AC T08474
XX
ID T08474
XX
DT 24.01.2006 (created); ran.
DT 15.05.2014 (updated); sup.
CO Copyright (C), QIAGEN.
XX
FA beta-catenin-isoform1
XX
SY beta-catenin; CTNNB; CTNNB1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G001701 CTNNB1; HGNC: CTNNB1.
XX
SZ 781 AA; 85.5 kDa (cDNA) (calc.).
XX
SQ MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTS
SQ QVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPT
SQ NVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSK
SQ KEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPAL
SQ VKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDC
SQ LQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEA
SQ GGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCA
SQ AGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEM
SQ AQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLL
SQ VRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFV
SQ QLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLF
SQ RMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFH
SQ SGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTD
SQ L
XX
SC translated from EMBL #X87838
XX
FT 1 131 
N terminus [15].
FT 29 45 
GSK3-beta phosphorylation domain (GSK) [14].
FT 141 180 
SM00185; arm_5.
FT 146 182 
PF02985; HEAT repeat.
FT 151 191 
PS50176; ARM_REPEAT.
FT 181 223 
SM00185; arm_5.
FT 187 284 
harbours a binding site for pontin52 [16].
FT 193 236 
PS50176; ARM_REPEAT.
FT 224 264 
PF00514; Armadillo/beta-catenin-like repeat.
FT 224 264 
SM00185; arm_5.
FT 235 277 PS50176; ARM_REPEAT.
FT 265 306 SM00185; arm_5.
FT 277 319 PS50176; ARM_REPEAT.
FT 308 349 SM00185; arm_5.
FT 319 362 PS50176; ARM_REPEAT.
FT 329 624 PF00478; IMP dehydrogenase / GMP reductase domain.
FT 350 390 PF00514; Armadillo/beta-catenin-like repeat.
FT 350 390 SM00185; arm_5.
FT 391 429 PF00514; Armadillo/beta-catenin-like repeat.
FT 392 429 SM00185; arm_5.
FT 400 442 PS50176; ARM_REPEAT.
FT 430 473 SM00185; arm_5.
FT 431 473 PF00514; Armadillo/beta-catenin-like repeat.
FT 442 484 PS50176; ARM_REPEAT.
FT 478 519 SM00185; arm_5.
FT 489 532 PS50176; ARM_REPEAT.
FT 520 582 SM00185; arm_5.
FT 583 623 PF00514; Armadillo/beta-catenin-like repeat.
FT 583 623 SM00185; arm_5.
FT 594 636 PS50176; ARM_REPEAT.
FT 624 664 PF00514; Armadillo/beta-catenin-like repeat.
FT 624 664 SM00185; arm_5.
FT 696 781 C-terminus [15].
XX
IN T06029 Sox-17; mouse, Mus musculus.
IN T06030 Sox-17; human, Homo sapiens.
IN T01838 Sox-4; mouse, Mus musculus.
IN T00794 TBP; human, Homo sapiens.
IN T02918 TCF-4; human, Homo sapiens.
XX
DR TRANSPATH: MO000058538.
DR EMBL: BC058926;
DR UniProtKB: P35222-1;
XX
RN [1]; RE0035178.
RX PUBMED: 11463391.
RA Yu J., Zhang L., Hwang P. M., Kinzler K. W., Vogelstein B.
RT PUMA induces the rapid apoptosis of colorectal cancer cells.
RL Mol. Cell 7:673-682 (2001).
RN [2]; RE0052419.
RX PUBMED: 17468517.
RA Saegusa M., Hashimura M., Kuwata T., Hamano M., Wani Y., Okayasu I.
RT A functional role of Cdx2 in beta-catenin signaling during transdifferentiation in endometrial carcinomas.
RL Carcinogenesis 28:1885-1892 (2007).
RN [3]; RE0053289.
RX PUBMED: 9739078.
