TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00306 AS T00224. XX ID T00306 XX DT 21.01.1993 (created); ewi. DT 27.02.2015 (updated); pro. CO Copyright (C), QIAGEN. XX FA GATA-1 XX SY EF1 (chick); EFgammaa; Eryf1 (chick); GATA-1; GF-1; NF-E1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G003926 GATA1; HGNC: GATA1. XX CL C0004; CC; XX SF chromosomal position at Xp21-11 [21]; SF zinc finger 2 is able to bind DNA on its own but zinc finger 1 contributes strongly to the stability of DNA binding at some particular sites [31]; XX CP eosinophils [35]; MG-63 and MCF-7 [46]; Erythro-megakaryotic cell lines Dami, K562, UT-7/TPO, UT-7/EPO Mpl [40]. EX blood,basophilic erythroblast,,adult; detectable; RT-PCR; mRNA (poly-A); [48]. EX blood,basophilic erythroblast,,adult; detectable; RT-PCR; mRNA (poly-A); [49]. EX blood,neutrophil granulocyte,,adult; very low; Northern blot; total RNA; [35]. EX blood,orthochromatophilic erythroblast,,adult; detectable; RT-PCR; mRNA (poly-A); [48]. EX blood,proerythroblast,,adult; detectable; RT-PCR; mRNA (poly-A); [48]. EX blood,red blood cell,,adult; detectable; RT-PCR; total RNA; [29]. EX human, Homo sapiens,megakaryocyte,,adult; detectable; Northern blot; total RNA; [14]. XX FF Butyric acid treated K562 significantly increased the GATA-1 mRNA expression level and PMA treated K562 cells decrease the GATA-1 mRNA expression level [36]; FF TPO-inducible in UT-7/TPO cells [40]; FF activator; FF negative regulator of gamma-globin in adults; FF down-regulated by TPA [4]; FF up-regulated by aclacinomycin (ACM) [33]; FF acts on the PBGD and gamma-globin promoter in association with Sp1 or CCACC binding proteins [32] [23] [27]; FF significantly enhanced GATA-1 levels (mRNA and DNA-binding activity) in response to erythropoietin, peaking after 7-9 days [25]; FF downregulated in K562 cells induced with HMBA to undergo myeloid differentiation [34]; FF upregulated in eosinophilic subline HL-60 after induction with IL-5 or butyric acid [35]; FF associated with hematopoietic disorders at the fetal and neonatal stages in individuals with Down syndrome [37]; XX IN T21924 BCL-11A; human, Homo sapiens. IN T09410 C/EBPbeta; Mammalia. IN T09000 Fli-1-isoform1; human, Homo sapiens. IN T13841 HES-1; Mammalia. IN T21984 p300; human, Homo sapiens. IN T02336 PLZF; human, Homo sapiens. IN T09976 PU.1; human, Homo sapiens. IN T09328 USF1-isoform1; human, Homo sapiens. XX MX M00075 V$GATA1_01. MX M00126 V$GATA1_02. MX M00127 V$GATA1_03. MX M00128 V$GATA1_04. MX M00346 V$GATA1_05. MX M00347 V$GATA1_06. MX M04713 V$GATA1_10. MX M08765 V$GATA1_12. MX M02004 V$GATA1_Q6. MX M00203 V$GATA_C. MX M00789 V$GATA_Q6. XX BS R06881. BS R06882. BS R06883. BS R06884. BS R06885. BS R06886. BS R06887. BS R06888. BS R06889. BS R06890. BS R06891. BS R06892. BS R06893. BS R06894. BS R06895. BS R06896. BS R06897. BS R06898. BS R06899. BS R06900. BS R06901. BS R06902. BS R06903. BS R06904. BS R06905. BS R06906. BS R06907. BS R06908. BS R06909. BS R06910. BS R06911. BS R06912. BS R06913. BS R06914. BS R06915. BS R06916. BS R06917. BS R06918. BS R06919. BS R06920. BS R06921. BS R06922. BS R06923. BS R23675. BS R26555. BS R04798. BS R04799. BS R66452. BS R28280. BS R23352. BS R23353. BS R38239. BS R38240. BS R58717. BS R58410. BS R20862. BS R58743. BS R37398. BS R00525. BS R08236. BS R08239. BS R08241. BS R08243. BS R03491. BS R36562. BS R37789. BS R38408. BS R33718. BS R33721. BS R33722. BS R33723. BS R33724. BS R33725. BS R33726. BS