AC T14063
XX
ID T14063
XX
DT 10.03.2005 (created); nvo.
DT 02.04.2014 (updated); yre.
CO Copyright (C), QIAGEN.
XX
FA SRF
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SY Serum Responsive Factor.
XX
OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
XX
IN T00040 AR; human, Homo sapiens.
IN T08702 ATF-6; Mammalia.
IN T09410 C/EBPbeta; Mammalia.
IN T15118 CBP; Mammalia.
IN T14062 Elk-1; Mammalia.
IN T10472 Fli-1; Mammalia.
IN T09068 Hey2; mouse, Mus musculus.
IN T25635 myocardin; mouse, Mus musculus.
IN T16719 Net; Mammalia.
IN T08563 NF-YA; Mammalia.
IN T16654 SAP-1; Mammalia.
IN T04210 Smad3; mouse, Mus musculus.
IN T09538 Smad3; Mammalia.
IN T08342 Smad7-isoform1; human, Homo sapiens.
IN T08326 Sp1; Mammalia.
IN T21552 SRC-1; Mammalia.
IN T16641 TFII-I; Mammalia.
IN T27282 Tip60-isoform1; mouse, Mus musculus.
IN T09133 YY1; Mammalia.
XX
MX M00152 V$SRF_01.
MX M01257 V$SRF_02.
MX M00215 V$SRF_C.
MX M07618 V$SRF_Q3.
MX M00810 V$SRF_Q4.
MX M00922 V$SRF_Q5_01.
MX M01007 V$SRF_Q5_02.
MX M00186 V$SRF_Q6.
XX
BS R00031.
BS R00460.
BS R23154.
BS R71255.
BS R21513.
BS R09706.
XX
DR TRANSPATH: MO000046834.
DR TRANSCOMPEL: C00008.
DR TRANSCOMPEL: C00009.
XX
RN [1]; RE0005332.
RX PUBMED: 7540136.
RA Price M. A., Rogers A. E., Treisman R.
RT Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET)
RL EMBO J. 14:2589-2601 (1995).
RN [2]; RE0005335.
RX PUBMED: 8477450.
RA Hill C. S., Marais R., John S., Wynne J., Dalton S., Treisman R.
RT Functional analysis of a growth factor-responsive transcription factor complex
RL Cell 73:395-406 (1993).
RN [3]; RE0005739.
RX PUBMED: 7854423.
RA Joliot V., Demma M., Prywes R.
RT Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor
RL Nature 373:632-635 (1995).
RN [4]; RE0006768.
RX PUBMED: 7565750.
RA Natesan S., Gilman M.
RT YY1 facilitates the association of serum response factor with the c-fos serum response element
RL Mol. Cell. Biol. 15:5975-5982 (1995).
RN [5]; RE0007354.
RX PUBMED: 8423791.
RA Vincent C. K., Gualberto A., Patel C. V., Walsh K.
RT Different regulatory sequences control creatine Kinase-M Gene expression in directly injected skeletal and cardiac muscle
RL Mol. Cell. Biol. 13:1264-1272 (1993).
RN [6]; RE0015298.
RX PUBMED: 8617811.
RA Groisman R., Masutani H., Leibovitch M. P., Robin P., Soudant I., Trouche D., Harel-Bellan A.
RT Physical interaction between the mitogen-responsive serum response factor and myogenic basic-helix-loop-helix proteins
RL J. Biol. Chem. 271:5258-5264 (1996).
RN [7]; RE0015301.
RX PUBMED: 9584171.
RA Kim D. W., Cheriyath V., Roy A. L., Cochran B. H.
RT TFII-I enhances activation of the c-fos promoter through interactions with upstream elements
RL Mol. Cell. Biol. 18:3310-3320 (1998).
RN [8]; RE0015392.
RX PUBMED: 10777532.
RA Lee S. K., Kim J. H., Lee Y. C., Cheong J., Lee J. W.
RT Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor
RL J. Biol. Chem. 275:12470-12474 (2000).
RN [9]; RE0015397.
RX PUBMED: 11038368.
RA Moore M. L., Wang G. L., Belaguli N. S., Schwartz R. J., McMillin J. B.
RT GATA-4 and Serum Response Factor Regulate Transcription of the Muscle-Specific Carnitine Palmitoyltransferase I {beta} in Rat Heart
RL J. Biol. Chem. 276:1026-1033 (2001).
RN [10]; RE0015489.
RX PUBMED: 8604338.
RA Magnaghi-Jaulin L., Masutani H., Robin P., Lipinski M., Harel-Bellan A.