RA Kowalczyk A. P., Navarro P., Dejana E., Bornslaeger E. A., Green K. J., Kopp D. S., Borgwardt J. E.
RT VE-cadherin and desmoplakin are assembled into dermal microvascular endothelial intercellular junctions: a pivotal role for plakoglobin in the recruitment of desmoplakin to intercellular junctions.
RL J. Cell Sci. 111:3045-3057 (1998).
RN [4]; RE0064296.
RX PUBMED: 15853773.
RA Ghiselli G., Agrawal A.
RT The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway.
RL Biochem. J. 390:493-499 (2005).
RN [5]; RE0066740.
RX PUBMED: 18667832.
RA Ress A., Moelling K.
RT The PDZ protein erbin modulates beta-catenin-dependent transcription.
RL Eur. Surg. Res. 41:284-289 (2008).
RN [6]; RE0067112.
RX PUBMED: 17875931.
RA Sinner D., Kordich J. J., Spence J. R., Opoka R., Rankin S., Lin S. C., Jonatan D., Zorn A. M., Wells J. M.
RT Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells.
RL Mol. Cell. Biol. 27:7802-7815 (2007).
RN [7]; RE0068708.
RX PUBMED: 20307497.
RA Kim E. A., Kim J. E., Sung K. S., Choi D. W., Lee B. J., Choi C. Y.
RT Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation.
RL Biochem. Biophys. Res. Commun. 394:966-971 (2010).
RN [8]; RE0071192.
RX PUBMED: 15371335.
RA Brembeck F. H., Schwarz-Romond T., Bakkers J., Wilhelm S., Hammerschmidt M., Birchmeier W.
RT Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.
RL Genes Dev. 18:2225-2230 (2004).
RN [9]; RE0071270.
RX PUBMED: 9110993.
RA Obama H., Ozawa M.
RT Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin (gamma-catenin).
RL J. Biol. Chem. 272:11017-11020 (1997).
RN [10]; RE0071364.
RX PUBMED: 15254236.
RA Hogan C., Serpente N., Cogram P., Hosking C. R., Bialucha C. U., Feller S. M., Braga V. M., Birchmeier W., Fujita Y.
RT Rap1 regulates the formation of E-cadherin-based cell-cell contacts.
RL Mol. Cell. Biol. 24:6690-6700 (2004).
RN [11]; RE0071593.
RX PUBMED: 11716761.
RA Woodfield R. J., Hodgkin M. N., Akhtar N., Morse M. A., Fuller K. J., Saqib K., Thompson N. T., Wakelam M. J.
RT The p85 subunit of phosphoinositide 3-kinase is associated with beta-catenin in the cadherin-based adhesion complex.
RL Biochem. J. 360:335-344 (2001).
RN [12]; RE0071618.
RX PUBMED: 19001871.
RA Arai T., Haze K., Iimura-Morita Y., Machida T., Iida M., Tanaka K., Komatani H.
RT Identification of beta-catenin as a novel substrate of Polo-like kinase 1.
RL Cell Cycle 7:3556-3563 (2008).
RN [13]; RE0072503.
RX PUBMED: 20840866.
RA Simoneau M., Coulombe G., Vandal G., Vezina A., Rivard N.
RT SHP-1 inhibits beta-catenin function by inducing its degradation and interfering with its association with TATA-binding protein.
RL Cell. Signal. 23:269-279 (2011).
RN [14]; RE0014117.
RX PUBMED: 10580987.
RA Morin P. J.
RT Beta-catenin signaling and cancer
RL BioEssays 21:1021-1030 (1999).
RN [15]; RE0014125.
RX PUBMED: 7806582.
RA Hulsken J., Birchmeier W., Behrens J.
RT E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
RL J. Cell Biol. 127:2061-2069 (1994).
RN [16]; RE0014262.
RX PUBMED: 9843967.
RA Bauer A., Huber O., Kemler R.
RT Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein
RL Proc. Natl. Acad. Sci. USA 95:14787-14792 (1998).
XX
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