R42222. BS R32144. BS R35881. BS R20887. BS R66513. BS R66518. BS R58155. BS R08149. BS R20913. BS R35698. BS R61453. BS R28627. BS R28653. BS R32178. BS R33075. BS R38386. BS R00548. BS R00552. BS R02826. BS R02829. BS R02831. BS R03261. BS R04196. BS R04197. BS R04200. BS R04201. BS R08245. BS R21050. BS R08209. BS R08210. BS R02882. BS R02883. BS R02884. BS R02885. BS R02886. BS R03437. BS R03438. BS R03442. BS R03443. BS R03113. BS R35646. BS R35648. BS R35655. BS R35657. BS R35665. BS R35667. BS R35674. BS R35677. BS R40828. BS R40832. BS R40834. BS R26573. BS R00566. BS R00569. BS R20602. BS R30925. BS R31961. BS R60002. BS R60004. BS R26550. BS R60986. BS R23649. BS R39832. BS R39835. BS R03304. BS R08205. BS R08206. BS R21233. BS R24051. BS R69967. BS R61872. BS R61884. BS R60759. BS R60760. BS R61890. BS R25413. BS R39880. BS R01247. BS R01253. BS R01254. BS R39885. BS R39888. BS R37307. BS R37309. BS R39465. BS R20599. BS R23716. BS R26950. BS R26951. BS R31492. BS R31494. BS R31495. BS R23437. BS R55948. BS R21080. BS R21081. BS R33100. BS R31067. BS R01432. BS R56235. BS R14558. BS R40428. BS R21076. BS R39463. BS R20702. BS R00544. BS R22290. BS R03213. BS R31332. BS R00507. BS R22886. BS R39841. BS R39844. BS R34943. BS R34944. BS R23029. BS R19646. BS R19654. BS R21700. BS R01218. BS R20315. XX DR TRANSPATH: MO000046001. DR TRANSCOMPEL: C00477. DR TRANSCOMPEL: C00612. DR UniProtKB: P15976; GAT1_HUMAN. XX RN [1]; RE0000167. RX PUBMED: 2225071. RA Orkin S. H. RT Globin gene regulation and switching: Circa 1990 RL Cell 63:665-672 (1990). RN [2]; RE0000452. RX PUBMED: 2050118. RA Joulin V., Bouries D., Eleouet J.-F., Labastie M.-C., Chretien S., Mattei M.-G., Romeo P.-H. RT A t-cell specific TCR delta DNA binding protein is a member of the human GATA family RL EMBO J. 10:1809-1816 (1991). RN [3]; RE0000948. RX PUBMED: 1714909. RA Lee M.-H., Temizer D. H., Clifford J. A., Quertermous T. RT Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells RL J. Biol. Chem. 266:16188-16192 (1991). RN [4]; RE0000979. RX PUBMED: 2266112. RA Mignotte V., Navarro S., Eleouet F.-F., Zon L. I., Romeo P.-H. RT The extinction of erythroid genes after tetradecanoylphorbol acetate treatment of erythroleukemic cells correlates with down-regulation of the tissue-specific factors NF-E1 and NF-E2 RL J. Biol. Chem. 265:22090-22092 (1990). RN [5]; RE0001005. RX PUBMED: 2050690. RA McDonagh K. T., Lin H. J., Lowrey C. H., Bodine D. M., Nienhuis A. W. RT The upstream region of the human gamma-globin gene promoter RL J. Biol. Chem. 266:11965-11974 (1991). RN [6]; RE0001022. RX PUBMED: 2026603. RA Yu C.-Y., Motamed K., Chen J., Bailey A. D., Shen C.-K. J. RT The CACC box upstream of human embryonic epsilon globin gene binds Sp1 and is a functional promoter element in vitro and in vivo RL J. Biol. Chem. 266:8907-8915 (1991). RN [7]; RE0001256. RX PUBMED: 2761541. RA Barnhart K. M., Kim C. G., Sheffery M. RT Purification and characterization of an erythroid cell-specific factor that binds the murine alpha- and beta-globin genes RL Mol. Cell. Biol. 9:2606-2614 (1989). RN [8]; RE0001263. RX PUBMED: 2468996. RA Gumucio D. L., Rood K. L., Gray T. A., Riordan M. F., Sartor C. I., Collins F. S. RT Nuclear Proteins That Bind the Human gamma-Globin Gene Promoter: Alterations in Binding Produced by Point Mutations Associated with Hereditary Persistence of Fetal Hemoglobin RL Mol. Cell. Biol. 8:5310-5322 (1988). RN [9]; RE0001472. RX PUBMED: 1990287. RA Evans T., Felsenfeld G. RT trans-activation of a globin promoter in nonerythroid cells RL Mol. Cell. Biol. 11:843-853 (1991). RN [10]; RE0001622. RX PUBMED: 2017165. RA Gong Q.