AC T18455
XX
ID T18455
XX
DT 10.03.2005 (created); nvo.
DT 07.10.2014 (updated); spk.
CO Copyright (C), QIAGEN.
XX
FA IkappaB-alpha
XX
SY I-kappa-B-alpha; IkappaB-alpha; IKBA; MAD-3; MAD3; NF-kappa-B inhibitor alpha; NFKBI; NFKBIA.
XX
OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
XX
IN T11261 c-Rel; Mammalia.
IN T17574 NF-kappaB1-p50; mouse, Mus musculus.
IN T17520 NF-kappaB1; Mammalia.
IN T00594 RelA-p65-isoform1; human, Homo sapiens.
IN T08711 RelA-p65; human, Homo sapiens.
IN T10397 RelA-p65; Mammalia.
IN T08326 Sp1; Mammalia.
XX
BS R32906.
XX
DR TRANSPATH: MO000046599.
XX
RN [1]; RE0004536.
RX PUBMED: 7925301.
RA Dobrzanski P., Ryseck R.-P., Bravo R.
RT Differential interactions of RelB-NF-kappaB complexes with IkappaBalpha determine pools of constitutive and inducible NF-kappaB activity
RL EMBO J. 13:4608-4616 (1994).
RN [2]; RE0018977.
RX PUBMED: 9409737.
RA Desterro J. M., Thomson J., Hay R. T.
RT Ubch9 conjugates SUMO but not ubiquitin
RL FEBS Lett. 417:297-300 (1997).
RN [3]; RE0020688.
RX PUBMED: 10962033.
RA Leonardi A., Chariot A., Claudio E., Cunningham K., Siebenlist U.
RT CIKS, a connection to Ikappa B kinase and stress-activated protein kinase
RL Proc. Natl. Acad. Sci. USA 97:10494-10499 (2000).
RN [4]; RE0021990.
RX PUBMED: 9520446.
RA Ling L., Cao Z., Goeddel D. V.
RT NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176
RL Proc. Natl. Acad. Sci. USA 95:3792-3797 (1998).
RN [5]; RE0026516.
RX PUBMED: 10770292.
RA Garcia G. E., Xia Y., Chen S., Wang Y., Ye R. D., Harrison J. K., Bacon K. B., Zerwes H. G., Feng L.
RT NF-kappaB-dependent fractalkine induction in rat aortic endothelial cells stimulated by IL-1beta, TNF-alpha, and LPS.
RL J. Leukoc. Biol. 67:577-84 (2000).
RN [6]; RE0026911.
RX PUBMED: 9759865.
RA Lindroos P. M., Rice A. B., Wang Y. Z., Bonner J. C.
RT Role of nuclear factor-kappa B and mitogen-activated protein kinase signaling pathways in IL-1 beta-mediated induction of alpha-PDGF receptor expression in rat pulmonary myofibroblasts.
RL J. Immunol. 161:3464-8 (1998).
RN [7]; RE0027113.
RX PUBMED: 10616907.
RA Kirillova I., Chaisson M., Fausto N.
RT Tumor necrosis factor induces DNA replication in hepatic cells through nuclear factor kappaB activation.
RL Cell Growth Differ. 10:819-28 (1999).
RN [8]; RE0027341.
RX PUBMED: 11145682.
RA Delgado M., Ganea D.
RT Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide Inhibit Expression of Fas Ligand in Activated T Lymphocytes by Regulating c-Myc, NF-kappaB, NF-AT, and Early Growth Factors 2/3.
RL J. Immunol. 166:1028-1040 (2001).
RN [9]; RE0028252.
RX PUBMED: 11319224.
RA Lee S. H., Hannink M.
RT The N-terminal nuclear export sequence of IkappaBalpha is required for RanGTP-dependent binding to CRM1.
RL J. Biol. Chem. 276:23599-606 (2001).
RN [10]; RE0028505.
RX PUBMED: 11342414.
RA Rezzonico R., Imbert V., Chicheportiche R., Dayer J. M.
RT Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB.
RL Blood 97:2932-40 (2001).
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RX PUBMED: 11514608.
RA Tsuji S., Okamoto M., Yamada K., Okamoto N., Goitsuka R., Arnold R., Kiefer F., Kitamura D.
RT B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1.
