AC T02918
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ID T02918
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DT 28.01.2000 (created); sur.
DT 10.06.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA TCF-4
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SY hTCF-4; human TCF-4; RP11-357H24.1; TCF-4; Tcf4; TCF7L2; transcription factor 7-like 2 (T-cell specific, HMG-box); transcription factor-7-like-2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004017 TCF7L2; HGNC: TCF7L2.
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CL C0015; HMG; 4.1.3.0.3.
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SF 2 splice variants TCF-4B T02917 and TCF-4E T02878 [2];
SF TCF-4 is an element of the Wingless-Wnt signaling cascade: the presence of a Wnt-signal inhibits the activity of glycogen synthase kinase-3beta (GSK3beta) which in turn does not phosphorylate beta-Catenin (in the cytoplasm);
SF thus beta-Catenin can be translocated to the nucleus where it binds to TCF-4;
SF in luciferase reporter constructs is was shown, that a maximum activation of transcriptional activity was achieved when TCF-4/ beta-catenin, Ets-1 and c-Jun/ c-Fos were expressed [8];
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FF TCF-4/ beta-Catenin-complex activates transcription of target genes [2] [4];
FF in the absence of beta-Catenin TCF acts as a negative regulator of transcription [6];
FF cell lines CD-NCM425 and CC07 express high level of TCF-4, after beta-catenin transfection the expression of the proto-oncogenes c-jun and fra-1 as of uPAR mRNA level increased 2 to 4 fold, whereas mRNA expression of the tight-junction-associated ZO-1 was lowered 2 to 10 fold [7];
FF TCF-4 can be regulated by the TAK1-NLK-MAPK-related pathway: TAK1 leads to autophosphorylation of NLK which then phosphorylates TCF-4 which in turn cannot bind to DNA [9];
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IN T00040 AR; human, Homo sapiens.
IN T08474 beta-catenin-isoform1; human, Homo sapiens.
IN T02872 beta-catenin; human, Homo sapiens.
IN T02984 beta-catenin; mouse, Mus musculus.
IN T14513 beta-catenin; Mammalia.
IN T18222 beta-catenin; dog, Canis familiaris (Canis canis).
IN T01308 CREBPA; human, Homo sapiens.
IN T05222 CtBP1; human, Homo sapiens.
IN T08110 CtBP1; mouse, Mus musculus.
IN T06039 CtBP2; mouse, Mus musculus.
IN T05686 Grg4; mouse, Mus musculus.
IN T16340 hbp1; human, Homo sapiens.
IN T02512 HNF-3alpha; human, Homo sapiens.
IN T08297 Kaiso; human, Homo sapiens.
IN T05110 Ku70; human, Homo sapiens.
IN T33294 Ku70; mouse, Mus musculus.
IN T05111 Ku80; human, Homo sapiens.
IN T14054 PARP; human, Homo sapiens.
IN T14055 PARP; human, Homo sapiens.
IN T18226 plakoglobin; human, Homo sapiens.
IN T04096 Smad3-isoform1; human, Homo sapiens.
IN T09304 Smad4; human, Homo sapiens.
IN T06029 Sox-17; mouse, Mus musculus.
IN T01838 Sox-4; mouse, Mus musculus.
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MX M01705 V$TCF4_01.
MX M00671 V$TCF4_Q5.
MX M02033 V$TCF4_Q5_01.
MX M04633 V$TCF4_Q5_02.
MX M04775 V$TCF7L2_06.
MX M07136 V$TCF7L2_07.
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BS R08563.
BS R70450.
BS R70451.
BS R70452.
BS R70453.
BS R08576.
BS R28268.
BS R28269.
BS R66176.
BS R32369.
BS R71702.
BS R08639.
BS R36825.
BS R57143.
BS R57144.
BS R31411.
BS R32961.
BS R08640.
BS R08641.
BS R08584.
BS R08585.
BS R27837.
BS R27839.
BS R70425.
BS R35489.
BS R66394.
BS R66395.
BS R66396.
BS R66398.
BS R66399.
BS R60260.
BS R35462.
BS R35465.
BS R08647.
BS R08648.
BS R67694.
BS R67695.
BS R67697.
BS R34775.
BS R72304.
BS R72308.
BS R30721.
BS R73009.
BS R73012.
BS R63612.
BS R68211.
BS R68213.
XX
DR TRANSPATH: MO000026882.
DR EMBL: Y11306;
DR UniProtKB: Q9NQB0;
XX
RN [1]; RE0006329.
RX PUBMED: 9065402.
