AC T34291
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ID T34291
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DT 23.05.2006 (created); ran.
DT 03.02.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA NBS1
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SY AT-V1; AT-V2; ATV; Cell cycle regulatory protein p95; FLJ10155; MGC87362; NBN; NBS; NBS1; NIBRIN; Nijmegen breakage syndrome protein 1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G032212 NBN; HGNC: NBN.
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SZ 754 AA; 85.0 kDa (cDNA) (calc.).
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SQ MWKLLPAAGPAGGEPYRLLTGVEYVVGRKNCAILIENDQSISRNHAVLTANFSVTNLSQT
SQ DEIPVLTLKDNSKYGTFVNEEKMQNGFSRTLKSGDGITFGVFGSKFRIEYEPLVACSSCL
SQ DVSGKTALNQAILQLGGFTVNNWTEECTHLVMVSVKVTIKTICALICGRPIVKPEYFTEF
SQ LKAVESKKQPPQIESFYPPLDEPSIGSKNVDLSGRQERKQIFKGKTFIFLNAKQHKKLSS
SQ AVVFGGGEARLITEENEEEHNFFLAPGTCVVDTGITNSQTLIPDCQKKWIQSIMDMLQRQ
SQ GLRPIPEAEIGLAVIFMTTKNYCDPQGHPSTGLKTTTPGPSLSQGVSVDEKLMPSAPVNT
SQ TTYVADTESEQADTWDLSERPKEIKVSKMEQKFRMLSQDAPTVKESCKTSSNNNSMVSNT
SQ LAKMRIPNYQLSPTKLPSINKSKDRASQQQQTNSIRNYFQPSTKKRERDEENQEMSSCKS
SQ ARIETSCSLLEQTQPATPSLWKNKEQHLSENEPVDTNSDNNLFTDTDLKSIVKNSASKSH
SQ AAEKLRSNKKREMDDVAIEDEVLEQLFKDTKPELEIDVKVQKQEEDVNVRKRPRMDIETN
SQ DTFSDEAVPESSKISQENEIGKKRELKEDSLWSAKEISNNDKLQDDSEMLPKKLLLTEFR
SQ SLVIKNSTSRNPSGINDDYGQLKNFKKFKKVTYPGAGKLPHIIGGSDLIAHHARKNTELE
SQ EWLRQEMEVQNQHAKEESLADDLFRYNPYLKRRR
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SC translated from EMBL:AF051334
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IN T14323 Skp2; Mammalia.
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DR TRANSPATH: MO000081818.
DR EMBL: AF051334; AF051334.
DR UniProtKB: O60934;
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RN [1]; RE0027548.
RX PUBMED: 10608806.
RA Kim S. T., Lim D. S., Canman C. E., Kastan M. B.
RT Substrate specificities and identification of putative substrates of ATM kinase family members.
RL J. Biol. Chem. 274:37538-43 (1999).
RN [2]; RE0041985.
RX PUBMED: 15026416.
RA Cheng W. H., von Kobbe C., Opresko P. L., Arthur L. M., Komatsu K., Seidman M. M., Carney J. P., Bohr V. A.
RT Linkage between Werner syndrome protein and the Mre11 complex via Nbs1
RL J. Biol. Chem. 279:21169-76 (2004).
RN [3]; RE0047767.
RX PUBMED: 15734743.
RA Alt J. R., Bouska A., Fernandez M. R., Cerny R. L., Xiao H., Eischen C. M.
RT Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair.
RL J. Biol. Chem. 280:18771-18781 (2005).
RN [4]; RE0064397.
RX PUBMED: 17715134.
RA Lee A. Y., Liu E., Wu X.
RT The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells.
RL J. Biol. Chem. 282:32243-32255 (2007).
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