-H., Stern J., Dean A. RT Transcriptional role of a conserved GATA-1 site in the human epsilon-globin gene promoter RL Mol. Cell. Biol. 11:2558-2566 (1991). RN [11]; RE0001669. RX PUBMED: 1875946. RA Jarman A. P., Wood W. G., Sharpe J. A., Gourdon G., Ayyub H., Higgs D. R. RT Characterization of the major regulatory element upstream of the human alpha-globin gene cluster RL Mol. Cell. Biol. 11:4679-4689 (1991). RN [12]; RE0001786. RX PUBMED: 2104960. RA Trainor C. D., Evans T., Felsenfeld G., Boguski M. S. RT Structure and evolution of a human erythroid transcription factor RL Nature 343:92-96 (1990). RN [13]; RE0001787. RX PUBMED: 2467208. RA Martin D. I. K., Tsai S.-F., Orkin S. H. RT Increased gamma-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor RL Nature 338:435-438 (1989). RN [14]; RE0001848. RX PUBMED: 2320113. RA Romeo P.-H., Prandini M.-H., Joulin V., Mignotte V., Prenant M., Vainchenker W., Marguerie G., Uzan G. RT Megakaryocytic and erythrocytic lineages share specific transcription factors RL Nature 344:447-449 (1990). RN [15]; RE0001849. RX PUBMED: 2320112. RA Martin D. I. K., Zon L. I., Mutter G., Orkin S. H. RT Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages RL Nature 344:444-447 (1990). RN [16]; RE0001869. RX PUBMED: 1379347. RA Berry M., Grosveld F., Dillon N. RT A single point mutation is the cause of the Greek form of hereditary persistance of fetal hemoglobin RL Nature 358:499-502 (1992). RN [17]; RE0001982. RX PUBMED: 2922260. RA Broggini M., Ponti M., Ottolenghi S., D'Incalci M., Mongelli N., Mantovani R. RT Distamycins inhibit the binding of OTF-1 and NFE-1 transfactors to their conserved DNA elements RL Nucleic Acids Res. 17:1051-1059 (1989). RN [18]; RE0002047. RX PUBMED: 2476717. RA Mantovani R., Superti-Furga G., Gilman J., Ottolenghi S. RT The deletion of the distal CCAAT box region of the Agamma-globin gene in black HPFH abolishes the binding of the erythroid specific protein NFE3 and of the CCAAT displacement protein RL Nucleic Acids Res. 17:6681-6691 (1989). RN [19]; RE0002078. RX PUBMED: 1698280. RA Fucharoen S., Shimizu K., Fukumaki Y. RT A novel C-T transition within the distal CCAAT motif of the Ggamma-globin gene in the Japanese HPFH: implication of factor binding in elevated fetal globin expression RL Nucleic Acids Res. 18:5245 (1990). RN [20]; RE0002129. RX PUBMED: 2259631. RA Purucker M., Bodine D., Lin H., McDonagh K., Nienhuis A. W. RT Structure and function of the enhancer 3' to the human Agamma globin gene RL Nucleic Acids Res. 18:7407 (1990). RN [21]; RE0002456. RX PUBMED: 2300555. RA Zon L. I., Tsai S.-F., Burgess S., Matsudaira P., Bruns G. A. P., Orkin S. H. RT The major human erythroid DNA-binding protein (GF-1): primary sequence and localization of the gene to the X chromosome RL Proc. Natl. Acad. Sci. USA 87:668-672 (1990). RN [22]; RE0002473. RX PUBMED: 2014222. RA Hannon R., Evans T., Felsenfeld G., Gould H. RT Structure and promoter activity of the gene for the erythroid transcription factor GATA-1 RL Proc. Natl. Acad. Sci. USA 88:3004-3008 (1991). RN [23]; RE0006570. RX PUBMED: 8385011. RA Eleouet J.-F., Romeo P.-H. RT CCACC-binding or simian-virus-40-protein-1-binding proteins cooperate with human GATA-1 to direct erythroid-specific transcription and to mediate 5' hypersensitive site 2 sensitivity of a TATA-less promoter RL Eur. J. Biochem. 