AC T04961
XX
ID T04961
XX
DT 28.11.2001 (created); rge.
DT 18.10.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA Gli2-alpha
XX
SY GLI 2; tax helper protein; THP.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G006129 GLI2; HGNC: GLI2.
XX
CL C0001; CH; 2.3.3.1.2.1.
XX
SZ 1258 AA; 133.3 kDa (calc.).
XX
SQ MALTSINATPTQLSSSSNCLSDTNQNKQSSESAVSSTVNPVAIHKRSKVKTEPEGLRPAS
SQ PLALTQGQVLDTAHVGVPFPSPQEQLADLKEDLDRDDCKQEAEVVIYETNCHWEDCTKEY
SQ DTQEQLVHHINNEHIHGEKKEFVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTFE
SQ GCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKI
SQ PGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRNDVHLRTPLLKENGDSEAGTEPGGPEST
SQ EASSTSQAVEDCLHVRAIKTESSGLCQSSPGAQSSCSSEPSPLGSAPNNDSGVEMPGTGP
SQ GSLGDLTALDDTPPGADTSALAAPSAGGLQLRKHMTTMHRFEQLKKEKLKSLKDSCSWAG
SQ PTPHTRNTKLPPLPGSGSILENFSGSGGGGPAGLLPNPRLSELSASEVTMLSQLQERRDS
SQ STSTVSSAYTVSRRSSGISPYFSSRRSSEASPLGAGRPHNASSADSYDPISTDASRRSSE
SQ ASQCSGGSGLLNLTPAQQYSLRAKYAAATGGPPPTPLPGLERMSLRTRLALLDAAEGTLP
SQ AGCPRPLGPRRGSDGPTYGHGHAGAAPAFPHEAPGGGTRRASDPVRRPDALSLPRVQRFH
SQ STHNVNPGPLPPCADRRGLRLQSHPSTDGGLARGAYSPRPPSISENVAMEAVAAGVDGAG
SQ PEADLGLPEDDLVLPDDVVQYIKAHASGALDEGTGQVYPTESTGFSDNPRLPSPGLHGQR
SQ RMVAADSNVGPSAPMLGGCQLGFGAPSSLNKNNMPVQWNEVSSGTVDSLASQVKPPPFPQ
SQ GNLAVVQQKPAFGQYPGYSPQGLQASPGGLDSTQPHLQPRSGAPSQGIPRVNYMQQLRQP
SQ VAGSQCPGMTTTMSPHACYGQVHPQLSPSTISGALNQFPQSCSNMPAKPGHLGHPQQTEV
SQ APDPTTMGNRHRELGVPNSALAGVPPPHPVQSYPQQSHHLAASMSQEGYHQVPSLLPARQ
SQ PGFMEPQTGPMGVATAGFGLVQPRPPLEPSPTGRHRGVRAVQQQLAYARATGHAMAAMPS
SQ SQETAEAVPKGAMGNMGSVPPQPPPQDAGGAPDHSMLYYYGQIHMYEQDGGLENLGSCQV
SQ MRSQPPQPQACQDSIQPQPLPSPGVNQVSSTVDSQLLEAPQIDFDAIMDDGDHSSLFSGA
SQ LSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMSSMLTSLAEESKFLNMMT
XX
SC translated from EMBL #AB007295
XX
FT 91 1207 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 109 134 
PF00096; zf-C2H2.
FT 109 134 
SM00355; c2h2final6.
FT 142 169 
SM00355; c2h2final6.
FT 147 174 
PS50157; ZINC_FINGER_C2H2_2.
FT 175 199 
PF00096; zf-C2H2.
FT 175 199 
SM00355; c2h2final6.
FT 175 204 
PS50157; ZINC_FINGER_C2H2_2.
FT 205 230 
PF00096; zf-C2H2.
FT 205 230 
SM00355; c2h2final6.
FT 205 235 PS50157; ZINC_FINGER_C2H2_2.
FT 236 261 PF00096; zf-C2H2.
FT 236 261 SM00355; c2h2final6.
FT 236 266 PS50157; ZINC_FINGER_C2H2_2.
XX
CP plasmacytoma, basal cell carcinoma, outer root sheath cells of hair follicles [4] [5]; basal cell carcinoma tumor islands, sebaceous glands, interfollicular epidermis [5] [4] [5]; alpha isoform of hGli2 is expressed almost exclusively in the nucleus [2].
XX
FF The zinc finger DNA binding domain of Gli2 and GLI binding site bs3 R16160 is required for Gli2- specific activation of the BCL2 promoter [4];
FF positive feedback loop between GLI1 T00330 and Gli2-alphaalpha that potentiates the Shh signal in hair follicle morphogenesis and BCC (basal cell carcinoma) formation [5];
XX
IN T06538 c-Ski; human, Homo sapiens.
XX
MX M01703 V$GLI2_01.
MX M07455 V$GLI2_Q3.
MX M07291 V$GLI2_Q6.
MX M01037 V$GLI_Q2.
MX M07292 V$GLI_Q3.
XX
BS R16157.
BS R16165.
BS R16158.
BS R16159.
BS R16160.
BS R16191.
BS R17205.
XX
DR TRANSPATH: MO000028733.
DR EMBL: AB007295;
DR EMBL: D14827;
DR EMBL: D14828;
DR EMBL: M20672;
DR EMBL: M20673;
DR UniProtKB: P10070-1;
XX
RN [1]; RE0001643.
RX PUBMED: 2850480.
RA Ruppert J. M., Kinzler K. W., Wong A. J., Bigner S. H., Kao F.-T., Law M. L., Seuanez H. N., O'Brien S. J., Vogelstein B.
RT The GLI-Kruppel family of human genes
RL Mol. Cell. Biol. 8:3104-3113 (1988).
RN [2]; RE0017331.
RX PUBMED: 9557682.
RA Tanimura A., Dan S., Yoshida M.
RT Cloning of novel isoforms of the human Gli2 oncogene and their activities to enhance tax-dependent transcription of the human T-cell leukemia virus type 1 genome
RL J. Virol. 72:3958-3964 (1998).
RN [3]; RE0017332.
RX PUBMED: 8350401.
RA Tanimura A., Teshima H., Fujisawa J., Yoshida M.
RT A new regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1 and cloning of cDNAs encoding its binding proteins
RL J. Virol. 67:5375-5382 (1993).
RN [4]; RE0025258.
RX PUBMED: 15520176.
RA Regl G., Kasper M., Schnidar H., Eichberger T., Neill G. W., Philpott M. P., Esterbauer H., Hauser-Kronberger C., Frischauf A. M., Aberger F.
RT Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2.
RL Cancer Res. 64:7724-7731 (2004).
RN [5]; RE0025315.
RX PUBMED: 15175043.
RA Ikram M. S., Neill G. W., Regl G., Eichberger T., Frischauf A. M., Aberger F., Quinn A., Philpott M.
RT GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter.
RL J. Invest. Dermatol 122:1503-1509 (2004).
XX
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