AC T09068
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ID T09068
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DT 14.06.2006 (created); man.
DT 27.03.2008 (updated); dbh.
CO Copyright (C), QIAGEN.
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FA Hey2
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SY basic helix-loop-helix factor 1; CHF1; gridlock; hairy and enhancer of split related-2; hairy-related transcription factor 2; HERP1; Hes-related repressor protein 1; HRT2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004057 Hey2.
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CL C0010; bHLH.
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SZ 339 AA; 35.9 kDa (cDNA) (calc.).
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SQ MKRPCEETTSESDLDETIDVGSENNYPGHATSSVMRSNSPTTTSQIMARKKRRGIIEKRR
SQ RDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALATD
SQ FMSIGFRECLTEVARYLSSVEGLDPSDPLRVRLVSHLSTCASQREAAVMTSSMAHHHHPL
SQ HPHHWAAAFHHLPTALLQPNGLHTSESTPCRLSTSSEVPSAHGSALLTATFAHADSALRM
SQ PSGGTVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPSNAAAAAAVA
SQ AATAISPPLSVSAASSPQQTSTGTNNKPYQPWGTEVGAF
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SC translated from EMBL #AF173902
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FT 2 309 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 49 61 
basic region [1].
FT 49 103 
basic helix-loop-helix domain [1].
FT 49 104 
PS50888; HLH.
FT 50 103 
helix-loop-helix motif [1].
FT 51 104 
PF00010; Helix-loop-helix DNA-binding domain.
FT 54 109 
SM00353; finulus.
FT 119 166 
SM00511; ORANGE.
FT 120 164 
orange domain [1].
FT 120 166 
PF07527; Hairy Orange.
FT 122 157 PS51054; ORANGE.
FT 334 339 conserved motif TE(I/V)GAF [1].
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IN T08358 GATA-4; mouse, Mus musculus.
IN T04106 HDAC1; human, Homo sapiens.
IN T14216 Helt; mouse, Mus musculus.
IN T13841 HES-1; Mammalia.
IN T25617 sin3a; mouse, Mus musculus.
IN T14063 SRF; Mammalia.
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MX M08885 V$HAIRYLIKE_Q3.
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BS R12364.
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DR TRANSPATH: MO000082915.
DR EMBL: AF172287;
DR EMBL: AF173902;
DR EMBL: AY059384;
DR UniProtKB: Q9QUS4;
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RN [1]; RE0017655.
RX PUBMED: 10588864.
RA Nakagawa O., Nakagawa M., Richardson J. A., Olson E. N., Srivastava D.
RT HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments.
RL Dev. Biol. 216:72-84 (1999).
RN [2]; RE0017667.
RX PUBMED: 11095750.
RA Nakagawa O., McFadden D. G., Nakagawa M., Yanagisawa H., Hu T., Srivastava D., Olson E. N.
RT Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.
RL Proc. Natl. Acad. Sci. USA 97:13655-13660 (2000).
RN [3]; RE0047869.
RX PUBMED: 16151017.
RA Doi H., Iso T., Yamazaki M., Akiyama H., Kanai H., Sato H., Kawai-Kowase K., Tanaka T., Maeno T., Okamoto E., Arai M., Kedes L., Kurabayashi M.
RT HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box.
RL Arterioscler. Thromb. Vasc. Biol. 25:2328-2334 (2005).
RN [4]; RE0048851.
RX PUBMED: 11486045.
RA Iso T., Sartorelli V., Poizat C., Iezzi S., Wu H. Y., Chung G., Kedes L., Hamamori Y.
RT HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling.
RL Mol. Cell. Biol. 21:6080-6089 (2001).
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