AC T09998
XX
ID T09998
XX
DT 01.11.2005 (created); jma.
DT 09.03.2016 (updated); sup.
CO Copyright (C), QIAGEN.
XX
FA c-Myc
XX
SY c-Myc; MYC; v-myc myelocytomatosis viral oncogene homolog (avian).
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G000221 MYC; HGNC: MYC.
XX
CL C0012; bHLH-ZIP; 1.2.6.5.1.
XX
IN T09303 BAF47-isoformA; human, Homo sapiens.
IN T05499 BAF47; human, Homo sapiens.
IN T05451 BRG1; human, Homo sapiens.
IN T02211 BTEB2; human, Homo sapiens.
IN T18378 CBP; human, Homo sapiens.
IN T27165 Fbl11; human, Homo sapiens.
IN T27167 GATAD2B; human, Homo sapiens.
IN T04110 HDAC3; human, Homo sapiens.
IN T05056 Max; human, Homo sapiens.
IN T34277 mcm7; human, Homo sapiens.
IN T03477 MM-1; human, Homo sapiens.
IN T05299 NR1B1; human, Homo sapiens.
IN T05875 p160MBP; human, Homo sapiens.
IN T21984 p300; human, Homo sapiens.
IN T10683 Smad2; human, Homo sapiens.
IN T10378 Smad3; human, Homo sapiens.
XX
MX M01145 V$CMYC_01.
MX M01154 V$CMYC_02.
MX M07601 V$CMYC_Q3.
MX M03867 V$CMYC_Q6_01.
MX M01034 V$EBOX_Q6_01.
MX M00118 V$MYCMAX_01.
MX M00123 V$MYCMAX_02.
MX M00615 V$MYCMAX_03.
MX M00322 V$MYCMAX_B.
MX M04743 V$MYC_02.
MX M04784 V$MYC_03.
MX M00799 V$MYC_Q2.
XX
BS R39509.
BS R37902.
BS R71711.
BS R57934.
BS R66017.
BS R66018.
BS R27278.
BS R63755.
BS R30847.
BS R35549.
BS R40590.
BS R40591.
BS R60143.
BS R67481.
BS R67477.
BS R72891.
BS R70915.
BS R70919.
BS R70920.
BS R24522.
BS R71574.
BS R34311.
BS R67045.
BS R67949.
BS R67950.
BS R67951.
BS R64152.
BS R30843.
BS R63075.
BS R63076.
BS R56244.
BS R63608.
BS R69017.
BS R57885.
BS R63757.
BS R68115.
BS R68125.
BS R68126.
BS R68129.
BS R68130.
BS R68127.
BS R66123.
BS R68117.
BS R68118.
BS R68121.
BS R64699.
BS R68131.
BS R68132.
BS R65697.
BS R65698.
BS R25403.
BS R36881.
BS R36883.
BS R65664.
BS R30845.
BS R30846.
BS R70541.
BS R58062.
BS R67622.
BS R67624.
BS R66101.
BS R66103.
BS R66105.
BS R42453.
BS R42454.
BS R58064.
BS R61351.
BS R68021.
BS R35591.
BS R67038.
BS R67046.
BS R67047.
BS R67048.
BS R67049.
BS R67050.
BS R67051.
BS R67054.
BS R67055.
BS R67056.
BS R67057.
BS R67058.
BS R67059.
BS R67060.
BS R67062.
BS R67044.
BS R09484.
BS R22264.
BS R22295.
BS R25203.
BS R25723.
BS R58193.
BS R61572.
BS R71717.
BS R66144.
BS R66593.
BS R66595.
BS R66596.
BS R30305.
BS R55835.
BS R41718.
BS R41719.
BS R41720.
BS R41722.
BS R41728.
BS R41726.
BS R41727.
BS R41723.
BS R41724.
XX
DR TRANSPATH: MO000056483.
DR TRANSCOMPEL: C00617.
DR UniProtKB: P01106;
XX
RN [1]; RE0026903.
RX PUBMED: 9652748.
RA Fiddes R. J., Janes P. W., Sivertsen S. P., Sutherland R. L., Musgrove E. A., Daly R. J.
RT Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells.
RL Oncogene 16:2803-13 (1998).
RN [2]; RE0030480.
RX PUBMED: 14611815.
RA Xiao X., Athanasiou M., Sidorov I. A., Horikawa I., Cremona G., Blair D., Barret J. C., Dimitrov D. S.
RT Role of Ets/Id proteins for telomerase regulation in human cancer cells.
RL Exp. Mol. Pathol. 75:238-47 (2003).
RN [3]; RE0030944.
RX PUBMED: 14747478.
RA Golan T., Yaniv A., Bafico A., Liu G., Gazit A.
RT The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade.
RL J. Biol. Chem. 279:14879-88 (2004).
RN [4]; RE0032617.