RL J. Exp. Med. 194:529-39 (2001).
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RX PUBMED: 11994270.
RA Fong A., Sun S. C.
RT Genetic Evidence for the Essential Role of beta -Transducin Repeat-containing Protein in the Inducible Processing of NF-kappa B2/p100.
RL J. Biol. Chem. 277:22111-4 (2002).
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RX PUBMED: 12482991.
RA Lang V., Janzen J., Fischer G. Z., Soneji Y., Beinke S., Salmeron A., Allen H., Hay R. T., Ben-Neriah Y., Ley S. C.
RT betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.
RL Mol. Cell. Biol. 23:402-13 (2003).
RN [14]; RE0031419.
RX PUBMED: 12972430.
RA Viatour P., Legrand-Poels S., van Lint C., Warnier M., Merville M. P., Gielen J., Piette J., Bours V., Chariot A.
RT Cytoplasmic IkappaBalpha increases NF-kappaB-independent transcription through binding to histone deacetylase (HDAC) 1 and HDAC3.
RL J. Biol. Chem. 278:46541-8 (2003).
RN [15]; RE0031875.
RX PUBMED: 9733827.
RA Devergne O., Cahir McFarland E. D., Mosialos G., Izumi K. M., Ware C. F., Kieff E.
RT Role of the TRAF binding site and NF-kappaB activation in Epstein-Barr virus latent membrane protein 1-induced cell gene expression.
RL J. Virol. 72:7900-8 (1998).
RN [16]; RE0032401.
RX PUBMED: 10092088.
RA Pioli C., Gatta L., Frasca D., Doria G.
RT Cytotoxic T lymphocyte antigen 4 (CTLA-4) inhibits CD28-induced IkappaBalpha degradation and RelA activation.
RL Eur. J. Immunol. 29:856-63 (1999).
RN [17]; RE0033227.
RX PUBMED: 12740336.
RA Ogasa M., Miyazaki Y., Hiraoka S., Kitamura S., Nagasawa Y., Kishida O., Miyazaki T., Kiyohara T., Shinomura Y., Matsuzawa Y.
RT Gastrin activates nuclear factor kappaB (NFkappaB) through a protein kinase C dependent pathway involving NFkappaB inducing kinase, inhibitor kappaB (IkappaB) kinase, and tumour necrosis factor receptor associated factor 6 (TRAF6) in MKN-28 cells transfected with gastrin receptor.
RL Gut 52:813-9 (2003).
RN [18]; RE0033324.
RX PUBMED: 14976190.
RA Catley M. C., Cambridge L. M., Nasuhara Y., Ito K., Chivers J. E., Beaton A., Holden N. S., Bergmann M. W., Barnes P. J., Newton R.
RT Inhibitors of protein kinase C (PKC) prevent activated transcription: role of events downstream of NF-kappaB DNA binding.
RL J. Biol. Chem. 279:18457-66 (2004).
RN [19]; RE0034001.
RX PUBMED: 10339475.
RA Weber K. S., Draude G., Erl W., de Martin R., Weber C.
RT Monocyte arrest and transmigration on inflamed endothelium in shear flow is inhibited by adenovirus-mediated gene transfer of IkappaB-alpha.
RL Blood 93:3685-93 (1999).
RN [20]; RE0036182.
RX PUBMED: 10329681.
RA Gonen H., Bercovich B., Orian A., Carrano A., Takizawa C., Yamanaka K., Pagano M., Iwai K., Ciechanover A.
RT Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha
RL J. Biol. Chem. 274:14823-30 (1999).
RN [21]; RE0036770.
RX PUBMED: 9388242.
RA Jin D. Y., Chae H. Z., Rhee S. G., Jeang K. T.
RT Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation
RL J. Biol. Chem. 272:30952-61 (1997).
RN [22]; RE0037803.
RX PUBMED: 9778048.
RA Lee S. J., Dimtchev A., Lavin M. F., Dritschilo A., Jung M.
RT A novel ionizing radiation-induced signaling pathway that activates the transcription factor NF-kappaB
RL Oncogene 17:1821-6 (1998).
RN [23]; RE0038489.
RX PUBMED: 12885753.
RA Longo C. R., Arvelo M. B., Patel V. I., Daniel S., Mahiou J., Grey S. T., Ferran C.
