AC T02422
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ID T02422
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DT 28.04.1998 (created); ewi.
DT 14.02.2014 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA HNF-4alpha2
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SY Hepatocyte Nuclear Factor 1alpha, isoform 2; hepatocyte nuclear factor 4alpha2; HNF4alpha2; NR2A1.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004820 Hnf4a.
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CL C0002; CC (rec).
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SZ 465 AA; 51.7 kDa (cDNA) (calc.), 54 kDa (SDS)
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SQ MDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGANLNSSNSLGVSALCAICGDRATG
SQ KHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEA
SQ VQNERDRISTRRSSYEDSSLPSINALLQAEVLSQQITSPISGINGDIRAKKIANITDVCE
SQ SMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDY
SQ IVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPGKIK
SQ RLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL
SQ LQEMLLGGSASDAPHAHHPLHPHLMQEHMGTNVIVANTMPSHLSNGQMCEWPRPRGQAAT
SQ PETPQPSPPSGSGSESYKLLPGAITTIVKPPSAIPQPTITKQEAI
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SC translated from EMBL:D10554
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FT 48 119 
SM00399; c4gold.
FT 48 123 
PS51030; NUCLEAR_REC_DBD_2.
FT 49 124 
PF00105; Zinc finger, C4 type (two domains).
FT 117 377 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 180 339 
SM00430; holi.
FT 183 364 
PF00104; Ligand-binding domain of nuclear hormon.
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CP liver, kidney, intestine.
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FF transcriptional activator;
FF may be antagonized by ARP-1 and/or COUP-TF [4];
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IN T08439 TIF2; mouse, Mus musculus.
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MX M00158 V$COUP_01.
MX M00762 V$DR1_Q3.
MX M00638 V$HNF4ALPHA_Q6.
MX M07321 V$HNF4A_Q3.
MX M00764 V$HNF4DR1_Q3.
MX M00134 V$HNF4_01.
MX M00411 V$HNF4_01_B.
MX M00967 V$HNF4_Q6.
MX M01031 V$HNF4_Q6_01.
MX M01032 V$HNF4_Q6_02.
MX M01033 V$HNF4_Q6_03.
MX M03828 V$HNF4_Q6_04.
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BS R04591.
BS R02179.
BS R00114.
BS R16063.
BS R60270.
BS R02657.
BS R73922.
BS R01457.
BS R04770.
BS R03034.
BS R03035.
BS R03881.
BS R01183.
BS R01186.
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DR TRANSPATH: MO000026408.
DR TRANSCOMPEL: C00370.
DR EMBL: D10554;
DR UniProtKB: P22449;
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RN [1]; RE0000786.
RX PUBMED: 1748280.
RA Tian J.-M., Schibler U.
RT Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4
RL Genes Dev. 5:2225-2234 (1991).
RN [2]; RE0001457.
RX PUBMED: 2325638.
RA Paulson K. E., Darnell J. E., Rushmore T., Pickett C. B.
RT Analysis of the upstream elements of the xenobiotic compound-inducible and positionally regulated glutathione S-transferase Ya gene
RL Mol. Cell. Biol. 10:1841-1852 (1990).
RN [3]; RE0001476.
RX PUBMED: 2786140.
RA Costa R. H., Grayson D. R., Darnell J. E.
RT Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha1-antitrypsin genes
RL Mol. Cell. Biol. 9:1415-1425 (1989).
RN [4]; RE0003072.
RX PUBMED: 1312668.
RA Mietus-Snyder M., Sladek F. M., Ginsburg G. S., Kuo C. F., Ladias J. A. A., Darnell jr J. E., Karathanasis S. K.
RT Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells
RL Mol. Cell. Biol. 12:1708-1718 (1992).
RN [5]; RE0006829.
RX PUBMED: 1610903.
RA Hata S., Tsukamoto T., Osumi T.
RT A novel isoform of rat hepatocyte nuclear factor 4 (HNF-4)
RL Biochim. Biophys. Acta 1131:211-213 (1992).
RN [6]; RE0037964.
RX PUBMED: 9795230.
RA Masuda N., Yasumo H., Furusawa T., Tsukamoto T., Sadano H., Osumi T.
RT Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors
RL Gene 221:225-33 (1998).
RN [7]; RE0051638.
RX PUBMED: 10490591.
RA Sladek F. M., Ruse MD J. r., Nepomuceno L., Huang S. M., Stallcup M. R.
RT Modulation of transcriptional activation and coactivator interaction by a splicing variation in the F domain of nuclear receptor hepatocyte nuclear factor 4alpha1.
RL Mol. Cell. Biol. 19:6509-6522 (1999).
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