RT SRE elements are binding sites for the fusion protein EWS-FLI-1
RL Nucleic Acids Res. 24:1052-1058 (1996).
RN [11]; RE0015521.
RX PUBMED: 10993896.
RA Carson J. A., Fillmore R. A., Schwartz R. J., Zimmer W. E.
RT The smooth muscle gamma -actin gene promoter is a molecular target for the mouse bagpipe homologue, mNkx3-1, and serum response factor
RL J. Biol. Chem. 275:39061-39072 (2000).
RN [12]; RE0016596.
RX PUBMED: 8083220.
RA Latinkic B. V., Lau L. F.
RT Transcription activation of the immediate early gene pip92 by serum growth factors requires both Ets and CArG-like elements.
RL J. Biol. Chem. 269:23163-23170 (1994).
RN [13]; RE0018486.
RX PUBMED: 9488437.
RA Zohn I. E., Symons M., Chrzanowska-Wodnicka M., Westwick J. K., Der C. J.
RT Mas oncogene signaling and transformation require the small GTP-binding protein Rac
RL Mol. Cell. Biol. 18:1225-1235 (1998).
RN [14]; RE0022768.
RX PUBMED: 11500490.
RA Hanlon M., Sturgill T. W., Sealy L.
RT ERK2- and p90(Rsk2)-dependent pathways regulate the CCAAT/enhancer-binding protein-beta interaction with serum response factor.
RL J. Biol. Chem. 276:38449-38456 (2001).
RN [15]; RE0024587.
RX PUBMED: 10606656.
RA Dalgleish P., Sharrocks A. D.
RT The mechanism of complex formation between Fli-1 and SRF transcription factors.
RL Nucleic Acids Res. 28:560-569 (2000).
RN [16]; RE0025059.
RX PUBMED: 11136726.
RA Gupta M., Kogut P., Davis F. J., Belaguli N. S., Schwartz R. J., Gupta M. P.
RT Physical interaction between the MADS box of serum response factor and the TEA/ATTS DNA-binding domain of transcription enhancer factor-1.
RL J. Biol. Chem. 276:10413-10422 (2001).
RN [17]; RE0025066.
RX PUBMED: 11983708.
RA Sepulveda J. L., Vlahopoulos S., Iyer D., Belaguli N., Schwartz R. J.
RT Combinatorial expression of GATA4, Nkx2-5, and serum response factor directs early cardiac gene activity.
RL J. Biol. Chem. 277:25775-25782 (2002).
RN [18]; RE0025209.
RX PUBMED: 10318842.
RA Hanlon M., Sealy L.
RT Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein beta.
RL J. Biol. Chem. 274:14224-14228 (1999).
RN [19]; RE0026387.
RX PUBMED: 9271374.
RA Zhu C., Johansen F. E., Prywes R.
RT Interaction of ATF6 and serum response factor.
RL Mol. Cell. Biol. 17:4957-66 (1997).
RN [20]; RE0027715.
RX PUBMED: 10571058.
RA Yamada K., Osawa H., Granner D. K.
RT Identification of proteins that interact with NF-YA.
RL FEBS Lett. 460:41-5 (1999).
RN [21]; RE0028704.
RX PUBMED: 11335712.
RA de Jager T., Pelzer T., Muller-Botz S., Imam A., Muck J., Neyses L.
RT Mechanisms of estrogen receptor action in the myocardium. Rapid gene activation via the ERK1/2 pathway and serum response elements.
RL J. Biol. Chem. 276:27873-80 (2001).
RN [22]; RE0030891.
RX PUBMED: 14654367.
RA Qiu P., Feng X. H., Li L.
RT Interaction of Smad3 and SRF-associated complex mediates TGF-beta1 signals to regulate SM22 transcription during myofibroblast differentiation.
RL J. Mol. Cell. Cardiol. 35:1407-20 (2003).
RN [23]; RE0032140.
RX PUBMED: 9685422.
RA Thuerauf D. J., Arnold N. D., Zechner D., Hanford D. S., DeMartin K. M., McDonough P. M., Prywes R., Glembotski C. C.
RT p38 Mitogen-activated protein kinase mediates the transcriptional induction of the atrial natriuretic factor gene through a serum response element. A potential role for the transcription factor ATF6.
RL J. Biol. Chem. 273:20636-43 (1998).
RN [24]; RE0032762.
RX PUBMED: 12663674.
RA Davis F. J., Gupta M., Camoretti-Mercado B., Schwartz R. J., Gupta M. P.
RT Calcium/calmodulin-dependent protein kinase activates serum response factor transcription activity by its dissociation from histone deacetylase, HDAC4. Implications in cardiac muscle gene regulation during hypertrophy.
