TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T14435 XX ID T14435 XX DT 10.03.2005 (created); nvo. DT 04.02.2016 (updated); jmh. CO Copyright (C), QIAGEN. XX FA c-Myc XX SY c-Myc; MRTL; MYC; v-myc myelocytomatosis viral oncogene homolog (avian). XX OS Mammalia OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia XX IN T06126 BAF53a; human, Homo sapiens. IN T15118 CBP; Mammalia. IN T05056 Max; human, Homo sapiens. IN T09085 Max; Mammalia. IN T17701 Miz-1; Mammalia. IN T08564 NF-YB; Mammalia. IN T17293 NF-YC; Mammalia. IN T14193 NR1B1; Mammalia. IN T23091 p300; Mammalia. IN T16759 p73; Mammalia. IN T06377 PML; human, Homo sapiens. IN T09288 Pontin52-isoform1; human, Homo sapiens. IN T03214 Pontin52; human, Homo sapiens. IN T25008 pRb; Mammalia. IN T14323 Skp2; Mammalia. IN T10683 Smad2; human, Homo sapiens. IN T24830 Smad2; Mammalia. IN T09538 Smad3; Mammalia. IN T10378 Smad3; human, Homo sapiens. IN T08326 Sp1; Mammalia. IN T14175 TBP; Mammalia. IN T09133 YY1; Mammalia. XX MX M01145 V$CMYC_01. MX M01154 V$CMYC_02. MX M07601 V$CMYC_Q3. MX M03867 V$CMYC_Q6_01. MX M01034 V$EBOX_Q6_01. MX M00118 V$MYCMAX_01. MX M00123 V$MYCMAX_02. MX M00615 V$MYCMAX_03. MX M00322 V$MYCMAX_B. MX M00799 V$MYC_Q2. XX BS R29788. BS R71574. BS R62112. BS R62114. BS R62113. BS R32449. BS R61568. BS R35931. BS R35932. BS R72345. BS R72344. BS R65312. BS R24250. XX DR TRANSPATH: MO000047182. XX RN [1]; RE0003339. RX PUBMED: 1436095. RA Goodrich D. W., Lee W.-H. RT Abrogation by c-myc of G1 phase arrest induced by RB protein but not by p53 RL Nature 360:177-179 (1992). RN [2]; RE0003366. RX PUBMED: 8076603. RA Beijersbergen R. L., Hijmans E. M., Zhu L., Bernards R. RT Interaction of c-Myc with the Rb-related protein p107 results in inhibition of c-Myc-mediated transactivation RL EMBO J. 13:4080-4086 (1994). RN [3]; RE0009120. RX PUBMED: 8196628. RA Gaubatz S., Meichle A., Eilers M. RT An E-box element localized in the first intron mediates regulation of the prothymosin alpha gene by c-myc RL Mol. Cell. Biol. 14:3853-3862 (1994). RN [4]; RE0014659. RX PUBMED: 8855231. RA Shrivastava A., Yu J., Artandi S., Calame K. RT YY1 and c-Myc associate in vivo in a manner that depends on c-Myc levels RL Proc. Natl. Acad. Sci. USA 93:10638-10641 (1996). RN [5]; RE0015448. RX PUBMED: 10606642. RA Greasley P. J., Bonnard C., Amati B. RT Myc induces the nucleolin and BN51 genes: possible implications in ribosome biogenesis RL Nucleic Acids Res. 28:446-453 (2000). RN [6]; RE0022244. RX PUBMED: 9133424. RA Takeshita T., Arita T., Higuchi M., Asao H., Endo K., Kuroda H., Tanaka N., Murata K., Ishii N., Sugamura K. RT STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction. RL Immunity 6:449-457 (1997). RN [7]; RE0024398. RX PUBMED: 11844794. RA Watanabe K., Ozaki T., Nakagawa T., Miyazaki K., Takahashi M., Hosoda M., Hayashi S., Todo S., Nakagawara A. RT Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function. RL J. Biol. Chem. 277:15113-15123 (2002). RN [8]; RE0024915. RX PUBMED: 12907754. RA Acosta J. J., Munoz R. M., Gonzalez L., Subtil-Rodriguez A., Dominguez-Caceres M. A., Garcia-Martinez J. M., Calcabrini A., Lazaro-Trueba I., Martin-Perez J. RT Src mediates prolactin-dependent proliferation of T47D and MCF7 cells via the activation of focal adhesion kinase/Erk1/2 and phosphatidylinositol 3-kinase pathways. RL Mol. Endocrinol. 