AC T04669
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ID T04669
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DT 22.08.2001 (created); rio.
DT 06.06.2008 (updated); tgo.
CO Copyright (C), QIAGEN.
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FA Zic1
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SY zinc finger protein of the cerebellum 1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002593 Zic1.
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HO Opa (Drosophila) T04672.
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CL C0001; CH; 2.3.3.1.7.
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SF 91-97% amino acid homology in the zinc finger domain between Zic1, Zic2 T04670 and Zic3 T04671 [1];
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CP adult: very high in cerebellar internal granule cell layer (IGL) and their putative precursor cells, cerebellar external germinal layer, high in cerebellum, low in olfactory bulb, diencephalon, brainstem, medial habenula nucleus, thalamus, pontine nuclei, E9: neural tube, E15: anterior portion of the diencephalon, external germinal layer in the cerebellar anlage, dorsal midline of spinal cord [3]; E10,5: extending from roof plate to dorsal third of neural tube [4] [3] [4].
CN Purkinje cell, molecular layer [3].
EX cerebellum,,,adult; high; Northern blot; total RNA; [1].
EX cerebral cortex,,,adult; none; Northern blot; total RNA; [1].
EX granular layer of cerebellar cortex,granule cell,,adult; high; Northern blot; total RNA; [1].
EX granular layer of cerebellar cortex,granule cell,,adult; high; RNAse protection assay; total RNA; [1].
EX heart,,,adult; none; Northern blot; total RNA; [1].
EX hippocampus,,,adult; none; Northern blot; total RNA; [1].
EX kidney (right and left),,,adult; none; Northern blot; total RNA; [1].
EX liver,,,adult; none; Northern blot; total RNA; [1].
EX lung,,,adult; none; Northern blot; total RNA; [1].
EX mesencephalon,,,Theiler Stage 20; high; Northern blot; total RNA; [1].
EX mesencephalon,,,Theiler Stage 20; high; RNAse protection assay; total RNA; [1].
EX mesencephalon,,,Theiler Stage 22; high; Northern blot; total RNA; [1].
EX mesencephalon,,,Theiler Stage 22; high; RNAse protection assay; total RNA; [1].
EX mesencephalon,,,Theiler Stage 24; high; Northern blot; total RNA; [1].
EX mesencephalon,,,Theiler Stage 24; high; RNAse protection assay; total RNA; [1].
EX mesencephalon,,,Theiler Stage 26; high; Northern blot; total RNA; [1].
EX mesencephalon,,,Theiler Stage 26; high; RNAse protection assay; total RNA; [1].
EX mesencephalon,,,neonate (during the first month after birth); high; Northern blot; total RNA; [1].
EX mesencephalon,,,neonate (during the first month after birth); high; RNAse protection assay; total RNA; [1].
EX olfactory bulb,,,adult; none; Northern blot; total RNA; [1].
EX ovary,,,adult; none; Northern blot; total RNA; [1].
EX prosencephalon,,,Theiler Stage 20; high; Northern blot; total RNA; [1].
EX prosencephalon,,,Theiler Stage 20; high; RNAse protection assay; total RNA; [1].
EX prosencephalon,,,Theiler Stage 22; high; Northern blot; total RNA; [1].
EX prosencephalon,,,Theiler Stage 22; high; RNAse protection assay; total RNA; [1].
EX prosencephalon,,,Theiler Stage 24; high; Northern blot; total RNA; [1].
EX prosencephalon,,,Theiler Stage 24; high; RNAse protection assay; total RNA; [1].
EX prosencephalon,,,Theiler Stage 26; high; Northern blot; total RNA; [1].
EX prosencephalon,,,Theiler Stage 26; high; RNAse protection assay; total RNA; [1].
EX prosencephalon,,,neonate (during the first month after birth); high; Northern blot; total RNA; [1].
EX prosencephalon,,,neonate (during the first month after birth); high; RNAse protection assay; total RNA; [1].
EX rhombencephalon,,,Theiler Stage 20; high; Northern blot; total RNA; [1].
EX rhombencephalon,,,Theiler Stage 20; high; RNAse protection assay; total RNA; [1].
EX rhombencephalon,,,Theiler Stage 22; high; Northern blot; total RNA; [1].
EX rhombencephalon,,,Theiler Stage 22; high; RNAse protection assay; total RNA; [1].
EX rhombencephalon,,,Theiler Stage 24; high; Northern blot; total RNA; [1].
EX rhombencephalon,,,Theiler Stage 24; high; RNAse protection assay; total RNA; [1].
EX rhombencephalon,,,Theiler Stage 26; high; Northern blot; total RNA; [1].
EX rhombencephalon,,,Theiler Stage 26; high; RNAse protection assay; total RNA; [1].
EX rhombencephalon,,,neonate (during the first month after birth); high; Northern blot; total RNA; [1].
EX rhombencephalon,,,neonate (during the first month after birth); high; RNAse protection assay; total RNA; [1].
EX small intestine,,,adult; none; Northern blot; total RNA; [1].
EX spleen,,,adult; none; Northern blot; total RNA; [1].
EX testis (right and left),,,adult; none; Northern blot; total RNA; [1].
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FF may be involved in regional specification and cell lineage determination [1];
FF may act as transcriptional coactivator modulated by GLI family proteins [2];
FF Zic1 represses both the expression of endogenous Cath1 T04545 and the activity of a Math1 T01668 enhancer driven lacZ reporter when expressed in chick neural tubes [4];
FF Zic1 does not mediate global repression of neural differentiation, but instead is directed at distinct neuronal subtypes, in particular those descendant from Math1/Cath1- and Mash1/Cash1- expressing cells [4];
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IN T06386 Gli2; mouse, Mus musculus.
IN T00331 gli3; human, Homo sapiens.
IN T00330 GLI; human, Homo sapiens.
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MX M07292 V$GLI_Q3.
MX M00448 V$ZIC1_01.
MX M02835 V$ZIC1_04.
MX M02939 V$ZIC1_05.
MX M07344 V$ZIC1_Q2.
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BS R16215.
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DR TRANSPATH: MO000028492.
DR UniProtKB: P46684;
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RN [1]; RE0016751.
RX PUBMED: 8557628.
RA Aruga J., Nagai T., Tokuyama T., Hayashizaki Y., Okazaki Y., Chapman V. M., Mikoshiba K.
RT The mouse zic gene family. Homologues of the Drosophila pair-rule gene odd-paired
RL J. Biol. Chem. 271:1043-1047 (1996).
RN [2]; RE0016752.
RX PUBMED: 11053430.
RA Mizugishi K., Aruga J., Nakata K., Mikoshiba K.
RT Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins
RL J. Biol. Chem. 276:2180-2188 (2001).
RN [3]; RE0025319.
RX PUBMED: 7931345.
RA Aruga J., Yokota N., Hashimoto M., Furuichi T., Fukuda M., Mikoshiba K.
RT A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells.
RL J. Neurochem 63:1880-1890 (1994).
RN [4]; RE0035123.
RX PUBMED: 12642498.
RA Ebert P. J., Timmer J. R., Nakada Y., Helms A. W., Parab P. B., Liu Y., Hunsaker T. L., Johnson J. E.
RT Zic1 represses Math1 expression via interactions with the Math1 enhancer and modulation of Math1 autoregulation.
RL Development 130:1949-1959 (2003).
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