RT A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis
RL Circulation 108:1113-8 (2003).
RN [24]; RE0038902.
RX PUBMED: 12746218.
RA Lee A. K., Sung S. H., Kim Y. C., Kim S. G.
RT Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation
RL Br. J. Pharmacol. 139:11-20 (2003).
RN [25]; RE0039027.
RX PUBMED: 12640111.
RA Jeay S., Pianetti S., Kagan H. M., Sonenshein G. E.
RT Lysyl oxidase inhibits ras-mediated transformation by preventing activation of NF-kappa B
RL Mol. Cell. Biol. 23:2251-63 (2003).
RN [26]; RE0039911.
RX PUBMED: 15086555.
RA Schneider C., Strayhorn W. D., Brantley D. M., Nanney L. B., Yull F. E., Brash A. R.
RT Upregulation of 8-lipoxygenase in the dermatitis of IkappaB-alpha-deficient mice
RL J. Invest. Dermatol 122:691-8 (2004).
RN [27]; RE0040295.
RX PUBMED: 10969074.
RA Prigent M., Barlat I., Langen H., Dargemont C.
RT Ikappa Balpha and Ikappa Balpha /NF-kappa B Complexes Are Retained in the Cytoplasm through Interaction with a Novel Partner, RasGAP SH3-binding Protein 2
RL J. Biol. Chem. 275:36441-36449 (2000).
RN [28]; RE0041912.
RX PUBMED: 11571308.
RA Richter G., Hayden-Ledbetter M., Irgang M., Ledbetter J. A., Westermann J., Korner I., Daemen K., Clark E. A., Aicher A., Pezzutto A.
RT Tumor necrosis factor-alpha regulates the expression of inducible costimulator receptor ligand on CD34(+) progenitor cells during differentiation into antigen presenting cells
RL J. Biol. Chem. 276:45686-93 (2001).
RN [29]; RE0041976.
RX PUBMED: 10980195.
RA Delerive P., Gervois P., Fruchart J. C., Staels B.
RT Induction of ikappa balpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators
RL J. Biol. Chem. 275:36703-7 (2000).
RN [30]; RE0042228.
RX PUBMED: 12471041.
RA Tsai P. W., Shiah S. G., Lin M. T., Wu C. W., Kuo M. L.
RT Up-regulation of vascular endothelial growth factor C in breast cancer cells by heregulin-beta 1. A critical role of p38/nuclear factor-kappa B signaling pathway
RL J. Biol. Chem. 278:5750-9 (2003).
RN [31]; RE0042535.
RX PUBMED: 10318864.
RA Olsson C., Riesbeck K., Dohlsten M., Michaelsson E., Riebeck K.
RT CTLA-4 ligation suppresses CD28-induced NF-kappaB and AP-1 activity in mouse T cell blasts
RL J. Biol. Chem. 274:14400-5 (1999).
RN [32]; RE0042711.
RX PUBMED: 11694538.
RA Huber M. A., Denk A., Peter R. U., Weber L., Kraut N., Wirth T.
RT The IKK-2/Ikappa Balpha /NF-kappa B pathway plays a key role in the regulation of CCR3 and eotaxin-1 in fibroblasts. A critical link to dermatitis in Ikappa Balpha -deficient mice
RL J. Biol. Chem. 277:1268-75 (2002).
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RX PUBMED: 9456329.
RA Xu J., Zutter M. M., Santoro S. A., Clark R. A.
RT A three-dimensional collagen lattice activates NF-kappaB in human fibroblasts: role in integrin alpha2 gene expression and tissue remodeling
RL J. Cell Biol. 140:709-19 (1998).
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RX PUBMED: 12640121.
RA Guo G., Yan-Sanders Y., Lyn-Cook B. D., Wang T., Tamae D., Ogi J., Khaletskiy A., Li Z., Weydert C., Longmate J. A., Huang T. T., Spitz D. R., Oberley L. W., Li J. J.
RT Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responses
RL Mol. Cell. Biol. 23:2362-78 (2003).
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RX PUBMED: 9418849.
RA Miyamoto S., Seufzer B. J., Shumway S. D.
RT Novel IkappaB alpha proteolytic pathway in WEHI231 immature B cells
RL Mol. Cell. Biol. 18:19-29 (1998).
