AC T03224
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ID T03224
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DT 27.03.2000 (created); sur.
DT 22.01.2004 (updated); spi.
CO Copyright (C), QIAGEN.
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FA Grg-5
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SY AES; amino enhancer split (AES); Groucho-related gene 5; XAES.
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OS clawed frog, Xenopus laevis
OC eukaryota; animalia; metazoa; chordata; vertebrata; amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae
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SZ 197 AA; 22.0 kDa (cDNA) (calc.).
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SQ MMFPQSSSRHSGSSHMPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLAGEKSEMQ
SQ RHYVMYYEMSYGLNIEMHKQAEIVKRLHGICAQVLPYLSQEHQQQVLGAIERAKQVTAPE
SQ LNSIIRQLQVHQLSQLQALALPLTSLPMGLQAPSLPISASSGLLSLSALGSQGHLPKEDK
SQ NGHEGDRRPDDDGDKSD
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SC translated from EMBL #U18776
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FT 1 131 
Q domain [1].
FT 2 136 
PF03920; Groucho/TLE N-terminal Q-rich domain.
FT 132 197 
GP domain [1].
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SF Groucho-related gene 5;
SF naturally truncated Groucho-family member [1];
SF groucho T02451;
SF Grg-5 lacks carboxy-terminal amino acids 198 to 766 of Grg-4 T03225 [1];
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CP maternally expressed [2]; gastrula: mRNA in animal and vegetal region [2] [2].
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FF interacts with Xenopus member of the TCF family of transcription factors TCF-3;
FF Grg-5 derepresses a TCF reporter and potentiates Arm-TCF-3 mediated secondary axis duplication [2];
FF Grg-5 which lacks the C terminal WD40 domain enhances transcriptional activity of Armadillo-TCF-3 complexes [1];
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IN T01979 TCF-1E; human, Homo sapiens.
IN T02857 TCF-3; clawed frog, Xenopus laevis.
IN T02922 TCF-A; fruit fly, Drosophila melanogaster.
IN T02924 TCF-B; fruit fly, Drosophila melanogaster.
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DR TRANSPATH: MO000027171.
DR EMBL: U18776;
DR UniProtKB: O42470;
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RN [1]; RE0014087.
RX PUBMED: 9783587.
RA Roose J., Molenaar M., Peterson J., Hurenkamp J., Brantjes H., Moerer P., van de Wetering M., Destree O., Clevers H.
RT The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
RL Nature 395:608-612 (1998).
RN [2]; RE0014332.
RX PUBMED: 10704855.
RA Molenaar M., Brian E., Roose J., Clevers H., Destree O.
RT Differential expression of the Groucho-related genes 4 and 5 during early development of Xenopus laevis
RL Mech. Dev. 91:311-315 (2000).
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