AC T08439
XX
ID T08439
XX
DT 19.01.2006 (created); rad.
DT 22.12.2014 (updated); spk.
CO Copyright (C), QIAGEN.
XX
FA TIF2
XX
SY glucocorticoid receptor interacting protein 1; GRIP1; NCoA-2; NCOA2; nuclear receptor coactivator 2; SRC-2; TIF2; transcriptional intermediary factor 2.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G005150 Ncoa2.
XX
CL C0010; bHLH.
XX
SZ 1462 AA; 158.5 kDa (cDNA) (calc.).
XX
SQ MSGMGENTSDPSRAETRKRKECPDQLGPSPKRSTEKRNREQENKYIEELADLIFANFNDI
SQ DNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMML
SQ EALDGFFFVVNLEGSVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSM
SQ VNGGSWSGEPPRRTSHTFNCRMLVKPLPDSEEEGHDSQEAHQKYEAMQCFAVSQPKSIKE
SQ EGEDLQSCLICVARRVPMKERPTLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLV
SQ RRCIQKFHTQHEGESLSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQT
SQ TNEPQLVISLHMLHREQNVCVMNPDLTGQAMGKPLNPISSSSPAHQALCSGNPGQDMTLG
SQ SNINFPMNGPKEQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPG
SQ QASSVLSPRQRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNALQAL
SQ SEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQA
SQ EASCHPEEQKGPNDSSMPQAASGDRAEGHSRLHDSKGQTKLLQLLTTKSDQMEPSPLPSS
SQ LSDTNKDSTGSLPGPGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKELSQESS
SQ STAPGSEVTVKQEPASPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTK
SQ LIAMKTVKEEVSFEPSDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPTGSVDKQAII
SQ NDLMQLTADSSPVPPAGAQKAALRMSQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAG
SQ PFPPIRNSSPYSVIPQPGMMGNQGMLGSQGNLGNNSTGMIGSSTSRPSMPSGEWAPQSPA
SQ VRVTCAATTGAMNRPVQGGMIRNPTASIPMRANSQPGQRQMLQSQVMNIGPSELEMNMGG
SQ PQYNQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALL
SQ DQLYLALRNFDGLEEIDRALGIPELVSQSQAVDAEQFSSQESSIMLEQKPPVFPQQYASQ
SQ AQMAQGGYNPMQDPNFHTMGQRPNYTTLRMQPRPGLRPTGIVQNQPNQLRLQLQHRLQAQ
SQ QNRQPLMNQISSVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMQQQVQQRT
SQ LMMRGQGLNVTPSMVAPAGLPAAMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQ
SQ SPLMSPRMAHTQSPMMQQSQANPAYQPTSDMNGWAQGSMGGNSMFSQQSPPHFGQQANTS
SQ MYSNNMNISVSMATNTGGLSSMNQMTCQMSMTSVTSVPTSGLPSMGPEQVNDPALRGGNL
SQ FPNQLPGMDMIKQEGDASRKYC
XX
SC translated from EMBL #U39060
XX
FT 16 84 
PS50888; HLH.
FT 32 89 
SM00353; finulus.
FT 56 1441 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 114 181 
SM00091; pas_2.
FT 119 183 
PS50112; PAS.
FT 1279 1336 
PF07469; Domain of unknown function (DUF1518).
XX
IN T10341 (VDR-isoform1)2; human, Homo sapiens.
IN T05076 GR; human, Homo sapiens.
IN T00372 HNF-4alpha1; rat, Rattus norvegicus.
IN T02422 HNF-4alpha2; rat, Rattus norvegicus.
IN T01427 p300; human, Homo sapiens.
IN T02745 PPARdelta; human, Homo sapiens.
IN T17618 RXR-alpha:VDR-isoform1; human, Homo sapiens.
IN T24830 Smad2; Mammalia.
IN T08501 T3R-alpha; chick, Gallus gallus.
IN T01692 T3R-beta1; chick, Gallus gallus.
IN T01693 T3R-beta2; chick, Gallus gallus.
IN T08264 T3R-beta; human, Homo sapiens.
IN T08482 VDR-isoform1; human, Homo sapiens.
IN T00885 VDR; human, Homo sapiens.
IN T09401 VDR; mouse, Mus musculus.
XX
DR TRANSPATH: MO000057807.
DR EMBL: U39060;
DR UniProtKB: Q61026; NCOA2_MOUSE.
XX
RN [1]; RE0031544.
RX PUBMED: 11250942.
RA Issa L. L., Leong G. M., Barry J. B., Sutherland R. L., Eisman J. A.
