AC T00330
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ID T00330
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DT 15.10.1992 (created); ewi.
DT 10.09.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA GLI
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SY GLI; GLI 1; GLI family zinc finger 1; GLI1; glioma-associated oncogene homolog (zinc finger protein); glioma-associated oncogene homolog 1 (zinc finger protein).
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003929 GLI1; HGNC: GLI1.
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HO Ci (Drosophila).
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CL C0001; CH; 2.3.3.1.1.
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SF Two distinct regions of Su(fu) are required for interactions with GLI: N-terminal end and C-terminal end [10];
SF 5 zinc finger motifs;
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CP outer root sheath of hair follicle, mesenchymal cells in the burge region [6].
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FF Gli-1 intracellular localization regulated by nucleocytoplasmic shuttling by Su(fu) protein [11];
FF gene amplified in glioblastomas;
FF positive feedback loop between GLI and GLI2 T04961 that potentiates the Shh signal in hair follicle morphogenesis and BCC (basal cell carcinoma) formation [8];
FF there was no effect of CPB T01318 on GLI-induced transactivation in contrast to GLI3 T00331 [7];
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IN T25624 p/CAF; human, Homo sapiens.
IN T10683 Smad2; human, Homo sapiens.
IN T04292 Smad4; human, Homo sapiens.
IN T04669 Zic1; mouse, Mus musculus.
IN T04670 zic2; mouse, Mus musculus.
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MX M01702 V$GLI1_01.
MX M01042 V$GLI1_Q2.
MX M07290 V$GLI1_Q3.
MX M07454 V$GLI1_Q3_01.
MX M01037 V$GLI_Q2.
MX M07292 V$GLI_Q3.
MX M03871 V$GLI_Q6.
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BS R01930.
BS R16165.
BS R62443.
BS R62445.
BS R67402.
BS R63740.
BS R63741.
BS R41648.
BS R61880.
BS R60787.
BS R32213.
BS R32212.
BS R63828.
BS R69682.
BS R41651.
BS R16629.
BS R16630.
BS R35070.
BS R69556.
BS R69557.
BS R69558.
BS R69559.
BS R71294.
BS R71297.
BS R41653.
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DR TRANSPATH: MO000019117.
DR UniProtKB: P08151; GLI1_HUMAN.
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RN [1]; RE0001420.
RX PUBMED: 2105456.
RA Kinzler K. W., Vogelstein B.
RT The GLI Gene Encodes a Nuclear Protein Which Binds Specific Sequences in the Human Genome
RL Mol. Cell. Biol. 10:634-642 (1990).
RN [2]; RE0001643.
RX PUBMED: 2850480.
RA Ruppert J. M., Kinzler K. W., Wong A. J., Bigner S. H., Kao F.-T., Law M. L., Seuanez H. N., O'Brien S. J., Vogelstein B.
RT The GLI-Kruppel family of human genes
RL Mol. Cell. Biol. 8:3104-3113 (1988).
RN [3]; RE0001888.
RX PUBMED: 2832761.
RA Kinzler K. W., Ruppert J. M., Bigner S. H., Vogelstein B.
RT The GLI gene is a member of the Kruppel family of zinc finger proteins
RL Nature 332:371-374 (1988).
RN [4]; RE0006865.
RX PUBMED: 9613201.
RA Giles R. H., Peters D. J. M., Breuning M. H.
RT Conjunction dysfunction: CBP/p300 in human disease
RL Trends Genet. 14:178-183 (1998).
RN [5]; RE0021572.
RX PUBMED: 10579908.
RA Murone M., Rosenthal A., de Sauvage F. J.
RT Hedgehog signal transduction: from flies to vertebrates
RL Exp. Cell Res. 253:25-33 (1999).
RN [6]; RE0025303.
RX PUBMED: 14555646.
RA Bigelow R. L., Chari N. S., Unden A. B., Spurgers K. B., Lee S., Roop D. R., Toftgard R., McDonnell T. J.
RT Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1.
RL J. Biol. Chem. 279:1197-1205 (2004).
RN [7]; RE0025306.
RX PUBMED: 10075717.
RA Dai P., Akimaru H., Tanaka Y., Maekawa T., Nakafuku M., Ishii S.
RT Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3.
RL J. Biol. Chem. 274:8143-8152 (1999).
RN [8]; RE0025315.
RX PUBMED: 15175043.
RA Ikram M. S., Neill G. W., Regl G., Eichberger T., Frischauf A. M., Aberger F., Quinn A., Philpott M.
RT GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter.
RL J. Invest. Dermatol 122:1503-1509 (2004).
RN [9]; RE0035105.
RX PUBMED: 12426310.
RA Dunaeva M., Michelson P., Kogerman P., Toftgard R.
RT Characterization of the physical interaction of Gli proteins with SUFU proteins.
RL J. Biol. Chem. 278:5116-5122 (2003).
RN [10]; RE0035118.
RX PUBMED: 15367681.
RA Merchant M., Vajdos F. F., Ultsch M., Maun H. R., Wendt U., Cannon J., Desmarais W., Lazarus R. A., de Vos A. M., de Sauvage F. J.
RT Suppressor of fused regulates Gli activity through a dual binding mechanism.
RL Mol. Cell. Biol. 24:8627-8641 (2004).
RN [11]; RE0035372.
RX PUBMED: 10559945.
RA Kogerman P., Grimm T., Kogerman L., Krause D., Unden A. B., Sandstedt B., Toftgard R., Zaphiropoulos P. G.
RT Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1.
RL Nat. Cell Biol. 1:312-319 (1999).
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