AC T10683
XX
ID T10683
XX
DT 19.01.2006 (created); jma.
DT 22.09.2015 (updated); smt.
CO Copyright (C), QIAGEN.
XX
FA Smad2
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SY HMAD-2; MADH2.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002225 SMAD2; HGNC: SMAD2.
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CL C0041; SMAD; 7.1.1.1.2.
XX
IN T02211 BTEB2; human, Homo sapiens.
IN T09998 c-Myc; human, Homo sapiens.
IN T14435 c-Myc; Mammalia.
IN T09366 foxl2; mouse, Mus musculus.
IN T00330 GLI; human, Homo sapiens.
IN T22348 NF-1; human, Homo sapiens.
IN T21984 p300; human, Homo sapiens.
IN T00671 p53; human, Homo sapiens.
IN T10378 Smad3; human, Homo sapiens.
IN T04292 Smad4; human, Homo sapiens.
IN T05485 Sox-9; rat, Rattus norvegicus.
IN T00759 Sp1; human, Homo sapiens.
IN T04759 STAT1; human, Homo sapiens.
IN T01493 STAT3; human, Homo sapiens.
XX
MX M03580 V$SMAD2_Q6.
MX M08897 V$SMAD_Q4.
MX M00792 V$SMAD_Q6.
MX M00974 V$SMAD_Q6_01.
XX
BS R38826.
BS R38828.
BS R38829.
BS R38830.
BS R38831.
BS R29592.
BS R33292.
BS R33953.
BS R23096.
BS R38243.
BS R26795.
BS R26799.
BS R29688.
BS R63414.
BS R09967.
BS R10058.
BS R63415.
BS R21773.
BS R26661.
BS R72914.
XX
DR TRANSPATH: MO000057829.
DR TRANSCOMPEL: C00557.
DR UniProtKB: Q15796;
XX
RN [1]; RE0027996.
RX PUBMED: 11278410.
RA Sasaki A., Masuda Y., Ohta Y., Ikeda K., Watanabe K.
RT Filamin associates with Smads and regulates transforming growth factor-beta signaling.
RL J. Biol. Chem. 276:17871-7 (2001).
RN [2]; RE0035779.
RX PUBMED: 16109717.
RA Furumatsu T., Tsuda M., Yoshida K., Taniguchi N., Ito T., Hashimoto M., Ito T., Asahara H.
RT Sox9 and p300 cooperatively regulate chromatin-mediated transcription.
RL J. Biol. Chem. 280:35203-35208 (2005).
RN [3]; RE0047880.
RX PUBMED: 15356634.
RA Lin H. K., Bergmann S., Pandolfi P. P.
RT Cytoplasmic PML function in TGF-beta signalling.
RL Nature 431:205-211 (2004).
RN [4]; RE0047924.
RX PUBMED: 11387212.
RA Hocevar B. A., Smine A., Xu X. X., Howe P. H.
RT The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway.
RL EMBO J. 20:2789-2801 (2001).
RN [5]; RE0048582.
RX PUBMED: 11919190.
RA Czuwara-Ladykowska J., Sementchenko V. I., Watson D. K., Trojanowska M.
RT Ets1 is an effector of the transforming growth factor beta (TGF-beta ) signaling pathway and an antagonist of the profibrotic effects of TGF-beta.
RL J. Biol. Chem. 277:20399-20408 (2002).
RN [6]; RE0048990.
RX PUBMED: 16407286.
RA Choi S. H., Hwang S. B.
RT Modulation of the transforming growth factor-beta signal transduction pathway by hepatitis C virus nonstructural 5A protein.
RL J. Biol. Chem. 281:7468-7478 (2006).
RN [7]; RE0049583.
RX PUBMED: 17327236.
RA Seong H. A., Jung H., Kim K. T., Ha H.
RT 3-phosphoinositide-dependent protein kinase-1 (PDK1) negatively regulates TGF-beta -induced signaling in a kinase-dependent manner through physical interaction with Smad proteins.
RL J. Biol. Chem. 282:12272-12289 (2007).
RN [8]; RE0049598.
RX PUBMED: 16862174.