RX PUBMED: 14975242.
RA Wang L. H., Yang X. Y., Zhang X., Huang J., Hou J., Li J., Xiong H., Mihalic K., Zhu H., Xiao W., Farrar W. L.
RT Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells.
RL Immunity 20:205-18 (2004).
RN [5]; RE0035556.
RX PUBMED: 16126174.
RA Zhang K., Faiola F., Martinez E.
RT Six lysine residues on c-Myc are direct substrates for acetylation by p300.
RL Biochem. Biophys. Res. Commun. 336:274-280 (2005).
RN [6]; RE0035810.
RX PUBMED: 9155018.
RA Fukunaga R., Hunter T.
RT MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates.
RL EMBO J. 16:1921-1933 (1997).
RN [7]; RE0038632.
RX PUBMED: 11585818.
RA Satou A., Taira T., Iguchi-Ariga S. M., Ariga H.
RT A novel transrepression pathway of c-Myc. Recruitment of a transcriptional corepressor complex to c-Myc by MM-1, a c-Myc-binding protein
RL J. Biol. Chem. 276:46562-7 (2001).
RN [8]; RE0046069.
RX PUBMED: 10319872.
RA Cheng S. W., Davies K. P., Yung E., Beltran R. J., Yu J., Kalpana G. V.
RT c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function
RL Nat. Genet. 22:102-5 (1999).
RN [9]; RE0046437.
RX PUBMED: 12769843.
RA Kim S. Y., Herbst A., Tworkowski K. A., Salghetti S. E., Tansey W. P.
RT Skp2 regulates Myc protein stability and activity
RL Mol. Cell 11:1177-88 (2003).
RN [10]; RE0047547.
RX PUBMED: 11146623.
RA Mazumdar A., Wang R. A., Mishra S. K., Adam L., Bagheri-Yarmand R., Mandal M., Vadlamudi R. K., Kumar R.
RT Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor.
RL Nat. Cell Biol. 3:30-37 (2001).
RN [11]; RE0047829.
RX PUBMED: 16287840.
RA Faiola F., Liu X., Lo S., Pan S., Zhang K., Lymar E., Farina A., Martinez E.
RT Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription.
RL Mol. Cell. Biol. 25:10220-10234 (2005).
RN [12]; RE0048220.
RX PUBMED: 12776737.
RA Vervoorts J., Luscher-Firzlaff J. M., Rottmann S., Lilischkis R., Walsemann G., Dohmann K., Austen M., Luscher B.
RT Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP.
RL EMBO Rep. 4:484-490 (2003).
RN [13]; RE0048510.
RX PUBMED: 15674325.
RA Yu M., Schreek S., Cerni C., Schamberger C., Lesniewicz K., Poreba E., Vervoorts J., Walsemann G., Grotzinger J., Kremmer E., Mehraein Y., Mertsching J., Kraft R., Austen M., Luscher-Firzlaff J., Luscher B.
RT PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation.
RL Oncogene 24:1982-1993 (2005).
RN [14]; RE0055780.
RX PUBMED: 18322230.
RA Pazdrak K., Young T. W., Stafford S., Olszewska-Pazdrak B., Straub C., Starosta V., Brasier A., Kurosky A.
RT Cross-talk between ICAM-1 and granulocyte-macrophage colony-stimulating factor receptor signaling modulates eosinophil survival and activation.
RL J. Immunol. 180:4182-4190 (2008).
RN [15]; RE0066060.
RX PUBMED: 18275842.
RA Aragaki M., Tsuchiya K., Okamoto R., Yoshioka S., Nakamura T., Sakamoto N., Kanai T., Watanabe M.
RT Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer.
RL Biochem. Biophys. Res. Commun. 368:923-929 (2008).
RN [16]; RE0068708.
RX PUBMED: 20307497.
RA Kim E. A., Kim J. E., Sung K. S., Choi D. W., Lee B. J., Choi C. Y.
RT Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation.
RL Biochem. Biophys. Res. Commun. 394:966-971 (2010).
RN [17]; RE0068798.
RX PUBMED: 16269333.
RA Adhikary S., Marinoni F., Hock A., Hulleman E., Popov N., Beier R., Bernard S., Quarto M., Capra M., Goettig S., Kogel U., Scheffner M., Helin K., Eilers M.
RT The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation.
RL Cell 123:409-421 (2005).
RN [18]; RE0069431.
RX PUBMED: 18488021.
RA Zhao X., Heng J. I., Guardavaccaro D., Jiang R., Pagano M., Guillemot F., Iavarone A., Lasorella A.
RT The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.
RL Nat. Cell Biol. 10:643-653 (2008).
RN [19]; RE0070446.
RX PUBMED: 18692468.
RA Budanov A. V., Karin M.
RT p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.
RL Cell 134:451-460 (2008).
XX
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