17:2268-2282 (2003). RN [9]; RE0026903. RX PUBMED: 9652748. RA Fiddes R. J., Janes P. W., Sivertsen S. P., Sutherland R. L., Musgrove E. A., Daly R. J. RT Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells. RL Oncogene 16:2803-13 (1998). RN [10]; RE0027341. RX PUBMED: 11145682. RA Delgado M., Ganea D. RT Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide Inhibit Expression of Fas Ligand in Activated T Lymphocytes by Regulating c-Myc, NF-kappaB, NF-AT, and Early Growth Factors 2/3. RL J. Immunol. 166:1028-1040 (2001). RN [11]; RE0027531. RX PUBMED: 10882073. RA Wood M. A., McMahon S. B., Cole M. D. RT An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc. RL Mol. Cell 5:321-30 (2000). RN [12]; RE0027846. RX PUBMED: 9989826. RA Yokouchi M., Wakioka T., Sakamoto H., Yasukawa H., Ohtsuka S., Sasaki A., Ohtsubo M., Valius M., Inoue A., Komiya S., Yoshimura A. RT APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis. RL Oncogene 18:759-67 (1999). RN [13]; RE0028193. RX PUBMED: 9178894. RA Judware R., Culp L. A. RT Concomitant down-regulation of expression of integrin subunits by N-myc in human neuroblastoma cells: differential regulation of alpha2, alpha3 and beta1. RL Oncogene 14:1341-50 (1997). RN [14]; RE0029177. RX PUBMED: 11839798. RA Park J., Wood M. A., Cole M. D. RT BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation. RL Mol. Cell. Biol. 22:1307-16 (2002). RN [15]; RE0029269. RX PUBMED: 11983916. RA Menssen A., Hermeking H. RT From the Cover: Characterization of the c-MYC-regulated transcriptome by SAGE: Identification and analysis of c-MYC target genes. RL Proc. Natl. Acad. Sci. USA 99:6274-9 (2002). RN [16]; RE0030035. RX PUBMED: 12545156. RA Wu S., Cetinkaya C., Munoz-Alonso M. J., von der Lehr N., Bahram F., Beuger V., Eilers M., Leon J., Larsson L. G. RT Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter. RL Oncogene 22:351-60 (2003). RN [17]; RE0030153. RX PUBMED: 12037688. RA Fishman P., Madi L., Bar-Yehuda S., Barer F., Del Valle L., Khalili K. RT Evidence for involvement of Wnt signaling pathway in IB-MECA mediated suppression of melanoma cells. RL Oncogene 21:4060-4 (2002). RN [18]; RE0030687. RX PUBMED: 12819782. RA Kim M. J., Park B. J., Kang Y. S., Kim H. J., Park J. H., Kang J. W., Lee S. W., Han J. M., Lee H. W., Kim S. RT Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation. RL Nat. Genet. 34:330-6 (2003). RN [19]; RE0030761. RX PUBMED: 12552124. RA Paez-Pereda M., Giacomini D., Refojo D., Nagashima A. C., Hopfner U., Grubler Y., Chervin A., Goldberg V., Goya R., Hentges S. T., Low M. J., Holsboer F., Stalla G. K., Arzt E. RT Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk. RL Proc. Natl. Acad. Sci. USA 100:1034-9 (2003). RN [20]; RE0030896. RX PUBMED: 11369651. RA Ning Z. Q., Li J., Arceci R. J. RT Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells. RL Blood 