AC T14054
XX
ID T14054
XX
DT 18.01.2006 (created); rad.
DT 13.02.2013 (updated); uat.
CO Copyright (C), QIAGEN.
XX
FA PARP
XX
SY ADPRT; NAD+ ADP-ribosyltransferase-1; PARP-1; poly polymerase; poly(ADP-ribose) polymerase; poly-ADP-ribose synthetase-1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G001407 PARP1; HGNC: PARP1.
XX
SZ 1014 AA; 113.1 kDa (cDNA) (calc.), 114 kDa (SDS) [7]
XX
SQ MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKV
SQ GHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKS
SQ NRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQ
SQ LKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKA
SQ QNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSG
SQ QLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPE
SQ TSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLT
SQ GTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSP
SQ WGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLE
SQ HSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNK
SQ LEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPG
SQ TKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAV
SQ SQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRG
SQ GSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIE
SQ REGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADM
SQ VSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSA
SQ NISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW
XX
SC Swiss-Prot#P09874
XX
FT 8 92 
PF00645; Poly(ADP-ribose) polymerase and DNA-Ligase Z.
FT 8 92 
PS50064; PARP_ZN_FINGER_2.
FT 112 202 
PF00645; Poly(ADP-ribose) polymerase and DNA-Ligase Z.
FT 112 202 
PS50064; PARP_ZN_FINGER_2.
FT 278 331 
PF08063; PADR1 (NUC008) domain.
FT 384 460 
PS50172; BRCT.
FT 384 462 
PF00533; BRCA1 C Terminus (BRCT) domain.
FT 386 465 
SM00292; BRCT_7.
FT 387 861 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 547 632 
PF05406; WGR domain.
FT 661 778 PS51060; PARP_ALPHA_HD.
FT 661 794 PF02877; Poly(ADP-ribose) polymerase, regulatory doma.
FT 787 1013 PS51059; PARP_CATALYTIC.
FT 796 1006 PF00644; Poly(ADP-ribose) polymerase catalytic domain.
XX
IN T21852 HDAC1; Mammalia.
IN T10358 HMGIY; Mammalia.
IN T05056 Max; human, Homo sapiens.
IN T17520 NF-kappaB1; Mammalia.
IN T01427 p300; human, Homo sapiens.
IN T14054 PARP; human, Homo sapiens.
IN T10397 RelA-p65; Mammalia.
IN T15704 SNA; Mammalia.
IN T02918 TCF-4; human, Homo sapiens.
IN T02362 TEF-1; rat, Rattus norvegicus.
IN T10209 TTF-1; rat, Rattus norvegicus.
XX
MX M01211 V$PARP_Q3.
MX M02027 V$PARP_Q4.
XX
BS R34759.
BS R41750.
BS R23131.
BS R29551.
XX
DR TRANSPATH: MO000057417.
DR SMARTDB: SB000120.
DR EMBL: J03473; HSRISDAD.
DR EMBL: M18112;
DR EMBL: M32721; HSPPOL.
DR UniProtKB: P09874;
XX
RN [1]; RE0042226.
RX PUBMED: 12960163.
RA Hassa P. O., Buerki C., Lombardi C., Imhof R., Hottiger M. O.
RT Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1
RL J. Biol. Chem. 278:45145-53 (2003).
RN [2]; RE0048143.
RX PUBMED: 11010974.
RA Vyas D. R., McCarthy J. J., Tsika G. L., Tsika R. W.
RT Multiprotein complex formation at the beta myosin heavy chain distal muscle CAT element correlates with slow muscle expression but not mechanical overload responsiveness.
RL J. Biol. Chem. 276:1173-1184 (2001).
RN [3]; RE0049366.
RX PUBMED: 16461352.
RA Maeda Y., Hunter T. C., Loudy D. E., Dave V., Schreiber V., Whitsett J. A.
RT PARP-2 interacts with TTF-1 and regulates expression of surfactant protein-B.
RL J. Biol. Chem. 281:9600-9606 (2006).
RN [4]; RE0049828.
RX PUBMED: 16204234.
RA Hassa P. O., Haenni S. S., Buerki C., Meier N. I., Lane W. S., Owen H., Gersbach M., Imhof R., Hottiger M. O.
RT Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription.
RL J. Biol. Chem. 280:40450-40464 (2005).
RN [5]; RE0052860.
RX PUBMED: 17283121.
RA Idogawa M., Masutani M., Shitashige M., Honda K., Tokino T., Shinomura Y., Imai K., Hirohashi S., Yamada T.
RT Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling.
RL Cancer Res. 67:911-918 (2007).
RN [6]; RE0063586.
RX PUBMED: 17823654.
RA Cheriyath V., Glaser K. B., Waring J. F., Baz R., Hussein M. A., Borden E. C.
RT G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells.
RL J. Clin. Invest. 117:3107-3117 (2007).
RN [7]; RE0014969.
RX PUBMED: 10813395.
RA Galande S., Kohwi-Shigematsu T.
RT Caught in the act: binding of Ku and PARP to MARs reveals novel aspects of their functional interaction
RL Crit. Rev. Eukaryot. Gene Expr. 10:63-72 (2000).
XX
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