TRANSFAC-Logo

TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T02422 XX ID T02422 XX DT 28.04.1998 (created); ewi. DT 14.02.2014 (updated); jmh. CO Copyright (C), QIAGEN. XX FA HNF-4alpha2 XX SY Hepatocyte Nuclear Factor 1alpha, isoform 2; hepatocyte nuclear factor 4alpha2; HNF4alpha2; NR2A1. XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G004820 Hnf4a. XX CL C0002; CC (rec). XX SZ 465 AA; 51.7 kDa (cDNA) (calc.), 54 kDa (SDS) XX SQ MDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGANLNSSNSLGVSALCAICGDRATG SQ KHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEA SQ VQNERDRISTRRSSYEDSSLPSINALLQAEVLSQQITSPISGINGDIRAKKIANITDVCE SQ SMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDY SQ IVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPGKIK SQ RLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL SQ LQEMLLGGSASDAPHAHHPLHPHLMQEHMGTNVIVANTMPSHLSNGQMCEWPRPRGQAAT SQ PETPQPSPPSGSGSESYKLLPGAITTIVKPPSAIPQPTITKQEAI XX SC translated from EMBL:D10554 XX FT 48 119 SM00399; c4gold. FT 48 123 PS51030; NUCLEAR_REC_DBD_2. FT 49 124 PF00105; Zinc finger, C4 type (two domains). FT 117 377 PF00478; IMP dehydrogenase / GMP reductase domai. FT 180 339 SM00430; holi. FT 183 364 PF00104; Ligand-binding domain of nuclear hormon. XX CP liver, kidney, intestine. XX FF transcriptional activator; FF may be antagonized by ARP-1 and/or COUP-TF [4]; XX IN T08439 TIF2; mouse, Mus musculus. XX MX M00158 V$COUP_01. MX M00762 V$DR1_Q3. MX M00638 V$HNF4ALPHA_Q6. MX M07321 V$HNF4A_Q3. MX M00764 V$HNF4DR1_Q3. MX M00134 V$HNF4_01. MX M00411 V$HNF4_01_B. MX M00967 V$HNF4_Q6. MX M01031 V$HNF4_Q6_01. MX M01032 V$HNF4_Q6_02. MX M01033 V$HNF4_Q6_03. MX M03828 V$HNF4_Q6_04. XX BS R04591. BS R02179. BS R00114. BS R16063. BS R60270. BS R02657. BS R73922. BS R01457. BS R04770. BS R03034. BS R03035. BS R03881. BS R01183. BS R01186. XX DR TRANSPATH: MO000026408. DR TRANSCOMPEL: C00370. DR EMBL: D10554; DR UniProtKB: P22449; XX RN [1]; RE0000786. RX PUBMED: 1748280. RA Tian J.-M., Schibler U. RT Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4 RL Genes Dev. 5:2225-2234 (1991). RN [2]; RE0001457. RX PUBMED: 2325638. RA Paulson K. E., Darnell J. E., Rushmore T., Pickett C. B. RT Analysis of the upstream elements of the xenobiotic compound-inducible and positionally regulated glutathione S-transferase Ya gene RL Mol. Cell. Biol. 10:1841-1852 (1990). RN [3]; RE0001476. RX PUBMED: 2786140. RA Costa R. H., Grayson D. R., Darnell J. E. RT Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha1-antitrypsin genes RL Mol. Cell. Biol. 9:1415-1425 (1989). RN [4]; RE0003072. RX PUBMED: 1312668. RA Mietus-Snyder M., Sladek F. M., Ginsburg G. S., Kuo C. F., Ladias J. A. A., Darnell jr J. E., Karathanasis S. K. RT Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells RL Mol. Cell. Biol. 12:1708-1718 (1992). RN [5]; RE0006829. RX PUBMED: 1610903. RA Hata S., Tsukamoto T., Osumi T. RT A novel isoform of rat hepatocyte nuclear factor 4 (HNF-4) RL Biochim. Biophys. Acta 1131:211-213 (1992). RN [6]; RE0037964. RX PUBMED: 9795230. RA Masuda N., Yasumo H., Furusawa T., Tsukamoto T., Sadano H., Osumi T. RT Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors RL Gene 221:225-33 (1998). RN [7]; RE0051638. RX PUBMED: 10490591. RA Sladek F. M., Ruse MD J. r., Nepomuceno L., Huang S. M., Stallcup M. R. RT Modulation of transcriptional activation and coactivator interaction by a splicing variation in the F domain of nuclear receptor hepatocyte nuclear factor 4alpha1. RL Mol. Cell. Biol. 19:6509-6522 (1999). XX //