AC T17520
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ID T17520
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DT 04.05.2007 (created); man.
DT 29.03.2016 (updated); vis.
CO Copyright (C), QIAGEN.
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FA NF-kappaB1
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SY EBP-1; KBF1; NF-kappaB1 (p105); NF-kappaB1 (p110); NFkappaB1 precursor (p105); NFKB1; Nuclear factor NF-kappa-B p105 subunit; p105; p110.
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OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
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IN T17532 Bcl-3; Mammalia.
IN T15361 ESE-1; Mammalia.
IN T19181 GLEA2-isoform1; human, Homo sapiens.
IN T18455 IkappaB-alpha; Mammalia.
IN T22502 IkappaBzeta-isoform1; human, Homo sapiens.
IN T22504 IkappaBzeta-isoform2; human, Homo sapiens.
IN T01427 p300; human, Homo sapiens.
IN T14054 PARP; human, Homo sapiens.
IN T00594 RelA-p65-isoform1; human, Homo sapiens.
IN T09522 RelB; human, Homo sapiens.
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MX M00194 V$NFKB_Q6.
MX M00774 V$NFKB_Q6_01.
MX M03557 V$P50_Q6.
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BS R30143.
BS R25059.
BS R41089.
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DR TRANSPATH: MO000105769.
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RN [1]; RE0004538.
RX PUBMED: 8458581.
RA Mercurio F., Didonato J. A., Rosette C., Karin M.
RT p105 and p98 precursor proteins play an active role in NF-kappaB-mediated signal transduction
RL Genes Dev. 7:705-718 (1993).
RN [2]; RE0030766.
RX PUBMED: 12482991.
RA Lang V., Janzen J., Fischer G. Z., Soneji Y., Beinke S., Salmeron A., Allen H., Hay R. T., Ben-Neriah Y., Ley S. C.
RT betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.
RL Mol. Cell. Biol. 23:402-13 (2003).
RN [3]; RE0039134.
RX PUBMED: 14743216.
RA Bouwmeester T., Bauch A., Ruffner H., Angrand P. O., Bergamini G., Croughton K., Cruciat C., Eberhard D., Gagneur J., Ghidelli S., Hopf C., Huhse B., Mangano R., Michon A. M., Schirle M., Schlegl J., Schwab M., Stein M. A., Bauer A., Casari G., Drewes G., Gavin A. C., Jackson D. B., Joberty G., Neubauer G., Rick J., Kuster B., Superti-Furga G.
RT A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
RL Nat. Cell Biol. 6:97-105 (2004).
RN [4]; RE0042226.
RX PUBMED: 12960163.
RA Hassa P. O., Buerki C., Lombardi C., Imhof R., Hottiger M. O.
RT Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1
RL J. Biol. Chem. 278:45145-53 (2003).
RN [5]; RE0049828.
RX PUBMED: 16204234.
RA Hassa P. O., Haenni S. S., Buerki C., Meier N. I., Lane W. S., Owen H., Gersbach M., Imhof R., Hottiger M. O.
RT Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription.
RL J. Biol. Chem. 280:40450-40464 (2005).
RN [6]; RE0053748.
RX PUBMED: 12871932.
RA Demarchi F., Bertoli C., Sandy P., Schneider C.
RT Glycogen synthase kinase-3 beta regulates NF-kappa B1/p105 stability.
RL J. Biol. Chem. 278:39583-39590 (2003).
RN [7]; RE0054072.
RX PUBMED: 11687592.
RA Solan N. J., Miyoshi H., Carmona E. M., Bren G. D., Paya C. V.
RT RelB cellular regulation and transcriptional activity are regulated by p100.
RL J. Biol. Chem. 277:1405-1418 (2002).
RN [8]; RE0065087.
RX PUBMED: 17652082.
RA Patel D. N., King C. A., Bailey S. R., Holt J. W., Venkatachalam K., Agrawal A., Valente A. J., Chandrasekar B.
RT Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation.
RL J. Biol. Chem. 282:27229-27238 (2007).
RN [9]; RE0065527.
RX PUBMED: 19531803.
RA Wall E. A., Zavzavadjian J. R., Chang M. S., Randhawa B., Zhu X., Hsueh R. C., Liu J., Driver A., Bao X. R., Sternweis P. C., Simon M. I., Fraser I. D.
RT Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105.
RL Sci. Signal. 2:ra28 (2009).
RN [10]; RE0067621.
RX PUBMED: 16291755.
RA Eliopoulos A. G., Das S., Tsichlis P. N.
RT The tyrosine kinase Syk regulates TPL2 activation signals.
RL J. Biol. Chem. 281:1371-1380 (2006).
RN [11]; RE0069938.
RX PUBMED: 19783680.
RA Seshadri S., Kannan Y., Mitra S., Parker-Barnes J., Wewers M. D.
RT MAIL regulates human monocyte IL-6 production.
RL J. Immunol. 183:5358-5368 (2009).
RN [12]; RE0069949.
RX PUBMED: 16513645.
RA Totzke G., Essmann F., Pohlmann S., Lindenblatt C., Janicke R. U., Schulze-Osthoff K.
RT A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding.
RL J. Biol. Chem. 281:12645-12654 (2006).
RN [13]; RE0070618.
RX PUBMED: 20547759.
RA Keutgens A., Shostak K., Close P., Zhang X., Hennuy B., Aussems M., Chapelle J. P., Viatour P., Gothot A., Fillet M., Chariot A.
RT The repressing function of the oncoprotein BCL-3 requires CtBP, while its polyubiquitination and degradation involve the E3 ligase TBLR1.
RL Mol. Cell. Biol. 30:4006-4021 (2010).
RN [14]; RE0070954.
RX PUBMED: 20460684.
RA Tando T., Ishizaka A., Watanabe H., Ito T., Iida S., Haraguchi T., Mizutani T., Izumi T., Isobe T., Akiyama T., Inoue J., Iba H.
RT Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway.
RL J. Biol. Chem. 285:21951-21960 (2010).
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