AC T02745
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ID T02745
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DT 03.06.1999 (created); mpr.
DT 01.08.2014 (updated); pos.
CO Copyright (C), QIAGEN.
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FA PPARdelta
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SY FAAR; NR1C2; NUC1; NUCI; NUCII; peroxisome proliferator-activated receptor beta; PPAR-delta; PPARb/d; PPARbeta; PPARdelta.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G001639 PPARD; HGNC: PPARD.
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CL C0002; CC (rec); 2.1.2.5.2.
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SF closely related to the mouse PPARdelta (overall homology 62%) [2];
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CP heart, kidney, lung.
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FF ligands: fatty acids, non-thiazolidinedione xenobiotics [3];
FF ligand binding results in conformational alterations and binding to coactivator CBP [3];
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IN T02214 CBP-isoform1; human, Homo sapiens.
IN T19612 DRIP205; mouse, Mus musculus.
IN T04922 Prox-1; human, Homo sapiens.
IN T01345 RXR-alpha; human, Homo sapiens.
IN T01334 RXR-beta; human, Homo sapiens.
IN T02738 SHP; human, Homo sapiens.
IN T04632 SRC-1; human, Homo sapiens.
IN T08439 TIF2; mouse, Mus musculus.
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MX M00763 V$PPARDR1_Q2.
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BS R73519.
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DR TRANSPATH: MO000026720.
DR UniProtKB: Q03181;
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RN [1]; RE0013625.
RX PUBMED: 10219237.
RA Nuclear Receptors Nomenclature Committee.
RT A unified nomenclature system for the nuclear receptor superfamily
RL Cell 97:161-163 (1999).
RN [2]; RE0013632.
RX PUBMED: 1333051.
RA Schmidt A., Endo N., Rutledge S. J., Vogel R., Shinar D., Rodan G. A.
RT Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids
RL Mol. Endocrinol. 6:1634-1641 (1992).
RN [3]; RE0018257.
RX PUBMED: 10037770.
RA Berger J., Leibowitz M. D., Doebber T. W., Elbrecht A., Zhang B., Zhou G., Biswas C., Cullinan C. A., Hayes N. S., Li Y., Tanen M., Ventre J., Wu M. S., Berger G. D., Mosley R., Marquis R., Santini C., Sahoo S. P., Tolman R. L., Smith R. G., Moller D. E.
RT Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects.
RL J. Biol. Chem. 274:6718-6725 (1999).
RN [4]; RE0018281.
RX PUBMED: 8041794.
RA Kliewer S. A., Forman B. M., Blumberg B., Ong E. S., Borgmeyer U., Mangelsdorf D. J., Umesono K., Evans R. M.
RT Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.
RL Proc. Natl. Acad. Sci. USA 91:7355-7359 (1994).
RN [5]; RE0018282.
RX PUBMED: 12022867.
RA Leesnitzer L. M., Parks D. J., Bledsoe R. K., Cobb J. E., Collins J. L., Consler T. G., Davis R. G., Hull-Ryde E. A., Lenhard J. M., Patel L., Plunket K. D., Shenk J. L., Stimmel J. B., Therapontos C., Willson T. M., Blanchard S. G.
RT Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662.
RL Biochemistry 41:6640-6650 (2002).
RN [6]; RE0033105.
RX PUBMED: 15001550.
RA Lim H. J., Moon I., Han K.
RT Transcriptional cofactors exhibit differential preference toward peroxisome proliferator-activated receptors alpha and delta in uterine cells.
RL Endocrinology 145:2886-95 (2004).
RN [7]; RE0038430.
RX PUBMED: 12955147.
RA Fu J., Gaetani S., Oveisi F., Lo Verme J., Serrano A., Rodriguez de Fonseca F., Rosengarth A., Luecke H., Di Giacomo B., Tarzia G., Piomelli D.
RT Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha
RL Nature 425:90-3 (2003).
RN [8]; RE0047782.
RX PUBMED: 12444922.
RA Babb R., Bowen B. R.
RT SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain.
RL Biochem. J. 370:719-727 (2003).
RN [9]; RE0047832.
RX PUBMED: 15615782.
RA Patel H., Truant R., Rachubinski R. A., Capone J. P.