RT Glucocorticoid receptor-interacting protein-1 and receptor-associated coactivator-3 differentially interact with the vitamin D receptor (VDR) and regulate VDR-retinoid X receptor transcriptional cross-talk.
RL Endocrinology 142:1606-15 (2001).
RN [2]; RE0033105.
RX PUBMED: 15001550.
RA Lim H. J., Moon I., Han K.
RT Transcriptional cofactors exhibit differential preference toward peroxisome proliferator-activated receptors alpha and delta in uterine cells.
RL Endocrinology 145:2886-95 (2004).
RN [3]; RE0047657.
RX PUBMED: 11435616.
RA Yang Z., Privalsky M. L.
RT Isoform-specific transcriptional regulation by thyroid hormone receptors: hormone-independent activation operates through a steroid receptor mode of co-activator interaction.
RL Mol. Endocrinol. 15:1170-1185 (2001).
RN [4]; RE0047715.
RX PUBMED: 11266503.
RA Zilliacus J., Holter E., Wakui H., Tazawa H., Treuter E., Gustafsson J. A.
RT Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140.
RL Mol. Endocrinol. 15:501-511 (2001).
RN [5]; RE0048210.
RX PUBMED: 15988012.
RA Chen Y. H., Kim J. H., Stallcup M. R.
RT GAC63, a GRIP1-dependent nuclear receptor coactivator.
RL Mol. Cell. Biol. 25:5965-5972 (2005).
RN [6]; RE0048215.
RX PUBMED: 12351636.
RA Teyssier C., Chen D., Stallcup M. R.
RT Requirement for multiple domains of the protein arginine methyltransferase CARM1 in its transcriptional coactivator function.
RL J. Biol. Chem. 277:46066-46072 (2002).
RN [7]; RE0048277.
RX PUBMED: 15731352.
RA Lee Y. H., Coonrod S. A., Kraus W. L., Jelinek M. A., Stallcup M. R.
RT Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination.
RL Proc. Natl. Acad. Sci. USA 102:3611-3616 (2005).
RN [8]; RE0048886.
RX PUBMED: 11117528.
RA Webb P., Anderson C. M., Valentine C., Nguyen P., Marimuthu A., West B. L., Baxter J. D., Kushner P. J.
RT The nuclear receptor corepressor (N-CoR) contains three isoleucine motifs (I/LXXII) that serve as receptor interaction domains (IDs).
RL Mol. Endocrinol. 14:1976-1985 (2000).
RN [9]; RE0049300.
RX PUBMED: 16461774.
RA Lee D. Y., Northrop J. P., Kuo M. H., Stallcup M. R.
RT Histone H3 lysine 9 methyltransferase G9a is a transcriptional coactivator for nuclear receptors.
RL J. Biol. Chem. 281:8476-8485 (2006).
RN [10]; RE0051638.
RX PUBMED: 10490591.
RA Sladek F. M., Ruse MD J. r., Nepomuceno L., Huang S. M., Stallcup M. R.
RT Modulation of transcriptional activation and coactivator interaction by a splicing variation in the F domain of nuclear receptor hepatocyte nuclear factor 4alpha1.
RL Mol. Cell. Biol. 19:6509-6522 (1999).
RN [11]; RE0051855.
RX PUBMED: 10809746.
RA Chen S., Cui J., Nakamura K., Ribeiro R. C., West B. L., Gardner D. G.
RT Coactivator-vitamin D receptor interactions mediate inhibition of the atrial natriuretic peptide promoter.
RL J. Biol. Chem. 275:15039-15048 (2000).
RN [12]; RE0051975.
RX PUBMED: 11075811.
RA Liu Y. Y., Nguyen C., Peleg S.
RT Regulation of ligand-induced heterodimerization and coactivator interaction by the activation function-2 domain of the vitamin D receptor.
RL Mol. Endocrinol. 14:1776-1787 (2000).
RN [13]; RE0051983.
RX PUBMED: 12529369.
RA Barry J. B., Leong G. M., Church W. B., Issa L. L., Eisman J. A., Gardiner E. M.
RT Interactions of SKIP/NCoA-62, TFIIB, and retinoid X receptor with vitamin D receptor helix H10 residues.
RL J. Biol. Chem. 278:8224-8228 (2003).
RN [14]; RE0054280.
RX PUBMED: 17336575.
RA Chang Y. L., Huang C. J., Chan J. Y., Liu P. Y., Chang H. P., Huang S. M.
RT Regulation of nuclear receptor and coactivator functions by the carboxyl terminus of ubiquitin-conjugating enzyme 9.
RL Int. J. Biochem. Cell Biol. 39:1035-1046 (2007).
XX
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