212:763-770 (1993). RN [24]; RE0007084. RX PUBMED: 7607218. RA Busfield S. J., Spadaccini A., Riches K. J., Tilbrook P. A., Klinken S. P. RT The major erythroid DNA-binding protein GATA-1 is stimulated by erythropoietin but not by chemical inducers of erythroid differentiation RL Eur. J. Biochem. 230:475-480 (1995). RN [25]; RE0007089. RX PUBMED: 8371977. RA Dalyot N., Fibach E., Ronchi A., Rachmilewitz E. A., Ottolenghi S., Oppenheim A. RT Erythropoietin triggers a burst of GATA-1 in normal human erythroid cells differentiating in tissue culture RL Nucleic Acids Res. 21:4031-4037 (1993). RN [26]; RE0008192. RX PUBMED: 8449904. RA Max-Audit I., Eleouet J.-F., Romeo P.-H. RT Transcriptional regulation of the pyruvate kinase erythroid-specific promoter RL J. Biol. Chem. 268:5431-5437 (1993). RN [27]; RE0008556. RX PUBMED: 8226931. RA Fischer K. D., Haese A., Nowock J. RT Cooperation of GATA-1 and Sp1 can result in synergistic transcriptional activation or interference RL J. Biol. Chem. 268:23915-23923 (1993). RN [28]; RE0008992. RX PUBMED: 8164666. RA Baron M. H., Farrington S. M. RT Positive regulators of the lineage-specific transcription factor GATA-1 in differentiating erythroid cells RL Mol. Cell. Biol. 14:3108-3114 (1994). RN [29]; RE0009540. RX PUBMED: 1631130. RA Sposi N. M., Zon L. I., Care A., Valtieri M., Testa U., Gabbianelli M., Mariani G., Bottero L., Mather C., Orkin S. H., Peschle C. RT Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors RL Proc. Natl. Acad. Sci. USA 89:6353-6357 (1992). RN [30]; RE0011089. RX PUBMED: 7556215. RA Joulin V., Richard-Foy H. RT A new approach to isolate genomic control regions, Application to the GATA transcription factor family RL Eur. J. Biochem. 232:620-626 (1995). RN [31]; RE0012279. RX PUBMED: 8628290. RA Trainor C. D., Omichinski J. G., Vandergon T. L., Gronenborn A. M., Clore G. M., Felsenfeld G. RT A palindromic regulatory site within vertebtrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction RL Mol. Cell. Biol. 16:2238-2247 (1996). RN [32]; RE0013396. RX PUBMED: 1438231. RA Walters M., Martin D. I. K. RT Functional erythroid promoters created by interaction of the transcription factor GATA-1 with CACCC and AP-1/NFE-2 elements. RL Proc. Natl. Acad. Sci. USA 89:10444-10448 (1992). RN [33]; RE0013431. RX PUBMED: 8445949. RA Trentesaux C., Nyoung M. N., Aries A., Morceau F., Ronchi A., Ottolenghi S., Jardillier J.-C., Jeannesson P. RT Increased expression of GATA-1 and NFE-2 erythroid-specific transcription factors during aclacinomycin-mediated differentiation of human erythroleukemic cells. RL Leukemia 7:452-457 (1993). RN [34]; RE0013439. RX PUBMED: 8462662. RA Green A. R., Rockman S., DeLuca E., Begley C. G. RT Induced myeloid differentiation of K562 cells with downregulation of erythroid and megakaryocytic transcription factors: a novel experimental model for hemopoietic lineage restriction. RL Exp. Hematol. 21:525-531 (1993). RN [35]; RE0013448. RX PUBMED: 8507862. RA Zon L. I., Yamaguchi Y., Yee K., Albee E. A., Kimura A., Bennett J. C., Orkin S. H., Ackerman S. J. RT Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription. RL Blood 81:3234-3241 (1993). RN [36]; RE0032205. RX PUBMED: 12136940. RA Czyz M., Stasiak M., Boncela J., Cierniewsk C. S. RT GATA-1 binding to the alphaV promoter negatively regulates expression of the integrin alphaV subunit in human leukemic K562 cells. RL Acta Biochim. Pol. 49:19-28 (2002). RN [37]; RE0035245. RX PUBMED: 15895080. RA Li Z., Godinho F. J., Klusmann J. H., Garriga-Canut M., Yu C., Orkin S. H. RT Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. RL Nat. Genet. 