AC T01668
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ID T01668
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DT 14.02.1996 (created); ewi.
DT 17.03.2010 (updated); pos.
CO Copyright (C), QIAGEN.
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FA MATH1
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SY mammalian atonal homolog 1; mammalian atonal homolog 2; MATH-1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005797 Atoh1.
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HO Ato (Drosophila) T01628.
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CL C0010; bHLH; 1.2.3.4.8.
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SF bHLH domain is most closely related to that of MATH-2 (61%) and Ato (70%) [1] [2];
SF requires heterodimerization (E47) for DNA-binding [2];
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CP cranial ganglions (E9.5), dorsal part of CNS (E9.5, E10.5), external granular layer of cerebellum (E18), adult: epithelial cells of gastrointestinal tract [2]; E10,5: cells adjacent to the roof plate from dorsal neural tube [3] [5]; MATH1 appears to be expressed only in non-neural tissues in the adults, suggesting that MATH1 may have different functions in early embryos and adults [2]; neural tube [4] [2] [3] [4] [5].
CN adult nervous system, heart, kidney, lung, skeletal muscle, spleen [2].
EX alar plate of metencephalon,,,Theiler Stage 20; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX alar plate of myelencephalon,,,Theiler Stage 20; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX alimentary tract,,,Theiler Stage 26; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX alimentary tract,,,adult; detectable; Northern blot; total RNA; [2].
EX alimentary tract,epithelial cell,,adult; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX alimentary tract,neuroepithelial cell,,adult; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX brain,,,adult; none; Northern blot; total RNA; [2].
EX central nervous system,,,Theiler Stage 23; detectable; Northern blot; total RNA; [2].
EX cerebellum,,,Theiler Stage 26; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX cerebellum,,,adult; none; Northern blot; total RNA; [2].
EX cerebellum,granule cell,,Theiler Stage 20; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX external granular layer of cerebellar cortex,,,P11 (11 days after birth, postnatal development); detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX external granular layer of cerebellar cortex,,,P14 (14 days after birth, postnatal development); very low; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX external granular layer of cerebellar cortex,,,P28 (28 days after birth, postnatal development); none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX external granular layer of cerebellar cortex,,,P3 (3 day after birth, postnatal development); detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX future mesencephalon,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX future metencephalon,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX future metencephalon,,,Theiler Stage 17; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX future myelencephalon,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX heart,,,adult; none; Northern blot; total RNA; [2].
EX inferior olivery complex,,,Theiler Stage 20; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX internal granular layer of cerebellar cortex,granule cell,,P14 (14 days after birth, postnatal development); none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX internal granular layer of cerebellar cortex,granule cell,,P3 (3 day after birth, postnatal development); none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX kidney (right and left),,,adult; none; Northern blot; total RNA; [2].
EX lung,,,adult; none; Northern blot; total RNA; [2].
EX mesencephalon,,,Theiler Stage 17; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX mesencephalon,,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX mesencephalon,,,Theiler Stage 21; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX metencephalon,,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX metencephalon,,,Theiler Stage 21; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX mouse, Mus musculus,,,Theiler Stage 13; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX muscles,,,adult; none; Northern blot; total RNA; [2].
EX myelencephalon,,,Theiler Stage 17; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX myelencephalon,,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX myelencephalon,,,Theiler Stage 21; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX neural tube,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX neural tube,,,Theiler Stage 17; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [4].
EX neural tube,,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX pontine nuclei,,,Theiler Stage 20; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX prosencephalon,,,Theiler Stage 21; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX spinal cord,,,Theiler Stage 20; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX spinal cord,,,Theiler Stage 21; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX spinal cord,,,Theiler Stage 26; none; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX spleen,,,adult; none; Northern blot; total RNA; [2].
EX trigeminal ganglion [V],,,Theiler Stage 17; very low; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX trigeminal (V) neural crest tissue,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
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FF activator, activity repressed by HES-1 [2];
FF may be important for differentiation of subsets of neural cells [2];
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MX M07075 V$ATOH1_03.
MX M01716 V$MATH1_Q2.
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BS R16668.
BS R16669.
BS R16670.
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DR TRANSPATH: MO000025853.
DR UniProtKB: P48985;
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RN [1]; RE0003638.
RX PUBMED: 7744035.
RA Shimizu C., Akazawa C., Nakanishi S., Kageyama R.
RT MATH-2, a mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal, is specifically expressed in the nervous system
RL Eur. J. Biochem. 229:239-248 (1995).
RN [2]; RE0003803.
RX PUBMED: 7721778.
RA Akazawa C., Ishibashi M., Shimizu C., Nakanishi S., Kageyama R.
RT A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system
RL J. Biol. Chem. 270:8730-8738 (1995).
RN [3]; RE0035123.
RX PUBMED: 12642498.
RA Ebert P. J., Timmer J. R., Nakada Y., Helms A. W., Parab P. B., Liu Y., Hunsaker T. L., Johnson J. E.
RT Zic1 represses Math1 expression via interactions with the Math1 enhancer and modulation of Math1 autoregulation.
RL Development 130:1949-1959 (2003).
RN [4]; RE0035127.
RX PUBMED: 11502254.
RA Gowan K., Helms A. W., Hunsaker T. L., Collisson T., Ebert P. J., Odom R., Johnson J. E.
RT Crossinhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal interneurons.
RL Neuron 31:219-232 (2001).
RN [5]; RE0035128.
RX PUBMED: 10683172.
RA Helms A. W., Abney A. L., Ben-Arie N., Zoghbi H. Y., Johnson J. E.
RT Autoregulation and multiple enhancers control Math1 expression in the developing nervous system.
RL Development 127:1185-1196 (2000).
RN [6]; RE0066056.
RX PUBMED: 18652815.
RA Kirjavainen A., Sulg M., Heyd F., Alitalo K., Yla-Herttuala S., Moroy T., Petrova T. V., Pirvola U.
RT Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia.
RL Dev. Biol. 322:33-45 (2008).
RN [7]; RE0066070.
RX PUBMED: 19243219.
RA Bossuyt W., Kazanjian A., De Geest N., Van Kelst S., De Hertogh G., Geboes K., Boivin G. P., Luciani J., Fuks F., Chuah M., VandenDriessche T., Marynen P., Cools J., Shroyer N. F., Hassan B. A.
RT Atonal homolog 1 is a tumor suppressor gene.
RL PLoS Biol. 7:e39 (2009).
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