RN [36]; RE0042873.
RX PUBMED: 12486112.
RA Gupta S., Purcell N. H., Lin A., Sen S.
RT Activation of nuclear factor-kappaB is necessary for myotrophin-induced cardiac hypertrophy
RL J. Cell Biol. 159:1019-28 (2002).
RN [37]; RE0042947.
RX PUBMED: 12167702.
RA Kawai H., Nie L., Yuan Z. M.
RT Inactivation of NF-kappaB-dependent cell survival, a novel mechanism for the proapoptotic function of c-Abl
RL Mol. Cell. Biol. 22:6079-88 (2002).
RN [38]; RE0043715.
RX PUBMED: 15034071.
RA Henriksen P. A., Hitt M., Xing Z., Wang J., Haslett C., Riemersma R. A., Webb D. J., Kotelevtsev Y. V., Sallenave J. M.
RT Adenoviral gene delivery of elafin and secretory leukocyte protease inhibitor attenuates NF-kappa B-dependent inflammatory responses of human endothelial cells and macrophages to atherogenic stimuli
RL J. Immunol. 172:4535-44 (2004).
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RX PUBMED: 9632806.
RA Liu L., Kwak Y. T., Bex F., Garcia-Martinez L. F., Li X. H., Meek K., Lane W. S., Gaynor R. B.
RT DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties
RL Mol. Cell. Biol. 18:4221-34 (1998).
RN [40]; RE0044182.
RX PUBMED: 9514153.
RA Wissink S., van Heerde E. C., vand der Burg B., van der Saag P. T.
RT A dual mechanism mediates repression of NF-kappaB activity by glucocorticoids
RL Mol. Endocrinol. 12:355-63 (1998).
RN [41]; RE0044244.
RX PUBMED: 10364447.
RA Ichiyama T., Zhao H., Catania A., Furukawa S., Lipton J. M.
RT alpha-melanocyte-stimulating hormone inhibits NF-kappaB activation and IkappaBalpha degradation in human glioma cells and in experimental brain inflammation
RL Exp. Neurol. 157:359-65 (1999).
RN [42]; RE0044367.
RX PUBMED: 10597252.
RA Haridas V., Shrivastava A., Su J., Yu G. L., Ni J., Liu D., Chen S. F., Ni Y., Ruben S. M., Gentz R., Aggarwal B. B.
RT VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth
RL Oncogene 18:6496-504 (1999).
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RX PUBMED: 14621993.
RA Li J., Joo S. H., Tsai M. D.
RT An NF-kappaB-specific inhibitor, IkappaBalpha, binds to and inhibits cyclin-dependent kinase 4
RL Biochemistry 42:13476-83 (2003).
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RX PUBMED: 12084717.
RA Taggart C. C., Greene C. M., McElvaney N. G., O'Neill S.
RT Secretory leucoprotease inhibitor prevents lipopolysaccharide-induced IkappaBalpha degradation without affecting phosphorylation or ubiquitination
RL J. Biol. Chem. 277:33648-53 (2002).
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RX PUBMED: 9582369.
RA Manna S. K., Zhang H. J., Yan T., Oberley L. W., Aggarwal B. B.
RT Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1
RL J. Biol. Chem. 273:13245-54 (1998).
RN [46]; RE0044408.
RX PUBMED: 12675915.
RA Heneka M. T., Gavrilyuk V., Landreth G. E., O'Banion M. K., Weinberg G., Feinstein D. L.
RT Noradrenergic depletion increases inflammatory responses in brain: effects on IkappaB and HSP70 expression
RL J. Neurochem 85:387-98 (2003).
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RX PUBMED: 12384522.
RA Tsunoda T., Inokuchi J., Baba I., Okumura K., Naito S., Sasazuki T., Shirasawa S.
RT A novel mechanism of nuclear factor kappaB activation through the binding between inhibitor of nuclear factor-kappaBalpha and the processed NH(2)-terminal region of Mig-6
RL Cancer Res. 62:5668-71 (2002).
RN [48]; RE0044412.
RX PUBMED: 12672819.
RA Higuchi Y., Otsu K., Nishida K., Hirotani S., Nakayama H., Yamaguchi O., Hikoso S., Kashiwase K., Takeda T., Watanabe T., Mano T., Matsumura Y., Ueno H., Hori M.
