AC T05894
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ID T05894
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DT 23.03.2004 (created); abd.
CO Copyright (C), QIAGEN.
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FA NRF-isoform1
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SY ITBA4; NF-kappa B-repressing factor; NRF.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G009302 NKRF; HGNC: Nkrf.
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SZ 388 AA; 43.5 kDa (calc.).
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SQ MEKILQMAEGIDIGEMPSYDLVLSKPSKGQKRHLSTCDGQNPPKKQAGSKFHARPRFEPV
SQ HFVASSSKDEGQEDPYGPQTKEVNEQTHFASMPRDIYQDYTQDSFSIQDGNSQYCDSSGF
SQ ILTKDQPVTANMYFDSGNPAPSTTSQQANSQSTPEPSPSQTFPESVVAEKQYFIEKLTAT
SQ IWKNLSNPEMTSGSDKINYTYMLTRCIQACKTNPEYIYAPLKEIPPADIPKNKKLLTDGY
SQ ACEVRCQNIYLTTGYAGSKNGSRDRATELAVKLLQKRIEVRVVRRKFKHTFGEDLVVCQI
SQ GMSSYEFPPALKPPEDLVVLGKDASGQPIFNASAKHWTNFVITENANDAIGILNNSASFN
SQ KMSIEYKYEMMPNRTWRSSSVFTRSLLS
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SC translated from EMBL #AJ011812
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SF nuclear localization [1];
SF interacts with NF-kappaB factors T00588 [1];
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CP constitutive and ubiquitous [1].
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FF constitutive repressor of the IFN-beta gene [1];
FF binds to the NRE (negative regulatory element) of IFN-beta gene [1];
FF inhibitory effect of NRF-isoform1 on NF-kappaB dimers [1];
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IN T11261 c-Rel; Mammalia.
IN T10399 NF-kappaB1-p50; Mammalia.
IN T30850 p52; Mammalia.
IN T10397 RelA-p65; Mammalia.
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DR TRANSPATH: MO000041893.
DR EMBL: AJ011812;
DR UniProtKB: O15226;
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RN [1]; RE0024028.
RX PUBMED: 10562553.
RA Nourbakhsh M., Hauser H.
RT Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB.
RL EMBO J. 18:6415-6425 (1999).
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