RA Morin P. J., Sparks A. B., Korinek V., Barker N., Clevers H., Vogelstein B., Kinzler K. W.
RT Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
RL Science 275:1787-1790 (1997).
RN [2]; RE0014030.
RX PUBMED: 9065401.
RA Korinek V., Barker N., Morin P. J., van Wichen D., de Weger R., Kinzler K. W., Vogelstein B., Clevers H.
RT Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
RL Science 275:1784-1787 (1997).
RN [3]; RE0014033.
RX PUBMED: 10489374.
RA Roose J., Huls G., van Beest M., Moerer P., van der Horn K., Goldschmeding R., Logtenberg T., Clevers H.
RT Synergy Between Tumor Suppressor APC and the beta-Catenin-Tcf4 Target Tcf1
RL Science 285:1923-1926 (1999).
RN [4]; RE0014044.
RX PUBMED: 10080941.
RA Omer C. A., Miller P. J., Diehl R. E., Kral A. M.
RT Identification of Tcf4 residues involved in high-affinity beta-Catenin binding
RL Arch. Biochem. Biophys. 256:584-590 (1999).
RN [5]; RE0014046.
RX PUBMED: 9727977.
RA He T.-C., Sparks A. B., Rago C., Hermeking H., Zawel L., da Costa L. T., Morin P. J., Vogelstein B., Kinzler K. W.
RT Identification of c-MYC as a target of the APC pathway
RL Science 281:1509-1512 (1998).
RN [6]; RE0014047.
RX PUBMED: 10201372.
RA Tetsu O., McCormick F.
RT beta-Catenin regulates expression of cyclin D1 in colon carcinoma cells
RL Nature 398:422-426 (1999).
RN [7]; RE0014093.
RX PUBMED: 9990071.
RA Mann B., Gelos M., Siedow A., Hanski M. L., Gratchev A., Ilyas M., Bodmer W. F., Moyer M. P., Riecken E. O., Buhr H. J., Hanski C.
RT Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas
RL Proc. Natl. Acad. Sci. USA 96:1603-1608 (1999).
RN [8]; RE0014094.
RX PUBMED: 10514384.
RA Brabletz T., Jung A., Dag S., Hlubek F., Kirchner T.
RT beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer
RL Am. J. Pathol. 155:1033-1038 (1999).
RN [9]; RE0014386.
RX PUBMED: 10391247.
RA Ishitani T., Ninomiya-Tsuji J., Nagai S., Nishita M., Meneghini M., Barker N., Waterman M., Bowerman B., Clevers H., Shibuya H., Matsumoto K.
RT The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF
RL Nature 399:798-802 (1999).
RN [10]; RE0023725.
RX PUBMED: 12556497.
RA Ishitani T., Ninomiya-Tsuji J., Matsumoto K.
RT Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling.
RL Mol. Cell. Biol. 23:1379-1389 (2003).
RN [11]; RE0052383.
RX PUBMED: 16724116.
RA Valenta T., Lukas J., Doubravska L., Fafilek B., Korinek V.
RT HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies.
RL EMBO J. 25:2326-2337 (2006).
RN [12]; RE0052860.
RX PUBMED: 17283121.
RA Idogawa M., Masutani M., Shitashige M., Honda K., Tokino T., Shinomura Y., Imai K., Hirohashi S., Yamada T.
RT Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling.
RL Cancer Res. 67:911-918 (2007).
RN [13]; RE0062827.
RX PUBMED: 19443654.
RA Hong C. F., Chou Y. T., Lin Y. S., Wu C. W.
RT MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation.
RL J. Biol. Chem. 284:19613-19622 (2009).
RN [14]; RE0066628.
RX PUBMED: 11500377.
RA Sampson E. M., Haque Z. K., Ku M. C., Tevosian S. G., Albanese C., Pestell R. G., Paulson K. E., Yee A. S.
RT Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1.
RL EMBO J. 20:4500-4511 (2001).
RN [15]; RE0067112.
RX PUBMED: 17875931.
RA Sinner D., Kordich J. J., Spence J. R., Opoka R., Rankin S., Lin S. C., Jonatan D., Zorn A. M., Wells J. M.
RT Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells.
RL Mol. Cell. Biol. 27:7802-7815 (2007).
RN [16]; RE0071696.
RX PUBMED: 17318191.
RA Coluccia A. M., Vacca A., Dunach M., Mologni L., Redaelli S., Bustos V. H., Benati D., Pinna L. A., Gambacorti-Passerini C.
RT Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation.
RL EMBO J. 26:1456-1466 (2007).
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