97:3559-67 (2001). RN [21]; RE0031648. RX PUBMED: 12584569. RA Zhang F., Li C., Halfter H., Liu J. RT Delineating an oncostatin M-activated STAT3 signaling pathway that coordinates the expression of genes involved in cell cycle regulation and extracellular matrix deposition of MCF-7 cells. RL Oncogene 22:894-905 (2003). RN [22]; RE0032153. RX PUBMED: 11282029. RA Izumi H., Molander C., Penn L. Z., Ishisaki A., Kohno K., Funa K. RT Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor. RL J. Cell Sci. 114:1533-44 (2001). RN [23]; RE0032373. RX PUBMED: 14523011. RA Iavarone C., Catania A., Marinissen M. J., Visconti R., Acunzo M., Tarantino C., Carlomagno M. S., Bruni C. B., Gutkind J. S., Chiariello M. RT The platelet-derived growth factor controls c-myc expression through a JNK- and AP-1-dependent signaling pathway. RL J. Biol. Chem. 278:50024-30 (2003). RN [24]; RE0033362. RX PUBMED: 15199147. RA Kim J. W., Zeller K. I., Wang Y., Jegga A. G., Aronow B. J., O'Donnell K. A., Dang C. V. RT Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays. RL Mol. Cell. Biol. 24:5923-36 (2004). RN [25]; RE0033473. RX PUBMED: 12660246. RA Liu X., Tesfai J., Evrard Y. A., Dent S. Y., Martinez E. RT c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation. RL J. Biol. Chem. 278:20405-12 (2003). RN [26]; RE0034197. RX PUBMED: 8900191. RA Li Y., Davis K. L., Sytkowski A. J. RT Protein kinase C-epsilon is necessary for erythropoietin's up-regulation of c-myc and for factor-dependent DNA synthesis. Evidence for discrete signals for growth and differentiation. RL J. Biol. Chem. 271:27025-30 (1996). RN [27]; RE0036241. RX PUBMED: 12702757. RA Haggerty T. J., Zeller K. I., Osthus R. C., Wonsey D. R., Dang C. V. RT A strategy for identifying transcription factor binding sites reveals two classes of genomic c-Myc target sites RL Proc. Natl. Acad. Sci. USA 100:5313-8 (2003). RN [28]; RE0036726. RX PUBMED: 11420703. RA Yin X. Y., Grove L. E., Prochownik E. V. RT Mmip-2/Rnf-17 enhances c-Myc function and regulates some target genes in common with glucocorticoid hormones RL Oncogene 20:2908-17 (2001). RN [29]; RE0037008. RX PUBMED: 12091391. RA Tsuneoka M., Koda Y., Soejima M., Teye K., Kimura H. RT A novel myc target gene, mina53, that is involved in cell proliferation RL J. Biol. Chem. 277:35450-9 (2002). RN [30]; RE0037378. RX PUBMED: 10713672. RA Liao D. J., Natarajan G., Deming S. L., Jamerson M. H., Johnson M., Chepko G., Dickson R. B. RT Cell cycle basis for the onset and progression of c-Myc-induced, TGFalpha-enhanced mouse mammary gland carcinogenesis RL Oncogene 19:1307-17 (2000). RN [31]; RE0037435. RX PUBMED: 12947005. RA Gery S., Gombart A. F., Fung Y. K., Koeffler H. P. RT C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis RL Blood 103:828-35 (2004). RN [32]; RE0037518. RX PUBMED: 10465786. RA Okano H. J., Park W. Y., Corradi J. P., Darnell R. B. RT The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival RL Genes Dev. 13:2087-97 (1999). RN [33]; RE0037576. RX PUBMED: 15077166. RA Tong X., O'kelly J., Xie D., Mori A., Lemp N., McKenna R., Miller C. W., Koeffler H. P. RT