044325.
RX PUBMED: 11451945.
RA Dhamija S., Krebsbach P. H.
RT Role of Cbfa1 in ameloblastin gene transcription
RL J. Biol. Chem. 276:35159-64 (2001).
RN [27]; RE0046100.
RX PUBMED: 12070276.
RA Jheon A., Chen J., Teo W., Ganss B., Sodek J., Cheifetz S.
RT Temporal and spatial expression of a novel zinc finger transcription factor, AJ18, in developing murine skeletal tissues
RL J. Histochem. Cytochem. 50:973-82 (2002).
RN [28]; RE0046370.
RX PUBMED: 12606540.
RA Johnson K. A., van Etten D., Nanda N., Graham R. M., Terkeltaub R. A.
RT Distinct transglutaminase 2-independent and transglutaminase 2-dependent pathways mediate articular chondrocyte hypertrophy
RL J. Biol. Chem. 278:18824-32 (2003).
RN [29]; RE0046615.
RX PUBMED: 12952936.
RA Zheng Q., Zhou G., Morello R., Chen Y., Garcia-Rojas X., Lee B.
RT Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte-specific expression in vivo
RL J. Cell Biol. 162:833-42 (2003).
RN [30]; RE0048461.
RX PUBMED: 15703179.
RA Lengner C. J., Hassan M. Q., Serra R. W., Lepper C., van Wijnen A. J., Stein J. L., Lian J. B., Stein G. S.
RT Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation.
RL J. Biol. Chem. 280:15872-15879 (2005).
RN [31]; RE0048867.
RX PUBMED: 16195230.
RA Shen Q., Christakos S.
RT The vitamin D receptor, Runx2, and the Notch signaling pathway cooperate in the transcriptional regulation of osteopontin.
RL J. Biol. Chem. 280:40589-40598 (2005).
RN [32]; RE0048898.
RX PUBMED: 15107406.
RA Yoshida C. A., Yamamoto H., Fujita T., Furuichi T., Ito K., Inoue K., Yamana K., Zanma A., Takada K., Ito Y., Komori T.
RT Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog.
RL Genes Dev. 18:952-963 (2004).
RN [33]; RE0055016.
RX PUBMED: 18430783.
RA Sakamoto K., Tamamura Y., Katsube K., Yamaguchi A.
RT Zfp64 participates in Notch signaling and regulates differentiation in mesenchymal cells.
RL J. Cell Sci. 121:1613-1623 (2008).
RN [34]; RE0059766.
RX PUBMED: 15383550.
RA Kim Y. J., Lee M. H., Wozney J. M., Cho J. Y., Ryoo H. M.
RT Bone morphogenetic protein-2-induced alkaline phosphatase expression is stimulated by Dlx5 and repressed by Msx2.
RL J. Biol. Chem. 279:50773-50780 (2004).
RN [35]; RE0062876.
RX PUBMED: 16728531.
RA Lee H. W., Suh J. H., Kim A. Y., Lee Y. S., Park S. Y., Kim J. B.
RT Histone deacetylase 1-mediated histone modification regulates osteoblast differentiation.
RL Mol. Endocrinol. 20:2432-2443 (2006).
RN [36]; RE0065888.
RX PUBMED: 17215250.
RA Wang Q., Wei X., Zhu T., Zhang M., Shen R., Xing L., O'Keefe R. J., Chen D.
RT Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2.
RL J. Biol. Chem. 282:10742-10748 (2007).
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