AC T09304
XX
ID T09304
XX
DT 05.09.2006 (created); ili.
DT 18.04.2012 (updated); uat.
CO Copyright (C), QIAGEN.
XX
FA Smad4
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SY DPC-4; DPC4; JIP; MAD, mothers against decapentaplegic homolog 4 (Drosophila); MADH4; SMAD-4; SMAD4.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002389 SMAD4; HGNC: SMAD4.
XX
CL C0041; SMAD.
XX
SZ 552 AA; 60.4 kDa (cDNA) (calc.).
XX
SQ MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITA
SQ ITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFD
SQ LKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEGHSIQ
SQ TIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEGLLQI
SQ ASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGH
SQ YWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGD
SQ RFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGR
SQ APGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAP
SQ AISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVL
SQ HTMPIADPQPLD
XX
SC translated from EMBL #U44378
XX
FT 5 162 
MH1 domain [1].
FT 18 142 
PS51075; MH1.
FT 31 140 
SM00523; dwAneu5.
FT 33 137 
PF03165; MH1 domain.
FT 45 49 
defective Nuclear Localization Signal (NLS) [3].
FT 119 519 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 138 149 
NES (Nuclear Export Signal) [4].
FT 163 322 
Linker region [1].
FT 275 322 
SMAD-4 activation domain (SAD) [2].
FT 317 532 
PF03166; MH2 domain.
FT 321 530 SM00524; DWB.
FT 323 544 MH2 domain [1].
FT 323 552 PS51076; MH2.
XX
IN T02918 TCF-4; human, Homo sapiens.
XX
MX M07368 V$SMAD4_Q4.
MX M00733 V$SMAD4_Q6.
MX M01889 V$SMAD4_Q6_01.
MX M08897 V$SMAD_Q4.
MX M00792 V$SMAD_Q6.
MX M00974 V$SMAD_Q6_01.
XX
BS R13582.
BS R23280.
BS R23281.
BS R23282.
BS R23283.
XX
DR TRANSPATH: MO000086426.
DR EMBL: U44378; HS443781.
DR UniProtKB: Q13485;
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RN [1]; RE0015899.
RX PUBMED: 9502722.
RA Hudson J. B., Podos S. D., Keith K., Simpson S. L., Ferguson E. L.
RT The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4.
RL Development 125:1407-1420 (1998).
RN [2]; RE0016086.
RX PUBMED: 9153220.
RA de Caestecker M. P., Hemmati P., Larisch-Bloch S., Ajmera R., Roberts A. B., Lechleider R. J.
RT Characterization of functional domains within Smad4/DPC4.
RL J. Biol. Chem. 272:13690-13696 (1997).
RN [3]; RE0016203.
RX PUBMED: 10884415.
RA Xiao Z., Liu X., Henis Y. I., Lodish H. F.
RT A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation.
RL Proc. Natl. Acad. Sci. USA 97:7853-7858 (2000).
RN [4]; RE0016210.
RX PUBMED: 11265759.
RA Watanabe M., Masuyama N., Fukuda M., Nishida E.
RT Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal.
RL EMBO J. 1:176-182 (2000).
XX
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