RA Inoue Y., Itoh Y., Abe K., Okamoto T., Daitoku H., Fukamizu A., Onozaki K., Hayashi H.
RT Smad3 is acetylated by p300/CBP to regulate its transactivation activity.
RL Oncogene 26:500-508 (2007).
RN [9]; RE0050473.
RX PUBMED: 17478422.
RA Tu A. W., Luo K.
RT Acetylation of Smad2 by the Co-activator p300 Regulates Activin and Transforming Growth Factor beta Response.
RL J. Biol. Chem. 282:21187-21196 (2007).
RN [10]; RE0054878.
RX PUBMED: 15661740.
RA Zhang X. L., Topley N., Ito T., Phillips A.
RT Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling.
RL J. Biol. Chem. 280:12239-12245 (2005).
RN [11]; RE0065788.
RX PUBMED: 19198599.
RA Kajiro M., Hirota R., Nakajima Y., Kawanowa K., So-ma K., Ito I., Yamaguchi Y., Ohie S. H., Kobayashi Y., Seino Y., Kawano M., Kawabe Y., Takei H., Hayashi S., Kurosumi M., Murayama A., Kimura K., Yanagisawa J.
RT The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways.
RL Nat. Cell Biol. 11:312-319 (2009).
RN [12]; RE0066671.
RX PUBMED: 19026785.
RA Yang G., Li Y., Nishimura E. K., Xin H., Zhou A., Guo Y., Dong L., Denning M. F., Nickoloff B. J., Cui R.
RT Inhibition of PAX3 by TGF-beta modulates melanocyte viability.
RL Mol. Cell 32:554-563 (2008).
RN [13]; RE0066773.
RX PUBMED: 16549496.
RA Bandyopadhyay B., Fan J., Guan S., Li Y., Chen M., Woodley D. T., Li W.
RT A "traffic control" role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healing.
RL J. Cell Biol. 172:1093-1105 (2006).
RN [14]; RE0069543.
RX PUBMED: 18758450.
RA Sorrentino A., Thakur N., Grimsby S., Marcusson A., von Bulow V., Schuster N., Zhang S., Heldin C. H., Landstrom M.
RT The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner.
RL Nat. Cell Biol. 10:1199-1207 (2008).
RN [15]; RE0070931.
RX PUBMED: 20592275.
RA Giroux M., Delisle J. S., O Brien A., Hebert M. J., Perreault C.
RT T cell activation leads to protein kinase C theta-dependent inhibition of TGF-beta signaling.
RL J. Immunol. 185:1568-1576 (2010).
RN [16]; RE0071322.
RX PUBMED: 20699357.
RA Massam-Wu T., Chiu M., Choudhury R., Chaudhry S. S., Baldwin A. K., McGovern A., Baldock C., Shuttleworth C. A., Kielty C. M.
RT Assembly of fibrillin microfibrils governs extracellular deposition of latent TGF beta.
RL J. Cell Sci. 123:3006-3018 (2010).
RN [17]; RE0071582.
RX PUBMED: 21629263.
RA Mu Y., Sundar R., Thakur N., Ekman M., Gudey S. K., Yakymovych M., Hermansson A., Dimitriou H., Bengoechea-Alonso M. T., Ericsson J., Heldin C. H., Landstrom M.
RT TRAF6 ubiquitinates TGFbeta type I receptor to promote its cleavage and nuclear translocation in cancer.
RL Nat. Commun. 2:330 (2011).
RN [18]; RE0071919.
RX PUBMED: 19158279.
RA Asano Y., Trojanowska M.
RT Phosphorylation of Fli1 at threonine 312 by protein kinase C delta promotes its interaction with p300/CREB-binding protein-associated factor and subsequent acetylation in response to transforming growth factor beta.
RL Mol. Cell. Biol. 29:1882-1894 (2009).
RN [19]; RE0072535.
RX PUBMED: 18568018.
RA Varelas X., Sakuma R., Samavarchi-Tehrani P., Peerani R., Rao B. M., Dembowy J., Yaffe M. B., Zandstra P. W., Wrana J. L.
RT TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.
RL Nat. Cell Biol. 10:837-848 (2008).
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