Cyr61 suppresses the growth of non-small-cell lung cancer cells via the beta-catenin-c-myc-p53 pathway RL Oncogene 23:4847-55 (2004). RN [34]; RE0037779. RX PUBMED: 9371770. RA Lee T. C., Li L., Philipson L., Ziff E. B. RT Myc represses transcription of the growth arrest gene gas1 RL Proc. Natl. Acad. Sci. USA 94:12886-91 (1997). RN [35]; RE0037780. RX PUBMED: 11356029. RA Lee K. K., Leung A. K., Tang M. K., Cai D. Q., Schneider C., Brancolini C., Chow P. H. RT Functions of the growth arrest specific 1 gene in the development of the mouse embryo RL Dev. Biol. 234:188-203 (2001). RN [36]; RE0037991. RX PUBMED: 8266081. RA Shrivastava A., Saleque S., Kalpana G. V., Artandi S., Goff S. P., Calame K. RT Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc RL Science 262:1889-92 (1993). RN [37]; RE0038253. RX PUBMED: 12816952. RA Rishi A. K., Zhang L., Boyanapalli M., Wali A., Mohammad R. M., Yu Y., Fontana J. A., Hatfield J. S., Dawson M. I., Majumdar A. P., Reichert U. RT Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437 RL J. Biol. Chem. 278:33422-35 (2003). RN [38]; RE0038595. RX PUBMED: 11231578. RA Gavioli R., Frisan T., Vertuani S., Bornkamm G. W., Masucci M. G. RT c-myc overexpression activates alternative pathways for intracellular proteolysis in lymphoma cells RL Nat. Cell Biol. 3:283-8 (2001). RN [39]; RE0038632. RX PUBMED: 11585818. RA Satou A., Taira T., Iguchi-Ariga S. M., Ariga H. RT A novel transrepression pathway of c-Myc. Recruitment of a transcriptional corepressor complex to c-Myc by MM-1, a c-Myc-binding protein RL J. Biol. Chem. 276:46562-7 (2001). RN [40]; RE0039152. RX PUBMED: 9271375. RA Lewis B. C., Shim H., Li Q., Wu C. S., Lee L. A., Maity A., Dang C. V. RT Identification of putative c-Myc-responsive genes: characterization of rcl, a novel growth-related gene RL Mol. Cell. Biol. 17:4967-78 (1997). RN [41]; RE0039495. RX PUBMED: 12011429. RA Wonsey D. R., Zeller K. I., Dang C. V. RT The c-Myc target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation RL Proc. Natl. Acad. Sci. USA 99:6649-54 (2002). RN [42]; RE0039496. RX PUBMED: 10207076. RA Ben-Porath I., Yanuka O., Benvenisty N. RT The tmp gene, encoding a membrane protein, is a c-Myc target with a tumorigenic activity RL Mol. Cell. Biol. 19:3529-39 (1999). RN [43]; RE0039634. RX PUBMED: 11032017. RA Elliott K., Ge K., Du W., Prendergast G. C. RT The c-Myc-interacting adaptor protein Bin1 activates a caspase-independent cell death program RL Oncogene 19:4669-84 (2000). RN [44]; RE0040109. RX PUBMED: 10446203. RA Taira T., Sawai M., Ikeda M., Tamai K., Iguchi-Ariga S. M., Ariga H. RT Cell cycle-dependent switch of up-and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y RL J. Biol. Chem. 274:24270-9 (1999). RN [45]; RE0040424. RX PUBMED: 12196529. RA Mu Z. M., Yin X. Y., Prochownik E. V. RT Pag, a putative tumor suppressor, interacts with the Myc Box II domain of c-Myc and selectively alters its biological function and target gene expression RL J. Biol. Chem. 277:43175-84 (2002). RN [46]; RE0040467. RX PUBMED: 11146619. RA Raveh T., Droguett G., Horwitz M. S., DePinho R. A., Kimchi