AC T02103
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ID T02103
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DT 07.02.1997 (created); ewi.
DT 07.08.2007 (updated); man.
CO Copyright (C), QIAGEN.
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FA p53as
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G000583 Trp53.
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CL C0057; P53.
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SZ 381 AA; 42.5 kDa (cDNA) (calc.).
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SQ MTAMEESQSDISLELPLSQETFSGLWKLLPPEDILPSPHCMDDLLLPQDVEEFFEGPSEA
SQ LRVSGAPAAQDPVTETPGPVAPAPATPWPLSSFVPSQKTYQGNYGFHLGFLQSGTAKSVM
SQ CTYSPPLNKLFFQLAKTCPVQLWVSATPPAGSRVRAMAIYKKSQHMTEVVRRCPHHERCS
SQ DGDGLAPPQHLIRVEGNLYPEYLEDRQTFRHSVVVPYEPPEAGSEYTTIHYKYMCNSSCM
SQ GGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKKEVLCPELPPGS
SQ AKRALPTCTSASPPQKKKPLDGEYFTLKIRGRKRFEMFRELNEALELKDAHATEESGDSR
SQ AHSSLQPRAFQALIKEESPNC
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SC translated from EMBL #M13874
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FT 92 286 
PF00870; P53 DNA-binding domain.
FT 315 356 
PF07710; P53 tetramerisation motif.
FT 365 381 
replaced by 365-390 in p53 [3].
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SF 25-30% of cellular p53 mRNA consists of alternative spliced p53as mRNA [1] [2] [3];
SF in contrast to the masked DBD of 390 AA p53, that of the splice variant p53 as is constitutively active [1] [4] [5];
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FF in contrast to 390 AA p53, p53as is primarily expressed during G2 phase [3];
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IN T01806 p53; mouse, Mus musculus.
IN T24830 Smad2; Mammalia.
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MX M00761 V$P53DECAMER_Q2.
MX M00034 V$P53_01.
MX M00272 V$P53_02.
MX M01651 V$P53_03.
MX M01652 V$P53_04.
MX M07054 V$P53_Q3_01.
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DR TRANSPATH: MO000026166.
DR EMBL: AY212017;
DR EMBL: M13874;
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RN [1]; RE0005400.
RX PUBMED: 7624329.
RA Wolkowicz R., Peled A., Elkind N. B., Rotter V.
RT Augmented DNA-binding activity of p53 protein encoded by a carboxyl-terminal alternatively spliced mRNA is blocked by p53 protein encoded by the regularly spliced form
RL Proc. Natl. Acad. Sci. USA 92:6842-6846 (1995).
RN [2]; RE0005424.
RX PUBMED: 1579500.
RA Han K.-A., Kulesz-Martin M. F.
RT Alternatively splice p53 RNA in transformed and normal cells of different tissue types
RL Nucleic Acids Res. 20:1979-1981 (1992).
RN [3]; RE0005471.
RX PUBMED: 8114705.
RA Kulesz-Martin M. F., Lisafeld B., Huang H., Kisiel N. D., Lee L.
RT Endogenous p53 protein generated from wild-type alternatively spliced p53 RNA in mouse epidermal cells
RL Mol. Cell. Biol. 14:1698-1708 (1994).
RN [4]; RE0005478.
RX PUBMED: 7957051.
RA Wu Y., Liu Y., Lee L., Miner Z., Kulesz-Martin M.
RT Wild-type alternatively spliced p53: binding to DNA and interaction with the major p53 protein in vitro and in cells
RL EMBO J. 13:4823-4830 (1994).
RN [5]; RE0005479.
RX PUBMED: 7777576.
RA Bayle J. H., Elenbaas B., Levine A. J.
RT The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity
RL Proc. Natl. Acad. Sci. USA 92:5729-5733 (1995).
RN [6]; RE0050544.
RX PUBMED: 17234915.
RA Cordenonsi M., Montagner M., Adorno M., Zacchigna L., Martello G., Mamidi A., Soligo S., Dupont S., Piccolo S.
RT Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation.
RL Science 315:840-843 (2007).
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