AC T09000
XX
ID T09000
XX
DT 06.06.2006 (created); kau.
DT 10.10.2011 (updated); sla.
CO Copyright (C), QIAGEN.
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FA Fli-1-isoform1
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SY Erg-B; friend leukemia integration site 1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G007339 FLI1; HGNC: FLI1.
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CL C0016; ETS; 3.5.2.1.5.1.
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SZ 452 AA; 51.0 kDa (cDNA) (calc.), 55 kDa (SDS) [5]
XX
SQ MDGTIKEALSVVSDDQSLFDSAYGAAAHLPKADMTASGSPDYGQPHKINPLPPQQEWINQ
SQ PVRVNVKREYDHMNGSRESPVDCSVSKCSKLVGGGESNPMNYNSYMDEKNGPPPPNMTTN
SQ ERRVIVPADPTLWTQEHVRQWLEWAIKEYSLMEIDTSFFQNMDGKELCKMNKEDFLRATT
SQ LYNTEVLLSHLSYLRESSLLAYNTTSHTDQSSRLSVKEDPSYDSVRRGAWGNNMNSGLNK
SQ SPPLGGAQTISKNTEQRPQPDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSANASCI
SQ TWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKF
SQ DFHGIAQALQPHPTESSMYKYPSDISYMPSYHAHQQKVNFVPPHPSSMPVTSSSFFGAAS
SQ QYWTSPTGGIYPNPNVPRHPNTHVPSHLGSYY
XX
SC Swiss-Prot#Q01543-1
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FT 106 271 
ATA (amino-terminal transcriptional activation) domain [6].
FT 114 198 
PF02198; Sterile alpha motif (SAM)/Pointed domain.
FT 114 198 
SM00251; SAM2_3.
FT 129 196 
POINTED domain of homology [1].
FT 280 363 
PF00178; Ets-domain.
FT 280 365 
SM00413; etsneu2.
FT 281 361 
PS50061; ETS_DOMAIN_3.
FT 283 351 
PS50140; HSF_ETS.
FT 402 452 
CTA (carboxy-terminal transcriptional activation) domain [6].
XX
IN T08291 GATA-1-isoform1; mouse, Mus musculus.
IN T00306 GATA-1; human, Homo sapiens.
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MX M08881 V$ETSLIKE_Q4.
MX M00771 V$ETS_Q4.
MX M00971 V$ETS_Q6.
MX M02073 V$FLI1_02.
MX M07382 V$FLI1_Q5.
MX M01208 V$FLI1_Q6.
XX
BS R00460.
BS R25722.
BS R29136.
BS R29140.
BS R29146.
XX
DR TRANSPATH: MO000082496.
DR EMBL: M93255;
DR EMBL: M98833;
DR EMBL: S45205;
DR EMBL: X67001;
DR UniProtKB: Q01543-1;
DR PDB: 1FLI.
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RN [1]; RE0005316.
RX PUBMED: 8223245.
RA Klaembt C.
RT The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells
RL Development 117:163-176 (1993).
RN [2]; RE0005341.
RX PUBMED: 1445800.
RA Watson D. K., Smyth F. E., Thompson D. M., Cheng J. Q., Testa J. R., Papas T. S., Seth A.
RT The ERGB/Fli-1 gene: Isolation and characterization of a new member of the family of human ETS transcription factors
RL Cell Growth Differ. 3:705-713 (1992).
RN [3]; RE0005342.
RX PUBMED: 1522903.
RA Delattre O., Zucman J., Plougastel B., Desmaze C., Melot T., Peter M., Kovar H., Joubert I., de Jong P., Rouleau G.
RT Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours
RL Nature 359:162-165 (1992).
RN [4]; RE0005344.
RX PUBMED: 8439553.
RA Hromas R. A., Mau W., Denny C., Raskind W., Moore J., Maki R. A., Beck E., Klemsz M. J.
RT Human FLI-1 localizes to chromosome 11Q24 and has an aberrant transcript in neureopethelioma
RL Biochim. Biophys. Acta 1172:155-158 (1993).
RN [5]; RE0005345.
RX PUBMED: 1394211.
RA Prasad D. D. K., Rao V. N., Reddy E. S. P.
RT Structure and expression of human Fli-1 gene
RL Cancer Res. 52:5833-5837 (1992).
RN [6]; RE0005346.
RX PUBMED: 8336942.
RA Rao V. N., Ohno T., Prasad D. D. K., Battacharya G., Reddy E. S. P.
RT Analysis of the DNA binding and transcriptional activation functions of human Fli-1 protein
RL Oncogene 8:2167-2173 (1993).
RN [7]; RE0005347.
RX PUBMED: 7503813.
RA Ohno T., Rao V. N., Reddy E. S. P.
RT EWS/Fli-1 chimeric protein is a transcriptional activator
RL Cancer Res. 53:5859-5863 (1993).
RN [8]; RE0005348.
RX PUBMED: 8516324.
RA May W. A., Gishizky M. L., Lessnick S. L., Lunsford L. B., Lewis B. C., Delattre O., Zucman J., Thomas G., Denny X. C. T.
RT Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation
RL Proc. Natl. Acad. Sci. USA 90:5752-5756 (1993).
RN [9]; RE0005349.
RX PUBMED: 7972119.
RA Liang H., Olejniczak E. T., Mao X., Nettesheim D. G., Yu L., Thompson C. B., Fesik S. W.
RT The secondary structure of the ets domain of human Fli-1 resembles that of the helix-turn-helix DNA-binding motif of the Escherichia coli catabolite gene activator protein
RL Proc. Natl. Acad. Sci. USA 91:11655-11659 (1994).
RN [10]; RE0015489.
RX PUBMED: 8604338.
RA Magnaghi-Jaulin L., Masutani H., Robin P., Lipinski M., Harel-Bellan A.
RT SRE elements are binding sites for the fusion protein EWS-FLI-1
RL Nucleic Acids Res. 24:1052-1058 (1996).
RN [11]; RE0015517.
RX PUBMED: 8764983.
RA Magnaghi-Jaulin L., Masutani H., Lipinski M., Harel-Bellan A.
RT Analysis of SRF, SAP-1 and ELK-1 transcripts and proteins in human cell lines
RL FEBS Lett. 391:247-251 (1996).
RN [12]; RE0037433.
RX PUBMED: 12724402.
RA Eisbacher M., Holmes M. L., Newton A., Hogg P. J., Khachigian L. M., Crossley M., Chong B. H.
RT Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding
RL Mol. Cell. Biol. 23:3427-41 (2003).
RN [13]; RE0049074.
RX PUBMED: 16148010.
RA van den Akker E., Ano S., Shih H. M., Wang L. C., Pironin M., Palvimo J. J., Kotaja N., Kirsh O., Dejean A., Ghysdael J.
RT FLI-1 functionally interacts with PIASxalpha, a member of the PIAS E3 SUMO ligase family.
RL J. Biol. Chem. 280:38035-38046 (2005).
RN [14]; RE0049075.
RX PUBMED: 15798196.
RA Hu W., Philips A. S., Kwok J. C., Eisbacher M., Chong B. H.
RT Identification of nuclear import and export signals within Fli-1: roles of the nuclear import signals in Fli-1-dependent activation of megakaryocyte-specific promoters.
RL Mol. Cell. Biol. 25:3087-3108 (2005).
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