AC T04210
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ID T04210
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DT 23.01.2001 (created); dkl.
DT 22.09.2015 (updated); smt.
CO Copyright (C), QIAGEN.
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FA Smad3
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SY Smad-3.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002404 Smad3.
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CL C0041; SMAD; 7.1.1.1.3.
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CP (embryo): throughout embryonic development [3]; (adult): bone marrow, heart, brain, kidney [3]; lung, spleen, thymus [3] [4]; pituitary gonadotropes [5] [3] [4] [5].
CN (adult): liver [3]; brain, heart, kidney [4] conflict to [3] skeletal muscle, small intestine [4] [3] [4].
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FF -/- mice are smaller than wild-type littermates [3] [4];
FF some have an incompletely penetrant forepaw defect, torqued hind limbs, kyphosis or display marked rib cage malformation and die between 1 and 8 months [4];
FF death of -/- mice between 1 and 8 months after birth is associated with multifocal formation of pyogenic abscesses [3];
FF primary defect in immune function [3];
FF symptomatic mice exhibit thymic involution, enlarged lymph nodes, and formation of bacterial abscesses to mucosal surfaces [3];
FF chronic intestinal inflammation is infrequently associated with colonic adenocarcinoma in mice older than 6 months of age [3];
FF mediating the antiproliferative effects of TGF-beta and is implicated as a potential effector for TGF-beta in modulating immune system function [4];
FF in pituitary gonadotropes, is located in cytoplasm under basal conditions and translocated into the nucleus after stimulation with activin [5];
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IN T02516 foxm1-isoform2; human, Homo sapiens.
IN T00310 GATA-3; mouse, Mus musculus.
IN T31925 Oligo1; Mammalia.
IN T06379 PML; mouse, Mus musculus.
IN T34106 Smad1{p}; mouse, Mus musculus.
IN T05067 Smad4; mouse, Mus musculus.
IN T14063 SRF; Mammalia.
IN T20152 Trim33; mouse, Mus musculus.
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MX M02794 V$SMAD3_03.
MX M00701 V$SMAD3_Q6.
MX M01888 V$SMAD3_Q6_01.
MX M07429 V$SMAD3_Q6_02.
MX M02898 V$SMAD4_04.
MX M08897 V$SMAD_Q4.
MX M00792 V$SMAD_Q6.
MX M00974 V$SMAD_Q6_01.
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BS R10004.
BS R23469.
BS R63717.
BS R38455.
BS R73788.
BS R73790.
BS R67359.
BS R67362.
BS R69758.
BS R71637.
BS R13582.
BS R73964.
BS R68046.
BS R73248.
BS R36012.
BS R66072.
BS R68478.
BS R41627.
BS R41661.
BS R30936.
BS R67353.
BS R67356.
BS R29586.
BS R66648.
BS R19731.
BS R10063.
BS R24111.
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DR TRANSPATH: MO000020633.
DR TRANSCOMPEL: C00196.
DR TRANSCOMPEL: C00393.
DR TRANSCOMPEL: C00574.
DR TRANSCOMPEL: C00604.
DR UniProtKB: Q8BUN5;
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RN [1]; RE0015115.
RX PUBMED: 10767528.
RA Dick A., Mayr T., Bauer H., Meier A., Hammerschmidt M.
RT Cloning and characterization of zebrafish smad2, smad3 and smad4
RL Gene 246:69-80 (2000).
RN [2]; RE0015602.
RX PUBMED: 10331191.
RA Kano K., Notani A., Nam S. Y., Fujisawa M., Kurohmaru M., Hayashi Y.
RT Cloning and studies of the mouse cDNA encoding Smad3
RL J. Vet. Med. Sci. 61:213-219 (1999).
RN [3]; RE0015682.
RX PUBMED: 10064594.
RA Yang X., Letterio J. J., Lechleider R. J., Chen L., Hayman R., Gu H., Roberts A. B., Deng D.
RT Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta
RL EMBO J. 18:1280-1291 (1999).
RN [4]; RE0015683.
RX PUBMED: 10082515.
RA Datto M. B., Frederick J. P., Pan L., Borton A. J., Zhuang Y., Wang X. F.
RT Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction
RL Mol. Cell. Biol. 19:2495-2504 (1999).
