AC T16759
XX
ID T16759
XX
DT 10.03.2005 (created); nvo.
DT 14.08.2014 (updated); pro.
CO Copyright (C), QIAGEN.
XX
FA p73
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SY p53-like transcription factor; p53-related protein; p73; tp73.
XX
OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
XX
IN T17641 ASPP2; Mammalia.
IN T14435 c-Myc; Mammalia.
IN T16474 HMGB1; Mammalia.
IN T17293 NF-YC; Mammalia.
IN T23091 p300; Mammalia.
IN T16760 p63; Mammalia.
IN T14649 WT1; Mammalia.
IN T22875 YAP; Mammalia.
XX
MX M00761 V$P53DECAMER_Q2.
MX M03558 V$P73_Q6.
XX
BS R30903.
BS R30905.
BS R63344.
BS R15624.
BS R35909.
BS R33410.
XX
DR TRANSPATH: MO000046529.
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RN [1]; RE0017271.
RX PUBMED: 10391251.
RA Yuan Z. M., Shioya H., Ishiko T., Sun X., Gu J., Huang Y. Y., Lu H., Kharbanda S., Weichselbaum R., Kufe D.
RT p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage
RL Nature 399:814-817 (1999).
RN [2]; RE0024351.
RX PUBMED: 10648616.
RA Zeng X., Li X., Miller A., Yuan Z., Yuan W., Kwok R. P., Goodman R., Lu H.
RT The N-terminal domain of p73 interacts with the CH1 domain of p300/CREB binding protein and mediates transcriptional activation and apoptosis.
RL Mol. Cell. Biol. 20:1299-1310 (2000).
RN [3]; RE0024357.
RX PUBMED: 12676926.
RA Gaiddon C., Lokshin M., Gross I., Levasseur D., Taya Y., Loeffler J. P., Prives C.
RT Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73.
RL J. Biol. Chem. 278:27421-27431 (2003).
RN [4]; RE0024368.
RX PUBMED: 15070730.
RA Aqeilan R. I., Pekarsky Y., Herrero J. J., Palamarchuk A., Letofsky J., Druck T., Trapasso F., Han S. Y., Melino G., Huebner K., Croce C. M.
RT Functional association between Wwox tumor suppressor protein and p73, a p53 homolog.
RL Proc. Natl. Acad. Sci. USA 101:4401-4406 (2004).
RN [5]; RE0024372.
RX PUBMED: 15175157.
RA Mantovani F., Piazza S., Gostissa M., Strano S., Zacchi P., Mantovani R., Blandino G., Del Sal G.
RT Pin1 Links the Activities of c-Abl and p300 in Regulating p73 Function.
RL Mol. Cell 14:625-636 (2004).
RN [6]; RE0024381.
RX PUBMED: 10744705.
RA Scharnhorst V., Dekker P., van der Eb A. J., Jochemsen A. G.
RT Physical interaction between Wilms tumor 1 and p73 proteins modulates their functions.
RL J. Biol. Chem. 275:10202-10211 (2000).
RN [7]; RE0024398.
RX PUBMED: 11844794.
RA Watanabe K., Ozaki T., Nakagawa T., Miyazaki K., Takahashi M., Hosoda M., Hayashi S., Todo S., Nakagawara A.
RT Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function.
RL J. Biol. Chem. 277:15113-15123 (2002).
RN [8]; RE0024850.
RX PUBMED: 12167641.
RA Hackzell A., Uramoto H., Izumi H., Kohno K., Funa K.
RT p73 independent of c-Myc represses transcription of platelet-derived growth factor beta-receptor through interaction with NF-Y.
RL J. Biol. Chem. 277:39769-39776 (2002).
RN [9]; RE0024867.
RX PUBMED: 11748232.
RA Stros M., Ozaki T., Bacikova A., Kageyama H., Nakagawara A.
RT HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter.
RL J. Biol. Chem. 277:7157-7164 (2002).
RN [10]; RE0025178.
RX PUBMED: 14729977.
RA Bergamaschi D., Samuels Y., Jin B., Duraisingham S., Crook T., Lu X.
RT ASPP1 and ASPP2: common activators of p53 family members.
RL Mol. Cell. Biol. 24:1341-1350 (2004).
RN [11]; RE0025204.
RX PUBMED: 11706030.
RA Tsuji K., Mizumoto K., Yamochi T., Nishimoto I., Matsuoka M.
RT Differential effect of ik3-1/cables on p53- and p73-induced cell death.
RL J. Biol. Chem. 277:2951-2957 (2002).
RN [12]; RE0025255.
RX PUBMED: 12601175.
RA Shimodaira H., Yoshioka-Yamashita A., Kolodner R. D., Wang J. Y.
RT Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin.
RL Proc. Natl. Acad. Sci. USA 100:2420-2425 (2003).
RN [13]; RE0029914.
RX PUBMED: 12535517.
RA Basu S., Totty N. F., Irwin M. S., Sudol M., Downward J.
RT Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis.
RL Mol. Cell 11:11-23 (2003).
RN [14]; RE0038273.
RX PUBMED: 15116103.
RA Terrinoni A., Ranalli M., Cadot B., Leta A., Bagetta G., Vousden K. H., Melino G.
RT p73-alpha is capable of inducing scotin and ER stress
RL Oncogene 23:3721-5 (2004).
RN [15]; RE0039003.
RX PUBMED: 11231003.
RA Zheng X., Chen X.
RT Aquaporin 3, a glycerol and water transporter, is regulated by p73 of the p53 family
RL FEBS Lett. 489:4-7 (2001).
RN [16]; RE0040474.
RX PUBMED: 12370809.
RA Liu G., Chen X.
RT The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis
RL Oncogene 21:7195-204 (2002).
RN [17]; RE0044520.
RX PUBMED: 12642871.
RA Ohtsuka T., Ryu H., Minamishima Y. A., Ryo A., Lee S. W.
RT Modulation of p53 and p73 levels by cyclin G: implication of a negative feedback regulation
RL Oncogene 22:1678-87 (2003).
RN [18]; RE0046051.
RX PUBMED: 15031205.
RA Lunghi P., Costanzo A., Levrero M., Bonati A.
RT Treatment with arsenic trioxide (ATO) and MEK1 inhibitor activates the p73-p53AIP1 apoptotic pathway in leukemia cells
RL Blood 104:519-25 (2004).
RN [19]; RE0046141.
RX PUBMED: 12748190.
RA Lohr K., Moritz C., Contente A., Dobbelstein M.
RT p21/CDKN1A mediates negative regulation of transcription by p53
RL J. Biol. Chem. 278:32507-16 (2003).
RN [20]; RE0071837.
RX PUBMED: 21489991.
RA Donninger H., Allen N., Henson A., Pogue J., Williams A., Gordon L., Kassler S., Dunwell T., Latif F., Clark G. J.
RT Salvador protein is a tumor suppressor effector of RASSF1A with hippo pathway-independent functions.
RL J. Biol. Chem. 286:18483-18491 (2011).
XX
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