TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T11261 XX ID T11261 XX DT 10.03.2005 (created); nvo. DT 15.04.2016 (updated); vis. CO Copyright (C), QIAGEN. XX FA c-Rel XX SY c-Rel; HIVEN86A; Nuclear Factor kappa B c-Rel; p68; p82(hc-rel). XX OS Mammalia OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia XX IN T10237 ATF-1; Mammalia. IN T23082 ATF-4; Mammalia. IN T17532 Bcl-3; Mammalia. IN T15312 c-Ets-2; Mammalia. IN T10346 c-Fos; Mammalia. IN T09446 c-Jun; Mammalia. IN T09410 C/EBPbeta; Mammalia. IN T15700 HMGI-C; Mammalia. IN T18455 IkappaB-alpha; Mammalia. IN T14816 IRF-1; Mammalia. IN T08800 nanog-isoform1; mouse, Mus musculus. IN T11024 NFATc2; Mammalia. IN T05894 NRF-isoform1; human, Homo sapiens. IN T23091 p300; Mammalia. IN T14175 TBP; Mammalia. IN T17428 TFIIB; Mammalia. XX MX M00053 V$CREL_01. MX M03545 V$CREL_Q6. XX BS R03673. BS R40768. BS R64783. BS R72342. XX DR TRANSPATH: MO000048020. DR TRANSCOMPEL: C00168. DR TRANSCOMPEL: C00570. XX RN [1]; RE0003056. RX PUBMED: 1508203. RA Tan T.-H., Huang G. P., Sica A., Ghosh P., Young H. A., Longo D. L., Rice N. R. RT KappaB site-dependent activation of the interleukin-2 receptor alpha-chain gene promoter by human c-Rel RL Mol. Cell. Biol. 12:4067-4075 (1992). RN [2]; RE0004524. RX PUBMED: 8321203. RA Stein B., Cogswell P. C., Baldwin jr A. S. RT Functional and physical associations between NF-kappaB and C/EBP family members: a Rel domain-bZIP interaction RL Mol. Cell. Biol. 13:3964-3974 (1993). RN [3]; RE0004538. RX PUBMED: 8458581. RA Mercurio F., Didonato J. A., Rosette C., Karin M. RT p105 and p98 precursor proteins play an active role in NF-kappaB-mediated signal transduction RL Genes Dev. 7:705-718 (1993). RN [4]; RE0008774. RX PUBMED: 7508926. RA Xie Q., Kashiwabara Y., Nathan C. RT Role of transcription factor NF-kappaB/Rel in induction of nitric oxide synthase RL J. Biol. Chem. 269:4705-4708 (1994). RN [5]; RE0010649. RX PUBMED: 7565674. RA Murphy T. L., Cleveland M. G., Kulesza P., Magram J., Murphy K. M. RT Regulation of interleukin 12 p40 expression through an NF-kappaB half-site RL Mol. Cell. Biol. 15:5258-5267 (1995). RN [6]; RE0011319. RX PUBMED: 7665567. RA Lopez-Cabrera M., Munoz E., Blazquez M.V., Ursa M. A., Santis A. G., Sanchez-Madrid F. RT Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-alpha-responsive elements RL J. Biol. Chem. 270:21545-21551 (1995). RN [7]; RE0012437. RX PUBMED: 8756615. RA Lin S.-C., Stavnezer J. RT Activation of NF-kappaB/rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter RL Mol. Cell. Biol. 16:4591-4603 (1996). RN [8]; RE0023654. RX PUBMED: 12665576. RA Edelstein L. C., Lagos L., Simmons M., Tirumalai H., Gelinas C. RT NF-kappa B-dependent assembly of an enhanceosome-like complex on the promoter region of apoptosis inhibitor Bfl-1/A1. RL Mol. Cell. Biol. 23:2749-2761 (2003). RN [9]; RE0024028. RX PUBMED: 10562553. RA Nourbakhsh M., Hauser H. RT Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB. RL EMBO J. 18:6415-6425 (1999). RN [10]; RE0029138. RX PUBMED: 11756417. RA Kirito K., Watanabe T., Sawada K., Endo H., Ozawa K., Komatsu N. RT Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways. RL J. Biol. Chem. 277:8329-37 (2002). RN [11]; RE0030053. RX PUBMED: 12147627. RA Hsia C. Y., Cheng S., Owyang A. M., Dowdy S. F., Liou H. C. RT c-Rel regulation of the cell cycle in primary mouse B lymphocytes. RL Int. Immunol. 14:905-16 (2002). RN [12]; RE0032236. RX PUBMED: 9343416. RA Bash J., Zong W. X., Gelinas C. RT c-Rel arrests the proliferation of HeLa cells and affects critical regulators of the G1/S-phase transition. RL Mol. Cell. Biol. 17:6526-36 (1997). RN [13]; RE0037794. RX PUBMED: 9867853. RA Hall A. J., Vos H. L., Bertina R. M. RT Lipopolysaccharide induction of tissue factor in THP-1 cells involves Jun protein phosphorylation and nuclear factor kappaB nuclear translocation RL J. Biol. Chem. 274:376-83 (1999). RN [14]; RE0041832. RX PUBMED: 9837938. RA Hu M. C., Tang-Oxley Q., Qiu W. R., Wang Y. P., Mihindukulasuriya K. A., Afshar R., Tan T. H. RT Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity RL J. Biol. Chem. 273:33561-5 (1998). RN [15]; RE0042667. RX PUBMED: 10221648. RA Liou H. C., Jin Z., Tumang J., Andjelic S., Smith K. A., Liou M. L. RT c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function RL Int. Immunol. 