AC T14323
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ID T14323
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DT 10.03.2005 (created); nvo.
DT 27.08.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA Skp2
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SY FBL1; FBXL1; FLB1; MGC1366; p45; S-phase kinase-associated protein 2 (p45); SKP2.
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OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
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IN T14435 c-Myc; Mammalia.
IN T09570 E2F-1; Mammalia.
IN T14067 FOXO1A; Mammalia.
IN T08197 FOXO3a; human, Homo sapiens.
IN T34291 NBS1; human, Homo sapiens.
IN T34674 prohibitin-2; human, Homo sapiens.
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DR TRANSPATH: MO000047754.
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RN [1]; RE0030166.
RX PUBMED: 12481031.
RA Dias D. C., Dolios G., Wang R., Pan Z. Q.
RT CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex.
RL Proc. Natl. Acad. Sci. USA 99:16601-6 (2002).
RN [2]; RE0031225.
RX PUBMED: 11250155.
RA Mamillapalli R., Gavrilova N., Mihaylova V. T., Tsvetkov L. M., Wu H., Zhang H., Sun H.
RT PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2).
RL Curr. Biol. 11:263-7 (2001).
RN [3]; RE0031350.
RX PUBMED: 12717421.
RA Bhattacharya S., Garriga J., Calbo J., Yong T., Haines D. S., Grana X.
RT SKP2 associates with p130 and accelerates p130 ubiquitylation and degradation in human cells.
RL Oncogene 22:2443-51 (2003).
RN [4]; RE0033456.
RX PUBMED: 12435635.
RA Tedesco D., Lukas J., Reed S. I.
RT The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2).
RL Genes Dev. 16:2946-57 (2002).
RN [5]; RE0034390.
RX PUBMED: 15014502.
RA Bashir T., Dorrello N. V., Amador V., Guardavaccaro D., Pagano M.
RT Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase.
RL Nature 428:190-3 (2004).
RN [6]; RE0037440.
RX PUBMED: 10559858.
RA Marti A., Wirbelauer C., Scheffner M., Krek W.
RT Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation
RL Nat. Cell Biol. 1:14-9 (1999).
RN [7]; RE0037791.
RX PUBMED: 11585732.
RA Kudo Y., Kitajima S., Sato S., Miyauchi M., Ogawa I., Takata T.
RT High expression of S-phase kinase-interacting protein 2, human F-box protein, correlates with poor prognosis in oral squamous cell carcinomas
RL Cancer Res. 61:7044-7 (2001).
RN [8]; RE0039814.
RX PUBMED: 11689688.
RA Kiernan R. E., Emiliani S., Nakayama K., Castro A., Labbe J. C., Lorca T., Nakayama Ki K., Benkirane M.
RT Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome
RL Mol. Cell. Biol. 21:7956-70 (2001).
RN [9]; RE0043707.
RX PUBMED: 15314162.
RA Liang M., Liang Y. Y., Wrighton K., Ungermannova D., Wang X. P., Brunicardi F. C., Liu X., Feng X. H., Lin X.
RT Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2
RL Mol. Cell. Biol. 24:7524-37 (2004).
RN [10]; RE0046200.
RX PUBMED: 15342634.
RA Tokarz S., Berset C., La Rue J., Friedman K., Nakayama K., Nakayama K., Zhang D. E., Lanker S.
RT The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase
RL J. Biol. Chem. 279:46424-30 (2004).
RN [11]; RE0046430.
RX PUBMED: 14648698.
RA Lu Y., Zi X., Pollak M.
RT Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells
RL Int. J. Cancer 108:334-41 (2004).
RN [12]; RE0046431.
RX PUBMED: 15138278.
RA Knowles L. M., Axelrod F., Browne C. D., Smith J. W.
RT A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2
RL J. Biol. Chem. 279:30540-5 (2004).
RN [13]; RE0046432.
RX PUBMED: 15096506.
RA Mammoto A., Huang S., Moore K., Oh P., Ingber D. E.
RT Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition
RL J. Biol. Chem. 279:26323-30 (2004).
RN [14]; RE0046433.
RX PUBMED: 12840033.
RA Li X., Zhao Q., Liao R., Sun P., Wu X.
RT The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation
RL J. Biol. Chem. 278:30854-8 (2003).
RN [15]; RE0046437.
RX PUBMED: 12769843.
RA Kim S. Y., Herbst A., Tworkowski K. A., Salghetti S. E., Tansey W. P.
RT Skp2 regulates Myc protein stability and activity
RL Mol. Cell 11:1177-88 (2003).
RN [16]; RE0048309.
RX PUBMED: 15668399.
RA Huang H., Regan K. M., Wang F., Wang D., Smith D. I., van Deursen J. M., Tindall D. J.
RT Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.
RL Proc. Natl. Acad. Sci. USA 102:1649-1654 (2005).
RN [17]; RE0051098.
RX PUBMED: 16537899.
RA Bondar T., Kalinina A., Khair L., Kopanja D., Nag A., Bagchi S., Raychaudhuri P.
RT Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome.
RL Mol. Cell. Biol. 26:2531-2539 (2006).
RN [18]; RE0051102.
RX PUBMED: 16951159.
RA Hiramatsu Y., Kitagawa K., Suzuki T., Uchida C., Hattori T., Kikuchi H., Oda T., Hatakeyama S., Nakayama K. I., Yamamoto T., Konno H., Kitagawa M.
RT Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination.
RL Cancer Res. 66:8477-8483 (2006).
RN [19]; RE0052632.
RX PUBMED: 12642582.
RA Liu J. J., Hou S. C., Shen C. K.
RT Erythroid gene suppression by NF-kappa B.
RL J. Biol. Chem. 278:19534-19540 (2003).
RN [20]; RE0052864.
RX PUBMED: 17785450.
RA Umanskaya K., Radke S., Chander H., Monardo R., Xu X., Pan Z. Q., O'Connell M. J., Germain D.
RT Skp2B stimulates mammary gland development by inhibiting REA, the repressor of the estrogen receptor.
RL Mol. Cell. Biol. 27:7615-7622 (2007).
RN [21]; RE0064497.
RX PUBMED: 18243116.
RA Kitagawa M., Lee S. H., McCormick F.
RT Skp2 suppresses p53-dependent apoptosis by inhibiting p300.
RL Mol. Cell 29:217-231 (2008).
RN [22]; RE0065105.
RX PUBMED: 19270694.
RA Lin H. K., Wang G., Chen Z., Teruya-Feldstein J., Liu Y., Chan C. H., Yang W. L., Erdjument-Bromage H., Nakayama K. I., Nimer S., Tempst P., Pandolfi P. P.
RT Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB.
RL Nat. Cell Biol. 11:420-432 (2009).
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