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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T08342 XX ID T08342 XX DT 11.01.2006 (created); jma. CO Copyright (C), QIAGEN. XX FA Smad7-isoform1 XX SY Smad-7. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G002306 SMAD7; HGNC: SMAD7. XX CL C0041; SMAD. XX SZ 426 AA; 46.5 kDa (cDNA) (calc.). XX SQ MFRTKRSALVRRLWRSRAPGGEDEEEGAGGGGGGGELRGEGATDSRAHGAGGGGPGRAGC SQ CLGKAVRGAKCHHHPHPPAAGAGAAGGAEADLKALTHSVLKKLKERQLELLLQAVESRGG SQ TRTACLLLPGRLDCRLGPGAPAGAQPAQPPSSYSLPLLLCKVFRWPDLRHSSEVKRLCCC SQ ESYGKINPELVCCNPHHLSRLCELESPPPPYSRYPMDFLKPTADCPDAVPSSAETGGTNY SQ LAPGGLSDSQLLLEPGDRSHWCVVAYWEEKTRVGRLYCVQEPSLDIFYDLPQGNGFCLGQ SQ LNSDNKSQLVQKVRSKIGCGIQLTREVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKV SQ FPGFSIKAFDYEKAYSLQRPNDHEFMQQPWTGFTVQISFVKGWGQCYTRQFISSCPCWLE SQ VIFNSR XX SC translated from EMBL #AF015261 XX FT 1 156 N-terminal domain [3]. FT 64 207 PS51075; MH1. FT 87 205 SM00523; dwAneu5. FT 89 202 PF03165; MH1 domain. FT 157 258 Linker region [3]. FT 255 426 PF03166; MH2 domain. FT 259 426 C-terminal domain [3]. FT 259 424 SM00524; DWB. FT 261 426 PS51076; MH2. XX IN T14063 SRF; Mammalia. XX DR TRANSPATH: MO000056713. DR EMBL: AF015261; AF015261. DR UniProtKB: O15105; O14740. XX RN [1]; RE0025738. RX PUBMED: 12118366. RA Ferrigno O., Lallemand F., Verrecchia F., L'Hoste S., Camonis J., Atfi A., Mauviel A. RT Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling. RL Oncogene 21:4879-84 (2002). RN [2]; RE0060832. RX PUBMED: 16690609. RA Camoretti-Mercado B., Fernandes D. J., Dewundara S., Churchill J., Ma L., Kogut P. C., McConville J. F., Parmacek M. S., Solway J. RT Inhibition of transforming growth factor beta-enhanced serum response factor-dependent transcription by SMAD7. RL J. Biol. Chem. 281:20383-20392 (2006). RN [3]; RE0015540. RX PUBMED: 9705232. RA Bhushan A., Chen Y., Vale W. RT Smad7 inhibits mesoderm formation and promotes neural cell fate in Xenopus embryos RL Dev. Biol. 200:260-268 (1998). XX //