AC T03225
XX
ID T03225
XX
DT 27.03.2000 (created); sur.
DT 05.01.2009 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA Grg-4
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SY Groucho-related gene 4.
XX
OS clawed frog, Xenopus laevis
OC eukaryota; animalia; metazoa; chordata; vertebrata; amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae
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SZ 766 AA; 83.0 kDa (cDNA) (calc.).
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SQ MYPQTRHPAAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH
SQ YVMYYEMSYGLDIEMHKQAEIVKRLNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELN
SQ AIIGQQQLQAQHLSHAHGLPVPLTPHPSGLQPPAIPSIGSSAGLLALSSALGGQSHLPIK
SQ DEKKHHDSDHQRDRDSIKSSSVSPSASFRAAEKHRNSTDYSSESKKQKTEEKDIAARYSS
SQ DGEKSDDNLVRDVSNEDPSSPRGSPAHSPRENGLDKPRLLKKDAPISPASIASSSSTPSS
SQ KSKEHSHNEKSTTPVSKSNTPTPRTDAPTPGSNSSGLRPVPGKPPGVDPLTGLRTPMAVP
SQ VPYPTPFGIVPHAGMNGDLTSPGPAYASLHSISPQMSAAAAAAAAAAAYGRSPVVGFDPH
SQ HHMRVPGIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQINTLNHG
SQ EVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCRLLPDGRT
SQ LIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLH
SQ NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLG
SQ YCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNA
SQ WRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY
XX
SC translated from EMBL #XLA224945
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FT 1 131 
Q domain [1].
FT 1 136 
PF03920; Groucho/TLE N-terminal Q-rich domain.
FT 30 693 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 132 198 
GP domain [1].
FT 199 268 
CcN domain [1].
FT 269 416 
SP domain [1].
FT 418 766 
C terminal WD40 domain [1].
FT 470 507 
SM00320; WD40_4.
FT 472 507 
PF00400; WD40.
FT 476 649 
PS50294; WD_REPEATS_REGION.
FT 513 554 SM00320; WD40_4.
FT 517 554 PF00400; WD40.
FT 559 598 SM00320; WD40_4.
FT 561 598 PF00400; WD40.
FT 566 607 PS50082; WD_REPEATS_2.
FT 601 640 SM00320; WD40_4.
FT 603 640 PF00400; WD40.
FT 608 649 PS50082; WD_REPEATS_2.
FT 643 681 SM00320; WD40_4.
FT 683 722 SM00320; WD40_4.
FT 685 722 PF00400; WD40.
FT 690 721 PS50082; WD_REPEATS_2.
FT 690 766 PS50294; WD_REPEATS_REGION.
FT 723 763 SM00320; WD40_4.
FT 727 763 PF00400; WD40.
XX
SF Groucho-related gene 4;
SF groucho T02451;
SF injection of Grg-4 can lead to a strong reduction of transcription of target genes (like Siamois or Xnr-3) whereas injection of dominant-positive XTCF-3 enhances transcription [1];
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CP maternally expressed [2]; gastrula: mRNA in animal and vegetal region [2] [2].
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FF represses both Armadillo-TCF-3 driven transcriptional activation of a TCF reporter and Arm-TCF-3 mediated axis duplication [2];
FF represses specifically the activation of transcription by Armadillo-XTCF-3 [1];
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IN T04106 HDAC1; human, Homo sapiens.
IN T01979 TCF-1E; human, Homo sapiens.
IN T02857 TCF-3; clawed frog, Xenopus laevis.
XX
DR TRANSPATH: MO000027172.
DR EMBL: AJ224945;
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RN [1]; RE0014087.
RX PUBMED: 9783587.
RA Roose J., Molenaar M., Peterson J., Hurenkamp J., Brantjes H., Moerer P., van de Wetering M., Destree O., Clevers H.
RT The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
RL Nature 395:608-612 (1998).
RN [2]; RE0014332.
RX PUBMED: 10704855.
RA Molenaar M., Brian E., Roose J., Clevers H., Destree O.
RT Differential expression of the Groucho-related genes 4 and 5 during early development of Xenopus laevis
RL Mech. Dev. 91:311-315 (2000).
XX
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