TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T03214 XX ID T03214 XX DT 24.03.2000 (created); sur. DT 26.10.2012 (updated); prb. CO Copyright (C), QIAGEN. XX FA Pontin52 XX SY 49 kDa TBP-interacting protein; 49-kDa TATA box-binding protein-interacting protein; 54 kDa erythrocyte cytosolic protein; ECP-54; NMP238; nuclear matrix protein 238; RuvB-like 1; RUVBL1; TAP54-alpha; TIP49; TIP49a; TIP60-associated protein 54-alpha. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G009948 RUVBL1; HGNC: RUVBL1. XX SF Pontin52 binds direct to beta-catenin in the region of Armadillo repeats 2-5 and to the TBP (TATA box binding) protein (the name comes from pons, bridge in Latin); SF seems to build up a multiprotein complex with beta-catenin and TCF/ LEF transcription factors; SF localized in the nucleus; SF does not bind to LEF/ TCF directly [1]; XX CP appears to be rather ubiquitously expressed [1]. XX FF there is good evidence that Pontin52 bridges the LEF-1/ beta-catenin complex to TBP (TATA box binding protein) and thus to the basic transcriptional machinery; FF on wnt/ wg signaling pontin 52 could thus function as a coactivator in regulating the expression of target genes [1]; XX IN T22426 BAF170; human, Homo sapiens. IN T06126 BAF53a; human, Homo sapiens. IN T02872 beta-catenin; human, Homo sapiens. IN T14435 c-Myc; Mammalia. IN T22413 DMAP1; human, Homo sapiens. IN T06110 E2F-7; human, Homo sapiens. IN T06127 EP400; human, Homo sapiens. IN T05220 Evi-1; human, Homo sapiens. IN T10210 Evi-1; human, Homo sapiens. IN T22586 N-Myc; Mammalia. IN T34284 NFRKB; human, Homo sapiens. IN T09288 Pontin52-isoform1; human, Homo sapiens. IN T22463 SNF2H; human, Homo sapiens. IN T23907 SNF2L; human, Homo sapiens. IN T04151 SRCAP; human, Homo sapiens. IN T05140 trrap; human, Homo sapiens. IN T04939 YL-1; human, Homo sapiens. XX DR TRANSPATH: MO000021887. DR UniProtKB: Q9Y265; XX RN [1]; RE0014262. RX PUBMED: 9843967. RA Bauer A., Huber O., Kemler R. RT Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein RL Proc. Natl. Acad. Sci. USA 95:14787-14792 (1998). RN [2]; RE0020778. RX PUBMED: 11080158. RA Bauer A., Chauvet S., Huber O., Usseglio F., Rothbacher U., Aragnol D., Kemler R., Pradel J. RT Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity RL EMBO J. 19:6121-6130 (2000). RN [3]; RE0027531. RX PUBMED: 10882073. RA Wood M. A., McMahon S. B., Cole M. D. RT An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc. RL Mol. Cell 5:321-30 (2000). RN [4]; RE0029177. RX PUBMED: 11839798. RA Park J., Wood M. A., Cole M. D. RT BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation. RL Mol. Cell. Biol. 22:1307-16 (2002). RN [5]; RE0067198. RX PUBMED: 16387653. RA Doyon Y., Cayrou C., Ullah M., Landry A. J., Cote V., Selleck W., Lane W. S., Tan S., Yang X. J., Cote J. RT ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. RL Mol. Cell 21:51-64 (2006). XX //