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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T05894 XX ID T05894 XX DT 23.03.2004 (created); abd. CO Copyright (C), QIAGEN. XX FA NRF-isoform1 XX SY ITBA4; NF-kappa B-repressing factor; NRF. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G009302 NKRF; HGNC: Nkrf. XX SZ 388 AA; 43.5 kDa (calc.). XX SQ MEKILQMAEGIDIGEMPSYDLVLSKPSKGQKRHLSTCDGQNPPKKQAGSKFHARPRFEPV SQ HFVASSSKDEGQEDPYGPQTKEVNEQTHFASMPRDIYQDYTQDSFSIQDGNSQYCDSSGF SQ ILTKDQPVTANMYFDSGNPAPSTTSQQANSQSTPEPSPSQTFPESVVAEKQYFIEKLTAT SQ IWKNLSNPEMTSGSDKINYTYMLTRCIQACKTNPEYIYAPLKEIPPADIPKNKKLLTDGY SQ ACEVRCQNIYLTTGYAGSKNGSRDRATELAVKLLQKRIEVRVVRRKFKHTFGEDLVVCQI SQ GMSSYEFPPALKPPEDLVVLGKDASGQPIFNASAKHWTNFVITENANDAIGILNNSASFN SQ KMSIEYKYEMMPNRTWRSSSVFTRSLLS XX SC translated from EMBL #AJ011812 XX SF nuclear localization [1]; SF interacts with NF-kappaB factors T00588 [1]; XX CP constitutive and ubiquitous [1]. XX FF constitutive repressor of the IFN-beta gene [1]; FF binds to the NRE (negative regulatory element) of IFN-beta gene [1]; FF inhibitory effect of NRF-isoform1 on NF-kappaB dimers [1]; XX IN T11261 c-Rel; Mammalia. IN T10399 NF-kappaB1-p50; Mammalia. IN T30850 p52; Mammalia. IN T10397 RelA-p65; Mammalia. XX DR TRANSPATH: MO000041893. DR EMBL: AJ011812; DR UniProtKB: O15226; XX RN [1]; RE0024028. RX PUBMED: 10562553. RA Nourbakhsh M., Hauser H. RT Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB. RL EMBO J. 18:6415-6425 (1999). XX //