RL J. Biol. Chem. 278:20047-58 (2003).
RN [25]; RE0036183.
RX PUBMED: 11373293.
RA Reuther G. W., Lambert Q. T., Booden M. A., Wennerberg K., Becknell B., Marcucci G., Sondek J., Caligiuri M. A., Der C. J.
RT Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA
RL J. Biol. Chem. 276:27145-51 (2001).
RN [26]; RE0036194.
RX PUBMED: 14512443.
RA Niu J., Profirovic J., Pan H., Vaiskunaite R., Voyno-Yasenetskaya T.
RT G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production
RL Circ. Res. 93:848-56 (2003).
RN [27]; RE0036274.
RX PUBMED: 12270917.
RA Park B., Nguyen N. T., Dutt P., Merdek K. D., Bashar M., Sterpetti P., Tosolini A., Testa J. R., Toksoz D.
RT Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation
RL J. Biol. Chem. 277:45361-70 (2002).
RN [28]; RE0037577.
RX PUBMED: 12799187.
RA Witteck A., Yao Y., Fechir M., Forstermann U., Kleinert H.
RT Rho protein-mediated changes in the structure of the actin cytoskeleton regulate human inducible NO synthase gene expression
RL Exp. Cell Res. 287:106-15 (2003).
RN [29]; RE0039270.
RX PUBMED: 12099720.
RA Muller J. G., Thompson J. T., Edmonson A. M., Rackley M. S., Kasahara H., Izumo S., McQuinn T. C., Menick D. R., O'Brien T. X.
RT Differential regulation of the cardiac sodium calcium exchanger promoter in adult and neonatal cardiomyocytes by Nkx2.5 and serum response factor
RL J. Mol. Cell. Cardiol. 34:807-21 (2002).
RN [30]; RE0039927.
RX PUBMED: 11983702.
RA Arai A., Spencer J. A., Olson E. N.
RT STARS, a striated muscle activator of Rho signaling and serum response factor-dependent transcription
RL J. Biol. Chem. 277:24453-9 (2002).
RN [31]; RE0041096.
RX PUBMED: 11784081.
RA Lilly B., Olson E. N., Beckerle M. C.
RT Identification of a CArG box-dependent enhancer within the cysteine-rich protein 1 gene that directs expression in arterial but not venous or visceral smooth muscle cells
RL Dev. Biol. 240:531-47 (2001).
RN [32]; RE0041339.
RX PUBMED: 12061776.
RA Maeda T., Gupta M. P., Stewart A. F.
RT TEF-1 and MEF2 transcription factors interact to regulate muscle-specific promoters
RL Biochem. Biophys. Res. Commun. 294:791-7 (2002).
RN [33]; RE0041340.
RX PUBMED: 14999078.
RA Chang S. H., Poser S., Xia Z.
RT A novel role for serum response factor in neuronal survival
RL J. Neurosci. 24:2277-85 (2004).
RN [34]; RE0041341.
RX PUBMED: 12681447.
RA Davis A., Hogarth K., Fernandes D., Solway J., Niu J., Kolenko V., Browning D., Miano J. M., Orlov S. N., Dulin N. O.
RT Functional significance of protein kinase A activation by endothelin-1 and ATP: negative regulation of SRF-dependent gene expression by PKA
RL Cell. Signal. 15:597-604 (2003).
RN [35]; RE0041342.
RX PUBMED: 12297045.
RA Chen F., Kook H., Milewski R., Gitler A. D., Lu M. M., Li J., Nazarian R., Schnepp R., Jen K., Biben C., Runke G., MacKay J. P., Novotny J., Schwartz R. J., Harvey R. P., Mullins M. C., Epstein J. A.
RT Hop is an unusual homeobox gene that modulates cardiac development
RL Cell 110:713-23 (2002).
RN [36]; RE0041344.
RX PUBMED: 12622724.
RA Matsuzaki K., Minami T., Tojo M., Honda Y., Saitoh N., Nagahiro S., Saya H., Nakao M.
RT PML-nuclear bodies are involved in cellular serum response
RL Genes Cells 8:275-86 (2003).
RN [37]; RE0041345.
RX PUBMED: 12034774.
RA Geneste O., Copeland J. W., Treisman R.
RT LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics
RL J. Cell Biol. 157:831-8 (2002).
RN [38]; RE0041346.
RX PUBMED: 9388250.
RA Ramirez S., Ait-Si-Ali S., Robin P., Trouche D., Harel-Bellan A., Ait Si Ali S.
