AC T06029
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ID T06029
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DT 01.07.2004 (created); elf.
DT 11.01.2016 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA Sox-17
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SY Sox; Sox17; SRY-box containing gene 17.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009662 Sox17.
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CL C0015; HMG; 4.1.1.6.2.
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SF Isolation of two different mRNA isoforms (form Sox-17 and t-Sox-17 (truncated Sox-17)), form Sox-17 encodes an Sry-related protein of 419 amino-acids containing a single HMG box near the NH2 terminus, while from t-Sox-17 shows a unique mRNA isoform of the Sox-17 gene with a partial deletion of the HMG box region [1];
SF the isoform Sox-17 (intact HMG box region) was expressed in spermatogonia [1];
SF Sox-17 gene is the first Sox family gene that is found to produce multiple isoforms by alternative splicing with different expression profiles and DNA-binding activities [1];
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CP adult lung, adult testis [1]; testis on day 14 and 28 postpartum [1]; spermatogenic cell lineage [1] [1].
CN cerebellum, heart, liver, spleen, kidney, ovary [1]; immature testis on day 7 postpartum [1]; Sertoli cells, Leydig cells [1] [1].
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FF Sox-17 protein is a transcriptional activator through the AACAAT motif, while t-Sox-17 is a truncated protein that contains the activation domain but lacks both the DNA-binding domain and the nuclear localization signal [1];
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IN T08474 beta-catenin-isoform1; human, Homo sapiens.
IN T02872 beta-catenin; human, Homo sapiens.
IN T09576 LEF-1; mouse, Mus musculus.
IN T02857 TCF-3; clawed frog, Xenopus laevis.
IN T02918 TCF-4; human, Homo sapiens.
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MX M01016 V$SOX17_01.
MX M02904 V$SOX17_04.
MX M02191 V$SOX17_05.
MX M03803 V$SOX17_Q2.
MX M08899 V$SOX_Q4.
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BS R67642.
BS R39808.
BS R39811.
BS R39812.
BS R39814.
BS R39815.
BS R22462.
BS R22463.
BS R69787.
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DR TRANSPATH: MO000042710.
DR TRANSCOMPEL: C00510.
DR TRANSCOMPEL: C00576.
DR UniProtKB: Q61473; SX17_MOUSE.
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RN [1]; RE0024438.
RX PUBMED: 8636240.
RA Kanai Y., Kanai-Azuma M., Noce T., Saido T. C., Shiroishi T., Hayashi Y., Yazaki K.
RT Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis.
RL J. Cell Biol. 133:667-681 (1996).
RN [2]; RE0067112.
RX PUBMED: 17875931.
RA Sinner D., Kordich J. J., Spence J. R., Opoka R., Rankin S., Lin S. C., Jonatan D., Zorn A. M., Wells J. M.
RT Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells.
RL Mol. Cell. Biol. 27:7802-7815 (2007).
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