AC T02857
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ID T02857
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DT 12.01.2000 (created); sur.
DT 17.06.2010 (updated); jag.
CO Copyright (C), QIAGEN.
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FA TCF-3
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SY TCF-3; XTCF-3.
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OS clawed frog, Xenopus laevis
OC eukaryota; animalia; metazoa; chordata; vertebrata; amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae
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HO TCF-1; LEF-1 [1].
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CL C0015; HMG; 4.1.3.0.2.
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SF with regard to high similarity to mammalian TCF-3 the Xenopus genes were termed XTCF-3 [1];
SF member of the wingless/ Wnt pathway;
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CP maternal; mRNA: in unfertilized eggs until after midblastula transition; in situ: blastocoel roof in 7 stage embryos and in the marginal zone; nucleus.
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FF transcriptional activation of XTCF-3 is dependent on complex formation between XTCF-3 and beta-Catenin;
FF XTCF-1 binds to TCF/LEF DNA binding motif;
FF N terminus of XTCF-1 associates with the Armadillo repeat region of beta-Catenin;
FF XTCF-3 translocates beta-Catenin to the nucleus;
FF for embryonic axis specification see ref. [1];
FF TCF-3 interacts with members of the Groucho family of transcriptional repressors: XGrg-4 (Xenopus Groucho homologue) inhibits whereas the naturally truncated XGrg-5 enhances transcription;
FF expression of target genes seems to be regulated by balance between Armadillo and Groucho;
FF removal of the Grg-interacting domain abrogated interaction with Gro homologues and nuclear translocation oth the complexes [2];
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IN T02872 beta-catenin; human, Homo sapiens.
IN T03026 beta-catenin; clawed frog, Xenopus laevis.
IN T03243 CtBP; clawed frog, Xenopus laevis.
IN T03225 Grg-4; clawed frog, Xenopus laevis.
IN T03224 Grg-5; clawed frog, Xenopus laevis.
IN T06029 Sox-17; mouse, Mus musculus.
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MX M00805 V$LEF1_Q2.
MX M01594 V$TCF3_01.
MX M03858 V$TCF3_Q6.
MX M08901 V$TCF3_Q6_01.
MX M08902 V$TCF7RELATED_Q4.
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BS R08617.
BS R08594.
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DR TRANSPATH: MO000026826.
DR UniProtKB: P70062;
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RN [1]; RE0013000.
RX PUBMED: 8756721.
RA Molenaar M., van de Wetering M., Oosterwegel M., Peterson-Maduro J., Godsave S., Korinek V., Roose J., Destree O., Clevers H.
RT XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos
RL Cell 86:391-399 (1996).
RN [2]; RE0014087.
RX PUBMED: 9783587.
RA Roose J., Molenaar M., Peterson J., Hurenkamp J., Brantjes H., Moerer P., van de Wetering M., Destree O., Clevers H.
RT The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
RL Nature 395:608-612 (1998).
RN [3]; RE0014088.
RX PUBMED: 9488439.
RA Korinek V., Barker N., Willert K., Molenaar M., Roose J., Wagenaar G., Markman M., Lamers W., Destree O., Clevers H.
RT Two members of the Tcf family implicated in Wnt/beta-Catenin signaling during embryogenesis in the mouse
RL Mol. Cell. Biol. 18:1248-1256 (1998).
RN [4]; RE0014221.
RX PUBMED: 10375506.
RA Brannon M., Brown J. D., Bates R., Kimelman D., Moon R. T.
RT XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development
RL Development 126:3159-3170 (1999).
RN [5]; RE0014397.
RX PUBMED: 9576934.
RA Fan M. J., Gruening W., Walz G., Sokol S. Y.
RT Wnt signaling and transcriptional control of Siamois in Xenopus embryos
RL Proc. Natl. Acad. Sci. USA 95:5626-5631 (1998).
RN [6]; RE0067112.
RX PUBMED: 17875931.
RA Sinner D., Kordich J. J., Spence J. R., Opoka R., Rankin S., Lin S. C., Jonatan D., Zorn A. M., Wells J. M.
RT Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells.
RL Mol. Cell. Biol. 27:7802-7815 (2007).
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