AC T09153
XX
ID T09153
XX
DT 31.07.2006 (created); man.
DT 10.04.2013 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA SnoN
XX
SY SKI-like; SKIL.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G006727 SKIL; HGNC: SKIL.
XX
SZ 684 AA; 77.0 kDa (cDNA) (calc.).
XX
SQ MENLQTNFSLVQGSTKKLNGMGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEA
SQ PVETDGEHVKRTCTSVPETLHLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTV
SQ FLPLPSPQVLPGPLLIPSDSSTELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTL
SQ QQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFP
SQ QNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAP
SQ QTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSG
SQ KRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVS
SQ QSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASI
SQ SNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLK
SQ QQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQ
SQ KDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREA
SQ RQKLEMMIKELKLQILKSSKTAKE
XX
SC Swiss-Prot#P12757-1
XX
FT 124 236 
PF02437; SKI/SNO/DAC family.
FT 138 255 
SMAD-4 interaction domain [1].
FT 176 653 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 589 684 
SMAD-2, SMAD-3 interaction domain [1].
XX
IN T24830 Smad2; Mammalia.
IN T09538 Smad3; Mammalia.
XX
DR TRANSPATH: MO000083915.
DR EMBL: X15219;
DR UniProtKB: P12757-1;
XX
RN [1]; RE0016418.
RX PUBMED: 10531062.
RA Stroschein S. L., Wang W., Zhou S., Zhou Q., Luo K.
RT Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein.
RL Science 286:771-774 (1999).
RN [2]; RE0023955.
RX PUBMED: 11691834.
RA Stroschein S. L., Bonni S., Wrana J. L., Luo K.
RT Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN.
RL Genes Dev. 15:2822-2836 (2001).
XX
//