AC T08342
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ID T08342
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DT 11.01.2006 (created); jma.
CO Copyright (C), QIAGEN.
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FA Smad7-isoform1
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SY Smad-7.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002306 SMAD7; HGNC: SMAD7.
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CL C0041; SMAD.
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SZ 426 AA; 46.5 kDa (cDNA) (calc.).
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SQ MFRTKRSALVRRLWRSRAPGGEDEEEGAGGGGGGGELRGEGATDSRAHGAGGGGPGRAGC
SQ CLGKAVRGAKCHHHPHPPAAGAGAAGGAEADLKALTHSVLKKLKERQLELLLQAVESRGG
SQ TRTACLLLPGRLDCRLGPGAPAGAQPAQPPSSYSLPLLLCKVFRWPDLRHSSEVKRLCCC
SQ ESYGKINPELVCCNPHHLSRLCELESPPPPYSRYPMDFLKPTADCPDAVPSSAETGGTNY
SQ LAPGGLSDSQLLLEPGDRSHWCVVAYWEEKTRVGRLYCVQEPSLDIFYDLPQGNGFCLGQ
SQ LNSDNKSQLVQKVRSKIGCGIQLTREVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKV
SQ FPGFSIKAFDYEKAYSLQRPNDHEFMQQPWTGFTVQISFVKGWGQCYTRQFISSCPCWLE
SQ VIFNSR
XX
SC translated from EMBL #AF015261
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FT 1 156 
N-terminal domain [3].
FT 64 207 
PS51075; MH1.
FT 87 205 
SM00523; dwAneu5.
FT 89 202 
PF03165; MH1 domain.
FT 157 258 
Linker region [3].
FT 255 426 
PF03166; MH2 domain.
FT 259 426 
C-terminal domain [3].
FT 259 424 
SM00524; DWB.
FT 261 426 
PS51076; MH2.
XX
IN T14063 SRF; Mammalia.
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DR TRANSPATH: MO000056713.
DR EMBL: AF015261; AF015261.
DR UniProtKB: O15105; O14740.
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RN [1]; RE0025738.
RX PUBMED: 12118366.
RA Ferrigno O., Lallemand F., Verrecchia F., L'Hoste S., Camonis J., Atfi A., Mauviel A.
RT Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling.
RL Oncogene 21:4879-84 (2002).
RN [2]; RE0060832.
RX PUBMED: 16690609.
RA Camoretti-Mercado B., Fernandes D. J., Dewundara S., Churchill J., Ma L., Kogut P. C., McConville J. F., Parmacek M. S., Solway J.
RT Inhibition of transforming growth factor beta-enhanced serum response factor-dependent transcription by SMAD7.
RL J. Biol. Chem. 281:20383-20392 (2006).
RN [3]; RE0015540.
RX PUBMED: 9705232.
RA Bhushan A., Chen Y., Vale W.
RT Smad7 inhibits mesoderm formation and promotes neural cell fate in Xenopus embryos
RL Dev. Biol. 200:260-268 (1998).
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