AC T00331
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ID T00331
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DT 10.11.1992 (created); ewi.
DT 31.10.2013 (updated); prb.
CO Copyright (C), QIAGEN.
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FA gli3
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SY GCPS; GLI 3; GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome); GLI3; PAP-A; PAPA; PAPA1; PAPB; PHS; PPDIV.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G009134 GLI3; HGNC: GLI3.
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CL C0001; CH; 2.3.3.1.3.
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SF 5 zinc finger motifs;
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FF interrupted by translocations causing Greig syndrome [1];
FF maps to 7p13 [1];
FF CBP T01318 potentiates gli3- induced transactivation [3];
FF activation and repression domains in gli3 [3];
FF in the presence of exogenous gli3, PKA suppressed Gli1 promoter activity, whereas Shh enhanced Gli1 promoter activity in a dose dependent manner in MNS-70 cells, the CBP-binding domain mediates the antagonistic actions of PKA and Shh [3];
FF gli3 is a mediator of Shh-dependent transcriptional activation of Gli1-promoter G013711 [3];
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IN T06538 c-Ski; human, Homo sapiens.
IN T01318 CBP; mouse, Mus musculus.
IN T04106 HDAC1; human, Homo sapiens.
IN T04669 Zic1; mouse, Mus musculus.
IN T04670 zic2; mouse, Mus musculus.
IN T04671 Zic3; mouse, Mus musculus.
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MX M01596 V$GLI3_01.
MX M01704 V$GLI3_02.
MX M08766 V$GLI3_03.
MX M01657 V$GLI3_Q5_01.
MX M01037 V$GLI_Q2.
MX M07292 V$GLI_Q3.
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BS R16165.
BS R16158.
BS R16159.
BS R16160.
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DR TRANSPATH: MO000019113.
DR UniProtKB: P10071; GLI3_HUMAN.
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RN [1]; RE0001891.
RX PUBMED: 1650914.
RA Vortkamp A., Gessler M., Grzeschik K.-H.
RT GLI3 zinc finger gene interrupted by translocations in Greig syndrome families
RL Nature 352:539-540 (1991).
RN [2]; RE0021572.
RX PUBMED: 10579908.
RA Murone M., Rosenthal A., de Sauvage F. J.
RT Hedgehog signal transduction: from flies to vertebrates
RL Exp. Cell Res. 253:25-33 (1999).
RN [3]; RE0025306.
RX PUBMED: 10075717.
RA Dai P., Akimaru H., Tanaka Y., Maekawa T., Nakafuku M., Ishii S.
RT Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3.
RL J. Biol. Chem. 274:8143-8152 (1999).
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