A. RT DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation RL Nat. Cell Biol. 3:1-7 (2001). RN [47]; RE0040506. RX PUBMED: 11318876. RA Fujimoto H., Tanaka Y., Liu Z. J., Yagita H., Okumura K., Kosugi A., Morinobu A., Umehara H., Yamamura H., Minami Y. RT Down-regulation of alpha6 integrin, an anti-oncogene product, by functional cooperation of H-Ras and c-Myc RL Genes Cells 6:337-43 (2001). RN [48]; RE0040985. RX PUBMED: 15024088. RA Berasi S. P., Xiu M., Yee A. S., Paulson K. E. RT HBP1 repression of the p47phox gene: cell cycle regulation via the NADPH oxidase RL Mol. Cell. Biol. 24:3011-24 (2004). RN [49]; RE0041240. RX PUBMED: 10899310. RA Endo K., Takeshita T., Kasai H., Sasaki Y., Tanaka N., Asao H., Kikuchi K., Yamada M., Chenb M., O'Shea J. J., Sugamura K. RT STAM2, a new member of the STAM family, binding to the Janus kinases RL FEBS Lett. 477:55-61 (2000). RN [50]; RE0041530. RX PUBMED: 11968011. RA Zelinski D. P., Zantek N. D., Walker-Daniels J., Peters M. A., Taparowsky E. J., Kinch M. S. RT Estrogen and Myc negatively regulate expression of the EphA2 tyrosine kinase RL J. Cell. Biochem. 85:714-20 (2002). RN [51]; RE0041671. RX PUBMED: 8649790. RA Li W., Park J. W., Nuijens A., Sliwkowski M. X., Keller G. A. RT Heregulin is rapidly translocated to the nucleus and its transport is correlated with c-myc induction in breast cancer cells RL Oncogene 12:2473-7 (1996). RN [52]; RE0041683. RX PUBMED: 12048235. RA Tsuruyama T., Nakamura T., Jin G., Ozeki M., Yamada Y., Hiai H. RT Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice RL Proc. Natl. Acad. Sci. USA 99:8253-8 (2002). RN [53]; RE0041782. RX PUBMED: 9328468. RA Drouin R., Angers M., Dallaire N., Rose T. M., Khandjian E. W., Rousseau F. RT Structural and functional characterization of the human FMR1 promoter reveals similarities with the hnRNP-A2 promoter region RL Hum. Mol. Genet. 6:2051-60 (1997). RN [54]; RE0041987. RX PUBMED: 12637527. RA Chiang Y. C., Teng S. C., Su Y. N., Hsieh F. J., Wu K. J. RT c-Myc directly regulates the transcription of the NBS1 gene involved in DNA double-strand break repair RL J. Biol. Chem. 278:19286-91 (2003). RN [55]; RE0042592. RX PUBMED: 14764675. RA Poe J. C., Haas K. M., Uchida J., Lee Y., Fujimoto M., Tedder T. F. RT Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background RL J. Immunol. 172:2100-10 (2004). RN [56]; RE0042630. RX PUBMED: 11511535. RA Bouchard C., Dittrich O., Kiermaier A., Dohmann K., Menkel A., Eilers M., Luscher B. RT Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter RL Genes Dev. 15:2042-7 (2001). RN [57]; RE0042876. RX PUBMED: 9240448. RA Conner E. A., Wirth P. J., Kiss A., Santoni-Rugiu E., Thorgeirsson S. S. RT Growth inhibition and induction of apoptosis by HGF in transformed rat liver epithelial cells RL Biochem. Biophys. Res. Commun. 