AC T11261
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ID T11261
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DT 10.03.2005 (created); nvo.
DT 15.04.2016 (updated); vis.
CO Copyright (C), QIAGEN.
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FA c-Rel
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SY c-Rel; HIVEN86A; Nuclear Factor kappa B c-Rel; p68; p82(hc-rel).
XX
OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
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IN T10237 ATF-1; Mammalia.
IN T23082 ATF-4; Mammalia.
IN T17532 Bcl-3; Mammalia.
IN T15312 c-Ets-2; Mammalia.
IN T10346 c-Fos; Mammalia.
IN T09446 c-Jun; Mammalia.
IN T09410 C/EBPbeta; Mammalia.
IN T15700 HMGI-C; Mammalia.
IN T18455 IkappaB-alpha; Mammalia.
IN T14816 IRF-1; Mammalia.
IN T08800 nanog-isoform1; mouse, Mus musculus.
IN T11024 NFATc2; Mammalia.
IN T05894 NRF-isoform1; human, Homo sapiens.
IN T23091 p300; Mammalia.
IN T14175 TBP; Mammalia.
IN T17428 TFIIB; Mammalia.
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MX M00053 V$CREL_01.
MX M03545 V$CREL_Q6.
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BS R03673.
BS R40768.
BS R64783.
BS R72342.
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DR TRANSPATH: MO000048020.
DR TRANSCOMPEL: C00168.
DR TRANSCOMPEL: C00570.
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RN [1]; RE0003056.
RX PUBMED: 1508203.
RA Tan T.-H., Huang G. P., Sica A., Ghosh P., Young H. A., Longo D. L., Rice N. R.
RT KappaB site-dependent activation of the interleukin-2 receptor alpha-chain gene promoter by human c-Rel
RL Mol. Cell. Biol. 12:4067-4075 (1992).
RN [2]; RE0004524.
RX PUBMED: 8321203.
RA Stein B., Cogswell P. C., Baldwin jr A. S.
RT Functional and physical associations between NF-kappaB and C/EBP family members: a Rel domain-bZIP interaction
RL Mol. Cell. Biol. 13:3964-3974 (1993).
RN [3]; RE0004538.
RX PUBMED: 8458581.
RA Mercurio F., Didonato J. A., Rosette C., Karin M.
RT p105 and p98 precursor proteins play an active role in NF-kappaB-mediated signal transduction
RL Genes Dev. 7:705-718 (1993).
RN [4]; RE0008774.
RX PUBMED: 7508926.
RA Xie Q., Kashiwabara Y., Nathan C.
RT Role of transcription factor NF-kappaB/Rel in induction of nitric oxide synthase
RL J. Biol. Chem. 269:4705-4708 (1994).
RN [5]; RE0010649.
RX PUBMED: 7565674.
RA Murphy T. L., Cleveland M. G., Kulesza P., Magram J., Murphy K. M.
RT Regulation of interleukin 12 p40 expression through an NF-kappaB half-site
RL Mol. Cell. Biol. 15:5258-5267 (1995).
RN [6]; RE0011319.
RX PUBMED: 7665567.
RA Lopez-Cabrera M., Munoz E., Blazquez M.V., Ursa M. A., Santis A. G., Sanchez-Madrid F.
RT Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-alpha-responsive elements
RL J. Biol. Chem. 270:21545-21551 (1995).
RN [7]; RE0012437.
RX PUBMED: 8756615.
RA Lin S.-C., Stavnezer J.
RT Activation of NF-kappaB/rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter
RL Mol. Cell. Biol. 16:4591-4603 (1996).
RN [8]; RE0023654.
RX PUBMED: 12665576.
RA Edelstein L. C., Lagos L., Simmons M., Tirumalai H., Gelinas C.
RT NF-kappa B-dependent assembly of an enhanceosome-like complex on the promoter region of apoptosis inhibitor Bfl-1/A1.
RL Mol. Cell. Biol. 23:2749-2761 (2003).
RN [9]; RE0024028.
RX PUBMED: 10562553.
RA Nourbakhsh M., Hauser H.
RT Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB.
RL EMBO J. 18:6415-6425 (1999).
RN [10]; RE0029138.
RX PUBMED: 11756417.
RA Kirito K., Watanabe T., Sawada K., Endo H., Ozawa K., Komatsu N.
RT Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways.
RL J. Biol. Chem. 277:8329-37 (2002).
RN [11]; RE0030053.
RX PUBMED: 12147627.
RA Hsia C. Y., Cheng S., Owyang A. M., Dowdy S. F., Liou H. C.
RT c-Rel regulation of the cell cycle in primary mouse B lymphocytes.
RL Int. Immunol. 14:905-16 (2002).
RN [12]; RE0032236.
RX PUBMED: 9343416.
RA Bash J., Zong W. X., Gelinas C.
RT c-Rel arrests the proliferation of HeLa cells and affects critical regulators of the G1/S-phase transition.
RL Mol. Cell. Biol. 17:6526-36 (1997).
RN [13]; RE0037794.
RX PUBMED: 9867853.
RA Hall A. J., Vos H. L., Bertina R. M.
RT Lipopolysaccharide induction of tissue factor in THP-1 cells involves Jun protein phosphorylation and nuclear factor kappaB nuclear translocation
RL J. Biol. Chem. 274:376-83 (1999).