RT The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptosis signal-regulating kinase 1 and nuclear factor-kappa B
RL J. Biol. Chem. 278:20770-7 (2003).
RN [49]; RE0044416.
RX PUBMED: 12748192.
RA Kim Y. S., Lee J. Y., Son M. Y., Park W., Bae Y. S.
RT Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1
RL J. Biol. Chem. 278:28462-9 (2003).
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RX PUBMED: 8655581.
RA Kretz-Remy C., Mehlen P., Mirault M. E., Arrigo A. P.
RT Inhibition of I kappa B-alpha phosphorylation and degradation and subsequent NF-kappa B activation by glutathione peroxidase overexpression
RL J. Cell Biol. 133:1083-93 (1996).
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RX PUBMED: 12882972.
RA Morishima A., Ohkubo N., Maeda N., Miki T., Mitsuda N.
RT NFkappaB regulates plasma apolipoprotein A-I and high density lipoprotein cholesterol through inhibition of peroxisome proliferator-activated receptor alpha
RL J. Biol. Chem. 278:38188-93 (2003).
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RX PUBMED: 15125834.
RA Gao H., Sun Y., Wu Y., Luan B., Wang Y., Qu B., Pei G.
RT Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways
RL Mol. Cell 14:303-17 (2004).
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RX PUBMED: 15231833.
RA Zamora M., Merono C., Vinas O., Mampel T.
RT Recruitment of NF-kappaB into mitochondria is involved in adenine nucleotide translocase 1 (ANT1)-induced apoptosis
RL J. Biol. Chem. 279:38415-23 (2004).
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RX PUBMED: 10383397.
RA Jeong S. Y., Ahn S. G., Lee J. H., Kim H. S., Kim J. W., Rhim H., Jeong S. W., Kim I. K.
RT 3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation. Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation
RL J. Biol. Chem. 274:18981-8 (1999).
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RX PUBMED: 9918798.
RA Chang N. S., Mattison J., Cao H., Pratt N., Zhao Y., Lee C.
RT Cloning and characterization of a novel transforming growth factor- beta1-induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity
RL Biochem. Biophys. Res. Commun. 253:743-9 (1998).
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RX PUBMED: 10788437.
RA Manna S. K., Mukhopadhyay A., Aggarwal B. B.
RT Human chorionic gonadotropin suppresses activation of nuclear transcription factor-kappa B and activator protein-1 induced by tumor necrosis factor
RL J. Biol. Chem. 275:13307-14 (2000).
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RX PUBMED: 14630924.
RA Takada Y., Aggarwal B. B.
RT Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9
RL J. Biol. Chem. 279:4750-9 (2004).
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RX PUBMED: 16547522.
RA Wu C. J., Conze D. B., Li T., Srinivasula S. M., Ashwell J. D.
RT Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation.
RL Nat. Cell Biol. 8:398-406 (2006).
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RA Joo M., Hahn Y. S., Kwon M., Sadikot R. T., Blackwell T. S., Christman J. W.
RT Hepatitis C virus core protein suppresses NF-kappaB activation and cyclooxygenase-2 expression by direct interaction with IkappaB kinase beta.
RL J. Virol. 79:7648-7657 (2005).
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RX PUBMED: 16448710.
RA Babu G. R., Jin W., Norman L., Waterfield M., Chang M., Wu X., Zhang M., Sun S. C.
RT Phosphorylation of NF-kappaB1/p105 by oncoprotein kinase Tpl2: implications for a novel mechanism of Tpl2 regulation.
RL Biochim. Biophys. Acta 1763:174-181 (2006).
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RX PUBMED: 17158449.
RA Besse A., Lamothe B., Campos A. D., Webster W. K., Maddineni U., Lin S. C., Wu H., Darnay B. G.
RT TAK1-dependent signaling requires functional interaction with TAB2/TAB3.
RL J. Biol. Chem. 282:3918-3928 (2007).
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RX PUBMED: 11244088.
RA Wooten M. W., Seibenhener M. L., Mamidipudi V., Diaz-Meco M. T., Barker P. A., Moscat J.
RT The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor.
RL J. Biol. Chem. 276:7709-7712 (2001).