236:396-401 (1997). RN [58]; RE0042888. RX PUBMED: 9500466. RA Sapi E., Flick M. B., Rodov S., Kacinski B. M. RT Ets-2 transdominant mutant abolishes anchorage-independent growth and macrophage colony-stimulating factor-stimulated invasion by BT20 breast carcinoma cells RL Cancer Res. 58:1027-33 (1998). RN [59]; RE0043057. RX PUBMED: 9125156. RA Kallay E., Kifor O., Chattopadhyay N., Brown E. M., Bischof M. G., Peterlik M., Cross H. S. RT Calcium-dependent c-myc proto-oncogene expression and proliferation of Caco-2 cells: a role for a luminal extracellular calcium-sensing receptor RL Biochem. Biophys. Res. Commun. 232:80-3 (1997). RN [60]; RE0043940. RX PUBMED: 14749374. RA Huang Z., Traugh J. A., Bishop J. M. RT Negative control of the Myc protein by the stress-responsive kinase Pak2 RL Mol. Cell. Biol. 24:1582-94 (2004). RN [61]; RE0044465. RX PUBMED: 12646044. RA Desbiens K. M., Deschesnes R. G., Labrie M. M., Desfosses Y., Lambert H., Landry J., Bellmann K. RT c-Myc potentiates the mitochondrial pathway of apoptosis by acting upstream of apoptosis signal-regulating kinase 1 (Ask1) in the p38 signalling cascade RL Biochem. J. 372:631-41 (2003). RN [62]; RE0044505. RX PUBMED: 7689933. RA Plummer H. 3rd, Catlett J., Leftwich J., Armstrong B., Carlson P., Huff T., Krystal G. RT c-myc expression correlates with suppression of c-kit protooncogene expression in small cell lung cancer cell lines RL Cancer Res. 53:4337-42 (1993). RN [63]; RE0044526. RX PUBMED: 9315667. RA Satijn D. P., Olson D. J., van der Vlag J., Hamer K. M., Lambrechts C., Masselink H., Gunster M. J., Sewalt R. G., van Driel R., Otte A. P. RT Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis RL Mol. Cell. Biol. 17:6076-86 (1997). RN [64]; RE0044763. RX PUBMED: 12818373. RA Kanayasu-Toyoda T., Yamaguchi T., Oshizawa T., Uchida E., Hayakawa T. RT The role of c-Myc on granulocyte colony-stimulating factor-dependent neutrophilic proliferation and differentiation of HL-60 cells RL Biochem. Pharmacol. 66:133-40 (2003). RN [65]; RE0044768. RX PUBMED: 15103331. RA Yada M., Hatakeyama S., Kamura T., Nishiyama M., Tsunematsu R., Imaki H., Ishida N., Okumura F., Nakayama K., Nakayama K. I. RT Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7 RL EMBO J. 23:2116-25 (2004). RN [66]; RE0044769. RX PUBMED: 15150404. RA Welcker M., Orian A., Jin J., Grim J. A., Harper J. W., Eisenman R. N., Clurman B. E. RT The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation RL Proc. Natl. Acad. Sci. USA 101:9085-90 (2004). RN [67]; RE0045145. RX PUBMED: 12697688. RA Matsushita M., Shichiri M., Fukai N., Ozawa N., Yoshimoto T., Takasu N., Hirata Y. RT Urotensin II is an autocrine/paracrine growth factor for the porcine renal epithelial cell line, LLCPK1 RL Endocrinology 144:1825-31 (2003). RN [68]; RE0045223. RX PUBMED: 9315742. RA Alexandrov I., Shlyakhova L., Vartanian A., Zajac-Kaye M., Alexandrova N. RT c-Raf kinase binds to N-terminal domain of c-Myc RL FEBS Lett. 414:465-70 (1997). RN [69]; RE0045304. RX PUBMED: 14673150. RA Murphy L. O., MacKeigan J. P., Blenis J. RT A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration RL Mol. Cell. Biol. 24:144-53 (2004). RN [70]; RE0045605. RX PUBMED: 12721301. RA Sarkar D., Leszczyniecka M., Kang D. C., Lebedeva I. V., Valerie K., Dhar S., Pandita T. K., Fisher P. B. RT Down-regulation of Myc as a potential target for growth arrest induced by human polynucleotide phosphorylase (hPNPaseold-35) in human melanoma cells RL J. Biol. Chem. 278:24542-51 (2003). RN [71]; RE0045947. RX PUBMED: 15332117. RA Li C. Y., Zhan Y. Q., Xu C. W., Xu W. X., Wang S. Y., Lv J., Zhou Y., Yue P. B., Chen B., Yang X. M. RT EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of nuclear factor-kappa B RL Cell Death Differ. 