RN [14]; RE0041832.
RX PUBMED: 9837938.
RA Hu M. C., Tang-Oxley Q., Qiu W. R., Wang Y. P., Mihindukulasuriya K. A., Afshar R., Tan T. H.
RT Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity
RL J. Biol. Chem. 273:33561-5 (1998).
RN [15]; RE0042667.
RX PUBMED: 10221648.
RA Liou H. C., Jin Z., Tumang J., Andjelic S., Smith K. A., Liou M. L.
RT c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function
RL Int. Immunol. 11:361-71 (1999).
RN [16]; RE0042728.
RX PUBMED: 12426000.
RA Tumang J. R., Hsia C. Y., Tian W., Bromberg J. F., Liou H. C.
RT IL-6 rescues the hyporesponsiveness of c-Rel deficient B cells independent of Bcl-xL, Mcl-1, and Bcl-2
RL Cell. Immunol. 217:47-57 (2002).
RN [17]; RE0042741.
RX PUBMED: 10542221.
RA Delgado M., Ganea D.
RT Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit interleukin-12 transcription by regulating nuclear factor kappaB and Ets activation
RL J. Biol. Chem. 274:31930-40 (1999).
RN [18]; RE0042747.
RX PUBMED: 12488457.
RA Fujimori K., Fujitani Y., Kadoyama K., Kumanogoh H., Ishikawa K., Urade Y.
RT Regulation of lipocalin-type prostaglandin D synthase gene expression by Hes-1 through E-box and interleukin-1 beta via two NF-kappa B elements in rat leptomeningeal cells
RL J. Biol. Chem. 278:6018-26 (2003).
RN [19]; RE0042761.
RX PUBMED: 12218154.
RA Oda T., Ueda A., Shimizu N., Handa H., Kasahara T.
RT Suppression of monocyte chemoattractant protein 1, but not IL-8, by alprazolam: effect of alprazolam on c-Rel/p65 and c-Rel/p50 binding to the monocyte chemoattractant protein 1 promoter region
RL J. Immunol. 169:3329-35 (2002).
RN [20]; RE0042764.
RX PUBMED: 12202402.
RA Kaku H., Horikawa K., Obata Y., Kato I., Okamoto H., Sakaguchi N., Gerondakis S., Takatsu K.
RT NF-kappaB is required for CD38-mediated induction of C(gamma)1 germline transcripts in murine B lymphocytes
RL Int. Immunol. 14:1055-64 (2002).
RN [21]; RE0042790.
RX PUBMED: 12360408.
RA Huang Y. H., Wu J. Y., Zhang Y., Wu M. X.
RT Synergistic and opposing regulation of the stress-responsive gene IEX-1 by p53, c-Myc, and multiple NF-kappaB/rel complexes
RL Oncogene 21:6819-28 (2002).
RN [22]; RE0042791.
RX PUBMED: 12833156.
RA Yamazaki T., Kurosaki T.
RT Contribution of BCAP to maintenance of mature B cells through c-Rel
RL Nat. Immunol. 4:780-6 (2003).
RN [23]; RE0042864.
RX PUBMED: 9418849.
RA Miyamoto S., Seufzer B. J., Shumway S. D.
RT Novel IkappaB alpha proteolytic pathway in WEHI231 immature B cells
RL Mol. Cell. Biol. 18:19-29 (1998).
RN [24]; RE0043894.
RX PUBMED: 15312903.
RA Kogel D., Peters M., Konig H. G., Hashemi S. M., Bui N. T., Arolt V., Rothermundt M., Prehn J. H.
RT S100B potently activates p65/c-Rel transcriptional complexes in hippocampal neurons: Clinical implications for the role of S100B in excitotoxic brain injury
RL Neuroscience 127:913-20 (2004).
RN [25]; RE0044227.
RX PUBMED: 7969133.
RA Bryan R. G., Li Y., Lai J. H., Van M., Rice N. R., Rich R. R., Tan T. H.
RT Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells
RL Mol. Cell. Biol. 14:7933-42 (1994).
RN [26]; RE0053788.
RX PUBMED: 16888014.
RA Harris J., Oliere S., Sharma S., Sun Q., Lin R., Hiscott J., Grandvaux N.
RT Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon.
RL J. Immunol. 177:2527-2535 (2006).
RN [27]; RE0054100.
RX PUBMED: 15858576.
RA Lawrence T., Bebien M., Liu G. Y., Nizet V., Karin M.
RT IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation.
RL Nature 434:1138-1143 (2005).
RN [28]; RE0055018.
RX PUBMED: 17273900.
RA Huang Y. C., Chang W. C., Su J. G., Cai J. L., Chen C. C., Hung J. J., Liu Y. W.
RT Peptidoglycan enhances transcriptional expression of CCAAT/enhancer-binding protein delta gene in mouse macrophages.
RL J. Biomed. Sci. 14:407-418 (2007).
RN [29]; RE0063120.
RX PUBMED: 19393188.
RA Johnston D. A., Dong B., Hughes C. C.
RT TNF induction of jagged-1 in endothelial cells is NFkappaB-dependent.
RL Gene 435:36-44 (2009).
RN [30]; RE0064775.
RX PUBMED: 18223644.
RA Torres J., Watt F. M.
RT Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkappaB and cooperating with Stat3.
RL Nat. Cell Biol. 10:194-201 (2008).
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