AC T13841
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ID T13841
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DT 10.03.2005 (created); nvo.
DT 13.01.2015 (updated); spk.
CO Copyright (C), QIAGEN.
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FA HES-1
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SY hairy and enhancer of split 1; Hes1.
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OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
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FF Overexpression increases the activity of AML3 and there by stimulates osteogenesis;
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IN T09552 AML3; Mammalia.
IN T00306 GATA-1; human, Homo sapiens.
IN T10217 GATA-1; Mammalia.
IN T19634 HES 7; Mammalia.
IN T27193 Hes6; mouse, Mus musculus.
IN T09068 Hey2; mouse, Mus musculus.
IN T19198 PTF1A; rat, Rattus norvegicus.
IN T16056 RBPJK; Mammalia.
IN T14458 STAT3; Mammalia.
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MX M01009 V$HES1_Q2.
MX M07042 V$HES1_Q3.
MX M07420 V$HES1_Q4.
MX M02011 V$HES1_Q6.
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BS R22845.
BS R22843.
BS R22844.
BS R22846.
BS R26836.
BS R57319.
BS R22847.
BS R57318.
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DR TRANSPATH: MO000047044.
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RN [1]; RE0032546.
RX PUBMED: 15156153.
RA Kamakura S., Oishi K., Yoshimatsu T., Nakafuku M., Masuyama N., Gotoh Y.
RT Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling.
RL Nat. Cell Biol. 6:547-54 (2004).
RN [2]; RE0046005.
RX PUBMED: 9790495.
RA Issack P. S., Ziff E. B.
RT Altered expression of helix-loop-helix transcriptional regulators and cyclin D1 in Wnt-1-transformed PC12 cells
RL Cell Growth Differ. 9:837-45 (1998).
RN [3]; RE0046403.
RX PUBMED: 12167404.
RA Mustonen T., Tummers M., Mikami T., Itoh N., Zhang N., Gridley T., Thesleff I.
RT Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth
RL Dev. Biol. 248:281-93 (2002).
RN [4]; RE0048842.
RX PUBMED: 10851137.
RA Bae S., Bessho Y., Hojo M., Kageyama R.
RT The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation.
RL Development 127:2933-2943 (2000).
RN [5]; RE0048851.
RX PUBMED: 11486045.
RA Iso T., Sartorelli V., Poizat C., Iezzi S., Wu H. Y., Chung G., Kedes L., Hamamori Y.
RT HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling.
RL Mol. Cell. Biol. 21:6080-6089 (2001).
RN [6]; RE0048867.
RX PUBMED: 16195230.
RA Shen Q., Christakos S.
RT The vitamin D receptor, Runx2, and the Notch signaling pathway cooperate in the transcriptional regulation of osteopontin.
RL J. Biol. Chem. 280:40589-40598 (2005).
RN [7]; RE0048868.
RX PUBMED: 16682003.
RA King I. N., Kathiriya I. S., Murakami M., Nakagawa M., Gardner K. A., Srivastava D., Nakagawa O.
RT Hrt and Hes negatively regulate Notch signaling through interactions with RBP-Jkappa.
RL Biochem. Biophys. Res. Commun. 345:446-452 (2006).
RN [8]; RE0048885.
RX PUBMED: 16201968.
RA Ghosh B., Leach S. D.
RT Interactions between hairy/enhancer of split-related proteins and the pancreatic transcription factor Ptf1-p48 modulate function of the PTF1 transcriptional complex.
RL Biochem. J. 393:679-685 (2006).
RN [9]; RE0048895.
RX PUBMED: 15563463.
RA Ishiko E., Matsumura I., Ezoe S., Gale K., Ishiko J., Satoh Y., Tanaka H., Shibayama H., Mizuki M., Era T., Enver T., Kanakura Y.
RT Notch signals inhibit the development of erythroid/megakaryocytic cells by suppressing GATA-1 activity through the induction of HES1.
RL J. Biol. Chem. 280:4929-4939 (2005).
RN [10]; RE0051924.
RX PUBMED: 18162173.
RA Suh J. H., Lee H. W., Lee J. W., Kim J. B.
RT Hes1 stimulates transcriptional activity of Runx2 by increasing protein stabilization during osteoblast differentiation.
RL Biochem. Biophys. Res. Commun. 367:97-102 (2008).
RN [11]; RE0066431.
RX PUBMED: 18604200.
RA Kolev V., Mandinova A., Guinea-Viniegra J., Hu B., Lefort K., Lambertini C., Neel V., Dummer R., Wagner E. F., Dotto G. P.
RT EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer.
RL Nat. Cell Biol. 10:902-911 (2008).
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