11:1299-308 (2004). RN [72]; RE0046018. RX PUBMED: 15195135. RA Munz M., Kieu C., Mack B., Schmitt B., Zeidler R., Gires O. RT The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation RL Oncogene 23:5748-58 (2004). RN [73]; RE0046069. RX PUBMED: 10319872. RA Cheng S. W., Davies K. P., Yung E., Beltran R. J., Yu J., Kalpana G. V. RT c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function RL Nat. Genet. 22:102-5 (1999). RN [74]; RE0046169. RX PUBMED: 8822200. RA Gulli L. F., Palmer K. C., Chen Y. Q., Reddy K. B. RT Epidermal growth factor-induced apoptosis in A431 cells can be reversed by reducing the tyrosine kinase activity RL Cell Growth Differ. 7:173-8 (1996). RN [75]; RE0046437. RX PUBMED: 12769843. RA Kim S. Y., Herbst A., Tworkowski K. A., Salghetti S. E., Tansey W. P. RT Skp2 regulates Myc protein stability and activity RL Mol. Cell 11:1177-88 (2003). RN [76]; RE0046489. RX PUBMED: 10551811. RA Noguchi K., Kitanaka C., Yamana H., Kokubu A., Mochizuki T., Kuchino Y. RT Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase RL J. Biol. Chem. 274:32580-7 (1999). RN [77]; RE0046677. RX PUBMED: 12743600. RA Junqueira D., Cilenti L., Musumeci L., Sedivy J. M., Zervos A. S. RT Random mutagenesis of PDZ(Omi) domain and selection of mutants that specifically bind the Myc proto-oncogene and induce apoptosis RL Oncogene 22:2772-81 (2003). RN [78]; RE0046939. RX PUBMED: 12185582. RA Dugan K. A., Wood M. A., Cole M. D. RT TIP49, but not TRRAP, modulates c-Myc and E2F1 dependent apoptosis RL Oncogene 21:5835-43 (2002). RN [79]; RE0046949. RX PUBMED: 10886373. RA Takayama M. A., Taira T., Tamai K., Iguchi-Ariga S. M., Ariga H. RT ORC1 interacts with c-Myc to inhibit E-box-dependent transcription by abrogating c-Myc-SNF5/INI1 interaction RL Genes Cells 5:481-90 (2000). RN [80]; RE0047306. RX PUBMED: 10737769. RA Sun H., Taneja R. RT Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms RL Proc. Natl. Acad. Sci. USA 97:4058-63 (2000). RN [81]; RE0047310. RX PUBMED: 10744629. RA Daugas E., Susin S. A., Zamzami N., Ferri K. F., Irinopoulou T., Larochette N., Prevost M. C., Leber B., Andrews D., Penninger J., Kroemer G. RT Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis RL FASEB J. 14:729-39 (2000). RN [82]; RE0048190. RX PUBMED: 15572685. RA Patel J. H., Du Y., Ard P. G., Phillips C., Carella B., Chen C. J., Rakowski C., Chatterjee C., Lieberman P. M., Lane W. S., Blobel G. A., McMahon S. B. RT The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. RL Mol. Cell. Biol. 24:10826-10834 (2004). RN [83]; RE0048196. RX PUBMED: 10421840. RA Miyata Y., Akashi M., Nishida E. RT Molecular cloning and characterization of a novel member of the MAP kinase superfamily. 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