RN [5]; RE0023194.
RX PUBMED: 12145309.
RA Norwitz E. R., Xu S., Xu J., Spiryda L. B., Park J. S., Jeong K. H., McGee E. A., Kaiser U. B.
RT Direct binding of AP-1 (Fos/Jun) proteins to a SMAD binding element facilitates both gonadotropin-releasing hormone (GnRH)- and activin-mediated transcriptional activation of the mouse GnRH receptor gene.
RL J. Biol. Chem. 277:37469-37478 (2002).
RN [6]; RE0037868.
RX PUBMED: 10574984.
RA Rich J. N., Zhang M., Datto M. B., Bigner D. D., Wang X. F.
RT Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines
RL J. Biol. Chem. 274:35053-8 (1999).
RN [7]; RE0047880.
RX PUBMED: 15356634.
RA Lin H. K., Bergmann S., Pandolfi P. P.
RT Cytoplasmic PML function in TGF-beta signalling.
RL Nature 431:205-211 (2004).
RN [8]; RE0052119.
RX PUBMED: 16314499.
RA Zhu Q., Pearson-White S., Luo K.
RT Requirement for the SnoN oncoprotein in transforming growth factor beta-induced oncogenic transformation of fibroblast cells.
RL Mol. Cell. Biol. 25:10731-10744 (2005).
RN [9]; RE0052559.
RX PUBMED: 18024957.
RA Cocolakis E., Dai M., Drevet L., Ho J., Haines E., Ali S., Lebrun J. J.
RT Smad signaling antagonizes STAT5-mediated gene transcription and mammary epithelial cell differentiation.
RL J. Biol. Chem. 283:1293-1307 (2008).
RN [10]; RE0053353.
RX PUBMED: 11592788.
RA Aschenbrenner J. K., Sollinger H. W., Becker B. N., Hullett D. A.
RT 1,25-(OH(2))D(3) alters the transforming growth factor beta signaling pathway in renal tissue.
RL J. Surg. Res. 100:171-175 (2001).
RN [11]; RE0053736.
RX PUBMED: 17942918.
RA Jin W., Yun C., Kim H. S., Kim S. J.
RT TrkC binds to the bone morphogenetic protein type II receptor to suppress bone morphogenetic protein signaling.
RL Cancer Res. 67:9869-9877 (2007).
RN [12]; RE0071379.
RX PUBMED: 21493862.
RA Holm T. M., Habashi J. P., Doyle J. J., Bedja D., Chen Y., van Erp C., Lindsay M. E., Kim D., Schoenhoff F., Cohn R. D., Loeys B. L., Thomas C. J., Patnaik S., Marugan J. J., Judge D. P., Dietz H. C.
RT Noncanonical TGFbeta signaling contributes to aortic aneurysm progression in Marfan syndrome mice.
RL Science 332:358-361 (2011).
RN [13]; RE0071921.
RX PUBMED: 18321991.
RA Kim W., Seok Kang Y., Soo Kim J., Shin N. Y., Hanks S. K., Song W. K.
RT The integrin-coupled signaling adaptor p130Cas suppresses Smad3 function in transforming growth factor-beta signaling.
RL Mol. Biol. Cell 19:2135-2146 (2008).
RN [14]; RE0073082.
RX PUBMED: 18337748.
RA Rudini N., Felici A., Giampietro C., Lampugnani M., Corada M., Swirsding K., Garre M., Liebner S., Letarte M., ten Dijke P., Dejana E.
RT VE-cadherin is a critical endothelial regulator of TGF-beta signalling.
RL EMBO J. 27:993-1004 (2008).
RN [15]; RE0073126.
RX PUBMED: 18835815.
RA Atsawasuwan P., Mochida Y., Katafuchi M., Kaku M., Fong K. S., Csiszar K., Yamauchi M.
RT Lysyl oxidase binds transforming growth factor-beta and regulates its signaling via amine oxidase activity.
RL J. Biol. Chem. 283:34229-34240 (2008).
RN [16]; RE0021341.
RX PUBMED: 11927552.
RA Yamakawa N., Tsuchida K., Sugino H.
RT The rasGAP-binding protein, Dok-1, mediates activin signaling via serine/threonine kinase receptors.
RL EMBO J. 21:1684-1694 (2002).
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