RT Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350.
RL J. Cell Sci. 118:175-186 (2005).
RN [10]; RE0049914.
RX PUBMED: 11923221.
RA Heim M., Johnson J., Boess F., Bendik I., Weber P., Hunziker W., Fluhmann B.
RT Phytanic acid, a natural peroxisome proliferator-activated receptor (PPAR) agonist, regulates glucose metabolism in rat primary hepatocytes.
RL FASEB J. 16:718-720 (2002).
RN [11]; RE0050013.
RX PUBMED: 16288226.
RA Zuo X., Wu Y., Morris J. S., Stimmel J. B., Leesnitzer L. M., Fischer S. M., Lippman S. M., Shureiqi I.
RT Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity.
RL Oncogene 25:1225-1241 (2006).
RN [12]; RE0050025.
RX PUBMED: 10198642.
RA Xu H. E., Lambert M. H., Montana V. G., Parks D. J., Blanchard S. G., Brown P. J., Sternbach D. D., Lehmann J. M., Wisely G. B., Willson T. M., Kliewer S. A., Milburn M. V.
RT Molecular recognition of fatty acids by peroxisome proliferator-activated receptors.
RL Mol. Cell 3:397-403 (1999).
RN [13]; RE0050070.
RX PUBMED: 7592593.
RA Yu K., Bayona W., Kallen C. B., Harding H. P., Ravera C. P., McMahon G., Brown M., Lazar M. A.
RT Differential activation of peroxisome proliferator-activated receptors by eicosanoids.
RL J. Biol. Chem. 270:23975-23983 (1995).
RN [14]; RE0050208.
RX PUBMED: 15701701.
RA Schopfer F. J., Lin Y., Baker P. R., Cui T., Garcia-Barrio M., Zhang J., Chen K., Chen Y. E., Freeman B. A.
RT Nitrolinoleic acid: an endogenous peroxisome proliferator-activated receptor gamma ligand.
RL Proc. Natl. Acad. Sci. USA 102:2340-2345 (2005).
RN [15]; RE0050293.
RX PUBMED: 9449199.
RA Johnson T. E., Holloway M. K., Vogel R., Rutledge S. J., Perkins J. J., Rodan G. A., Schmidt A.
RT Structural requirements and cell-type specificity for ligand activation of peroxisome proliferator-activated receptors.
RL J. Steroid Biochem. Mol. Biol. 63:1-8 (1997).
RN [16]; RE0050299.
RX PUBMED: 16227625.
RA Baker P. R., Lin Y., Schopfer F. J., Woodcock S. R., Groeger A. L., Batthyany C., Sweeney S., Long M. H., Iles K. E., Baker L. M., Branchaud B. P., Chen Y. E., Freeman B. A.
RT Fatty acid transduction of nitric oxide signaling: multiple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferator-activated receptor ligands.
RL J. Biol. Chem. 280:42464-42475 (2005).
RN [17]; RE0050363.
RX PUBMED: 16202384.
RA Goto T., Takahashi N., Kato S., Egawa K., Ebisu S., Moriyama T., Fushiki T., Kawada T.
RT Phytol directly activates peroxisome proliferator-activated receptor alpha (PPARalpha) and regulates gene expression involved in lipid metabolism in PPARalpha-expressing HepG2 hepatocytes.
RL Biochem. Biophys. Res. Commun. 337:440-445 (2005).
RN [18]; RE0050518.
RX PUBMED: 12419306.
RA Lee J. Y., Hwang D. H.
RT Docosahexaenoic acid suppresses the activity of peroxisome proliferator-activated receptors in a colon tumor cell line.
RL Biochem. Biophys. Res. Commun. 298:667-674 (2002).
RN [19]; RE0050744.
RX PUBMED: 17324937.
RA Genini D., Catapano C. V.
RT Block of nuclear receptor ubiquitination. A mechanism of ligand-dependent control of peroxisome proliferator-activated receptor delta activity.
RL J. Biol. Chem. 282:11776-11785 (2007).
RN [20]; RE0054989.
RX PUBMED: 15604093.
RA Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M.
RT Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
RL Mol. Cell. Proteomics 4:205-213 (2005).
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