37:613-619 (2005). RN [38]; RE0035546. RX PUBMED: 9859997. RA Boyes J., Byfield P., Nakatani Y., Ogryzko V. RT Regulation of activity of the transcription factor GATA-1 by acetylation. RL Nature 396:594-598 (1998). RN [39]; RE0037433. RX PUBMED: 12724402. RA Eisbacher M., Holmes M. L., Newton A., Hogg P. J., Khachigian L. M., Crossley M., Chong B. H. RT Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding RL Mol. Cell. Biol. 23:3427-41 (2003). RN [40]; RE0046278. RX PUBMED: 12359731. RA Holmes M. L., Bartle N., Eisbacher M., Chong B. H. RT Cloning and analysis of the thrombopoietin-induced megakaryocyte-specific glycoprotein VI promoter and its regulation by GATA-1, Fli-1, and Sp1 RL J. Biol. Chem. 277:48333-41 (2002). RN [41]; RE0046847. RX PUBMED: 14744791. RA Ge Y., Jensen T. L., Stout M. L., Flatley R. M., Grohar P. J., Ravindranath Y., Matherly L. H., Taub J. W. RT The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines RL Cancer Res. 64:728-35 (2004). RN [42]; RE0048127. RX PUBMED: 10411939. RA Zhang P., Behre G., Pan J., Iwama A., Wara-Aswapati N., Radomska H. S., Auron P. E., Tenen D. G., Sun Z. RT Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1. RL Proc. Natl. Acad. Sci. USA 96:8705-8710 (1999). RN [43]; RE0048300. RX PUBMED: 16225938. RA Payton S. G., Liu M., Ge Y., Matherly L. H. RT Transcriptional regulation of the human reduced folate carrier A1/A2 promoter: Identification of critical roles for the USF and GATA families of transcription factors. RL Biochim. Biophys. Acta 1731:115-124 (2005). RN [44]; RE0048895. RX PUBMED: 15563463. RA Ishiko E., Matsumura I., Ezoe S., Gale K., Ishiko J., Satoh Y., Tanaka H., Shibayama H., Mizuki M., Era T., Enver T., Kanakura Y. RT Notch signals inhibit the development of erythroid/megakaryocytic cells by suppressing GATA-1 activity through the induction of HES1. RL J. Biol. Chem. 280:4929-4939 (2005). RN [45]; RE0049701. RX PUBMED: 17167422. RA Ribeil J. A., Zermati Y., Vandekerckhove J., Cathelin S., Kersual J., Dussiot M., Coulon S., Moura I. C., Zeuner A., Kirkegaard-Sorensen T., Varet B., Solary E., Garrido C., Hermine O. RT Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1. RL Nature 445:102-105 (2007). RN [46]; RE0049888. RX PUBMED: 12659635. RA Lambertini E., Penolazzi L., Giordano S., Del Senno L., Piva R. RT Expression of the human oestrogen receptor-alpha gene is regulated by promoter F in MG-63 osteoblastic cells. RL Biochem. J. 372:831-839 (2003). RN [47]; RE0054749. RX PUBMED: 18586828. RA Cho Y., Song S. H., Lee J. J., Choi N., Kim C. G., Dean A., Kim A. RT The role of transcriptional activator GATA-1 at human beta-globin HS2. RL Nucleic Acids Res. 36:4521-4528 (2008). RN [48]; RE0017541. RX PUBMED: 10863975. RA Pope S. H., Fibach E., Sun J., Chin K., Rodgers G. P. RT Two-phase liquid culture system models normal human adult erythropoiesis at the molecular level. RL Eur. J. Haematol. 64:292-303 (2000). RN [49]; RE0017451. RX PUBMED: 9104808. RA Serdobova I., Pla M., Reichenbach P., Sperisen P., Ghysdael J., Wilson A., Freeman J., Nabholz M. RT Elf-1 contributes to the function of the complex interleukin (IL)-2-responsive enhancer in the mouse IL-2 receptor alpha gene RL J. Exp. Med. 185:1211-1221 (1997). XX //