RN [63]; RE0051693.
RX PUBMED: 18037881.
RA Ahmad R., Raina D., Trivedi V., Ren J., Rajabi H., Kharbanda S., Kufe D.
RT MUC1 oncoprotein activates the IkappaB kinase beta complex and constitutive NF-kappaB signalling.
RL Nat. Cell Biol. 9:1419-1427 (2007).
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RX PUBMED: 16267042.
RA Carter R. S., Pennington K. N., Arrate P., Oltz E. M., Ballard D. W.
RT Site-specific monoubiquitination of IkappaB kinase IKKbeta regulates its phosphorylation and persistent activation.
RL J. Biol. Chem. 280:43272-43279 (2005).
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RX PUBMED: 16382138.
RA Hoberg J. E., Popko A. E., Ramsey C. S., Mayo M. W.
RT IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300.
RL Mol. Cell. Biol. 26:457-471 (2006).
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RX PUBMED: 15494311.
RA Hoberg J. E., Yeung F., Mayo M. W.
RT SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival.
RL Mol. Cell 16:245-255 (2004).
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RX PUBMED: 17595324.
RA Choudhary S., Lu M., Cui R., Brasier A. R.
RT Involvement of a novel Rac/RhoA guanosine triphosphatase-nuclear factor-kappaB inducing kinase signaling pathway mediating angiotensin II-induced RelA transactivation.
RL Mol. Endocrinol. 21:2203-2217 (2007).
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RA Park M. Y., Moon J. H., Lee K. S., Choi H. I., Chung J., Hong H. J., Kim E.
RT FAF1 suppresses IkappaB kinase (IKK) activation by disrupting the IKK complex assembly.
RL J. Biol. Chem. 282:27572-27577 (2007).
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RX PUBMED: 17991436.
RA Hochrainer K., Racchumi G., Anrather J.
RT Hypo-phosphorylation leads to nuclear retention of NF-kappaB p65 due to impaired IkappaBalpha gene synthesis.
RL FEBS Lett. 581:5493-5499 (2007).
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RX PUBMED: 17878357.
RA Kang Y. J., Kusler B., Otsuka M., Hughes M., Suzuki N., Suzuki S., Yeh W. C., Akira S., Han J., Jones P. P.
RT Calcineurin negatively regulates TLR-mediated activation pathways.
RL J. Immunol. 179:4598-4607 (2007).
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RX PUBMED: 15334086.
RA Boone D. L., Turer E. E., Lee E. G., Ahmad R. C., Wheeler M. T., Tsui C., Hurley P., Chien M., Chai S., Hitotsumatsu O., McNally E., Pickart C., Ma A.
RT The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses.
RL Nat. Immunol. 5:1052-1060 (2004).
RN [72]; RE0053290.
RX PUBMED: 18342009.
RA Hitotsumatsu O., Ahmad R. C., Tavares R., Wang M., Philpott D., Turer E. E., Lee B. L., Shiffin N., Advincula R., Malynn B. A., Werts C., Ma A.
RT The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals.
RL Immunity 28:381-390 (2008).
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RX PUBMED: 16125763.
RA Seth R. B., Sun L., Ea C. K., Chen Z. J.
RT Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.
RL Cell 122:669-682 (2005).
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RX PUBMED: 16378096.
RA Wang Y., Tang Y., Teng L., Wu Y., Zhao X., Pei G.
RT Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling.
RL Nat. Immunol. 7:139-147 (2006).
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RA Harris J., Oliere S., Sharma S., Sun Q., Lin R., Hiscott J., Grandvaux N.
RT Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon.
RL J. Immunol. 177:2527-2535 (2006).
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RX PUBMED: 16822942.
RA Xu S., Bayat H., Hou X., Jiang B.
RT Ribosomal S6 kinase-1 modulates interleukin-1beta-induced persistent activation of NF-kappaB through phosphorylation of IkappaBbeta.
RL Am. J. Physiol. Cell Physiol. 291:C1336-45 (2006).
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RA Li X., Commane M., Nie H., Hua X., Chatterjee-Kishore M., Wald D., Haag M., Stark G. R.
RT Act1, an NF-kappa B-activating protein.
RL Proc. Natl. Acad. Sci. USA 97:10489-10493 (2000).
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