11:361-71 (1999). RN [16]; RE0042728. RX PUBMED: 12426000. RA Tumang J. R., Hsia C. Y., Tian W., Bromberg J. F., Liou H. C. RT IL-6 rescues the hyporesponsiveness of c-Rel deficient B cells independent of Bcl-xL, Mcl-1, and Bcl-2 RL Cell. Immunol. 217:47-57 (2002). RN [17]; RE0042741. RX PUBMED: 10542221. RA Delgado M., Ganea D. RT Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit interleukin-12 transcription by regulating nuclear factor kappaB and Ets activation RL J. Biol. Chem. 274:31930-40 (1999). RN [18]; RE0042747. RX PUBMED: 12488457. RA Fujimori K., Fujitani Y., Kadoyama K., Kumanogoh H., Ishikawa K., Urade Y. RT Regulation of lipocalin-type prostaglandin D synthase gene expression by Hes-1 through E-box and interleukin-1 beta via two NF-kappa B elements in rat leptomeningeal cells RL J. Biol. Chem. 278:6018-26 (2003). RN [19]; RE0042761. RX PUBMED: 12218154. RA Oda T., Ueda A., Shimizu N., Handa H., Kasahara T. RT Suppression of monocyte chemoattractant protein 1, but not IL-8, by alprazolam: effect of alprazolam on c-Rel/p65 and c-Rel/p50 binding to the monocyte chemoattractant protein 1 promoter region RL J. Immunol. 169:3329-35 (2002). RN [20]; RE0042764. RX PUBMED: 12202402. RA Kaku H., Horikawa K., Obata Y., Kato I., Okamoto H., Sakaguchi N., Gerondakis S., Takatsu K. RT NF-kappaB is required for CD38-mediated induction of C(gamma)1 germline transcripts in murine B lymphocytes RL Int. Immunol. 14:1055-64 (2002). RN [21]; RE0042790. RX PUBMED: 12360408. RA Huang Y. H., Wu J. Y., Zhang Y., Wu M. X. RT Synergistic and opposing regulation of the stress-responsive gene IEX-1 by p53, c-Myc, and multiple NF-kappaB/rel complexes RL Oncogene 21:6819-28 (2002). RN [22]; RE0042791. RX PUBMED: 12833156. RA Yamazaki T., Kurosaki T. RT Contribution of BCAP to maintenance of mature B cells through c-Rel RL Nat. Immunol. 4:780-6 (2003). RN [23]; RE0042864. RX PUBMED: 9418849. RA Miyamoto S., Seufzer B. J., Shumway S. D. RT Novel IkappaB alpha proteolytic pathway in WEHI231 immature B cells RL Mol. Cell. Biol. 18:19-29 (1998). RN [24]; RE0043894. RX PUBMED: 15312903. RA Kogel D., Peters M., Konig H. G., Hashemi S. M., Bui N. T., Arolt V., Rothermundt M., Prehn J. H. RT S100B potently activates p65/c-Rel transcriptional complexes in hippocampal neurons: Clinical implications for the role of S100B in excitotoxic brain injury RL Neuroscience 127:913-20 (2004). RN [25]; RE0044227. RX PUBMED: 7969133. RA Bryan R. G., Li Y., Lai J. H., Van M., Rice N. R., Rich R. R., Tan T. H. RT Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells RL Mol. Cell. Biol. 14:7933-42 (1994). RN [26]; RE0053788. RX PUBMED: 16888014. RA Harris J., Oliere S., Sharma S., Sun Q., Lin R., Hiscott J., Grandvaux N. RT Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon. RL J. Immunol. 177:2527-2535 (2006). RN [27]; RE0054100. RX PUBMED: 15858576. RA Lawrence T., Bebien M., Liu G. Y., Nizet V., Karin M. RT IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. RL Nature 434:1138-1143 (2005). RN [28]; RE0055018. RX PUBMED: 17273900. RA Huang Y. C., Chang W. C., Su J. G., Cai J. L., Chen C. C., Hung J. J., Liu Y. W. RT Peptidoglycan enhances transcriptional expression of CCAAT/enhancer-binding protein delta gene in mouse macrophages. RL J. Biomed. Sci. 14:407-418 (2007). RN [29]; RE0063120. RX PUBMED: 19393188. RA Johnston D. A., Dong B., Hughes C. C. RT TNF induction of jagged-1 in endothelial cells is NFkappaB-dependent. RL Gene 435:36-44 (2009). RN [30]; RE0064775. RX PUBMED: 18223644. RA Torres J., Watt F. M. RT Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkappaB and cooperating with Stat3. RL Nat. Cell Biol. 10:194-201 (2008). XX //