TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T22586 XX ID T22586 XX DT 10.03.2005 (created); nvo. DT 13.02.2012 (updated); mka. CO Copyright (C), QIAGEN. XX FA N-Myc XX SY MYCN; N-myc proto-oncogene protein; NMYC. XX OS Mammalia OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia XX IN T23078 MASH-1; Mammalia. IN T09085 Max; Mammalia. IN T03214 Pontin52; human, Homo sapiens. IN T25008 pRb; Mammalia. IN T05140 trrap; human, Homo sapiens. XX MX M01034 V$EBOX_Q6_01. MX M00055 V$NMYC_01. MX M01808 V$NMYC_02. MX M03834 V$NMYC_Q3. XX BS R37902. BS R36831. BS R36833. XX DR TRANSPATH: MO000046853. XX RN [1]; RE0013501. RX PUBMED: 9030690. RA Tevosian S. G., Shih H. H., Mendelson K. G., Sheppard K. A., Paulson K. E., Yee A. S. RT HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family. RL Genes Dev. 11:383-396 (1997). RN [2]; RE0017604. RX PUBMED: 10593926. RA Billin A. N., Eilers A. L., Queva C., Ayer D. E. RT Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors. RL J. Biol. Chem. 274:36344-36350 (1999). RN [3]; RE0027531. RX PUBMED: 10882073. RA Wood M. A., McMahon S. B., Cole M. D. RT An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc. RL Mol. Cell 5:321-30 (2000). RN [4]; RE0028193. RX PUBMED: 9178894. RA Judware R., Culp L. A. RT Concomitant down-regulation of expression of integrin subunits by N-myc in human neuroblastoma cells: differential regulation of alpha2, alpha3 and beta1. RL Oncogene 14:1341-50 (1997). RN [5]; RE0029632. RX PUBMED: 12153570. RA Hatzi E., Murphy C., Zoephel A., Ahorn H., Tontsch U., Bamberger A. M., Yamauchi-Takihara K., Schweigerer L., Fotsis T. RT N-myc oncogene overexpression down-regulates leukemia inhibitory factor in neuroblastoma. RL Eur. J. Biochem. 269:3732-41 (2002). RN [6]; RE0031461. RX PUBMED: 14691455. RA Woo C. W., Lucarelli E., Thiele C. J. RT NGF activation of TrkA decreases N-myc expression via MAPK path leading to a decrease in neuroblastoma cell number. RL Oncogene 23:1522-30 (2004). RN [7]; RE0032531. RX PUBMED: 12553057. RA Wittrock J., Schweizer P., Girgert R. RT Induction of N-myc in neuroblastoma by autocrine IGF-II depends on farnesylated Ras. Application of farnesyltransferase inhibitors. RL Anticancer Res. 22:4205-9 (2002). RN [8]; RE0032551. RX PUBMED: 12107114. RA Yazawa T., Ito T., Kamma H., Suzuki T., Okudela K., Hayashi H., Horiguchi H., Ogata T., Mitsui H., Ikeda M., Kitamura H. RT Complicated mechanisms of class II transactivator transcription deficiency in small cell lung cancer and neuroblastoma. RL Am. J. Pathol. 161:291-300 (2002). RN [9]; RE0032601. RX PUBMED: 12032857. RA Hatzi E., Murphy C., Zoephel A., Rasmussen H., Morbidelli L., Ahorn H., Kunisada K., Tontsch U., Klenk M., Yamauchi-Takihara K., Ziche M., Rofstad E. K., Schweigerer L., Fotsis T. RT N-myc oncogene overexpression down-regulates IL-6; evidence that IL-6 inhibits angiogenesis and suppresses neuroblastoma tumor growth. RL Oncogene 21:3552-61 (2002). RN [10]; RE0039438. RX PUBMED: 8761302. RA Lutz W., Stohr M., Schurmann J., Wenzel A., Lohr A., Schwab M. RT Conditional expression of N-myc in human neuroblastoma cells increases expression of alpha-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells RL Oncogene 13:803-12 (1996). RN [11]; RE0040956. RX PUBMED: 10050884. RA Fulda S., Lutz W., Schwab M., Debatin K. M. RT MycN sensitizes neuroblastoma cells for drug-induced apoptosis RL Oncogene 18:1479-86 (1999). RN [12]; RE0040957. RX PUBMED: 10348353. RA Haber M., Bordow S. B., Gilbert J., Madafiglio J., Kavallaris M., Marshall G. M., Mechetner E. B., Fruehauf J. P., Tee L., Cohn S. L., Salwen H., Schmidt M. L., Norris M. D. RT Altered expression of the MYCN oncogene modulates MRP gene expression and response to cytotoxic drugs in neuroblastoma cells RL Oncogene 18:2777-82 (1999). RN [13]; RE0040966. RX PUBMED: 1902412. RA Bernards R. RT N-myc disrupts protein kinase C-mediated signal transduction in neuroblastoma RL EMBO J. 10:1119-25 (1991). RN [14]; RE0040975. RX PUBMED: 15117961. RA Thomas