AC T08146
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ID T08146
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DT 10.06.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA AP-2alpha
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SY activating enhancer binding protein 2 alpha; activator protein-2; AP-2 transcription factor; AP2TF; TFAP2; TFAP2A; transcription factor AP-2 alpha.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002615 TFAP2A; HGNC: TFAP2A.
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CL C0032; bHSH; 1.3.1.0.1.
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CP BL-13 and HT137 cells [1]; HeLa [7].
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FF SV40-transformation of cell lines W138 and MRC5 dramatically increases expression of this protein [6];
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IN T08146 AP-2alpha; human, Homo sapiens.
IN T04074 brca1; human, Homo sapiens.
IN T17240 DEK; rat, Rattus norvegicus.
IN T02368 HMGIY; human, Homo sapiens.
IN T01427 p300; human, Homo sapiens.
IN T08321 p53-isoform1; human, Homo sapiens.
IN T00671 p53; human, Homo sapiens.
IN T09500 p53; Mammalia.
IN T09155 pax-6; human, Homo sapiens.
IN T00759 Sp1; human, Homo sapiens.
IN T08326 Sp1; Mammalia.
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MX M00469 V$AP2ALPHA_01.
MX M01045 V$AP2ALPHA_02.
MX M01047 V$AP2ALPHA_03.
MX M07348 V$AP2ALPHA_Q4.
MX M01857 V$AP2ALPHA_Q6.
MX M00800 V$AP2_Q3.
MX M08867 V$AP2_Q4.
MX M00189 V$AP2_Q6.
MX M00915 V$AP2_Q6_01.
MX M04896 V$TFAP2A_09.
MX M07231 V$TFAP2A_10.
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BS R16482.
BS R20748.
BS R41764.
BS R60653.
BS R73252.
BS R73253.
BS R73254.
BS R73255.
BS R73256.
BS R29798.
BS R25629.
BS R25632.
BS R25633.
BS R25634.
BS R25635.
BS R55874.
BS R66093.
BS R27283.
BS R21382.
BS R40846.
BS R31519.
BS R31522.
BS R35627.
BS R36953.
BS R26337.
BS R26340.
BS R28270.
BS R28271.
BS R28272.
BS R38038.
BS R23016.
BS R57808.
BS R21214.
BS R21215.
BS R21216.
BS R21217.
BS R21220.
BS R21221.
BS R27595.
BS R17164.
BS R21565.
BS R65314.
BS R68199.
BS R68206.
BS R32712.
BS R21559.
BS R18670.
BS R65168.
BS R65169.
BS R65644.
BS R21581.
BS R56247.
BS R25356.
BS R64362.
BS R32435.
BS R29796.
BS R27597.
BS R31099.
BS R03674.
BS R27593.
BS R38328.
BS R69918.
BS R69921.
BS R69922.
BS R69923.
BS R73268.
BS R63531.
BS R30017.
BS R01034.
BS R33028.
BS R33029.
BS R33030.
BS R25412.
BS R25042.
BS R34361.
BS R57893.
BS R57897.
BS R34842.
BS R34846.
BS R64868.
BS R64869.
BS R27827.
BS R33805.
BS R61601.
BS R38553.
BS R33131.
BS R17162.
BS R21035.
BS R20728.
BS R20963.
BS R26283.
BS R27596.
BS R63060.
BS R26460.
BS R34829.
BS R34831.
BS R34833.
BS R34837.
BS R31073.
BS R21644.
BS R36345.
BS R36346.
BS R36347.
BS R36348.
BS R21704.
BS R34303.
BS R34304.
BS R58683.
BS R22105.
BS R23014.
BS R22241.
BS R21434.
BS R33179.
BS R20944.
BS R36195.
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DR TRANSPATH: MO000001275.
DR TRANSCOMPEL: C00588.
DR EMBL: M36711;
DR UniProtKB: P05549;
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RN [1]; RE0034231.
RX PUBMED: 12527206.
RA Marreiros A., Czolij R., Yardley G., Crossley M., Jackson P.
RT Identification of regulatory regions within the KAI1 promoter: a role for binding of AP1, AP2 and p53.
RL Gene 302:155-64 (2003).
RN [2]; RE0045540.
RX PUBMED: 12621057.
RA Del Valle J. M., Engel P., Martin M.
RT The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2)
RL J. Biol. Chem. 278:17430-7 (2003).
RN [3]; RE0046987.
RX PUBMED: 9169421.
RA Pirozzi G., McConnell S. J., Uveges A. J., Carter J. M., Sparks A. B., Kay B. K., Fowlkes D. M.
RT Identification of novel human WW domain-containing proteins by cloning of ligand targets
RL J. Biol. Chem. 272:14611-6 (1997).
RN [4]; RE0047974.
RX PUBMED: 14673159.
RA Sivak J. M., West-Mays J. A., Yee A., Williams T., Fini M. E.
RT Transcription Factors Pax6 and AP-2alpha Interact To Coordinate Corneal Epithelial Repair by Controlling Expression of Matrix Metalloproteinase Gelatinase B.
RL Mol. Cell. Biol. 24:245-257 (2004).
RN [5]; RE0048014.
RX PUBMED: 12226108.
RA McPherson L. A., Loktev A. V., Weigel R. J.
RT Tumor suppressor activity of AP2alpha mediated through a direct interaction with p53.
RL J. Biol. Chem. 277:45028-45033 (2002).
RN [6]; RE0049731.
RX PUBMED: 10190980.
RA Huang Y., Domann F. E.
RT Transcription factor AP-2 mRNA and DNA binding activity are constitutively expressed in SV40-immortalized but not normal human lung fibroblasts.
RL Arch. Biochem. Biophys. 364:241-246 (1999).
RN [7]; RE0050486.
RX PUBMED: 10860846.
RA Jiang J. G., DeFrances M. C., Machen J., Johnson C., Zarnegar R.
RT The repressive function of AP2 transcription factor on the hepatocyte growth factor gene promoter.
RL Biochem. Biophys. Res. Commun. 272:882-886 (2000).
RN [8]; RE0053460.
RX PUBMED: 16707431.
RA Paonessa F., Foti D., Costa V., Chiefari E., Brunetti G., Leone F., Luciano F., Wu F., Lee A. S., Gulletta E., Fusco A., Brunetti A.
RT Activator protein-2 overexpression accounts for increased insulin receptor expression in human breast cancer.
RL Cancer Res. 66:5085-5093 (2006).
RN [9]; RE0054310.
RX PUBMED: 16260418.
RA Mitchell D. C., Abdelrahim M., Weng J., Stafford L. J., Safe S., Bar-Eli M., Liu M.
RT Regulation of KiSS-1 metastasis suppressor gene expression in breast cancer cells by direct interaction of transcription factors activator protein-2alpha and specificity protein-1.
RL J. Biol. Chem. 281:51-58 (2006).
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