RT The CREB-binding protein (CBP) cooperates with the serum response factor for transactivation of the c-fos serum response element
RL J. Biol. Chem. 272:31016-21 (1997).
RN [39]; RE0041347.
RX PUBMED: 9325329.
RA Liao J., Hodge C., Meyer D., Ho P. S., Rosenspire K., Schwartz J.
RT Growth hormone regulates ternary complex factors and serum response factor associated with the c-fos serum response element
RL J. Biol. Chem. 272:25951-8 (1997).
RN [40]; RE0041348.
RX PUBMED: 9786846.
RA Kim H. J., Kim J. H., Lee J. W.
RT Steroid receptor coactivator-1 interacts with serum response factor and coactivates serum response element-mediated transactivations
RL J. Biol. Chem. 273:28564-7 (1998).
RN [41]; RE0041659.
RX PUBMED: 14565952.
RA Selvaraj A., Prywes R.
RT Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation
RL J. Biol. Chem. 278:41977-87 (2003).
RN [42]; RE0041687.
RX PUBMED: 12077347.
RA Jung D. J., Sung H. S., Goo Y. W., Lee H. M., Park O. K., Jung S. Y., Lim J., Kim H. J., Lee S. K., Kim T. S., Lee J. W., Lee Y. C.
RT Novel transcription coactivator complex containing activating signal cointegrator 1
RL Mol. Cell. Biol. 22:5203-11 (2002).
RN [43]; RE0042440.
RX PUBMED: 12576482.
RA Kim K. H., Min Y. K., Baik J. H., Lau L. F., Chaqour B., Chung K. C.
RT Expression of angiogenic factor Cyr61 during neuronal cell death via the activation of c-Jun N-terminal kinase and serum response factor
RL J. Biol. Chem. 278:13847-54 (2003).
RN [44]; RE0043515.
RX PUBMED: 15282327.
RA Wheaton K., Riabowol K.
RT Protein kinase C delta blocks immediate-early gene expression in senescent cells by inactivating serum response factor
RL Mol. Cell. Biol. 24:7298-311 (2004).
RN [45]; RE0045123.
RX PUBMED: 9670022.
RA Alberts A. S., Treisman R.
RT Activation of RhoA and SAPK/JNK signalling pathways by the RhoA- specific exchange factor mNET1
RL EMBO J. 17:4075-85 (1998).
RN [46]; RE0047216.
RX PUBMED: 15623502.
RA Vlahopoulos S., Zimmer W. E., Jenster G., Belaguli N. S., Balk S. P., Brinkmann A. O., Lanz R. B., Zoumpourlis V. C., Schwartz R. J.
RT Recruitment of the androgen receptor via serum response factor facilitates expression of a myogenic gene
RL J. Biol. Chem. 280:7786-92 (2005).
RN [47]; RE0047857.
RX PUBMED: 15492011.
RA Zhang X., Azhar G., Zhong Y., Wei J. Y.
RT Identification of a novel serum response factor cofactor in cardiac gene regulation.
RL J. Biol. Chem. 279:55626-55632 (2004).
RN [48]; RE0047866.
RX PUBMED: 16135793.
RA Kawai-Kowase K., Kumar M. S., Hoofnagle M. H., Yoshida T., Owens G. K.
RT PIAS1 activates the expression of smooth muscle cell differentiation marker genes by interacting with serum response factor and class I basic helix-loop-helix proteins.
RL Mol. Cell. Biol. 25:8009-8023 (2005).
RN [49]; RE0047869.
RX PUBMED: 16151017.
RA Doi H., Iso T., Yamazaki M., Akiyama H., Kanai H., Sato H., Kawai-Kowase K., Tanaka T., Maeno T., Okamoto E., Arai M., Kedes L., Kurabayashi M.
RT HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box.
RL Arterioscler. Thromb. Vasc. Biol. 25:2328-2334 (2005).
RN [50]; RE0048996.
RX PUBMED: 17101795.
RA Wang J., Li A., Wang Z., Feng X., Olson E. N., Schwartz R. J.
RT Myocardin Sumoylation Transactivates Cardiogenic Genes in Pluripotent 10T1/2 Fibroblasts.
RL Mol. Cell. Biol. 27:622-632 (2006).
RN [51]; RE0059888.
RX PUBMED: 15591049.
RA Barron M. R., Belaguli N. S., Zhang S. X., Trinh M., Iyer D., Merlo X., Lough J. W., Parmacek M. S., Bruneau B. G., Schwartz R. J.
RT Serum response factor, an enriched cardiac mesoderm obligatory factor, is a downstream gene target for Tbx genes.
RL J. Biol. Chem. 280:11816-11828 (2005).
XX
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