S. K., Messam C. A., Spengler B. A., Biedler J. L., Ross R. A. RT Nestin is a potential mediator of malignancy in human neuroblastoma cells RL J. Biol. Chem. 279:27994-9 (2004). RN [15]; RE0040978. RX PUBMED: 12085233. RA Noujaim D., van Golen C. M., van Golen K. L., Grauman A., Feldman E. L. RT N-Myc and Bcl-2 coexpression induces MMP-2 secretion and activation in human neuroblastoma cells RL Oncogene 21:4549-57 (2002). RN [16]; RE0040980. RX PUBMED: 11861392. RA Shohet J. M., Hicks M. J., Plon S. E., Burlingame S. M., Stuart S., Chen S. Y., Brenner M. K., Nuchtern J. G. RT Minichromosome maintenance protein MCM7 is a direct target of the MYCN transcription factor in neuroblastoma RL Cancer Res. 62:1123-8 (2002). RN [17]; RE0040981. RX PUBMED: 12777630. RA Oliver T. G., Grasfeder L. L., Carroll A. L., Kaiser C., Gillingham C. L., Lin S. M., Wickramasinghe R., Scott M. P., Wechsler-Reya R. J. RT Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors RL Proc. Natl. Acad. Sci. USA 100:7331-6 (2003). RN [18]; RE0040984. RX PUBMED: 9545244. RA Nutt S. L., Morrison A. M., Dorfler P., Rolink A., Busslinger M. RT Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments RL EMBO J. 17:2319-33 (1998). RN [19]; RE0040986. RX PUBMED: 8858107. RA Paravicini G., Steinmayr M., Andre E., Becker-Andre M. RT The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily RL Biochem. Biophys. Res. Commun. 227:82-7 (1996). RN [20]; RE0041016. RX PUBMED: 8180130. RA Schmidt M. L., Salwen H. R., Manohar C. F., Ikegaki N., Cohn S. L. RT The biological effects of antisense N-myc expression in human neuroblastoma RL Cell Growth Differ. 5:171-8 (1994). RN [21]; RE0041020. RX PUBMED: 10383152. RA Chambery D., Mohseni-Zadeh S., de Galle B., Babajko S. RT N-myc regulation of type I insulin-like growth factor receptor in a human neuroblastoma cell line RL Cancer Res. 59:2898-902 (1999). RN [22]; RE0041022. RX PUBMED: 11146231. RA Wittke I., Madge B., Wiedemeyer R., Kimchi A., Schwab M. RT DAP-5 is involved in MycN/IFNgamma-induced apoptosis in human neuroblastoma cells RL Cancer Lett. 162:237-43 (2001). RN [23]; RE0041040. RX PUBMED: 12077335. RA Nikiforov M. A., Chandriani S., Park J., Kotenko I., Matheos D., Johnsson A., McMahon S. B., Cole M. D. RT TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins RL Mol. Cell. Biol. 22:5054-63 (2002). RN [24]; RE0041046. RX PUBMED: 9856457. RA ElShamy W. M., Fridvall L. K., Ernfors P. RT Growth arrest failure, G1 restriction point override, and S phase death of sensory precursor cells in the absence of neurotrophin-3 RL Neuron 21:1003-15 (1998). RN [25]; RE0046726. RX PUBMED: 15064733. RA Ren Y., Chan H. M., Li Z., Lin C., Nicholls J., Chen C. F., Lee P. Y., Lui V., Bacher M., Tam P. K. RT Upregulation of macrophage migration inhibitory factor contributes to induced N-Myc expression by the activation of ERK signaling pathway and increased expression of interleukin-8 and VEGF in neuroblastoma RL Oncogene 23:4146-54 (2004). RN [26]; RE0047183. RX PUBMED: 15833843. RA Valentijn L. J., Koppen A., van Asperen R., Root H. A., Haneveld F., Versteeg R. RT Inhibition of a new differentiation pathway in neuroblastoma by copy number defects of N-myc, Cdc42, and nm23 genes RL Cancer Res. 65:3136-45 (2005). RN [27]; RE0048190. RX PUBMED: 15572685. RA Patel J. H., Du Y., Ard P. G., Phillips C., Carella B., Chen C. J., Rakowski C., Chatterjee C., Lieberman P. M., Lane W. S., Blobel G. A., McMahon S. B. RT The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. RL Mol. Cell. Biol. 24:10826-10834 (2004). RN [28]; RE0048383. RX PUBMED: 16139224. RA Sjostrom S. K., Finn G., Hahn W. C., Rowitch D. H., Kenney A. M. RT The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. RL Dev. Cell 9:327-338 (2005). RN [29]; RE0069431. RX PUBMED: 18488021. RA Zhao X., Heng J. I., Guardavaccaro D., Jiang R., Pagano M., Guillemot F., Iavarone A., Lasorella A. RT The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein. RL Nat. Cell Biol. 10:643-653 (2008). XX //