
AC   T02211
XX
ID   T02211
XX
DT   15.10.1997 (created); ewi.
DT   23.06.2016 (updated); sup.
CO   Copyright (C), QIAGEN.
XX
FA   BTEB2
XX
SY   basic transcription element binding protein 2; BTEB-2; KLF5.
XX
OS   human, Homo sapiens
OC   eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE   G003991 KLF5; HGNC: KLF5.
XX
CL   C0001; CH; 2.3.1.2.5.
XX
CP   placenta, testis [1]; smooth muscle cells [2] [2] [1].
XX
FF   activator [1];
FF   gene is induced by PMA, bFGF, MAPK pathway [2];
XX
IN   T09998 c-Myc; human, Homo sapiens.
IN   T00671 p53; human, Homo sapiens.
IN   T10683 Smad2; human, Homo sapiens.
IN   T09538 Smad3; Mammalia.
IN   T04292 Smad4; human, Homo sapiens.
XX
MX   M03814 V$BTEB2_Q3.
MX   M07277 V$BTEB2_Q3_01.
MX   M07409 V$KLF5_01.
MX   M07461 V$KLF_Q3.
XX
BS   R12217.
BS   R27100.
BS   R57741.
BS   R63615.
BS   R63617.
BS   R63618.
BS   R63614.
BS   R63613.
BS   R29685.
BS   R29687.
BS   R59274.
BS   R59278.
BS   R59281.
BS   R73725.
BS   R73726.
BS   R73739.
BS   R73719.
BS   R73720.
BS   R73721.
BS   R73722.
BS   R60048.
BS   R70414.
BS   R70415.
BS   R70416.
BS   R70417.
XX
DR   TRANSPATH: MO000026229.
DR   UniProtKB: Q13887;
XX
RN   [1]; RE0005869.
RX   PUBMED: 8479902.
RA   Sogawa K., Imataka H., Yamasaki Y., Kusume H., Abe H., Fujii-Kuriyama Y.
RT   cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2
RL   Nucleic Acids Res. 21:1527-1532 (1993).
RN   [2]; RE0023688.
RX   PUBMED: 10532946.
RA   Kawai-Kowase K., Kurabayashi M., Hoshino Y., Ohyama Y., Nagai R.
RT   Transcriptional activation of the zinc finger transcription factor BTEB2 gene by Egr-1 through mitogen-activated protein kinase pathways in vascular smooth muscle cells.
RL   Circ. Res. 85:787-795 (1999).
RN   [3]; RE0055994.
RX   PUBMED: 16595680.
RA   Zhu N., Gu L., Findley H. W., Chen C., Dong J. T., Yang L., Zhou M.
RT   KLF5 Interacts with p53 in regulating survivin expression in acute lymphoblastic leukemia.
RL   J. Biol. Chem. 281:14711-14718 (2006).
RN   [4]; RE0064516.
RX   PUBMED: 19411256.
RA   Liu R., Zheng H. Q., Zhou Z., Dong J. T., Chen C.
RT   KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization.
RL   J. Biol. Chem. 284:16791-16798 (2009).
XX
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